Immune attack: the role of inflammation in Alzheimer disease.

scientific article published on June 2015

Immune attack: the role of inflammation in Alzheimer disease. is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1005784241
P356DOI10.1038/NRN3880
P2888exact matchhttps://scigraph.springernature.com/pub.10.1038/nrn3880
P8608Fatcat IDrelease_aethxgergrdbtgmiemu6luifsq
P698PubMed publication ID25991443

P50authorFrank L. HeppnerQ56955724
Richard M RansohoffQ87833085
Burkhard BecherQ48129628
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Microglia and neurodegeneration: the role of systemic inflammation.Q38016812
Proteolytic degradation of amyloid β-proteinQ38016899
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Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's diseaseQ29614374
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Distinct and non-redundant roles of microglia and myeloid subsets in mouse models of Alzheimer's disease.Q46389933
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Transforming growth factor-beta 1 is in plaques in Alzheimer and Down pathologies.Q46609616
Adult mouse astrocytes degrade amyloid-beta in vitro and in situQ46779933
Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's diseaseQ46942969
Passive amyloid immunotherapy clears amyloid and transiently activates microglia in a transgenic mouse model of amyloid deposition.Q47230871
Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-beta peptidesQ47349499
The LPS receptor (CD14) links innate immunity with Alzheimer's diseaseQ47405789
SnapShot: pathobiology of Alzheimer's diseaseQ47975976
Hippocampal expression of murine TNFα results in attenuation of amyloid deposition in vivoQ34633199
Multi-target action of the novel anti-Alzheimer compound CHF5074: in vivo study of long term treatment in Tg2576 mice.Q34656871
Transcriptome-based network analysis reveals a spectrum model of human macrophage activation.Q34659689
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Inside, outside, upside down: damage-associated molecular-pattern molecules (DAMPs) and redoxQ34685501
A neurodegeneration-specific gene-expression signature of acutely isolated microglia from an amyotrophic lateral sclerosis mouse modelQ34746889
Neurovascular dysfunction, inflammation and endothelial activation: implications for the pathogenesis of Alzheimer's diseaseQ34774194
Long-term effects of Abeta42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trialQ34798154
Massive gliosis induced by interleukin-6 suppresses Abeta deposition in vivo: evidence against inflammation as a driving force for amyloid depositionQ34878224
Neuroinflammation in Alzheimer's disease and prion disease.Q34963776
Differential role of CCR2 in the dynamics of microglia and perivascular macrophages during prion diseaseQ35071802
Extended results of the Alzheimer's disease anti-inflammatory prevention trialQ35146385
TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models.Q35161472
The potential of anti-inflammatory drugs for the treatment of Alzheimer's diseaseQ35172428
Osteoarthritis accelerates and exacerbates Alzheimer's disease pathology in mice.Q35231254
A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases.Q35350543
Intrathecal inflammation precedes development of Alzheimer's diseaseQ35476365
Masitinib as an adjunct therapy for mild-to-moderate Alzheimer's disease: a randomised, placebo-controlled phase 2 trialQ35579238
Obesity is associated with hypothalamic injury in rodents and humansQ35640638
TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease modelQ35771760
Amyloid beta-peptide interactions with neuronal and glial cell plasma membrane: binding sites and implications for Alzheimer's diseaseQ35782497
Microglia and Alzheimer's disease pathogenesisQ35805628
Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray studyQ36164195
Plasma multianalyte profiling in mild cognitive impairment and Alzheimer diseaseQ36183810
Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activationQ36231523
Hippocampal expression of murine IL-4 results in exacerbation of amyloid depositionQ36232140
Cellular resistance to infectionQ36265994
Neurovascular dysfunction and faulty amyloid β-peptide clearance in Alzheimer diseaseQ36330297
Identification of interferon-gamma as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activityQ36348121
CD36 mediates the innate host response to beta-amyloidQ36370903
Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microgliaQ36487090
Effect of complement CR1 on brain amyloid burden during aging and its modification by APOE genotypeQ36503998
Neuroinflammatory phenotype in early Alzheimer's diseaseQ36629135
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectinflammationQ101991
Alzheimer's diseaseQ11081
P304page(s)358-372
P577publication date2015-06-01
P1433published inNature Reviews NeuroscienceQ2108225
P1476titleImmune attack: the role of inflammation in Alzheimer disease
P478volume16

Reverse relations

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Q37054001Cognitive Stimulation Modulates Platelet Total Phospholipases A2 Activity in Subjects with Mild Cognitive Impairment
Q46463478Combinatorial Treatment Effects in a Cell Culture Model of Alzheimer's Disease.
Q37559815Combined Plasma and Cerebrospinal Fluid Signature for the Prediction of Midterm Progression From Mild Cognitive Impairment to Alzheimer Disease
Q47105056Comparative profiling of cortical gene expression in Alzheimer's disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation
Q39447009Complement Biomarkers as Predictors of Disease Progression in Alzheimer's Disease
Q37248499Complement-Mediated Regulation of Metabolism and Basic Cellular Processes
Q52315330Complex role of chemokine mediators in animal models of Alzheimer's Disease.
Q60923543Condition-specific gene co-expression network mining identifies key pathways and regulators in the brain tissue of Alzheimer's disease patients
Q47651485Conserved brain myelination networks are altered in Alzheimer's and other neurodegenerative diseases
Q59791994Contribution of Neurons and Glial Cells to Complement-Mediated Synapse Removal during Development, Aging and in Alzheimer's Disease
Q42085409Copper Exposure Perturbs Brain Inflammatory Responses and Impairs Clearance of Amyloid-Beta
Q38763060Copper, differently from zinc, affects the conformation, oligomerization state and activity of bradykinin.
