Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activation

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Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activation is …
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scholarly articleQ13442814

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P356DOI10.1084/JEM.176.1.287
P932PMC publication ID2119288
P698PubMed publication ID1613462
P5875ResearchGate publication ID277549513

P50authorSatish KeshavQ39185485
P2093author name stringS Gordon
M Stein
N Harris
P2860cites workCloning and expression in Escherichia coli of the cDNA for murine tumor necrosis factorQ28507398
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Monomeric IgG2a promotes maturation of bone-marrow macrophages and expression of the mannose receptorQ37411181
The macrophage mannose receptor: current statusQ37912609
Recombinant interleukin-4 enhances the chemiluminescent oxidative burst of murine peritoneal macrophagesQ41680999
Priming the macrophage respiratory burst with IL-4: enhancement with TNF-alpha but inhibition by IFN-gamma.Q44491658
Differential regulation of class II MHC determinants on macrophages by IFN-gamma and IL-4.Q44938035
Influences of interleukins 2 and 4 on tumor necrosis factor production by murine mononuclear phagocytes.Q46263029
Augmentation of glucocorticoid action on human monocytes by interleukin-4Q67290338
IL-4 and granulocyte-macrophage colony-stimulating factor selectively increase HLA-DR and HLA-DP antigens but not HLA-DQ antigens on human monocytesQ67296179
Interleukin 4 down-regulates the expression of CD14 in normal human monocytesQ67676596
Modulation of phenotypic and functional properties of human peripheral blood monocytes by IL-4Q68128479
Differential regulation of IL-1 production in human monocytes by IFN-gamma and IL-4Q68340490
IL-4 inhibits superoxide production by human mononuclear phagocytesQ68447056
IL-4 inhibits the expression of IL-8 from stimulated human monocytesQ68533598
Maintenance of granuloma macrophages in serum-free mediumQ70325516
Interferon-gamma and B cell stimulatory factor-1 reciprocally regulate Ig isotype productionQ70338857
B cell stimulatory factor-1 (interleukin 4) activates macrophages for increased tumoricidal activity and expression of Ia antigensQ70341808
Receptor-mediated pinocytosis of mannose glycoconjugates by macrophages: characterization and evidence for receptor recyclingQ71494370
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectmacrophageQ184204
P304page(s)287-292
P577publication date1992-07-01
P1433published inJournal of Experimental MedicineQ3186912
P1476titleInterleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activation
P478volume176

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Q92513187Immunopathology of Airway Surface Liquid Dehydration Disease
Q35470983Immunopathology of tuberculosis: roles of macrophages and monocytes
Q41727507Immunoproteasome dysfunction augments alternative polarization of alveolar macrophages
Q41480089Immunoregulation by Taenia crassiceps and its antigens
Q24532069Immunosenescence and macrophage functional plasticity: dysregulation of macrophage function by age-associated microenvironmental changes
Q33557388Impact of endobronchial allergen provocation on macrophage phenotype in asthmatics
Q49890355Implications of macrophage polarization in autoimmunity.
Q33713080Improvement of spinal non-viral IL-10 gene delivery by D-mannose as a transgene adjuvant to control chronic neuropathic pain
Q35133965In vitro comparison of the effects of probiotic, commensal and pathogenic strains on macrophage polarization.
Q36103380In vivo downregulation of innate and adaptive immune responses in corneal allograft rejection by HC-HA/PTX3 complex purified from amniotic membrane
Q34302328Increased percentages of T helper cells producing IL-17 and monocytes expressing markers of alternative activation in patients with sepsis
Q58612977Induction of M2 Macrophages Prevents Bone Loss in Murine Periodontitis Models
Q34157473Induction of M2 regulatory macrophages through the β2-adrenergic receptor with protection during endotoxemia and acute lung injury
Q36414300Induction of alternatively activated macrophages enhances pathogenesis during severe acute respiratory syndrome coronavirus infection
Q22253372Induction of functional IL-8 receptors by IL-4 and IL-13 in human monocytes
Q37965038Induction of protective immunity against cryptococcosis
Q92461599Infection drives meningeal engraftment by inflammatory monocytes that impairs CNS immunity
Q57477502Infection, modulation and responses of antigen-presenting cells to African swine fever viruses
Q37148129Infiltration of m2 tumor-associated macrophages in oral squamous cell carcinoma correlates with tumor malignancy.
Q36679987Inflammation and wound healing: the role of the macrophage
Q55397625Inflammation-Induced Adverse Pregnancy and Neonatal Outcomes Can Be Improved by the Immunomodulatory Peptide Exendin-4.
Q29622851Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesis
Q81163080Influence of pathological progression on the balance between cellular and humoral immune responses in bovine tuberculosis
Q33831146Influences of age-related changes in mesenchymal stem cells on macrophages during in-vitro culture.
Q35422948Ingestion of acapsular Cryptococcus neoformans occurs via mannose and beta-glucan receptors, resulting in cytokine production and increased phagocytosis of the encapsulated form
Q34055968Innate immune regulation by STAT-mediated transcriptional mechanisms.
Q35073787Innate immune responses to lung-stage helminth infection induce alternatively activated alveolar macrophages
Q64970090Integrated Functional Analysis of the Nuclear Proteome of Classically and Alternatively Activated Macrophages.
Q53646506Interaction between pancreatic cancer cells and tumor-associated macrophages promotes the invasion of pancreatic cancer cells and the differentiation and migration of macrophages.
Q77329375Interactions between Mycobacterium tuberculosis and host cells: are mycobacterial sugars the key?
Q33649222Interferon and alternative activation of monocyte/macrophages in systemic sclerosis-associated pulmonary arterial hypertension.
