Matrix metalloproteinase-9 is required for tumor vasculogenesis but not for angiogenesis: role of bone marrow-derived myelomonocytic cells

scientific article

Matrix metalloproteinase-9 is required for tumor vasculogenesis but not for angiogenesis: role of bone marrow-derived myelomonocytic cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.CCR.2007.11.032
P932PMC publication ID2967441
P698PubMed publication ID18328424
P5875ResearchGate publication ID5524663

P50authorG-One AhnQ89392327
P2093author name stringJ Martin Brown
P2860cites workCell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesisQ24610450
Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligandQ24644662
Targeting HIF-1 for cancer therapyQ27860504
The biology of VEGF and its receptorsQ27860704
Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesisQ28140740
Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growthQ28203327
Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasisQ28275735
Matrix Metalloproteinase Inhibitors and Cancer--Trials and TribulationsQ29544430
Distinct role of macrophages in different tumor microenvironmentsQ29614304
Expression of vascular endothelial growth factor by macrophages is up-regulated in poorly vascularized areas of breast carcinomasQ58212133
Nonbone Marrow-Derived Circulating Progenitor Cells Contribute to Postnatal Neovascularization Following Tissue IschemiaQ58816235
Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesisQ59276609
Retardation of tumor growth in mice caused by radiation-induced injury of tumor bed stroma: dependency on tumor typeQ69989389
Reduced oxygenation in a rat mammary carcinoma post-radiation and reoxygenation with a perflubron emulsion/carbogen breathingQ72115839
Contribution of monocytes/macrophages to compensatory neovascularization: the drilling of metalloelastase-positive tunnels in ischemic myocardiumQ74253951
Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularizationQ77323614
Matrix metalloproteinase-9 expression correlated with tumor response in patients with locally advanced rectal cancer undergoing preoperative chemoradiotherapyQ79312562
Effects of radiotherapy and chemotherapy on angiogenesis and leukocyte infiltration in rectal cancerQ79404723
VEGF-induced adult neovascularization: recruitment, retention, and role of accessory cellsQ82264553
Ionizing radiation inhibits tumor neovascularization by inducing ineffective angiogenesisQ83290621
Tumour-educated macrophages promote tumour progression and metastasisQ29614307
Colony-stimulating factor 1 promotes progression of mammary tumors to malignancyQ29614312
Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1Q29615241
Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic diseaseQ29619726
MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesisQ33744153
Extrinsic regulators of epithelial tumor progression: metalloproteinasesQ33840437
Regulation of HIF-1alpha stability through S-nitrosylationQ34001616
Angiogenesis: vascular remodeling of the extracellular matrix involves metalloproteinasesQ34176489
Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granulesQ34320910
Matrix metalloproteinases in vascular remodeling and atherogenesis: the good, the bad, and the ugly.Q34542211
Anti-inflammatory properties of the novel antitumor agent yondelis (trabectedin): inhibition of macrophage differentiation and cytokine productionQ34556431
Macrophages regulate the angiogenic switch in a mouse model of breast cancerQ34582812
Targeting tumor-associated macrophages as a novel strategy against breast cancerQ34803221
Vascular and haematopoietic stem cells: novel targets for anti-angiogenesis therapy?Q34988256
Myeloid lineage progenitors give rise to vascular endothelium.Q35016546
Uniform vascular-endothelial-cell-specific gene expression in both embryonic and adult transgenic miceQ36077023
Tumour-associated macrophages are a distinct M2 polarised population promoting tumour progression: potential targets of anti-cancer therapyQ36414978
Monocyte/macrophage infiltration in tumors: modulators of angiogenesisQ36602360
Clodronate-liposome-mediated depletion of tumour-associated macrophages: a new and highly effective antiangiogenic therapy approachQ36612202
The multifaceted circulating endothelial cell in cancer: towards marker and target identification.Q36621435