Q47349501Correcting miR92a-vGAT-Mediated GABAergic Dysfunctions Rescues Human Tau-Induced Anxiety in Mice
Q36048502Correlative Light and Electron Microscopy to Study Microglial Interactions with β-Amyloid Plaques
Q26799411Coupled cell networks are target cells of inflammation, which can spread between different body organs and develop into systemic chronic inflammation
Q48192562Crocus sativus Extract Tightens the Blood-Brain Barrier, Reduces Amyloid β Load and Related Toxicity in 5XFAD Mice.
Q89497672Culprit or Bystander: Defective Mitophagy in Alzheimer's Disease
Q54968424Curcumin Treatment is Associated with Increased Expression of the N-Methyl-D-Aspartate Receptor (NMDAR) Subunit, NR2A, in a Rat PC12 Cell Line Model of Alzheimer's Disease Treated with the Acetyl Amyloid-β Peptide, Aβ(25-35).
Q52689556Curcuminoid submicron particle ameliorates cognitive deficits and decreases amyloid pathology in Alzheimer's disease mouse model.
Q48153970Cyclodextrins 3-Functionalized with 8-Hydroxyquinolines: Copper-Binding Ability and Inhibition of Synuclein Aggregation
Q39029104Cytokine networks in neuroinflammation
Q59128496Cytokine profiles and diagnoses in elderly, hospitalized psychiatric patients
Q39220104Cytokines and cytokine networks target neurons to modulate long-term potentiation
Q42094554Dark microglia: A new phenotype predominantly associated with pathological states.
Q64093643Data-Driven Analysis of Age, Sex, and Tissue Effects on Gene Expression Variability in Alzheimer's Disease
Q55517504Death-associated protein kinase 1 mediates interleukin-1β production through regulating inlfammasome activation in Bv2 microglial cells and mice.
Q48630247Deep Brain Stimulation of the Fornix: Engaging Therapeutic Circuits and Networks in Alzheimer Disease.
Q58698087Deficient Wnt Signaling and Synaptic Vulnerability in Alzheimer’s Disease: Emerging Roles for the LRP6 Receptor
Q37694473Dementia with Lewy Bodies: Molecular Pathology in the Frontal Cortex in Typical and Rapidly Progressive Forms.
Q89285825Dendritic Cells as an Alternate Approach for Treatment of Neurodegenerative Disorders
Q42368761Determining the Molecular Pathways Underlying the Protective Effect of Non-Steroidal Anti-Inflammatory Drugs for Alzheimer's Disease: A Bioinformatics Approach
Q57030267Development of a Human APOE Knock-in Mouse Model for Study of Cognitive Function After Cancer Chemotherapy
Q38915171Diagnostic function of the neuroinflammatory biomarker YKL-40 in Alzheimer's disease and other neurodegenerative diseases
Q92193185Diet Associated with Inflammation and Alzheimer's Disease
Q64075735Diet and Inflammation in Cognitive Ageing and Alzheimer's Disease
Q47429414Dietary fish oil, and to a lesser extent the fat-1 transgene, increases astrocyte activation in response to intracerebroventricular amyloid-β 1-40 in mice
Q89578540Different Effects of Nicotine and N-Stearoyl-ethanolamine on Episodic Memory and Brain Mitochondria of α7 Nicotinic Acetylcholine Receptor Knockout Mice
Q59335552Different Patterns of Neurodegeneration and Glia Activation in CA1 and CA3 Hippocampal Regions of TgCRND8 Mice
Q41887011Differential Kv1.3, KCa3.1, and Kir2.1 expression in "classically" and "alternatively" activated microglia
Q58794404Differential chemokine expression under the control of peripheral blood mononuclear cells issued from Alzheimer's patients in a human blood brain barrier model
Q48141250Differential contribution of microglia and monocytes in neurodegenerative diseases.
Q40240888Direct Evidence of Internalization of Tau by Microglia In Vitro and In Vivo.
Q36329594Discovery of the first dual GSK3β inhibitor/Nrf2 inducer. A new multitarget therapeutic strategy for Alzheimer's disease
Q59328931Distinct Microglial Responses in Two Transgenic Murine Models of TAU Pathology
Q90573489Divergent roles of astrocytic versus neuronal EAAT2 deficiency on cognition and overlap with aging and Alzheimer's molecular signatures
Q59128213Diverse Protein Profiles in CNS Myeloid Cells and CNS Tissue From Lipopolysaccharide- and Vehicle-Injected APP/PS1 Transgenic Mice Implicate Cathepsin Z in Alzheimer's Disease
Q89855148Drug Development for Central Nervous System Diseases Using In Vitro Blood-brain Barrier Models and Drug Repositioning
Q39217121Dynamics of the Complement, Cytokine, and Chemokine Systems in the Regulation of Synaptic Function and Dysfunction Relevant to Alzheimer's Disease
Q90072371Dysregulated Gut Homeostasis Observed Prior to the Accumulation of the Brain Amyloid-β in Tg2576 Mice
Q50420748Dysregulation of the epigenetic landscape of normal aging in Alzheimer's disease.
