| scholarly article | Q13442814 |
| P50 | author | Colleen A Flanagan | Q57191799 |
| P2093 | author name string | Ashmeetha Manilall | |
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| Role of aspartate7.32(302) of the human gonadotropin-releasing hormone receptor in stabilizing a high-affinity ligand conformation | Q43809153 | ||
| Rescue of hypogonadotropic hypogonadism-causing and manufactured GnRH receptor mutants by a specific protein-folding template: misrouted proteins as a novel disease etiology and therapeutic target | Q44055174 | ||
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| A case of complete hypogonadotropic hypogonadism with a mutation in the gonadotropin-releasing hormone receptor gene. | Q44303639 | ||
| Two common naturally occurring mutations in the human gonadotropin-releasing hormone (GnRH) receptor have differential effects on gonadotropin gene expression and on GnRH-mediated signal transduction | Q44306852 | ||
| Four naturally occurring mutations in the human GnRH receptor affect ligand binding and receptor function | Q44532281 | ||
| Structural Basis for Apelin Control of the Human Apelin Receptor | Q46135586 | ||
| Identification of Tyr(290(6.58)) of the human gonadotropin-releasing hormone (GnRH) receptor as a contact residue for both GnRH I and GnRH II: importance for high-affinity binding and receptor activation | Q46389997 | ||
| Antagonist and agonist binding models of the human gonadotropin-releasing hormone receptor | Q46541425 | ||
| Overlapping, nonidentical binding sites of different classes of nonpeptide antagonists for the human gonadotropin-releasing hormone receptor | Q46637623 | ||
| Activation mechanism of endothelin ETB receptor by endothelin-1 | Q27727996 | ||
| UCSF Chimera--a visualization system for exploratory research and analysis | Q27860666 | ||
| GPCRdb: the G protein-coupled receptor database - an introduction | Q28077608 | ||
| Generic GPCR residue numbers - aligning topology maps while minding the gaps | Q28087587 | ||
| Gonadotropin-releasing hormone receptors | Q28256257 | ||
| Congenital hypogonadotropic hypogonadism due to GnRH receptor mutations in three brothers reveal sites affecting conformation and coupling | Q28484094 | ||
| Structure-Based Sequence Alignment of the Transmembrane Domains of All Human GPCRs: Phylogenetic, Structural and Functional Implications | Q28551072 | ||
| Structural biology. Crystal structure of the chemokine receptor CXCR4 in complex with a viral chemokine | Q28910426 | ||
| Residues within transmembrane helices 2 and 5 of the human gonadotropin-releasing hormone receptor contribute to agonist and antagonist binding | Q31406998 | ||
| Signaling responses to pulsatile gonadotropin-releasing hormone in LbetaT2 gonadotrope cells | Q33924442 | ||
| Allosteric sodium in class A GPCR signaling | Q33931569 | ||
| GnRH and GnRH receptors in metazoa: a historical, comparative, and evolutive perspective. | Q34002878 | ||
| GnRH signaling, the gonadotrope and endocrine control of fertility | Q34073929 | ||
| Role of gonadotropin-releasing hormone receptor mutations in patients with a wide spectrum of pubertal delay. | Q34112165 | ||
| Action of molecular switches in GPCRs--theoretical and experimental studies. | Q34251407 | ||
| Structural mimicry in G protein-coupled receptors: implications of the high-resolution structure of rhodopsin for structure-function analysis of rhodopsin-like receptors | Q34283954 | ||
| Molecular signatures of G-protein-coupled receptors | Q34327700 | ||
| Highly conserved tyrosine stabilizes the active state of rhodopsin | Q34359302 | ||
| Restoration of testis function in hypogonadotropic hypogonadal mice harboring a misfolded GnRHR mutant by pharmacoperone drug therapy | Q34390847 | ||
| Structural insights into µ-opioid receptor activation | Q34488374 | ||
| Dynamic evolution of the GnRH receptor gene family in vertebrates. | Q34515371 | ||
| Mutations in the human gonadotropin-releasing hormone receptor: insights into receptor biology and function | Q34665597 | ||
| A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor | Q34708055 | ||
| A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model | Q34726898 | ||
| Suppression of gonadotropins and estradiol in premenopausal women by oral administration of the nonpeptide gonadotropin-releasing hormone antagonist elagolix | Q34888651 | ||
| Relevance of rhodopsin studies for GPCR activation. | Q34991031 | ||
| Sequence analyses of G-protein-coupled receptors: similarities to rhodopsin | Q35081967 | ||
| Salt bridges overlapping the gonadotropin-releasing hormone receptor agonist binding site reveal a coincidence detector for G protein-coupled receptor activation | Q35122859 | ||
| Structural biology. Structural basis for chemokine recognition and activation of a viral G protein-coupled receptor | Q35652476 | ||
| Protein origami: therapeutic rescue of misfolded gene products | Q35679450 | ||
| Structural prerequisites for G-protein activation by the neurotensin receptor | Q35891222 | ||
| G proteins and autocrine signaling differentially regulate gonadotropin subunit expression in pituitary gonadotrope | Q36033325 | ||
| The High-Resolution Structure of Activated Opsin Reveals a Conserved Solvent Network in the Transmembrane Region Essential for Activation | Q36348894 | ||
| The dynamic process of β(2)-adrenergic receptor activation | Q36651876 | ||
| The role of internal water molecules in the structure and function of the rhodopsin family of G protein-coupled receptors | Q36685974 | ||
| Molecular mechanism of action of pharmacoperone rescue of misrouted GPCR mutants: the GnRH receptor | Q37106881 | ||