An amino-bisphosphonate targets MMP-9-expressing macrophages and angiogenesis to impair cervical carcinogenesis.Q37486791
Tumor refractoriness to anti-VEGF treatment is mediated by CD11b+Gr1+ myeloid cells.Q40100311
Macrophages from irradiated tumors express higher levels of iNOS, arginase-I and COX-2, and promote tumor growth.Q40151555
Therapy-induced acute recruitment of circulating endothelial progenitor cells to tumors.Q40228810
Angiogenesis and tumor growth inhibition by a matrix metalloproteinase inhibitor targeting radiation-induced invasionQ40353398
The contribution of bone marrow-derived cells to the tumor vasculature in neuroblastoma is matrix metalloproteinase-9 dependent.Q40434427
Endostatin improves radioresponse and blocks tumor revascularization after radiation therapy for A431 xenografts in miceQ41902466
The SDF-1-CXCR4 signaling pathway: a molecular hub modulating neo-angiogenesisQ42411644
Bone Marrow Monocyte Lineage Cells Adhere on Injured Endothelium in a Monocyte Chemoattractant Protein-1–Dependent Manner and Accelerate Reendothelialization as Endothelial Progenitor CellsQ42451021
Vascular trauma induces rapid but transient mobilization of VEGFR2(+)AC133(+) endothelial precursor cellsQ42498432
Monocyte/macrophage suppression in CD11b diphtheria toxin receptor transgenic mice differentially affects atherogenesis and established plaquesQ42612056
G-CSF and AMD3100 mobilize monocytes into the blood that stimulate angiogenesis in vivo through a paracrine mechanismQ42742048
A new mouse tumor model system (RIF-1) for comparison of end-point studiesQ42799818
Breast stroma plays a dominant regulatory role in breast epithelial growth and differentiation: implications for tumor development and progression.Q43540226
Malignant astrocytomas: focal tumor recurrence after focal external beam radiation therapyQ43870174
Effect of angiogenesis inhibition by Id loss and the contribution of bone-marrow-derived endothelial cells in spontaneous murine tumorsQ44636591
Genetically tagging endothelial cells in vivo: bone marrow-derived cells do not contribute to tumor endothelium.Q44928916
Targeting exogenous genes to tumor angiogenesis by transplantation of genetically modified hematopoietic stem cellsQ45862226
The influence of irradiation of the tumor bed on tumor hypoxia: measurements by radiation response, oxygen electrodes, and nitroimidazole binding.Q45962049
The tumor bed effect: increased metastatic dissemination from hypoxia-induced up-regulation of metastasis-promoting gene productsQ46395684
Blood monocytes mimic endothelial progenitor cellsQ46686010
Chronic suppression of angiogenesis following radiation exposure is independent of hematopoietic reconstitution.Q50695105
Matrix metalloproteinase-9 is required for adequate angiogenic revascularization of ischemic tissues: potential role in capillary branching.Q51786158
Growth factor-induced angiogenesis in vivo requires specific cleavage of fibrillar type I collagen.Q54013783
P433issue3
P921main subjectangiogenesisQ539568
bone marrowQ546523
vasculogenesisQ1424593
P304page(s)193-205
P577publication date2008-03-01
P1433published inCancer CellQ280018
P1476titleMatrix metalloproteinase-9 is required for tumor vasculogenesis but not for angiogenesis: role of bone marrow-derived myelomonocytic cells
P478volume13

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cites work (P2860)
Q34328033A bioinformatics filtering strategy for identifying radiation response biomarker candidates
Q42413251A catalytic role for proangiogenic marrow-derived cells in tumor neovascularization
Q34870640A novel role for platelet secretion in angiogenesis: mediating bone marrow-derived cell mobilization and homing.
Q39193551A preclinical study to explore vasculature differences between primary and recurrent tumors using ultrasound Doppler imaging.
Q52714962Abemaciclib, a Selective CDK4/6 Inhibitor Enhances the Radiosensitivity of Non-Small Cell Lung Cancer in vitro and in vivo.
Q35958252Ablative Tumor Radiation Can Change the Tumor Immune Cell Microenvironment to Induce Durable Complete Remissions
Q37672893Altered macrophage phenotype transition impairs skeletal muscle regeneration
Q90353123An update on biomarkers of potential benefit with bevacizumab for breast cancer treatment: Do we make progress?
Q30559417Angiogenic capacity of M1- and M2-polarized macrophages is determined by the levels of TIMP-1 complexed with their secreted proMMP-9.