Q58549216Early Life Stress and Epigenetics in Late-onset Alzheimer's Dementia: A Systematic Review
Q36265825Early astrocytosis in autosomal dominant Alzheimer's disease measured in vivo by multi-tracer positron emission tomography
Q38676509Early-Life Toxic Insults and Onset of Sporadic Neurodegenerative Diseases-an Overview of Experimental Studies
Q38734833Effective expression of Drebrin in hippocampus improves cognitive function and alleviates lesions of Alzheimer's disease in APP (swe)/PS1 (ΔE9) mice.
Q61811616Effects of BIS-MEP on Reversing Amyloid Plaque Deposition and Spatial Learning and Memory Impairments in a Mouse Model of β-Amyloid Peptide- and Ibotenic Acid-Induced Alzheimer's Disease
Q46022682Effects of HLA-DRB1/DQB1 Genetic Variants on Neuroimaging in Healthy, Mild Cognitive Impairment, and Alzheimer's Disease Cohorts.
Q48059413Effects of interleukin-1ß on cortical spreading depolarization and cerebral vasculature
Q90680244Effects of the Novel IDO Inhibitor DWG-1036 on the Behavior of Male and Female 3xTg-AD Mice
Q50852421Efficient synthesis of longer Aβ peptides via removable backbone modification.
Q58751451Emerging PET Radiotracers and Targets for Imaging of Neuroinflammation in Neurodegenerative Diseases: Outlook Beyond TSPO
Q26769059Emerging Roles of Filopodia and Dendritic Spines in Motoneuron Plasticity during Development and Disease
Q36643093Endothelial Dysfunction and Amyloid-β-Induced Neurovascular Alterations.
Q92581386Endothelial Immune Activation by Medin: Potential Role in Cerebrovascular Disease and Reversal by Monosialoganglioside-Containing Nanoliposomes
Q92856694Entanglement of CCR5 and Alzheimer's Disease
Q37638090Entorhinal Cortex dysfunction can be rescued by inhibition of microglial RAGE in an Alzheimer's disease mouse model
Q103803412Epigenome-wide meta-analysis of DNA methylation differences in prefrontal cortex implicates the immune processes in Alzheimer's disease
Q38838452Estrogens, Neuroinflammation, and Neurodegeneration.
Q39428145Evaluation of dietary and lifestyle changes as modifiers of S100β levels in Alzheimer's disease.
Q47766786Examining the Role of Microglia and Astroglia During the Pathogenesis of Alzheimer's Disease via the Puri-Li Model.
Q60045416Exercise-Induced Modulation of Neuroinflammation in Models of Alzheimer's Disease
Q64072899Exploiting microglial and peripheral immune cell crosstalk to treat Alzheimer's disease
Q26750366Exploring the Homeostatic and Sensory Roles of the Immune System
Q91583516Exploring the Role of P2X Receptors in Alzheimer's Disease
Q90574605Exposure to Ambient Air Pollution and Cognitive Impairment in Community-Dwelling Older Adults: The Korean Frailty and Aging Cohort Study
Q38888419Fas apoptosis inhibitory molecules: more than death-receptor antagonists in the nervous system
Q57464776Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration
Q30764311Formyl-Peptide Receptor 2/3/Lipoxin A4 Receptor Regulates Neutrophil-Platelet Aggregation and Attenuates Cerebral Inflammation: Impact for Therapy in Cardiovascular Disease
Q92912277Frailty effects on non-demented cognitive trajectories are moderated by sex and Alzheimer's genetic risk
Q28077869Friend or foe: the dichotomous impact of T cells on neuro-de/re-generation during aging
Q92535560Friend, Foe or Both? Immune Activity in Alzheimer's Disease
Q38608481From inflamm-aging to immune-paralysis: a slippery slope during aging for immune-adaptation
Q48159157From peroxisomal disorders to common neurodegenerative diseases - the role of ether phospholipids in the nervous system.
Q57174266Functional neuroanatomy of peripheral inflammatory physiology: A meta-analysis of human neuroimaging studies
Q42373554Gad67 haploinsufficiency reduces amyloid pathology and rescues olfactory memory deficits in a mouse model of Alzheimer's disease
Q93152973Gemfibrozil, a Lipid-Lowering Drug, Lowers Amyloid Plaque Pathology and Enhances Memory in a Mouse Model of Alzheimer's Disease via Peroxisome Proliferator-Activated Receptor α
Q46113901Genetic Association of HLA Gene Variants with MRI Brain Structure in Alzheimer's Disease
Q38616054Genetic Deletion of Tumor Necrosis Factor-α Attenuates Amyloid-β Production and Decreases Amyloid Plaque Formation and Glial Response in the 5XFAD Model of Alzheimer's Disease
Q64939313Genetic and Real-World Clinical Data, Combined with Empirical Validation, Nominate Jak-Stat Signaling as a Target for Alzheimer's Disease Therapeutic Development.
Q26767289Genetic and Transcriptomic Profiles of Inflammation in Neurodegenerative Diseases: Alzheimer, Parkinson, Creutzfeldt-Jakob and Tauopathies
Q60044492Genome-wide RNAseq study of the molecular mechanisms underlying microglia activation in response to pathological tau perturbation in the rTg4510 tau transgenic animal model
Q38752201Genome-wide association study identifies four novel loci associated with Alzheimer's endophenotypes and disease modifiers
Q91583298Ginsenoside Rg1 Exerts Anti-inflammatory Effects via G Protein-Coupled Estrogen Receptor in Lipopolysaccharide-Induced Microglia Activation
Q49397357Glia maturation factor-β: a potential therapeutic target in neurodegeneration and neuroinflammation.