Q86049622Interferon regulatory factor 7 participates in the M1-like microglial polarization switch
Q52731929Interleukin 4 modulates microglia homeostasis and attenuates the early slowly progressive phase of amyotrophic lateral sclerosis.
Q56943358Interleukin-10 increases mannose receptor expression and endocytic activity in monocyte-derived dendritic cells
Q34505654Interleukin-10 reduces the pathology of mdx muscular dystrophy by deactivating M1 macrophages and modulating macrophage phenotype
Q72680200Interleukin-13 alters the activation state of murine macrophages in vitro: comparison with interleukin-4 and interferon-gamma
Q36846054Interleukin-19 in breast cancer
Q33722773Interleukin-33 contributes to both M1 and M2 chemokine marker expression in human macrophages
Q33678403Interleukin-33 regulates intestinal inflammation by modulating macrophages in inflammatory bowel disease
Q58085764Interleukin-4 Induces Expression of the Integrin αvβ3via Transactivation of the β3Gene
Q54685581Interleukin-4 and dexamethasone counterregulate extracellular matrix remodelling and phagocytosis in type-2 macrophages.
Q33761762Interleukin-4 enhances pulmonary clearance of Pseudomonas aeruginosa.
Q36711467Interleukin-4- and interleukin-13-mediated alternatively activated macrophages: roles in homeostasis and disease.
Q35782114Interleukin-4-induced macrophage fusion is prevented by inhibitors of mannose receptor activity
Q37295266Interstitial cells of Cajal, macrophages and mast cells in the gut musculature: morphology, distribution, spatial and possible functional interactions
Q36245798Intimal lining layer macrophages but not synovial sublining macrophages display an IL-10 polarized-like phenotype in chronic synovitis
Q34962285Intracellular survival and persistence of Chlamydia muridarum is determined by macrophage polarization
Q37058442Investigation of macrophage polarization using bone marrow derived macrophages
Q40891697Involvement of IGF-1 and Akt in M1/M2 activation state in bone marrow-derived macrophages.
Q35544447Involvement of mannose receptor in cytokine interleukin-1beta (IL-1beta), IL-6, and granulocyte-macrophage colony-stimulating factor responses, but not in chemokine macrophage inflammatory protein 1beta (MIP-1beta), MIP-2, and KC responses, caused b
Q91638697Iron nanoparticle-labeled murine mesenchymal stromal cells in an osteoarthritic model persists and suggests anti-inflammatory mechanism of action
Q38898354Is Synovial Macrophage Activation the Inflammatory Link Between Obesity and Osteoarthritis?
Q52921513Isolation and Differentiation of Murine Macrophages.
Q92418418JAK/STAT inhibition in macrophages promotes therapeutic resistance by inducing expression of protumorigenic factors
Q37401084Key role of macrophages in the pathogenesis of CD18 hypomorphic murine model of psoriasis
Q30276711Knowledge gaps to understanding cardiac macrophage polarization following myocardial infarction
Q94402057Kupffer Cell Metabolism and Function
Q57025342LC3-Associated Phagocytosis in Myeloid Cells Promotes Tumor Immune Tolerance
Q77675906Langerhans cells do not express alternative macrophage activation-associated CC chemokine (AMAC)-1
Q45880966Lentiviral-mediated administration of IL-25 in the CNS induces alternative activation of microglia
Q37052936Lipocalin 2 deactivates macrophages and worsens pneumococcal pneumonia outcomes
Q89624108Liver fibrosis and CD206+ macrophage accumulation are suppressed by anti-GM-CSF therapy
Q61941964Location or origin? What is critical for macrophage propagation of lung fibrosis?
Q42623032Long-term culture of multibacillary leprosy macrophages isolated from skin lesions: a new model to study Mycobacterium leprae-human cell interaction
Q37583613Low molecular weight hyaluronan activates cytosolic phospholipase A2α and eicosanoid production in monocytes and macrophages.
Q38021705Lymphocytes in obesity-related adipose tissue inflammation
Q42948860Lymphocytes modulate innate immune responses and neuronal damage in experimental meningitis
Q36200878Lymphocytic Microparticles Modulate Angiogenic Properties of Macrophages in Laser-induced Choroidal Neovascularization
Q48327546M1 Means Kill; M2 Means Heal.
Q35600855M1 and M2 macrophages: the chicken and the egg of immunity
Q87712013M1- and M2-macrophage polarization in rat liver cirrhosis induced by thioacetamide (TAA), focusing on Iba1 and galectin-3
Q64120737M2 Macrophages as a Potential Target for Antiatherosclerosis Treatment
Q51008909M2 macrophages induce EMT through the TGF-β/Smad2 signaling pathway.
Q35473223M2-polarized tumor-associated macrophages are associated with poor prognoses resulting from accelerated lymphangiogenesis in lung adenocarcinoma
Q52718712MK2 contributes to tumor progression by promoting M2 macrophage polarization and tumor angiogenesis.
Q38450486MR detection of LPS-induced neutrophil activation using mannan-coated superparamagnetic iron oxide nanoparticles
Q90601875Macrophage Activation and Functions during Helminth Infection: Recent Advances from the Laboratory Mouse
Q37978620Macrophage Phenotype Modulation by CXCL4 in Atherosclerosis
Q38615856Macrophage Polarization and Bone Formation: A review.
Q63740086Macrophage Polarization in Physiological and Pathological Pregnancy
Q38816403Macrophage Polarization: Decisions That Affect Health
Q92617815Macrophage Polarization: Different Gene Signatures in M1(LPS+) vs. Classically and M2(LPS-) vs. Alternatively Activated Macrophages
Q30354651Macrophage Recruitment and Polarization During Collateral Vessel Remodeling in Murine Adipose Tissue.