Q37951606Antiangiogenic effects of zoledronate on cancer neovasculature
Q33638344Antitumor activity of targeting SRC kinases in endothelial and myeloid cell compartments of the tumor microenvironment
Q38806270Antitumorigenic targets of cannabinoids - current status and implications
Q38818713Balancing efficacy of and host immune responses to cancer therapy: the yin and yang effects
Q28288148Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9): the next decade
Q37409716Blockade of SDF-1 after irradiation inhibits tumor recurrences of autochthonous brain tumors in rats
Q36390700Bone marrow derived myeloid cells orchestrate antiangiogenic resistance in glioblastoma through coordinated molecular networks
Q34369895Bone marrow is a reservoir for proangiogenic myelomonocytic cells but not endothelial cells in spontaneous tumors
Q34520820Bone marrow-derived cells contribute to vascular endothelial growth factor-induced angiogenesis in the adult mouse brain by supplying matrix metalloproteinase-9
Q58734172Brcal Defective Breast Cancer Cells Induce in vitro Transformation of Cancer Associated Fibroblasts (CAFs) to Metastasis Associated Fibroblasts (MAF)
Q53287381CEACAM1 creates a pro-angiogenic tumor microenvironment that supports tumor vessel maturation.
Q34518337CXCR2-Dependent Endothelial Progenitor Cell Mobilization in Pancreatic Cancer Growth
Q37769017Cancer-associated myeloproliferation: old association, new therapeutic target
Q22242922Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability
Q35093740Caspase 3-mediated stimulation of tumor cell repopulation during cancer radiotherapy
Q37739010Cell-based methods for ex vivo evaluation of human endothelial biology.
Q45056870Cerebrovascular Remodeling and Neuroinflammation is a Late Effect of Radiation-Induced Brain Injury in Non-Human Primates
Q46104713Chapter 3. Bone marrow-derived vascular progenitors and proangiogenic monocytes in tumors
Q38800593Chimeric Mouse model to track the migration of bone marrow derived cells in glioblastoma following anti-angiogenic treatments
Q44050700Class A scavenger receptor deficiency exacerbates lung tumorigenesis by cultivating a procarcinogenic microenvironment in humans and mice
Q30930526Clinical applications of iron oxide nanoparticles for magnetic resonance imaging of brain tumors
Q35043560Clinical significance of sIL-2R levels in B-cell lymphomas
Q39388167Coevolution of the tumor microenvironment revealed by quantum dot-based multiplexed imaging of hepatocellular carcinoma
Q48049656Collateral Damage Intended-Cancer-Associated Fibroblasts and Vasculature Are Potential Targets in Cancer Therapy.
Q34582640Combinations of immunotherapy and radiation in cancer therapy.
Q35645125Combined blockade of integrin-α4β1 plus cytokines SDF-1α or IL-1β potently inhibits tumor inflammation and growth
Q37148144Combined hyperthermia and radiotherapy for the treatment of cancer
Q60939646Combining Radiotherapy and Immunotherapy in Lung Cancer: Can We Expect Limitations Due to Altered Normal Tissue Toxicity?
Q36079807Context Matters: Distinct Disease Outcomes as a Result of Crebbp Hemizygosity in Different Mouse Bone Marrow Compartments
Q37028696Contribution of bone marrow-derived cells associated with brain angiogenesis is primarily through leukocytes and macrophages.
Q28576485Cross-talk between vascular endothelial growth factor and matrix metalloproteinases in the induction of neovascularization in vivo
Q36278280Cyclophosphamide creates a receptive microenvironment for prostate cancer skeletal metastasis.
Q57144581DNA methylation derived systemic inflammation indices are associated with head and neck cancer development and survival
Q39456092Delta-like ligand 4-notch blockade and tumor radiation response
Q35766758Dequalinium blocks macrophage-induced metastasis following local radiation
Q37978661Dermal mast cells affect the development of sunlight-induced skin tumours.
Q37594031Different but synergistic effects of bone marrow-derived VEGFR2+ and VEGFR2-CD45+ cells during hepatocellular carcinoma progression
Q34578277Distinct patterns of cytokine and angiogenic factor modulation and markers of benefit for vandetanib and/or chemotherapy in patients with non-small-cell lung cancer.
Q41961732Dual role of the leukocyte integrin αMβ2 in angiogenesis
Q55304879Durvalumab: a potential maintenance therapy in surgery-ineligible non-small-cell lung cancer.
Q35926659Dying tumor cells stimulate proliferation of living tumor cells via caspase-dependent protein kinase Cδ activation in pancreatic ductal adenocarcinoma
Q27345020Effects of high-dose microbeam irradiation on tumor microvascular function and angiogenesis.