Q52593849Glial alterations in human prion diseases: A correlative study of astroglia, reactive microglia, protein deposition, and neuropathological lesions.
Q38819291Glial cells as drug targets: What does it take?
Q30313120Glutaminyl cyclase activity correlates with levels of Aβ peptides and mediators of angiogenesis in cerebrospinal fluid of Alzheimer's disease patients
Q52145262Gx-50 reduces β-amyloid-induced TNF-α, IL-1β, NO, and PGE2 expression and inhibits NF-κB signaling in a mouse model of Alzheimer's disease.
Q46561810HLA-A2 Alleles Mediate Alzheimer's Disease by Altering Hippocampal Volume
Q37199557HMGB1 and thrombin mediate the blood-brain barrier dysfunction acting as biomarkers of neuroinflammation and progression to neurodegeneration in Alzheimer's disease.
Q55690891Hallmarks of Brain Aging: Adaptive and Pathological Modification by Metabolic States.
Q47888806Heparan Sulfate Proteoglycans as Relays of Neuroinflammation.
Q49885816Hepcidin, an emerging and important player in brain iron homeostasis.
Q39034668High Dimensional Cytometry of Central Nervous System Leukocytes During Neuroinflammation
Q50182771High complement levels in astrocyte-derived exosomes of Alzheimer's disease.
Q48009605High-dimensional, single-cell characterization of the brain's immune compartment
Q39292060Hippocampal proteomics defines pathways associated with memory decline and resilience in normal aging and Alzheimer's disease mouse models
Q38902023Human IL-6, IL-17, IL-1β, and TNF-α differently regulate the expression of pro-inflammatory related genes, tissue factor, and swine leukocyte antigen class I in porcine aortic endothelial cells.
Q92238669Human Inner Ear Immune Activity: A Super-Resolution Immunohistochemistry Study
Q42374946Human TAUP301L overexpression results in TAU hyperphosphorylation without neurofibrillary tangles in adult zebrafish brain
Q40757303IFN-γ promotes τ phosphorylation without affecting mature tangles
Q54979990IL-1β suppresses cLTP-induced surface expression of GluA1 and actin polymerization via ceramide-mediated Src activation.
Q27315329IL-33 ameliorates Alzheimer's disease-like pathology and cognitive decline.
Q58607667Ibuprofen prevents progression of ataxia telangiectasia symptoms in ATM-deficient mice
Q58773839IgM response against amyloid-beta in aging: a potential peripheral protective mechanism
Q26770766Imaging Multimodalities for Dissecting Alzheimer's Disease: Advanced Technologies of Positron Emission Tomography and Fluorescence Imaging
Q60950130Imaging and Molecular Mechanisms of Alzheimer's Disease: A Review
Q26766489Imaging of Leukocyte Trafficking in Alzheimer's Disease
Q89850629Immune and Inflammatory Determinants Underlying Alzheimer's Disease Pathology
Q38731476Immune-mediated processes in neurodegeneration: where do we stand?
Q38675216Immunotherapies in Alzheimer's disease: Too much, too little, too late or off-target?
Q89658608Impact of HMGB1, RAGE, and TLR4 in Alzheimer's Disease (AD): From Risk Factors to Therapeutic Targeting
Q47097794Impact of diabetes mellitus and chronic liver disease on the incidence of dementia and all-cause mortality among patients with dementia
Q92820179Impact of mesenchymal stem cell senescence on inflammaging
Q54941846Impacts of Acute Hypoxia on Alzheimer's Disease-Like Pathologies in APPswe/PS1dE9 Mice and Their Wild Type Littermates.
Q89659517Impaired Innate Immunity Mechanisms in the Brain of Alzheimer's Disease
Q47133736Impaired Resolution of Inflammation in Alzheimer's Disease: A Review
Q91129691Implications of sleep disturbance and inflammation for Alzheimer's disease dementia
Q31059488In Vivo Imaging of Human Neuroinflammation
Q38779574In vivo PET imaging of neuroinflammation in Alzheimer's disease.
Q36135752Increased Levels of Extracellular Microvesicle Markers and Decreased Levels of Endocytic/Exocytic Proteins in the Alzheimer's Disease Brain
Q33857828Increased White Matter Inflammation in Aging- and Alzheimer's Disease Brain
Q47150841Increased expression of Myc-interacting zinc finger protein 1 in APP/PS1 mice.
Q37628290Individual Patient Research (IPR) Outcomes with Alzheimer's Disease: The Psycho-neuro-immune Viewpoint
Q26749360Induced pluripotent stem cells in Alzheimer's disease: applications for disease modeling and cell-replacement therapy
Q55017301Infection of Fungi and Bacteria in Brain Tissue From Elderly Persons and Patients With Alzheimer's Disease.
Q90333330Inferring the Molecular Mechanisms of Noncoding Alzheimer's Disease-Associated Genetic Variants
Q34547897Inflammasomes as therapeutic targets for Alzheimer's disease
Q95856653Inflammation and Oxidative Stress in Multiple Sclerosis: Consequences for Therapy Development
Q41448365Inflammation and bone mineral density: A Mendelian randomization study.
Q88248784Inflammation-induced iron transport and metabolism by brain microglia
Q47634569Inflammatory pathology markers (activated microglia and reactive astrocytes) in early and late onset Alzheimer disease: a post mortem study
Q47968289Influence of Flaxseed Lignan Supplementation to Older Adults on Biochemical and Functional Outcome Measures of Inflammation.