Q45418471Macrophage activation and human immunodeficiency virus infection: HIV replication directs macrophages towards a pro-inflammatory phenotype while previous activation modulates macrophage susceptibility to infection and viral production
Q29620642Macrophage activation and polarization: nomenclature and experimental guidelines
Q39565014Macrophage activation and skeletal muscle healing following traumatic injury
Q46811059Macrophage activation switching: an asset for the resolution of inflammation
Q33999220Macrophage control of phagocytosed mycobacteria is increased by factors secreted by alveolar epithelial cells through nitric oxide independent mechanisms
Q34937306Macrophage diversity in cardiac inflammation: a review
Q33537990Macrophage dysfunction impairs resolution of inflammation in the wounds of diabetic mice
Q38893448Macrophage form, function, and phenotype in mycobacterial infection: lessons from tuberculosis and other diseases
Q36692041Macrophage heterogeneity in respiratory diseases
Q44899038Macrophage mannose receptor in chronic sinus disease
Q41228225Macrophage membrane molecules: markers of tissue differentiation and heterogeneity
Q36850453Macrophage phenotypes during tissue repair
Q38260570Macrophage phenotypes in atherosclerosis.
Q29614349Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm
Q33527405Macrophage plasticity in experimental atherosclerosis
Q33716370Macrophage polarization in inflammatory diseases
Q42920879Macrophage polarization in response to wear particles in vitro.
Q28084850Macrophage responses to implants: prospects for personalized medicine
Q33802153Macrophage roles following myocardial infarction
Q37728093Macrophage signaling in HIV-1 infection
Q28392242Macrophage silica nanoparticle response is phenotypically dependent
Q28731852Macrophage sub-populations and the lipoxin A4 receptor implicate active inflammation during equine tendon repair
Q89463384Macrophage subsets in atherosclerosis as defined by single-cell technologies
Q37364177Macrophage-derived MCPIP1 mediates silica-induced pulmonary fibrosis via autophagy
Q38056128Macrophage-targeted therapy: CD64-based immunotoxins for treatment of chronic inflammatory diseases.
Q27027100Macrophage: SHIP of Immunity
Q99551345Macrophages and the maintenance of homeostasis
Q59880046Macrophages are exploited from an innate wound healing response to facilitate cancer metastasis
Q33694114Macrophages are necessary for epimorphic regeneration in African spiny mice.
Q89454243Macrophages directly contribute collagen to scar formation during zebrafish heart regeneration and mouse heart repair
Q34983474Macrophages from patients with cirrhotic ascites showed function alteration of host defense receptor
Q40610652Macrophages in chronic type 2 inflammation have a novel phenotype characterized by the abundant expression of Ym1 and Fizz1 that can be partly replicated in vitro.
Q30525251Macrophages in collateral arteriogenesis.
Q35535915Macrophages in diabetic gastroparesis--the missing link?
Q37289610Macrophages in hepatitis B and hepatitis C virus infections
Q35595537Macrophages in immunopathology of atherosclerosis: a target for diagnostics and therapy.
Q36722852Macrophages in inflammatory multiple sclerosis lesions have an intermediate activation status
Q38965333Macrophages in neuroinflammation: role of the renin-angiotensin-system.
Q38194688Macrophages in solid organ transplantation
Q47368141Macrophages under pressure: the role of macrophage polarization in hypertension.
Q37179242Macrophages-Key cells in the response to wear debris from joint replacements.
Q49609112Macrophages: Key orchestrators of a tumor microenvironment defined by therapeutic resistance.
Q34076279Macrophages: master regulators of inflammation and fibrosis
Q33617258Macrophagic and microglial responses after focal traumatic brain injury in the female rat.
Q37628185Mammary Gland Involution Provides a Unique Model to Study the TGF-β Cancer Paradox
Q28137872Mannose receptor and its putative ligands in normal murine lymphoid and nonlymphoid organs: In situ expression of mannose receptor by selected macrophages, endothelial cells, perivascular microglia, and mesangial cells, but not dendritic cells
Q40665049Mannose receptor determination by an ELISA-like method
Q48107825Mannose receptor high, M2 dermal macrophages mediate nonhealing Leishmania major infection in a Th1 immune environment.
Q36118366Mannose receptor regulates myoblast motility and muscle growth
Q38680574Mannosylated liposomes improve therapeutic effects of paclitaxel in colon cancer models
Q45005983Markers of macrophage differentiation in experimental silicosis
Q35980874Mast cell TLR2 signaling is crucial for effective killing of Francisella tularensis
Q34579554Mast cell/IL-4 control of Francisella tularensis replication and host cell death is associated with increased ATP production and phagosomal acidification
Q41757918Mast cells aggravate sepsis by inhibiting peritoneal macrophage phagocytosis
Q47593606Mechanical ventilation induces IL-4 secretion in lungs and reduces the phagocytic capacity of lung macrophages
Q41722140Membrane molecules as differentiation antigens of murine macrophages.
Q26800098Mesenchymal Stromal Cells Affect Disease Outcomes via Macrophage Polarization
Q34502380Mesenchymal stem cells ameliorate rhabdomyolysis-induced acute kidney injury via the activation of M2 macrophages
Q48469192Mesenchymal stem cells enhance α-synuclein clearance via M2 microglia polarization in experimental and human parkinsonian disorder.
