Evolution of constrained gonadotropin-releasing hormone ligand conformation and receptor selectivity

scientific article published on 12 September 2005

Evolution of constrained gonadotropin-releasing hormone ligand conformation and receptor selectivity is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M503086200
P698PubMed publication ID16157590
P5875ResearchGate publication ID7604484

P50authorRobert P. MillarQ38304462
Adam J PawsonQ42660485
Takehiro KusakabeQ48218252
Zhi-Liang LuQ56494703
P2093author name stringMotoyuki Tsuda
Robin Sellar
Perdita E Barran
Kevin Morgan
Michael T Bowers
Roger W Roeske
P2860cites workGonadotropin-releasing hormone receptorsQ28256257
A chicken gonadotropin-releasing hormone receptor that confers agonist activity to mammalian antagonists. Identification of D-Lys(6) in the ligand and extracellular loop two of the receptor as determinantsQ31668486
Generalized born models of macromolecular solvation effectsQ34059768
Follistatins: more than follicle-stimulating hormone suppressing proteinsQ34363270
Force fields for protein simulationsQ35590728
Two new forms of gonadotropin-releasing hormone in a protochordate and the evolutionary implicationsQ36820891
Sequence of two gonadotropin releasing hormones from tunicate suggest an important role of conformation in receptor activationQ36880281
Gonadotropin-releasing hormone analog design. Structure-function studies toward the development of agonists and antagonists: rationale and perspectiveQ38160875
Asn102 of the gonadotropin-releasing hormone receptor is a critical determinant of potency for agonists containing C-terminal glycinamideQ38356237
Molecular mechanisms of ligand interaction with the gonadotropin-releasing hormone receptorQ41430675
Gonadotropin-releasing hormone in mulberry cells of Saccoglossus and Ptychodera (Hemichordata: Enteropneusta).Q42469674
Two gonadotropin-releasing hormone receptors in the African catfish: no differences in ligand selectivity, but differences in tissue distributionQ44226015
Differential G protein coupling preference of mammalian and nonmammalian gonadotropin-releasing hormone receptorsQ44532291
Multiple determinants for rapid agonist-induced internalization of a nonmammalian gonadotropin-releasing hormone receptor: a putative palmitoylation site and threonine doublet within the carboxyl-terminal tail Are criticalQ44559291
Tunicate gonadotropin-releasing hormone (GnRH) peptides selectively activate Ciona intestinalis GnRH receptors and the green monkey type II GnRH receptor.Q46551534
Six novel gonadotropin-releasing hormones are encoded as triplets on each of two genes in the protochordate, Ciona intestinalis.Q47971351
Structure, expression, and cluster organization of genes encoding gonadotropin-releasing hormone receptors found in the neural complex of the ascidian Ciona intestinalisQ48218167
Synthetic analogs of the hypothalamic luteinizing hormone releasing factor with increased agonist or antatonist propertiesQ48619634
Isolation and characterization of a GnRH-like peptide from Octopus vulgarisQ48667037
Mutations remote from the human gonadotropin-releasing hormone (GnRH) receptor-binding sites specifically increase binding affinity for GnRH II but not GnRH I: evidence for ligand-selective, receptor-active conformations.Q52564801
Structural investigation of naturally occurring peptides by electron capture dissociation and AMBER force field modellingQ58166304
Conformational Constraint of Mammalian, Chicken, and Salmon GnRHs, But Not GnRH II, Enhances Binding at Mammalian and Nonmammalian Receptors: Evidence for Preconfiguration of GnRH IIQ58853763
A Locus of the Gonadotropin-releasing Hormone Receptor That Differentiates Agonist and Antagonist Binding SitesQ58853853
P433issue46
P407language of work or nameEnglishQ1860
P304page(s)38569-38575
P577publication date2005-09-12
P1433published inJournal of Biological ChemistryQ867727
P1476titleEvolution of constrained gonadotropin-releasing hormone ligand conformation and receptor selectivity
P478volume280

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cites work (P2860)
Q38118569Current and future applications of GnRH, kisspeptin and neurokinin B analogues
Q30439870Diversity of actions of GnRHs mediated by ligand-induced selective signaling
Q79616024Effect of immunisation against gonadotrophin releasing hormone isoforms (mammalian GnRH-I, chicken GnRH-II and lamprey GnRH-III) on murine spermatogenesis
Q34002878GnRH and GnRH receptors in metazoa: a historical, comparative, and evolutive perspective.
Q38238340GnRH receptors and peptides: skating backward
Q33642701Gonadotropin-releasing hormone analog structural determinants of selectivity for inhibition of cell growth: support for the concept of ligand-induced selective signaling
Q37785763How useful is ion mobility mass spectrometry for structural biology? The relationship between protein crystal structures and their collision cross sections in the gas phase
Q36496992Hypothalamic gonadotropin-releasing hormone (GnRH) receptor neurons fire in synchrony with the female reproductive cycle.
Q37888870Ion mobility mass spectrometry for peptide analysis
Q36049867Molecular cloning and pharmacological characterization of two novel GnRH receptors in the lamprey (Petromyzon marinus).
Q41899896Probing the GnRH receptor agonist binding site identifies methylated triptorelin as a new anti-proliferative agent
Q37211545The emergence and loss of gonadotropin-releasing hormone in protostomes: orthology, phylogeny, structure, and function
Q92768615Understanding Peptide Binding in Class A G Protein-Coupled Receptors

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