Q89786611Influenza vaccination in early Alzheimer's disease rescues amyloidosis and ameliorates cognitive deficits in APP/PS1 mice by inhibiting regulatory T cells
Q55613035Inhaled Xenon Washout as a Biomarker of Alzheimer's Disease.
Q41186266Inhibition of Inflammation Mediated Through the Tumor Necrosis Factor α Biochemical Pathway Can Lead to Favorable Outcomes in Alzheimer Disease
Q92711503Innate Immune Cells: Monocytes, Monocyte-Derived Macrophages and Microglia as Therapeutic Targets for Alzheimer's Disease and Multiple Sclerosis
Q60920839Innate Immunity Cells and the Neurovascular Unit
Q55289589Innate immune activation in Alzheimer’s disease.
Q49611026Innate immunity and inflammation in Alzheimer´s disease pathogenesis.
Q90266297Integration of Machine Learning Methods to Dissect Genetically Imputed Transcriptomic Profiles in Alzheimer's Disease
Q89461791Interleukin-12/23 deficiency differentially affects pathology in male and female Alzheimer's disease-like mice
Q39076924Interleukin-2 improves amyloid pathology, synaptic failure and memory in Alzheimer's disease mice.
Q64096969Interleukin-6 and lipoprotein-associated phospholipase A2 are associated with functional trajectories
Q59132127Interplay Between the Unfolded Protein Response and Immune Function in the Development of Neurodegenerative Diseases
Q48103278Intracellular tracing of amyloid vaccines through direct fluorescent labelling
Q47216965Iridoids and Other Monoterpenes in the Alzheimer's Brain: Recent Development and Future Prospects
Q59812412Is Alzheimer's Also a Stem Cell Disease? - The Zebrafish Perspective
Q38938961Is Alzheimer's disease a Type 3 Diabetes? A critical appraisal
Q92800212Is Innate Memory a Double-Edge Sword in Alzheimer's Disease? A Reappraisal of New Concepts and Old Data
Q61799972Iso-α-acids, Hop-Derived Bitter Components of Beer, Attenuate Age-Related Inflammation and Cognitive Decline
Q55250888Krüppel-Like Factors in Metabolic Homeostasis and Cardiometabolic Disease.
Q50225528Kynurenine Pathway Metabolites in Alzheimer's Disease.
Q48505307LED enhances anti-inflammatory effect of luteolin (3',4',5,7-tetrahydroxyflavone) in vitro.
Q42987209La Deletion from Mouse Brain Alters Pre-tRNA Metabolism and Accumulation of Pre-5.8S rRNA, with Neuron Death and Reactive Astrocytosis.
Q42144867Lamotrigine Reduces Inflammatory Response and Ameliorates Executive Function Deterioration in an Alzheimer's-Like Mouse Model.
Q57810953Large-scale genome-wide enrichment analyses identify new trait-associated genes and pathways across 31 human phenotypes
Q46926746Let's make microglia great again in neurodegenerative disorders.
Q39159035Leukocyte-mediated Delivery of Nanotherapeutics in Inflammatory and Tumor Sites.
Q90326185Lifelong choline supplementation ameliorates Alzheimer's disease pathology and associated cognitive deficits by attenuating microglia activation
Q50586411Lifestyle and Neurocognition in Older Adults With Cardiovascular Risk Factors and Cognitive Impairment.
Q64990193Lipopolysaccharide-Induced Neuroinflammation as a Bridge to Understand Neurodegeneration.
Q91727697Longitudinal Changes in Regional Cerebral Perfusion and Cognition After Cardiac Operation
Q48369273Longitudinal In Vivo Imaging of the Cerebrovasculature: Relevance to CNS Diseases.
Q55380454Longitudinal chemokine profile expression in a blood-brain barrier model from Alzheimer transgenic versus wild-type mice.
Q47926820Macrophage Migration Inhibitory Factor is Associated with Biomarkers of Alzheimer's Disease Pathology and Predicts Cognitive Decline in Mild Cognitive Impairment and Mild Dementia.
Q54986341Macrophage inflammatory factors promote epithelial-mesenchymal transition in breast cancer.
Q92266717Macrophages at CNS interfaces: ontogeny and function in health and disease
Q97884460Magnolol Ameliorates Behavioral Impairments and Neuropathology in a Transgenic Mouse Model of Alzheimer's Disease
Q92309827Manganese promotes the aggregation and prion-like cell-to-cell exosomal transmission of α-synuclein
Q41622815Manual Acupuncture Suppresses the Expression of Proinflammatory Proteins Associated with the NLRP3 Inflammasome in the Hippocampus of SAMP8 Mice
Q47839893Mass cytometry analysis of immune cells in the brain
Q36198218Mathematical model on Alzheimer's disease
Q47870999Melatonin protects against Aβ-induced neurotoxicity in primary neurons via miR-132/PTEN/AKT/FOXO3a pathway.
Q60303872Meta-analysis of Alzheimer’s disease on 9,751 samples from Norway and IGAP study identifies four risk loci
Q90079761Meta-analysis of human prefrontal cortex reveals activation of GFAP and decline of synaptic transmission in the aging brain
Q92620152Metabolic Endotoxemia: A Potential Underlying Mechanism of the Relationship between Dietary Fat Intake and Risk for Cognitive Impairments in Humans?