Q47579457Mesenchymal stromal cells mediate a switch to alternatively activated monocytes/macrophages after acute myocardial infarction
Q64062371Metabolic Targets for Improvement of Allogeneic Hematopoietic Stem Cell Transplantation and Graft-vs.-Host Disease
Q47804954Metabolic characterization and RNA profiling reveal glycolytic dependence of profibrotic phenotype of alveolar macrophages in lung fibrosis
Q92664771Metabolic influence on macrophage polarization and pathogenesis
Q34117016Metabolic reprograming in macrophage polarization.
Q28080815Metabolic reprogramming in macrophages and dendritic cells in innate immunity
Q90214418Metformin induces CD11b+-cell-mediated growth inhibition of an osteosarcoma: implications for metabolic reprogramming of myeloid cells and anti-tumor effects
Q64074554MicroRNA Post-transcriptional Regulation of the NLRP3 Inflammasome in Immunopathologies
Q98726639MicroRNA sequences modulating inflammation and lipid accumulation in macrophage "foam" cells: Implications for atherosclerosis
Q36266476MicroRNA-223 is a crucial mediator of PPARγ-regulated alternative macrophage activation
Q47749757Microarray and bioinformatics analyses of gene expression profiles in BALB/c murine macrophage polarization
Q43169264Microenvironmental regulation of the progression of oral potentially malignant disorders towards malignancy
Q47106944Microglia and Monocytes/Macrophages Polarization Reveal Novel Therapeutic Mechanism against Stroke.
Q46445039Microglia in normal appearing white matter of multiple sclerosis are alerted but immunosuppressed
Q36547001Microglial M1/M2 polarization and metabolic states
Q36000073Mineralocorticoid receptor blockade prevents Western diet-induced diastolic dysfunction in female mice
Q36087549Model-Based Characterization of Inflammatory Gene Expression Patterns of Activated Macrophages.
Q37256953Modeling the immune rheostat of macrophages in the lung in response to infection
Q51336724Modulation of Immune Responses by Particulate Materials.
Q46368288Modulation of chitotriosidase during macrophage differentiation.
Q40841572Modulation of macrophage function by transforming growth factor beta, interleukin-4, and interleukin-10.
Q38890797Modulation of murine macrophage behavior in vivo and in vitro.
Q43235609Mono(2-ethylhexyl) phthalate induces both pro- and anti-inflammatory responses in rat alveolar macrophages through crosstalk between p38, the lipoxygenase pathway and PPARalpha
Q39271596Monocyte/Macrophage: NK Cell Cooperation-Old Tools for New Functions
Q36166316Monocytes/Macrophages Upregulate the Hyaluronidase HYAL1 and Adapt Its Subcellular Trafficking to Promote Extracellular Residency upon Differentiation into Osteoclasts
Q60958205More Than Just a Removal Service: Scavenger Receptors in Leukocyte Trafficking
Q38640912Morphologic, phenotypic, and transcriptomic characterization of classically and alternatively activated canine blood-derived macrophages in vitro
Q35646486Much More than M1 and M2 Macrophages, There are also CD169(+) and TCR(+) Macrophages
Q38105045Mucopolysaccharide diseases: a complex interplay between neuroinflammation, microglial activation and adaptive immunity.
Q46657854Multinucleated giant cell formation exhibits features of phagocytosis with participation of the endoplasmic reticulum
Q38721005Multinucleated giant cells in the implant bed of bone substitutes are foreign body giant cells-New insights into the material-mediated healing process.
Q71120130Multiple cutaneous B-cell pseudolymphomas after allergen injections
Q57073314Multivalent nanosystems: targeting monocytes/macrophages
Q33848355Mycobacteria induce TPL-2 mediated IL-10 in IL-4-generated alternatively activated macrophages
Q80171702Myelin-phagocytosing macrophages in isolated sciatic and optic nerves reveal a unique reactive phenotype
Q47761139Myeloid cell plasticity in the evolution of central nervous system autoimmunity
Q47123928Myeloid cell recruitment versus local proliferation differentiates susceptibility from resistance to filarial infection.
Q41106752Myeloid expression of the AP-1 transcription factor JUNB modulates outcomes of type 1 and type 2 parasitic infections.
Q33708751Myeloperoxidase-targeted imaging of active inflammatory lesions in murine experimental autoimmune encephalomyelitis
Q35722787NRF2 Signaling Negatively Regulates Phorbol-12-Myristate-13-Acetate (PMA)-Induced Differentiation of Human Monocytic U937 Cells into Pro-Inflammatory Macrophages
Q90327575Nanostructured titanium regulates osseointegration via influencing macrophage polarization in the osteogenic environment
Q40538969Neither classical nor alternative macrophage activation is required for Pneumocystis clearance during immune reconstitution inflammatory syndrome
Q26798236Nerve injury and neuropathic pain - A question of age
Q33768246Neuroinflammation and M2 microglia: the good, the bad, and the inflamed.
Q27014919Neuroinflammation in Alzheimer's disease; A source of heterogeneity and target for personalized therapy
Q38779873Neuroinflammation: the devil is in the details
Q41581503Neuropathic pain is constitutively suppressed in early life by anti-inflammatory neuroimmune regulation
Q54551338Neurotrophins modulate monocyte chemotaxis without affecting macrophage function.
Q93052075New Insights on the Role of Lipid Metabolism in the Metabolic Reprogramming of Macrophages
Q40866271New insights into the multidimensional concept of macrophage ontogeny, activation and function.
Q35825965Non-canonical alternatives: what a macrophage is 4
Q30252830Non-classical monocytes are biased progenitors of wound healing macrophages during soft tissue injury.
