Soluble immune complexes shift the TLR-induced cytokine production of distinct polarized human macrophage subsets towards IL-10

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Soluble immune complexes shift the TLR-induced cytokine production of distinct polarized human macrophage subsets towards IL-10 is …
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scholarly articleQ13442814

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P819ADS bibcode2012PLoSO...735994A
P356DOI10.1371/JOURNAL.PONE.0035994
P932PMC publication ID3338562
P698PubMed publication ID22563430
P5875ResearchGate publication ID224915911

P50authorPaul P TakQ89865007
P2093author name stringTimothy R D J Radstake
Dominique L P Baeten
Mark H Wenink
Lenny van Bon
Kim C M Santegoets
Carmen A Ambarus
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Reversing lipopolysaccharide toxicity by ligating the macrophage Fc gamma receptorsQ33947431
Immune complexes inhibit antimicrobial responses through interleukin-10 production. Effects in severe combined immunodeficient mice during Listeria infectionQ34208000
Systemic lupus erythematosus monocytes are less responsive to interleukin-10 in the presence of immune complexesQ34462053
Biochemical and functional characterization of three activated macrophage populations.Q34556828
Immune complexes from rheumatoid arthritis synovial fluid induce FcgammaRIIa dependent and rheumatoid factor correlated production of tumour necrosis factor-alpha by peripheral blood mononuclear cellsQ34897560
Immune complexes from SLE sera induce IL10 production from normal peripheral blood mononuclear cells by an FcgammaRII dependent mechanism: implications for a possible vicious cycle maintaining B cell hyperactivity in SLE.Q35552018
Macrophage deactivation by interleukin 10Q36230700
Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activationQ36231523
Immunomodulation of autoimmune and inflammatory diseases with intravenous immunoglobulinQ36346058
Inhibition of interleukin 10 signaling after Fc receptor ligation and during rheumatoid arthritisQ36370789
Selective suppression of interleukin-12 induction after macrophage receptor ligationQ36377302
Systematic validation of specific phenotypic markers for in vitro polarized human macrophages.Q54339805
Insoluble immune complexes are most effective at triggering IL-10 production in human monocytes and synergize with TLR ligands and C5a.Q54550641
Expression of the inhibitory CD200 receptor is associated with alternative macrophage activationQ58844204
Expression of the Inhibitory CD200 Receptor Is Associated with Alternative Macrophage ActivationQ58859867
Cross-linking of both Fc gamma RI and Fc gamma RII induces secretion of tumor necrosis factor by human monocytes, requiring high affinity Fc-Fc gamma R interactions. Functional activation of Fc gamma RII by treatment with proteases or neuraminidaseQ68410317
Cross-linking Fc receptors on monocytes triggers IL-6 production. Role in anti-CD3-induced T cell activationQ68425185
Differential regulation of the mannose and SP-A receptors on macrophagesQ70926932
Immune complex-induced interleukin-6, interleukin-10 and prostaglandin secretion by human monocytes: a network of pro- and anti-inflammatory cytokines dependent on the antigen:antibody ratioQ71118287
Regulatory effects of intrinsic IL-10 in IgG immune complex-induced lung injuryQ72646567
Cross-linking of monocyte plasma membrane Fc alpha, Fc gamma or mannose receptors induces TNF productionQ72660290
Induction of tumor necrosis factor alpha production by adhered human monocytes: a key role for Fcgamma receptor type IIIa in rheumatoid arthritisQ73574461
Immune complexes are potent inhibitors of interleukin-12 secretion by human monocytesQ73933730
Granulocyte-macrophage colony-stimulating factor (CSF) and macrophage CSF-dependent macrophage phenotypes display differences in cytokine profiles and transcription factor activities: implications for CSF blockade in inflammationQ80088055
Mphi1 and Mphi2 can be re-polarized by Th2 or Th1 cytokines, respectively, and respond to exogenous danger signalsQ80141341
A shift in the balance of inhibitory and activating Fcgamma receptors on monocytes toward the inhibitory Fcgamma receptor IIb is associated with prevention of monocyte activation in rheumatoid arthritisQ81129136
Phenotypic and functional profiling of human proinflammatory type-1 and anti-inflammatory type-2 macrophages in response to microbial antigens and IFN-gamma- and CD40L-mediated costimulationQ81579412
Fcγ receptor profile of monocytes and macrophages from rheumatoid arthritis patients and their response to immune complexes formed with autoantibodies to citrullinated proteinsQ83619527
Surface-bound anti-type II collagen-containing immune complexes induce production of tumor necrosis factor alpha, interleukin-1beta, and interleukin-8 from peripheral blood monocytes via Fc gamma receptor IIA: a potential pathophysiologic mechanismQ83880456
The inhibitory Fc gamma IIb receptor dampens TLR4-mediated immune responses and is selectively up-regulated on dendritic cells from rheumatoid arthritis patients with quiescent diseaseQ84521125
Anti-tumor necrosis factor-α antibodies induce regulatory macrophages in an Fc region-dependent mannerQ85213077
The complex role of Fcgamma receptors in the pathology of arthritisQ36624577
Reversal of proinflammatory responses by ligating the macrophage Fcgamma receptor type IQ36851783
Fc-receptors as regulators of immunity.Q36991445
Human monocyte CD14 is upregulated by lipopolysaccharide.Q39824929
Immune complexes suppress cellular immunityQ40203220
Immobilized IgG Immune Complex Induces Secretion of Tumor Necrosis Factor-α by Porcine Alveolar MacrophagesQ41667021
High production of proinflammatory and Th1 cytokines by dendritic cells from patients with rheumatoid arthritis, and down regulation upon FcgammaR triggering.Q41987472
Increased FcgammaRII expression and aberrant tumour necrosis factor alpha production by mature dendritic cells from patients with active rheumatoid arthritisQ42068422
ERK phosphorylation and tumor necrosis factor-alpha production by monocytes are persistent in response to immobilized IgG.Q42862285
Antigen-antibody complexes stimulate the synthesis and release of prostaglandins by mouse peritoneal macrophagesQ43705026
Secretion of granulocyte-macrophage colony-stimulating factor by human blood monocytes is stimulated by engagement of Fc gamma receptors type I by solid-phase immunoglobulins requiring high-affinity Fc-Fc gamma receptor type I interactionsQ43779182
Regulatory macrophages induced by infliximab are involved in healing in vivo and in vitro.Q45987643
Induction of macrophage secretion of tumor necrosis factor alpha through Fcgamma receptor IIa engagement by rheumatoid arthritis-specific autoantibodies to citrullinated proteins complexed with fibrinogenQ46724742
Cutting edge: biasing immune responses by directing antigen to macrophage Fc gamma receptors.Q52938612
A novel phenotype for an activated macrophage: the type 2 activated macrophage.Q52940996
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue4
P407language of work or nameEnglishQ1860
P921main subjecttoll-like receptorQ408004
macrophageQ184204
P304page(s)e35994
P577publication date2012-04-26
P1433published inPLOS OneQ564954
P1476titleSoluble immune complexes shift the TLR-induced cytokine production of distinct polarized human macrophage subsets towards IL-10
P478volume7

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