Gonadotrophin-releasing hormone (GnRH) and GnRH agonists: mechanisms of action.

scientific article

Gonadotrophin-releasing hormone (GnRH) and GnRH agonists: mechanisms of action. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/S1472-6483(11)60210-1
P698PubMed publication ID12537774

P2093author name stringJ M Weiss
O Ortmann
K Diedrich
P2860cites workCloning, sequencing, and expression of human gonadotropin releasing hormone (GnRH) receptorQ28645650
Differential expression and regulation of estrogen receptors (ERs) in rat pituitary and cell lines: estrogen decreases ERalpha protein and estrogen responsivenessQ30305690
LHRH analogues as anticancer agents: pituitary and extrapituitary sites of actionQ34204370
Intracellular signaling pathways mediated by the gonadotropin-releasing hormone (GnRH) receptorQ34466846
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The place of gonadotrophin-releasing hormone antagonists in reproductive medicine.Q35019228
Dose relationship between GnRH antagonists and pituitary suppressionQ36860197
Gonadotropin-releasing hormone and its analoguesQ37618010
Down-regulation of pituitary receptors for luteinizing hormone-releasing hormone (LH-RH) in rats by LH-RH antagonist CetrorelixQ37693657
Signal transduction mechanisms of Ca2+ mobilizing hormones: the case of gonadotropin-releasing hormoneQ37938857
Gonadotropin-releasing hormone analog design. Structure-function studies toward the development of agonists and antagonists: rationale and perspectiveQ38160875
Gonadotrophin-releasing hormone: its actions and receptorsQ38265398
Molecular mechanism of gonadotropin releasing hormone (GnRH) action. I. The GnRH receptorQ39313110
Steroid-independent activation of ER by GnRH in gonadotrope pituitary cellsQ40791718
Rapid down-regulation of the type I inositol 1,4,5-trisphosphate receptor and desensitization of gonadotropin-releasing hormone-mediated Ca2+ responses in alpha T3-1 gonadotropesQ40844029
Lack of a C-terminal tail in the mammalian gonadotropin-releasing hormone receptor confers resistance to agonist-dependent phosphorylation and rapid desensitizationQ40924312
Gonadotropin-releasing hormone receptors with intracellular carboxyl-terminal tails undergo acute desensitization of total inositol phosphate production and exhibit accelerated internalization kineticsQ41035109
The agonist-induced phosphorylation of the rat follitropin receptor maps to the first and third intracellular loopsQ41051222
Potent gonadotropin releasing hormone antagonists with low histamine-releasing activityQ41078573
Studies of gonadotropin-releasing hormone (GnRH) action using GnRH receptor-expressing pituitary cell linesQ41130838
Rapid desensitization of GnRH-stimulated intracellular signalling events in alpha T3-1 and HEK-293 cells expressing the GnRH receptorQ41277993
Ovarian steroids modulate gonadotropin-releasing hormone-induced biphasic luteinizing hormone secretory responses and inositol phosphate accumulation in rat anterior pituitary cells and αT3-1 gonadotrophsQ41316066
Molecular mechanisms of ligand interaction with the gonadotropin-releasing hormone receptorQ41430675
Phosphorylation of phospholipase C-coupled receptorsQ41680658
Intracellular Responses to Gonadotropin-Releasing Hormone in a Clonal Cell Line of the Gonadotrope LineageQ41694475
Mechanism of GnRH receptor signaling: combinatorial cross-talk of Ca2+ and protein kinase C.Q41701773
Gonadotropin-releasing hormone receptors in human pituitary: ligand structural requirements, molecular size, and cationic effectsQ41935725
Use of GnRH antagonists in the treatment of endometriosisQ44241545
Dose-related suppression of serum luteinizing hormone in women by a potent new gonadotropin-releasing hormone antagonist (Ganirelix) administered by intranasal sprayQ46280407
Suppression of follicular phase pituitary-gonadal function by a potent new gonadotropin-releasing hormone antagonist with reduced histamine-releasing properties (ganirelix).Q46493685
Differences in structure-function relations between nonmammalian and mammalian gonadotropin-releasing hormone receptorsQ46990046
Modulatory actions of estradiol and progesterone on phorbol ester-stimulated LH secretion from cultured rat pituitary cellsQ48399161
Effects of progesterone on gonadotropin-releasing hormone receptor concentration in cultured estrogen-primed female rat pituitary cellsQ48442506
Synthetic analogs of the hypothalamic luteinizing hormone releasing factor with increased agonist or antatonist propertiesQ48619634
Specific, estrogen-sensitive alterations in anterior pituitary cytoplasmic and nuclear estrogen receptors actuated by LHRH.Q48769372
Local Ca2+ release from internal stores controls exocytosis in pituitary gonadotrophsQ48819860
Modulatory actions of progesterone on gonadotropin-releasing hormone-induced arachidonic acid liberation from perifused rat pituitary cellsQ48869956
Suppression of the endogenous luteinizing hormone surge by the gonadotrophin-releasing hormone antagonist Cetrorelix during ovarian stimulationQ49106785
The role of LHRH agonists and antagonists.Q54622516
Removal of phosphorylation sites from the β2-adrenergic receptor delays onset of agonist-promoted desensitizationQ56648662
The Functional Microdomain in Transmembrane Helices 2 and 7 Regulates Expression, Activation, and Coupling Pathways of the Gonadotropin-releasing Hormone ReceptorQ58853821
A Locus of the Gonadotropin-releasing Hormone Receptor That Differentiates Agonist and Antagonist Binding SitesQ58853853
Effect of gonadotropin-releasing hormone on estrogen receptor messenger ribonucleic acid level in perifused pituitary cellsQ71561306
Preserved pituitary response under ovarian stimulation with HMG and GnRH antagonists (Cetrorelix) in women with tubal infertilityQ71736673
Pivotal role for the cytoplasmic carboxyl-terminal tail of a nonmammalian gonadotropin-releasing hormone receptor in cell surface expression, ligand binding, and receptor phosphorylation and internalizationQ73201608
Comparison of different doses of gonadotropin-releasing hormone antagonist Cetrorelix during controlled ovarian hyperstimulationQ73296595
Biochemical and functional aspects of gonadotrophin-releasing hormone and gonadotrophinsQ73519292
P304page(s)1-7
P577publication date2002-01-01
P1433published inReproductive BioMedicine OnlineQ15762964
P1476titleGonadotrophin-releasing hormone (GnRH) and GnRH agonists: mechanisms of action
P478volume5 Suppl 1

Reverse relations

cites work (P2860)
Q44624341Depot GnRH agonist versus the single dose GnRH antagonist regimen (cetrorelix, 3 mg) in patients undergoing assisted reproduction treatment
Q91692711Endocrine and Targeted Therapy for Hormone-Receptor-Positive, HER2-Negative Advanced Breast Cancer: Insights to Sequencing Treatment and Overcoming Resistance Based on Clinical Trials
Q35934317Fertility preservation in reproductive-age women facing gonadotoxic treatments
Q92719703Phase I trial of TAK-385 in hormone treatment-naïve Japanese patients with nonmetastatic prostate cancer
Q92245139Population pharmacokinetics of pevonedistat alone or in combination with standard of care in patients with solid tumours or haematological malignancies
Q40191078Regulation of GnRH I receptor gene expression by the GnRH agonist triptorelin, estradiol, and progesterone in the gonadotroph-derived cell line alphaT3-1.
Q49608951Triptorelin: A Review of its Use as an Adjuvant Anticancer Therapy in Early Breast Cancer
Q61811467Uterine fibroids: an update on current and emerging medical treatment options

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