Q39243680Norepinephrine suppresses wound macrophage phagocytic efficiency through alpha- and beta-adrenoreceptor dependent pathways
Q38183358Novel biological strategies for treatment of wear particle-induced periprosthetic osteolysis of orthopaedic implants for joint replacement
Q38415235Novel grooved substrata stimulate macrophage fusion, CCL2 and MMP-9 secretion
Q91497015Obesity: a neuroimmunometabolic perspective
Q30601730Omega-1 knockdown in Schistosoma mansoni eggs by lentivirus transduction reduces granuloma size in vivo
Q39011826One microenvironment does not fit all: heterogeneity beyond cancer cells
Q90629499Optimization of T-cell receptor-modified T cells for cancer therapy
Q90282347Oral squamous carcinoma cells promote macrophage polarization in an MIF-dependent manner
Q50190677Orchestrating liver repair - a newly discovered function of hepatic iNKT cells.
Q41910192Origin and Functions of Tumor-Associated Myeloid Cells (TAMCs).
Q36632387Origin of monocytes and their differentiation to macrophages and dendritic cells
Q38963160Osseointegration of Zirconia in the Presence of Multinucleated Giant Cells.
Q39738927Osteopontin affects macrophage polarization promoting endocytic but not inflammatory properties.
Q33540045Other functions, other genes: alternative activation of antigen-presenting cells
Q42378990Overexpression of OSM and IL-6 impacts the polarization of pro-fibrotic macrophages and the development of bleomycin-induced lung fibrosis
Q24682128Oxidative metabolism and PGC-1beta attenuate macrophage-mediated inflammation
Q91739144PAM3 protects against DSS-induced colitis by altering the M2:M1 ratio
Q40944312Paracrine effects of IL-4 transfection on TS/A adenocarcinoma cells mediate reduced in vivo growth
Q38550186Parasites: what are they good for?
Q37349951Parasitic helminths: a pharmacopeia of anti-inflammatory molecules.
Q92760428Peptide-based targeting of immunosuppressive cells in cancer
Q92421234Pericytes in Cutaneous Wound Healing
Q37209286Peritoneal macrophages from patients with cirrhotic ascites show impaired phagocytosis and vigorous respiratory burst
Q91048642Perivascular macrophages in health and disease
Q41730593Phagocyte-bacteria interactions
Q91706849Pharmacological Targeting of Microglial Activation: New Therapeutic Approach
Q46728072Phenotypic Characterization of Human Monocytes following Macronutrient Intake in Healthy Humans
Q37998021Phenotypic and functional heterogeneity of macrophages and dendritic cell subsets in the healthy and atherosclerosis-prone aorta
Q37246771Phenotypic characterization of lung macrophages in asthmatic patients: overexpression of CCL17.
Q45830978Phenotypic correlations between monocytes and CD4+ T cells in allergic patients.
Q36470642Phenotypic dichotomies in the foreign body reaction
Q34978459Phenotypic expression in human monocyte-derived interleukin-4-induced foreign body giant cells and macrophages in vitro: dependence on material surface properties
Q53546016Phenotypic, functional, and plasticity features of classical and alternatively activated human macrophages.
Q38272127Pleiotropic role of PPARγ in intracerebral hemorrhage: an intricate system involving Nrf2, RXR, and NF-κB.
Q88929744Polymer-augmented liposomes enhancing antibiotic delivery against intracellular infections
Q46546679Polysaccharide-rich fraction of Agaricus brasiliensis enhances the candidacidal activity of murine macrophages
Q38444555Porous implants modulate healing and induce shifts in local macrophage polarization in the foreign body reaction.
Q34298543Porphyromonas gingivalis lipopolysaccharide weakly activates M1 and M2 polarized mouse macrophages but induces inflammatory cytokines.
Q35116475Possible role of arginase-1 in concomitant tumor immunity
Q92856462Potential Immunotherapeutic Targets on Myeloid Cells for Neurovascular Repair After Ischemic Stroke
Q35627060Potential role for alternatively activated macrophages in the secondary bacterial infection during recovery from influenza
Q36508642Preterm birth and single nucleotide polymorphisms in cytokine genes
Q40717214Primary Heligmosomoides polygyrus bakeri infection induces myeloid-derived suppressor cells that suppress CD4+ Th2 responses and promote chronic infection
Q34139938Progressive visceral leishmaniasis is driven by dominant parasite-induced STAT6 activation and STAT6-dependent host arginase 1 expression
Q36862833Properties of human blood monocytes. II. Monocytes from healthy adults are highly heterogeneous within and among individuals
Q36303538Protective immunity against pulmonary cryptococcosis is associated with STAT1-mediated classical macrophage activation
Q47831410Proteomic Signature Reveals Modulation of Human Macrophage Polarization and Functions Under Differing Environmental Oxygen Conditions.
Q33597147Pulmonary infection with an interferon-gamma-producing Cryptococcus neoformans strain results in classical macrophage activation and protection
Q42436985Pulmonary surfactant protein A regulates TLR expression and activity in human macrophages
Q46667650Purinergic signaling during macrophage differentiation results in M2 alternative activated macrophages
Q47169463RANKL-induced M1 macrophages are involved in bone formation
Q33831780RBP4 activates antigen-presenting cells, leading to adipose tissue inflammation and systemic insulin resistance
Q33796715Rapid host defense against Aspergillus fumigatus involves alveolar macrophages with a predominance of alternatively activated phenotype
Q90426278Recombinant Listeria promotes tumor rejection by CD8+ T cell-dependent remodeling of the tumor microenvironment
Q51698784Recombinant Trichinella spiralis 53-kDa protein activates M2 macrophages and attenuates the LPS-induced damage of endotoxemia.