Q33767975Effects of ionizing radiation on biological molecules--mechanisms of damage and emerging methods of detection
Q38983908Effects of pre-irradiation and SDF-1 suppression on the progression of murine astrocytoma cells grown in different stromal beds.
Q37694918Elusive identities and overlapping phenotypes of proangiogenic myeloid cells in tumors
Q38869603Emerging targets for radioprotection and radiosensitization in radiotherapy
Q33873312Endothelium originated from colorectal cancer stem cells constitute cancer blood vessels
Q30408302Enhanced cancer radiotherapy through immunosuppressive stromal cell destruction in tumors
Q37593466Enhancing the efficacy of cancer vaccines in urologic oncology: new directions
Q64891812Gastric carcinogenesis.
Q24568374Gelatinase B/MMP-9 in Tumour Pathogenesis and Progression
Q88450845Gene Expression Profiles in Chemokine (C-C Motif) Ligand 21-Overexpressing Pancreatic Cancer Cells
Q44671365Gene expression changes after ionizing radiation in endothelial cells derived from human endometrial cancer-preliminary outcomes
Q39030742Gr-1+CD11b+ cells facilitate Lewis lung cancer recurrence by enhancing neovasculature after local irradiation
Q34354547Head and neck cancer relapse after chemoradiotherapy correlates with CD163+ macrophages in primary tumour and CD11b+ myeloid cells in recurrences
Q43009524Henry S. Kaplan Distinguished Scientist Award Lecture 2007. The remarkable yin and yang of tumour hypoxia
Q24606366Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche
Q38332863Identification of high-risk human papillomavirus (hrHPV)-associated genes in early stage cervical squamous cell carcinomas
Q37246401Identifying alemtuzumab as an anti-myeloid cell antiangiogenic therapy for the treatment of ovarian cancer
Q83575417Increased invasiveness of MMP-9-deficient tumors in two mouse models of neuroendocrine tumorigenesis
Q36337310Inflammatory malignant fibrous histiocytoma associated with leukemoid reaction or leukocytosis: a comprehensive review
Q26767150Influence of Immune Myeloid Cells on the Extracellular Matrix During Cancer Metastasis
Q33822929Influence of bone marrow-derived hematopoietic cells on the tumor response to radiotherapy: experimental models and clinical perspectives
Q38135118Inhibiting vasculogenesis after radiation: a new paradigm to improve local control by radiotherapy
Q37632115Inhibition of CXCR7 extends survival following irradiation of brain tumours in mice and rats.
Q33929607Inhibition of Mac-1 (CD11b/CD18) enhances tumor response to radiation by reducing myeloid cell recruitment
Q37057231Inhibition of hypoxia inducible factor-1α attenuates abdominal aortic aneurysm progression through the down-regulation of matrix metalloproteinases
Q33915046Inhibition of neovascularization to simultaneously ameliorate graft-vs-host disease and decrease tumor growth
Q28274091Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice.
Q38501776Integrin-mediated cell-matrix interaction in physiological and pathological blood vessel formation
Q34469812Ionizing radiation induces tumor cell lysyl oxidase secretion
Q36142366Irradiation promotes an m2 macrophage phenotype in tumor hypoxia.
Q42684094Is vasculogenesis crucial for the regrowth of irradiated tumours?
Q24598701Late SV40 factor (LSF) enhances angiogenesis by transcriptionally up-regulating matrix metalloproteinase-9 (MMP-9)
Q44243239Locoregional Confinement and Major Clinical Benefit of 188Re-Loaded CXCR4-Targeted Nanocarriers in an Orthotopic Human to Mouse Model of Glioblastoma.
Q53090556Loss of stromal JUNB does not affect tumor growth and angiogenesis.
Q64241048MDSCs: Key Criminals of Tumor Pre-metastatic Niche Formation
Q37189109MIF produced by bone marrow-derived macrophages contributes to teratoma progression after embryonic stem cell transplantation
Q54362749MMP-9 from sublethally irradiated tumor promotes Lewis lung carcinoma cell invasiveness and pulmonary metastasis.
Q35086941MMP-9 gene deletion mitigates microvascular loss in a model of ischemic acute kidney injury.
Q42364151MMP2 and MMP9 as candidate biomarkers to monitor bevacizumab therapy in high-grade glioma
Q27853354MMP2 and MMP9 serum levels are associated with favorable outcome in patients with inflammatory breast cancer treated with bevacizumab-based neoadjuvant chemotherapy in the BEVERLY-2 study.