Q55425209Metabolic Risk Factors of Alzheimer's Disease, Dementia with Lewy Bodies, and Normal Elderly: A Population-Based Study.
Q38877855Metabolic network failures in Alzheimer's disease: A biochemical road map.
Q36100673Metabolic profiling distinguishes three subtypes of Alzheimer's disease
Q89498986Methotrexate causes persistent deficits in memory and executive function in a juvenile animal model
Q92994436MicroRNA-181a protects against pericyte apoptosis via directly targeting FOXO1: implication for ameliorated cognitive deficits in APP/PS1 mice
Q92089602Microenvironment Remodeling Micelles for Alzheimer's Disease Therapy by Early Modulation of Activated Microglia
Q92649247Microglia Express Insulin-Like Growth Factor-1 in the Hippocampus of Aged APPswe/PS1ΔE9 Transgenic Mice
Q38814802Microglia across the lifespan: from origin to function in brain development, plasticity and cognition
Q28074099Microglia communication: Parallels between aging and Alzheimer's disease
Q91137024Microglia heterogeneity along a spatio-temporal axis: More questions than answers
Q55073016Microglia in Alzheimer's Disease: Activated, Dysfunctional or Degenerative.
Q90671281Microglia in Pain: Detrimental and Protective Roles in Pathogenesis and Resolution of Pain
Q57153215Microglia prevent peripheral immune cell invasion and promote an anti-inflammatory environment in the brain of APP-PS1 transgenic mice
Q48137631Microglia turnover with aging and in an Alzheimer's model via long-term in vivo single-cell imaging.
Q42038294Microglia-Synapse Pathways: Promising Therapeutic Strategy for Alzheimer's Disease.
Q36413131Microglia-targeted stem cell therapies for Alzheimer disease: A preclinical data review
Q90049859Microglial Drug Targets in AD: Opportunities and Challenges in Drug Discovery and Development
Q47805553Microglial Function during Glucose Deprivation: Inflammatory and Neuropsychiatric Implications
Q26739495Microglial Priming and Alzheimer's Disease: A Possible Role for (Early) Immune Challenges and Epigenetics?
Q47899668Microglial modulation of neuronal activity in the healthy brain
Q38815779Microglial phenotypes in Parkinson's disease and animal models of the disease
Q55358469Microglial priming in Alzheimer's disease.
Q36812046Microglial priming through the lung-brain axis: the role of air pollution-induced circulating factors.
Q98727149Mito-Omics and immune function: Applying novel mitochondrial omic techniques to the context of the aging immune system
Q92483746Modeling Alzheimer's disease with iPSC-derived brain cells
Q92000754Modeling and Targeting Alzheimer's Disease With Organoids
Q47844178Modelling Neurodegenerative Microenvironment Using Cortical Organoids Derived from Human Stem Cells
Q47140966Modulating Neuroinflammation to Treat Neuropsychiatric Disorders
Q36364053Molecular Imaging of Neuroinflammation in Neurodegenerative Dementias: The Role of In Vivo PET Imaging
Q36661061Molecular Mechanisms Regulating LPS-Induced Inflammation in the Brain.
Q60954959Molecular Mechanisms of Synaptotoxicity and Neuroinflammation in Alzheimer's Disease
Q38840105Molecular Mechanisms of Vascular Dementia: What Can Be Learned from Animal Models of Chronic Cerebral Hypoperfusion?
Q64233563Molecular Network Analysis of the Urinary Proteome of Alzheimer's Disease Patients
Q55093166Molecular Pharmacology of Rosmarinic and Salvianolic Acids: Potential Seeds for Alzheimer's and Vascular Dementia Drugs.
Q26744105Multi-Target Directed Donepezil-Like Ligands for Alzheimer's Disease
Q90266767Multicrossover Randomized Controlled Trial Designs in Alzheimer Disease
Q30276094Multifaceted interactions between adaptive immunity and the central nervous system
Q47950553Multiple Sclerosis: Implications of Obesity in Neuroinflammation
Q92479151Myeloid Cell and Transcriptome Signatures Associated With Inflammation Resolution in a Model of Self-Limiting Acute Brain Inflammation
Q39388337Myeloid Cells in the Central Nervous System
Q26770676Myeloid Dendritic Cells are Potential Players in Human Neurodegenerative Diseases
Q37675611NETosis in Alzheimer's Disease.
Q41051558Nanoplasmonic fiber tip probe detects significant reduction of intracellular Alzheimer's disease-related oligomers by curcumin
Q63246147Neonatal infection leads to increased susceptibility to Aβ oligomer-induced brain inflammation, synapse loss and cognitive impairment in mice
Q99579302Network Pharmacology Analysis and Molecular Characterization of the Herbal Medicine Formulation Qi-Fu-Yin for the Inhibition of the Neuroinflammatory Biomarker iNOS in Microglial BV-2 Cells: Implication for the Treatment of Alzheimer's Disease
Q38796950Network abnormalities and interneuron dysfunction in Alzheimer disease
Q58797942Network analysis of inflammatory responses to sepsis by neutrophils and peripheral blood mononuclear cells
Q26738352Neural stem/progenitor cells in Alzheimer's disease
Q93079510Neurodegeneration and Neuro-Regeneration-Alzheimer's Disease and Stem Cell Therapy
Q54978806Neuroimmflammation and microglia in glaucoma: time for a paradigm shift.