Q38785193Recruited Monocytes and Type 2 Immunity Promote Lung Regeneration following Pneumonectomy
Q38250319Recruiting specialized macrophages across the borders to restore brain functions
Q37032282Redox control of inflammation in macrophages
Q88298734Reduced substrate stiffness promotes M2-like macrophage activation and enhances peroxisome proliferator-activated receptor γ expression
Q37440504Reduction of eotaxin production and eosinophil recruitment by pulmonary autologous macrophage transfer in a cockroach allergen-induced asthma model
Q58692657Regulation of Energy Expenditure and Brown/Beige Thermogenic Activity by Interleukins: New Roles for Old Actors
Q38979320Regulation of IL-4 Expression in Immunity and Diseases
Q61807003Regulation of Type 2 Immunity in Myocardial Infarction
Q36040842Regulation of alternative macrophage activation in the liver following acetaminophen intoxication by stem cell-derived tyrosine kinase
Q26773786Regulation of epithelial-mesenchymal transition by tumor-associated macrophages in cancer
Q36472048Regulation of fibrosis by the immune system
Q38411808Regulation of immunity by Taeniids: lessons from animal models and in vitro studies
Q36232198Regulation of inflammation by interleukin-4: a review of "alternatives"
Q35125229Regulation of macrophage motility by the water channel aquaporin-1: crucial role of M0/M2 phenotype switch
Q37313634Regulation of metabolic health and adipose tissue function by group 2 innate lymphoid cells
Q54587789Regulators of macrophage activation.
Q34219837Regulatory macrophages: setting the threshold for therapy
Q36934619Repair of astrocytes, blood vessels, and myelin in the injured brain: possible roles of blood monocytes
Q37889633Repertoire of microglial and macrophage responses after spinal cord injury
Q90521533Resolution of Deep Venous Thrombosis: Proposed Immune Paradigms
Q92715753Resolution of inflammation in periodontitis: a review
Q38068503Review: activation patterns of microglia and their identification in the human brain.
Q37657853Rheb1 deletion in myeloid cells aggravates OVA-induced allergic inflammation in mice
Q35207665Rhinovirus infection induces interleukin-13 production from CD11b-positive, M2-polarized exudative macrophages
Q35524932Rhinovirus infection of allergen-sensitized and -challenged mice induces eotaxin release from functionally polarized macrophages.
Q33799737Rhinovirus-induced macrophage cytokine expression does not require endocytosis or replication
Q36277715Role for microglia in sex differences after ischemic stroke: importance of M2
Q34309028Role of IL-4 gene polymorphisms in HBV-related hepatocellular carcinoma in a Chinese population
Q37273123Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13-induced tissue responses and apoptosis
Q64111310Role of macrophages in experimental liver injury and repair in mice
Q33902198Role of macrophages in the progression of acute pancreatitis
Q37960792Role of tumor-associated macrophages in the progression of hepatocellular carcinoma
Q38396105Roles of microglia in brain development, tissue maintenance and repair.
Q24598566S100A7 enhances mammary tumorigenesis through upregulation of inflammatory pathways
Q34346340SPI-1 encoded genes of Salmonella Typhimurium influence differential polarization of porcine alveolar macrophages in vitro
Q34641231STAT6 transcription factor is a facilitator of the nuclear receptor PPARγ-regulated gene expression in macrophages and dendritic cells
Q34776805STAT6⁻/⁻ mice exhibit decreased cells with alternatively activated macrophage phenotypes and enhanced disease severity in murine neurocysticercosis
Q42726211Selective inhibition and augmentation of alternative macrophage activation by progesterone.
Q35173433Selenium levels affect the IL-4-induced expression of alternative activation markers in murine macrophages
Q44240692Sequential expression of macrophage anti-microbial/inflammatory and wound healing markers following innate, alternative and classical activation.
Q49921149Sex Differences in Abdominal Aortic Aneurysms.
Q37312771Shaping the murine macrophage phenotype: IL-4 and cyclic AMP synergistically activate the arginase I promoter
Q37618669Shared signaling systems in myeloid cell-mediated muscle regeneration
Q54530046Shift toward an alternatively activated macrophage response in lungs of NO2-exposed rats.
Q37959949Signal Transducers and Activators of Transcription (STAT) family members in helminth infections
Q38204175Signaling pathways involved in MDSC regulation
Q33633305Similarity and diversity in macrophage activation by nematodes, trematodes, and cestodes.
Q93125442Single cell transcriptomics based-MacSpectrum reveals novel macrophage activation signatures in diseases
Q87376871Soluble CD163 serum levels are elevated and correlated with IL-12 and CXCL10 in patients with long-standing rheumatoid arthritis
Q34259885Soluble immune complexes shift the TLR-induced cytokine production of distinct polarized human macrophage subsets towards IL-10
Q39348940Some aspects of the host response to methacrylic acid containing beads in a mouse air pouch
Q36255054Susceptibility of bone marrow-derived macrophages to influenza virus infection is dependent on macrophage phenotype.
Q39658224Synergistic activation by p38MAPK and glucocorticoid signaling mediates induction of M2-like tumor-associated macrophages expressing the novel CD20 homolog MS4A8A.
Q34544517Synthetic cationic peptide IDR-1018 modulates human macrophage differentiation
Q92292838Systemic Immuno-metabolic alterations in chronic obstructive pulmonary disease (COPD)
Q37588446TGF-β induces M2-like macrophage polarization via SNAIL-mediated suppression of a pro-inflammatory phenotype
Q34306291TGFβ signaling plays a critical role in promoting alternative macrophage activation
Q35145474TGR5 reduces macrophage migration through mTOR-induced C/EBPβ differential translation
Q27693193TH1/TH2 paradigm extended: macrophage polarization as an unappreciated pathogen-driven escape mechanism?