Q33570512MMP9 but Not EGFR, MET, ERCC1, P16, and P-53 Is Associated with Response to Concomitant Radiotherapy, Cetuximab, and Weekly Cisplatin in Patients with Locally Advanced Head and Neck Cancer
Q35025845MT-MMPS as Regulators of Vessel Stability Associated with Angiogenesis
Q92178524Markers of Cancer Cell Invasion: Are They Good Enough?
Q35043525Matrix metalloproteinases and genetic mouse models in cancer research: a mini-review.
Q35892721Matrix metalloproteinases as breast cancer drivers and therapeutic targets
Q33732496Matrix metalloproteinases contribute distinct roles in neuroendocrine prostate carcinogenesis, metastasis, and angiogenesis progression
Q36960275Matrix metalloproteinases: inflammatory regulators of cell behaviors in vascular formation and remodeling
Q29619858Matrix metalloproteinases: regulators of the tumor microenvironment
Q35720752Matrix-metalloproteinase-9 is cleaved and activated by cathepsin K.
Q38196881Mechanisms of tumour vascularization in cutaneous malignant melanoma: clinical implications
Q92995794Microparticles from tumors exposed to radiation promote immune evasion in part by PD-L1
Q37617724Molecular biology of cancer-associated fibroblasts: can these cells be targeted in anti-cancer therapy?
Q34948795Molecular mechanisms involved in tumor repopulation after radiotherapy
Q37729131Molecular pathways and targets in cancer-related inflammation
Q84744195Monitoring mmp-9 gene expression in stromal cells using a novel transgenic mouse model
Q38613648Myeloid Derived Suppressor Cells: Fuel the Fire
Q27014189Myeloid-derived suppressor cells in cancer: therapeutic, predictive, and prognostic implications
Q36047741Neovascularization after irradiation: what is the source of newly formed vessels in recurring tumors?
Q30490801Neutrophil MMP-9 proenzyme, unencumbered by TIMP-1, undergoes efficient activation in vivo and catalytically induces angiogenesis via a basic fibroblast growth factor (FGF-2)/FGFR-2 pathway.
Q36943936Neutrophil granulocyte derived MMP-9 is a VEGF independent functional component of the angiogenic switch in pancreatic ductal adenocarcinoma
Q51802063Neutrophils, a candidate biomarker and target for radiation therapy?
Q37981959New functions of the fibrinolytic system in bone marrow cell-derived angiogenesis
Q36983730Notch1 regulates angio-supportive bone marrow-derived cells in mice: relevance to chemoresistance.
Q64075507Novel Approaches to Improve the Efficacy of Immuno-Radiotherapy
Q92099132Obstructive sleep apnea syndrome promotes the progression of aortic dissection via a ROS- HIF-1α-MMPs associated pathway
Q42477969Oncogene-driven intrinsic inflammation induces leukocyte production of tumor necrosis factor that critically contributes to mammary carcinogenesis
Q39011826One microenvironment does not fit all: heterogeneity beyond cancer cells
Q99579151Organoids as Complex In Vitro Models for Studying Radiation-Induced Cell Recruitment
Q36982546Overexpression of interleukin-1beta induces gastric inflammation and cancer and mobilizes myeloid-derived suppressor cells in mice.
Q37338567Parathyroid hormone-related protein drives a CD11b+Gr1+ cell-mediated positive feedback loop to support prostate cancer growth
Q38588910Perioperative propofol-paravertebral anesthesia decreases the metastasis and progression of breast cancer
Q41413177Pharmacological targeting of β-adrenergic receptor functions abrogates NF-κB signaling and MMP-9 secretion in medulloblastoma cells
Q33665623Pleiotropic roles of matrix metalloproteinases in tumor angiogenesis: contrasting, overlapping and compensatory functions
Q38743711Pre-metastatic niches: organ-specific homes for metastases.
Q35745103Presence of insulin-like growth factor binding proteins correlates with tumor-promoting effects of matrix metalloproteinase 9 in breast cancer
Q53104093Pretreatment circulating monocyte count associated with poor prognosis in patients with oral cavity cancer.
Q53387643Prognostic significance of a pretreatment hematologic profile in patients with head and neck cancer.