Q28079115Neuroimmune mechanisms in Krabbe's disease
Q92000951Neuroinflammation and Functional Connectivity in Alzheimer's Disease: Interactive Influences on Cognitive Performance
Q92659576Neuroinflammation-Associated Aspecific Manipulation of Mouse Predator Fear by Toxoplasma gondii
Q98564963Neuronal regulation of immunity: why, how and where?
Q58773068Neuroprotective Activity of Sitagliptin via Reduction of Neuroinflammation beyond the Incretin Effect: Focus on Alzheimer's Disease
Q48497433Neuroprotective Effect of TREM-2 in Aging and Alzheimer's Disease Model.
Q33602850Neurotoxic reactive astrocytes are induced by activated microglia
Q89460111Neurovascular unit dysregulation, white matter disease, and executive dysfunction: the shared triad of vascular cognitive impairment and Alzheimer disease
Q38688856Neutrophils Induce Astroglial Differentiation and Migration of Human Neural Stem Cells via C1q and C3a Synthesis.
Q39175804Neutrophils as protagonists and targets in chronic inflammation.
Q26771804New Drugs from Marine Organisms in Alzheimer's Disease
Q89207621New role of P2X7 receptor in an Alzheimer's disease mouse model
Q99238404Nicotinamide, a Poly [ADP-Ribose] Polymerase 1 (PARP-1) Inhibitor, as an Adjunctive Therapy for the Treatment of Alzheimer's Disease
Q37554157Nitric Oxide: Exploring the Contextual Link with Alzheimer's Disease
Q47396517Novel mechanisms and functions of complement.
Q37615654Obesity and neuroinflammatory phenotype in mice lacking endothelial megalin.
Q41273323Of Mice and Men: Comparative Analysis of Neuro-Inflammatory Mechanisms in Human and Mouse Using Cause-and-Effect Models
Q36301505Oleocanthal enhances amyloid-β clearance from the brains of TgSwDI mice and in vitro across a human blood-brain barrier model
Q50138399Oleocanthal-rich extra-virgin olive oil enhances donepezil effect by reducing amyloid-β load and related toxicity in a mouse model of Alzheimer's disease.
Q26769864Olive Oil and the Hallmarks of Aging
Q35765830On the translocation of bacteria and their lipopolysaccharides between blood and peripheral locations in chronic, inflammatory diseases: the central roles of LPS and LPS-induced cell death
Q37736146Opening up the DNA methylome of dementia
Q30238775Overview of Traumatic Brain Injury: An Immunological Context
Q93155837Oxylipin Profiling of Alzheimer's Disease in Nondiabetic and Type 2 Diabetic Elderly
Q50068373Ozone exposure effect on systemic prostaglandin F2α in rat plasma and urine may not reveal pulmonary damage through inflammation.
Q124094891PSA-NCAM Regulatory Gene Expression Changes in the Alzheimer’s Disease Entorhinal Cortex Revealed with Multiplexed in situ Hybridization
Q58608796Palm Fruit Bioactives modulate human astrocyte activity in vitro altering the cytokine secretome reducing levels of TNFα, RANTES and IP-10
Q88651396Pathogenesis of Alzheimer's Disease Examined Using a Modified Puri-Li Model that Incorporates Calcium Ion Homeostasis
Q92854080Patterns of Expression of Purinergic Receptor P2RY12, a Putative Marker for Non-Activated Microglia, in Aged and Alzheimer's Disease Brains
Q39354673Peptidylarginine Deiminases-Roles in Cancer and Neurodegeneration and Possible Avenues for Therapeutic Intervention via Modulation of Exosome and Microvesicle (EMV) Release?
Q47607906PerSubs: A Graph-Based Algorithm for the Identification of Perturbed Subpathways Caused by Complex Diseases
Q38820131Peripheral Tumor Necrosis Factor-Alpha (TNF-α) Modulates Amyloid Pathology by Regulating Blood-Derived Immune Cells and Glial Response in the Brain of AD/TNF Transgenic Mice
Q57039635Peripheral immune system in aging and Alzheimer's disease
Q47739408Peroxisome proliferator-activated receptor γ (PPARγ): A master gatekeeper in CNS injury and repair
Q39192238Personalized genetics of the cholinergic blockade of neuroinflammation.
Q47361647Phagocytic clearance of presynaptic dystrophies by reactive astrocytes in Alzheimer's disease
Q33679220Pharmacological Modulation of Functional Phenotypes of Microglia in Neurodegenerative Diseases
Q48093692Phosphodiesterase-4B as a Therapeutic Target for Cognitive Impairment and Obesity-Related Metabolic Diseases
Q52680159Plaque-dependent morphological and electrophysiological heterogeneity of microglia in an Alzheimer's disease mouse model.
Q93051104Positive Allosteric Modulation of Alpha7 Nicotinic Acetylcholine Receptors Transiently Improves Memory but Aggravates Inflammation in LPS-Treated Mice
Q38831521Posttranslational modification impact on the mechanism by which amyloid-β induces synaptic dysfunction.
Q38917772Potassium channel expression and function in microglia: Plasticity and possible species variations
Q41099377Potential Roles of Exosomal MicroRNAs as Diagnostic Biomarkers and Therapeutic Application in Alzheimer's Disease
Q39084950Potential importance of B cells in aging and aging-associated neurodegenerative diseases
Q39142379Prenylated Xanthones from the Roots of Cudrania tricuspidata as Inhibitors of Lipopolysaccharide-Stimulated Nitric Oxide Production.