| Conserved waters mediate structural and functional activation of family A (rhodopsin-like) G protein-coupled receptors | Q37208884 | ||
| Diverse activation pathways in class A GPCRs converge near the G-protein-coupling region | Q37225841 | ||
| Signaling by G-protein-coupled receptor (GPCR): studies on the GnRH receptor | Q37245459 | ||
| Molecular mechanisms of gonadotropin-releasing hormone signaling: integrating cyclic nucleotides into the network. | Q37326059 | ||
| Structure and dynamics of a constitutively active neurotensin receptor | Q37479887 | ||
| Non-syndromic congenital hypogonadotropic hypogonadism: clinical presentation and genotype-phenotype relationships | Q37704009 | ||
| Structural insights into agonist-induced activation of G-protein-coupled receptors | Q37896916 | ||
| Conserved activation pathways in G-protein-coupled receptors | Q37995724 | ||
| Agonist-bound structures of G protein-coupled receptors | Q38000431 | ||
| Interactions of the GnRH receptor with heterotrimeric G proteins | Q38064157 | ||
| Unifying family A GPCR theories of activation | Q38190328 | ||
| Structure of Class B GPCRs: new horizons for drug discovery | Q38195892 | ||
| GnRH receptors and peptides: skating backward | Q38238340 | ||
| Impact of aromatic residues within transmembrane helix 6 of the human gonadotropin-releasing hormone receptor upon agonist and antagonist binding | Q38292817 | ||
| Asn102 of the gonadotropin-releasing hormone receptor is a critical determinant of potency for agonists containing C-terminal glycinamide | Q38356237 | ||
| Local duplication of gonadotropin-releasing hormone (GnRH) receptor before two rounds of whole genome duplication and origin of the mammalian GnRH receptor | Q38441646 | ||
| Role of the transmembrane domain 4/extracellular loop 2 junction of the human gonadotropin-releasing hormone receptor in ligand binding and receptor conformational selection. | Q38621958 | ||
| What Do Structures Tell Us About Chemokine Receptor Function and Antagonism? | Q38680670 | ||
| Theoretical Aspects of GPCR-Ligand Complex Pharmacology | Q38726263 | ||
| Hitchhiking on the heptahelical highway: structure and function of 7TM receptor complexes. | Q38812016 | ||
| Mechanistic insights into GPCR-G protein interactions | Q39015587 | ||
| Discovery of LHRH and development of LHRH analogs for prostate cancer treatment | Q39267156 | ||
| A single amino acid substitution in transmembrane helix VI results in overexpression of the human GnRH receptor | Q39286132 | ||
| Active state structures of G protein-coupled receptors highlight the similarities and differences in the G protein and arrestin coupling interfaces | Q39291009 | ||
| Comparative aspects of GnRH-Stimulated signal transduction in the vertebrate pituitary - Contributions from teleost model systems | Q39354904 | ||
| Structure of the adenosine A(2A) receptor bound to an engineered G protein. | Q39555371 | ||
| Allosteric coupling from G protein to the agonist-binding pocket in GPCRs | Q39643038 | ||
| Ancient origins of metazoan gonadotropin-releasing hormone and their receptors revealed by phylogenomic analyses | Q39673127 | ||
| A crucial role for Galphaq/11, but not Galphai/o or Galphas, in gonadotropin-releasing hormone receptor-mediated cell growth inhibition | Q39938380 | ||
| Activation of the beta 2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6. | Q40803165 | ||
| Dependence of agonist activation on an aromatic moiety in the DPLIY motif of the gonadotropin-releasing hormone receptor | Q41178889 | ||
| Molecular mechanisms of ligand interaction with the gonadotropin-releasing hormone receptor | Q41430675 | ||
| Glutamate 301 of the mouse gonadotropin-releasing hormone receptor confers specificity for arginine 8 of mammalian gonadotropin-releasing hormone. | Q41442800 | ||
| Histidine(7.36(305)) in the conserved peptide receptor activation domain of the gonadotropin releasing hormone receptor couples peptide binding and receptor activation | Q41547722 | ||
| Gonadotropin-releasing hormone receptors in human pituitary: ligand structural requirements, molecular size, and cationic effects | Q41935725 | ||
| Structural biology. Viral chemokine mimicry | Q42156841 | ||
| P275 | copyright license | Creative Commons Attribution 4.0 International | Q20007257 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P304 | page(s) | 274 | |
| P577 | publication date | 2017-10-24 | |
| P1433 | published in | Frontiers in Endocrinology | Q27723680 |
| P1476 | title | Gonadotropin-Releasing Hormone (GnRH) Receptor Structure and GnRH Binding | |
| P478 | volume | 8 |
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| Q55716781 | Evolutionary Viewpoint on GnRH (gonadotropin-releasing hormone) in Chordata - Amino Acid and Nucleic Acid Sequences. |
| Q92367684 | Optimal treatment for spermatogenesis in male patients with hypogonadotropic hypogonadism |
| Q100523483 | Special features of neuroendocrine interactions between stress and reproduction in teleosts |
| Q100750121 | Structure of the human gonadotropin-releasing hormone receptor GnRH1R reveals an unusual ligand binding mode |
| Q90151835 | The adipokinetic hormones and their cognate receptor from the desert locust, Schistocerca gregaria: solution structure of endogenous peptides and models of their binding to the receptor |
| Q89595669 | The gonadotropin-releasing hormones: Lessons from fish |
| Q55452158 | The role of mitogen-activated protein kinase-extracellular receptor kinase pathway in female fertility outcomes: a focus on pituitary gonadotropins regulation. |
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