Q34408248RBMS3 at 3p24 inhibits nasopharyngeal carcinoma development via inhibiting cell proliferation, angiogenesis, and inducing apoptosis
Q40508998Rab27a regulates GM-CSF-dependent priming of neutrophil exocytosis.
Q47703452Radiation effects on antitumor immune responses: current perspectives and challenges
Q28080006Radiation-induced immune responses: mechanisms and therapeutic perspectives
Q39434440Radiation-induced inflammatory cascade and its reverberating crosstalks as potential cause of post-radiotherapy second malignancies
Q27022685Radiotherapy and the tumor stroma: the importance of dose and fractionation
Q33605773Radiotherapy suppresses angiogenesis in mice through TGF-betaRI/ALK5-dependent inhibition of endothelial cell sprouting
Q38199128Recent advances and future trends in the targeted therapy of metastatic gastric cancer
Q40978947Recruitment of CD11b+Ly6C+ monocytes in non-small cell lung cancer xenografts challenged by anti-VEGF antibody
Q34052833Recruitment of myeloid but not endothelial precursor cells facilitates tumor regrowth after local irradiation
Q35793888Recurrence of glioblastoma after radio-chemotherapy is associated with an angiogenic switch to the CXCL12-CXCR4 pathway
Q35083186Relationship between vitreous levels of matrix metalloproteinases and vascular endothelial growth factor in proliferative diabetic retinopathy
Q51026487Relationships of MMP-9, E-cadherin, and VEGF expression with clinicopathological features and response to chemosensitivity in gastric cancer.
Q30476541Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer
Q28559652Replication Study: The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors
Q34381246Requirement for interactions of natural killer T cells and myeloid-derived suppressor cells for transplantation tolerance
Q33685705Resisting arrest: a switch from angiogenesis to vasculogenesis in recurrent malignant gliomas
Q33824295Role of endothelial progenitors and other bone marrow-derived cells in the development of the tumor vasculature
Q37373047Role of leukemia cell invadosome in extramedullary infiltration
Q35603122Roles of bone marrow cells in skeletal metastases: no longer bystanders
Q37491439SDF-1 Blockade Enhances Anti-VEGF Therapy of Glioblastoma and Can Be Monitored by MRI.
Q36860502Safety and efficacy of bevacizumab with hypofractionated stereotactic irradiation for recurrent malignant gliomas
Q51392451Salvage gamma knife stereotactic radiosurgery followed by bevacizumab for recurrent glioblastoma multiforme: a case-control study.
Q27306938Selective Allosteric Inhibition of MMP9 Is Efficacious in Preclinical Models of Ulcerative Colitis and Colorectal Cancer
Q43754838Should the cut-off values of the lymphocyte to monocyte ratio for prediction of prognosis in diffuse large B-cell lymphoma be changed in elderly patients?
Q28080262Signal transducer and activator of transcription 3 in myeloid-derived suppressor cells: an opportunity for cancer therapy
Q35551808Simultaneous irradiation of fibroblasts and carcinoma cells repress the secretion of soluble factors able to stimulate carcinoma cell migration
Q96430962Snail promotes the generation of vascular endothelium by breast cancer cells
Q38953409Sphingosine-1-phosphate promotes expansion of cancer stem cells via S1PR3 by a ligand-independent Notch activation
Q37806811Stem cells in tumor angiogenesis
Q37531724Strategies for optimizing the response of cancer and normal tissues to radiation
Q38015229Strategies for the discovery and development of therapies for metastatic breast cancer
Q37856721Strategies to improve radiotherapy with targeted drugs
Q28749398Stromal cell-derived factor-1/CXCL12 contributes to MMTV-Wnt1 tumor growth involving Gr1+CD11b+ cells
Q55518188Synergy between peroxisome proliferator-activated receptor γ agonist and radiotherapy in cancer.
Q37539309Systemic effects of local radiotherapy
Q55429319TGF-β signaling promotes tumor vasculature by enhancing the pericyte-endothelium association.
Q24606406TIE2-expressing macrophages limit the therapeutic efficacy of the vascular-disrupting agent combretastatin A4 phosphate in mice
Q37876686Targeting SDF-1/CXCR4 to inhibit tumour vasculature for treatment of glioblastomas
Q34082067Targeting immune suppressing myeloid-derived suppressor cells in oncology.