Q81245724TLR9 activation is a key event for the maintenance of a mycobacterial antigen-elicited pulmonary granulomatous response
Q37342405TNF-Mediated Restriction of Arginase 1 Expression in Myeloid Cells Triggers Type 2 NO Synthase Activity at the Site of Infection
Q48276186TREM-1 regulates macrophage polarization in ureteral obstruction
Q57911908Targeted IL-4 therapy synergizes with dexamethasone to induce a state of tolerance by promoting Treg cells and macrophages in mice with arthritis
Q33695357Targeting resolution of neuroinflammation after ischemic stroke with a lipoxin A4 analog: Protective mechanisms and long-term effects on neurological recovery.
Q34803221Targeting tumor-associated macrophages as a novel strategy against breast cancer
Q41854447Temporal Characterization of Microglia/Macrophage Phenotypes in a Mouse Model of Neonatal Hypoxic-Ischemic Brain Injury
Q36377797Temporal phenotypic features distinguish polarized macrophages in vitro
Q35567138Th2-M2 immunity in lesions of muscular sarcoidosis and macrophagic myofasciitis.
Q35565153Th2-associated alternative Kupffer cell activation promotes liver fibrosis without inducing local inflammation
Q88811523The ABP Dendrimer, a Drug-Candidate against Inflammatory Diseases That Triggers the Activation of Interleukin-10 Producing Immune Cells
Q39265394The Contribution of Immune Infiltrates to Ototoxicity and Cochlear Hair Cell Loss
Q39188002The Dr. Jekyll and Mr. Hyde complexity of the macrophage response in disease
Q47620705The Effects of Intestinal Nematode L4 Stage on Mouse Experimental Autoimmune Encephalomyelitis.
Q36005808The Interleukin-13 Receptor-α1 Chain Is Essential for Induction of the Alternative Macrophage Activation Pathway by IL-13 but Not IL-4.
Q57062755The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection
Q29615845The M1 and M2 paradigm of macrophage activation: time for reassessment
Q46241798The Mannose Receptor in Regulation of Helminth-Mediated Host Immunity
Q90705241The Metabolic Requirements of Th2 Cell Differentiation
Q92106730The Metabolic Signature of Macrophage Responses
Q38646389The Mononuclear Phagocyte System in Organ Transplantation.
Q92857858The Mononuclear Phagocytic System. Generation of Diversity
Q38691715The Role of Decidual Macrophages During Normal and Pathological Pregnancy
Q26852646The Role of Different Monocyte Subsets in the Pathogenesis of Atherosclerosis and Acute Coronary Syndromes
Q38315987The Role of Macrophages in Promoting and Maintaining Homeostasis at the Fetal-Maternal Interface.
Q35222060The Schistosoma mansoni hepatic egg granuloma provides a favorable microenvironment for sustained growth of Leishmania donovani
Q34072227The absence of MyD88 has no effect on the induction of alternatively activated macrophage during Fasciola hepatica infection
Q42234391The adenosine-dependent angiogenic switch of macrophages to an M2-like phenotype is independent of interleukin-4 receptor alpha (IL-4Rα) signaling
Q97092161The apparition macrophage and Döderlein bacillus is negatively correlated in class I Papanicolaou smear: A morphological examination
Q24606039The chemokine CCL18 causes maturation of cultured monocytes to macrophages in the M2 spectrum
Q38097660The complexity of arterial classical monocyte recruitment.
Q38195893The dynamic lives of macrophage and dendritic cell subsets in atherosclerosis
Q58701739The effects of insulin on the inflammatory activity of BV2 microglia
Q37400831The effects on weight loss and gene expression in adipose and hepatic tissues of very-low carbohydrate and low-fat isoenergetic diets in diet-induced obese mice
Q35338729The emerging understanding of myeloid cells as partners and targets in tumor rejection
Q42929951The expression of tumor-associated macrophages in papillary thyroid carcinoma.
Q40971693The extracellular matrix of eggshell displays anti-inflammatory activities through NF-κB in LPS-triggered human immune cells
Q35970492The generation of macrophages with anti-inflammatory activity in the absence of STAT6 signaling
Q34620962The heterogenic properties of monocytes/macrophages and neutrophils in inflammatory response in diabetes.
Q24646191The human macrophage mannose receptor directs Mycobacterium tuberculosis lipoarabinomannan-mediated phagosome biogenesis
Q34164767The human tissue-biomaterial interface: a role for PPARγ-dependent glucocorticoid receptor activation in regulating the CD163+ M2 macrophage phenotype
Q33525044The identification of markers of macrophage differentiation in PMA-stimulated THP-1 cells and monocyte-derived macrophages
Q37672033The immunomodulatory roles of macrophages at the maternal-fetal interface
Q61844835The immunophenotype of decidual macrophages in acute atherosis
Q38123243The impact of neuroimmune changes on development of amyloid pathology; relevance to Alzheimer's disease.
Q35565148The increase in mannose receptor recycling favors arginase induction and Trypanosoma cruzi survival in macrophages
Q28086874The ischemic environment drives microglia and macrophage function
Q46485632The mannose receptor binds Trichuris muris excretory/secretory proteins but is not essential for protective immunity
Q35200863The mannose receptor in the brain
Q28266161The mannose receptor is a pattern recognition receptor involved in host defense
Q38312058The mannose receptor is expressed by olfactory ensheathing cells in the rat olfactory bulb.
Q21090526The mannose receptor mediates dengue virus infection of macrophages
Q38008966The molecular profile of microglia under the influence of glioma
Q58582556The monocyte-macrophage-mast cell axis in dengue pathogenesis
Q58786407The plasticity of primary microglia and their multifaceted effects on endogenous neural stem cells in vitro and in vivo
Q43865526The polarization of T(h)1/T(h)2 balance is dependent on the intracellular thiol redox status of macrophages due to the distinctive cytokine production
Q55325629The puzzling mechanism of compensatory lung growth.