Q93129559Targeting myeloid-derived suppressor cells in combination with primary mammary tumor resection reduces metastatic growth in the lungs
Q64063956Targeting myeloid-derived suppressor cells in the treatment of hepatocellular carcinoma: current state and future perspectives
Q64071654Targeting the Immunomodulatory CD73/Adenosine System to Improve the Therapeutic Gain of Radiotherapy
Q37767356Targeting the tumour vasculature: insights from physiological angiogenesis
Q37625320The Prognostic Value of Baseline Lymphocyte, Neutrophil, and Monocyte Counts in Locally Advanced Cervical Carcinoma Treated with Radiation
Q92541856The Prognostic Value of Blood-Based Biomarkers in Patients With Testicular Diffuse Large B-Cell Lymphoma
Q38877313The Promise of Targeting Macrophages in Cancer Therapy
Q26775269The Role of Neutrophilic Inflammation, Angiotropism, and Pericytic Mimicry in Melanoma Progression and Metastasis
Q85317146The absolute lymphocyte to monocyte ratio is associated with poor prognosis in classical Hodgkin lymphoma patients younger than 60 years of age
Q37987661The biology of personalized cancer medicine: facing individual complexities underlying hallmark capabilities
Q37374031The definition of EPCs and other bone marrow cells contributing to neoangiogenesis and tumor growth: is there common ground for understanding the roles of numerous marrow-derived cells in the neoangiogenic process?
Q38091871The host immunological response to cancer therapy: An emerging concept in tumor biology
Q38028791The impact of tumor microenvironment on cancer treatment and its modulation by direct and indirect antivascular strategies
Q37518395The intersection of radiotherapy and immunotherapy: mechanisms and clinical implications
Q38123806The irradiated tumor microenvironment: role of tumor-associated macrophages in vascular recovery
Q38018809The metastatic niche and stromal progression
Q36051547The ratio of the absolute lymphocyte count to the absolute monocyte count is associated with prognosis in Hodgkin's lymphoma: correlation with tumor-associated macrophages
Q49634844The role of macrophage phenotype in regulating the response to radiation therapy
Q29614299The role of myeloid cells in the promotion of tumour angiogenesis
Q33511263The role of salvage reirradiation for malignant gliomas that progress on bevacizumab
Q37554682The role of tumor-associated macrophages in tumor vascularization
Q26823489The tumor radiobiology of SRS and SBRT: are more than the 5 Rs involved?
Q34444598The tumor-immune microenvironment and response to radiation therapy
Q48650505Therapeutic targeting of tumor-associated macrophages and microglia in glioblastoma
Q34065630Treatment of 4T1 metastatic breast cancer with combined hypofractionated irradiation and autologous T-cell infusion
Q49544289Tumor Associated Macrophages as Therapeutic Targets for Breast Cancer
Q33757096Tumor cell-produced matrix metalloproteinase 9 (MMP-9) drives malignant progression and metastasis of basal-like triple negative breast cancer
Q26995733Tumor endothelial cells
Q38043525Tumor endothelial markers as a target in cancer
Q42252540Tumor p38MAPK signaling enhances breast carcinoma vascularization and growth by promoting expression and deposition of pro-tumorigenic factors.
Q33829243Tumor-fibroblast interactions stimulate tumor vascularization by enhancing cytokine-driven production of MMP9 by tumor cells
Q37633861Tumors as organs: biologically augmenting radiation therapy by inhibiting transforming growth factor β activity in carcinomas
Q53025231Tumour-infiltrating Gr-1+ myeloid cells antagonize senescence in cancer.
Q59799227Tumour-vasculature development via endothelial-to-mesenchymal transition after radiotherapy controls CD44v6 cancer cell and macrophage polarization
Q40219738Type 1 Immune Mechanisms Driven by the Response to Infection with Attenuated Rabies Virus Result in Changes in the Immune Bias of the Tumor Microenvironment and Necrosis of Mouse GL261 Brain Tumors.
Q37948053Understanding tumor-stroma interplays for targeted therapies by armed mesenchymal stromal progenitors: the Mesenkillers
Q26999217Vasculogenesis: a crucial player in the resistance of solid tumours to radiotherapy
Q42257428Vasculogenic cytokines in wound healing
Q43170327Visualizing anti-tumor immune responses in vivo
Q37107054miR-155-deficient bone marrow promotes tumor metastasis

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