Q43873599The regulatory peptide pidotimod facilitates M2 macrophage polarization and its function
Q38975948The role of macrophage phenotype in vascularization of tissue engineering scaffolds
Q36913752The role of peritoneal alternatively activated macrophages in the process of peritoneal fibrosis related to peritoneal dialysis
Q38083804The role of pregnancy-specific glycoprotein 1a (PSG1a) in regulating the innate and adaptive immune response
Q58544871The signaling protein Wnt5a promotes TGFβ1-mediated macrophage polarization and kidney fibrosis by inducing the transcriptional regulators Yap/Taz
Q43995521The skewing to Th1 induced by lentinan is directed through the distinctive cytokine production by macrophages with elevated intracellular glutathione content
Q44045459The skin fungus-induced Th1- and Th2-related cytokine, chemokine and prostaglandin E2 production in peripheral blood mononuclear cells from patients with atopic dermatitis and psoriasis vulgaris
Q34343645The tumor microenvironment in colorectal carcinogenesis
Q36389337Therapeutic T cells induce tumor-directed chemotaxis of innate immune cells through tumor-specific secretion of chemokines and stimulation of B16BL6 melanoma to secrete chemokines
Q33556819Thioredoxin peroxidase secreted by Fasciola hepatica induces the alternative activation of macrophages
Q40109019Thymic Stromal Lymphopoietin Is Critical for Regulation of Proinflammatory Cytokine Response and Resistance to Experimental Trypanosoma congolense Infection
Q36545986Thymic stromal lymphopoietin amplifies the differentiation of alternatively activated macrophages
Q35201949Tissue-resident macrophages: then and now.
Q37690485Tissues in different anatomical sites can sculpt and vary the tumor microenvironment to affect responses to therapy
Q34264020Toll-like receptor 3 ligand polyinosinic:polycytidylic acid promotes wound healing in human and murine skin
Q91935631Toxoplasma ROP16I/III ameliorated inflammatory bowel diseases via inducing M2 phenotype of macrophages
Q37040044Transcriptome analysis reveals human cytomegalovirus reprograms monocyte differentiation toward an M1 macrophage
Q34011343Transcriptome profiles associated to VHSV infection or DNA vaccination in turbot (Scophthalmus maximus)
Q98303052Transcriptome sequencing supports a conservation of macrophage polarization in fish
Q28068273Transition from inflammation to proliferation: a critical step during wound healing
Q35894863Transmembrane protein 106a activates mouse peritoneal macrophages via the MAPK and NF-κB signaling pathways
Q89093850Tribbles homolog 1 deficiency modulates function and polarization of murine bone marrow-derived macrophages
Q46080947Truncated thioredoxin (Trx-80) promotes pro-inflammatory macrophages of the M1 phenotype and enhances atherosclerosis
Q49544289Tumor Associated Macrophages as Therapeutic Targets for Breast Cancer.
Q28071990Tumor Associated Macrophages in Kidney Cancer
Q39155704Tumor associated macrophage expressing CD204 is associated with tumor aggressiveness of esophageal squamous cell carcinoma.
Q37148134Tumor-associated macrophages as incessant builders and destroyers of the cancer stroma
Q96303449Tumor-associated macrophages in classical Hodgkin lymphoma: hormetic relationship to outcome
Q35737704Tumor-associated macrophages in oral premalignant lesions coexpress CD163 and STAT1 in a Th1-dominated microenvironment.
Q36849038Tumor-associated macrophages subvert T-cell function and correlate with reduced survival in clear cell renal cell carcinoma
Q99551899Tumor-associated macrophages: Role in the pathological process of tumorigenesis and prospective therapeutic use (Review)
Q38105286Tumor-associated macrophages: functional diversity, clinical significance, and open questions
Q38883475Tumour cell derived effects on monocyte/macrophage polarization and function and modulatory potential of Viscum album lipophilic extract in vitro
Q37238286Type 2 innate lymphoid cells constitutively express arginase-I in the naive and inflamed lung
Q83068118Type II-activated macrophages suppress the development of experimental autoimmune encephalomyelitis
Q37056347Understanding the multiple functions of Gr-1(+) cell subpopulations during microbial infection
Q37308827Unfolding the relationship between secreted molecular chaperones and macrophage activation states
Q88640276Unified nexus of macrophages and maresins in cardiac reparative mechanisms
Q89719700Unique Pro-Inflammatory Response of Macrophages during Apoptotic Cancer Cell Clearance
Q48505385Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α.
Q45864348Vessel-associated myogenic precursors control macrophage activation and clearance of apoptotic cells
Q50099553Wandering pathways in the regulation of innate immunity and inflammation.
Q47826206When Immune Cells Turn Bad-Tumor-Associated Microglia/Macrophages in Glioma.
Q37622424mTORC2 signalling regulates M2 macrophage differentiation in response to helminth infection and adaptive thermogenesis
Q37162763miR-155 Deletion in Mice Overcomes Neuron-Intrinsic and Neuron-Extrinsic Barriers to Spinal Cord Repair.
Q52655307miR-21 depletion in macrophages promotes tumoricidal polarization and enhances PD-1 immunotherapy.
Q34509678γ-Interferon-inducible lysosomal thiol reductase (GILT) maintains phagosomal proteolysis in alternatively activated macrophages
Q28397640γδ T Cells Are Required for M2 Macrophage Polarization and Resolution of Ozone-Induced Pulmonary Inflammation in Mice
Q36477914γδ T cells protect against LPS-induced lung injury

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