Q64912462Preventive Effects of Dairy Products on Dementia and the Underlying Mechanisms.
Q64087524Processing of Mutant β-Amyloid Precursor Protein and the Clinicopathological Features of Familial Alzheimer's Disease
Q47120805Prostaglandin I2 is responsible for ameliorating prostaglandin E2 stress in stimulating the expression of tumor necrosis factor α in a β-amyloid protein -dependent mechanism
Q36574214Prostaglandin I₂ Attenuates Prostaglandin E₂-Stimulated Expression of Interferon γ in a β-Amyloid Protein- and NF-κB-Dependent Mechanism
Q34508284Prostaglandin J2: a potential target for halting inflammation-induced neurodegeneration
Q49918651Protective Effect of Human Leukocyte Antigen (HLA) Allele DRB1*13:02 on Age-Related Brain Gray Matter Volume Reduction in Healthy Women.
Q36713555Protein Arginine Methylation and Citrullination in Epigenetic Regulation
Q37614594Protein Tyrosine Phosphatase 1B (PTP1B): A Potential Target for Alzheimer's Therapy?
Q37697832Protein misfolding in neurodegenerative diseases: implications and strategies
Q52662413Proteomic analysis of plasma from rheumatoid arthritis patients with mild cognitive impairment.
Q37650729Protocol for a 24-Week Randomized Controlled Study of Once-Daily Oral Dose of Flax Lignan to Healthy Older Adults.
Q41613567Proximate Mediators of Microvascular Dysfunction at the Blood-Brain Barrier: Neuroinflammatory Pathways to Neurodegeneration
Q98176768Psychiatric face of COVID-19
Q36844881Purinergic receptors as potential therapeutic targets in Alzheimer's disease
Q64099249Quantification of white matter cellularity and damage in preclinical and early symptomatic Alzheimer's disease
Q30371534REAC technology modifies pathological neuroinflammation and motor behaviour in an Alzheimer's disease mouse model
Q36774123RXR controlled regulatory networks identified in mouse brain counteract deleterious effects of Aβ oligomers.
Q47732929Rat brain glucose transporter-2, insulin receptor and glial expression are acute targets of intracerebroventricular streptozotocin: risk factors for sporadic Alzheimer's disease?
Q28071816Rat models of spinal cord injury: from pathology to potential therapies
Q92803555Rational discovery of dual-indication multi-target PDE/Kinase inhibitor for precision anti-cancer therapy using structural systems pharmacology
Q48000590Recent Advances in the Inhibition of p38 MAPK as a Potential Strategy for the Treatment of Alzheimer's Disease
Q52603658Recent Advances: Decoding Alzheimer's Disease With Stem Cells.
Q27317159Reduced β-amyloid pathology in an APP transgenic mouse model of Alzheimer's disease lacking functional B and T cells
Q61814310Relationship Between Alzheimer's Disease and the Immune System: A Meta-Analysis of Differentially Expressed Genes
Q38694251Resilience dysregulation in major depressive disorder: focus on glutamatergic imbalance and microglial activation
Q37619977Resolution of Cancer-Promoting Inflammation: A New Approach for Anticancer Therapy
Q26747410Resolution of Inflammation: What Controls Its Onset?
Q38708742Retention of normal glia function by an isoform-selective protein kinase inhibitor drug candidate that modulates cytokine production and cognitive outcomes.
Q38904336Review: Astrocytes in Alzheimer's disease and other age-associated dementias: a supporting player with a central role.
Q47305410Rheumatic diseases are associated with a higher risk of dementia: A nation-wide, population-based, case-control study
Q42373862Rheumatoid arthritis and risk for Alzheimer's disease: a systematic review and meta-analysis and a Mendelian Randomization study
Q47104106Rhinacanthin C Alleviates Amyloid-β Fibrils' Toxicity on Neurons and Attenuates Neuroinflammation Triggered by LPS, Amyloid-β, and Interferon-γ in Glial Cells
Q89621161Role of Host and Pathogen-Derived MicroRNAs in Immune Regulation During Infectious and Inflammatory Diseases
Q37542677Role of Mitochondria-Associated Endoplasmic Reticulum Membrane in Inflammation-Mediated Metabolic Diseases
Q26766462Role of docosahexaenoic acid in the modulation of glial cells in Alzheimer's disease
Q42376572Role of microglial amylin receptors in mediating beta amyloid (Aβ)-induced inflammation
Q99414286Roles of Specialized Pro-Resolving Lipid Mediators in Autophagy and Inflammation
Q96170632Rubus chingii Hu: an overview of botany, traditional uses, phytochemistry, and pharmacology
Q48034311Search for Alzheimer's disease biomarkers in blood cells: hypotheses-driven approach
Q63345230Selective disruption of TLR2-MyD88 interaction inhibits inflammation and attenuates Alzheimer's pathology
Q37716145Serum Hepcidin Levels, Iron Dyshomeostasis and Cognitive Loss in Alzheimer's Disease
Q47579436Sex differences in the phagocytic and migratory activity of microglia and their impairment by palmitic acid
Q43462638Shedding of membrane-associated LDL receptor-related protein-1 from microglia amplifies and sustains neuroinflammation
Q41158349Significance of long chain polyunsaturated fatty acids in human health.
Q87970835Single-cell mass cytometry reveals distinct populations of brain myeloid cells in mouse neuroinflammation and neurodegeneration models
Q36954949Single-cell whole genome sequencing reveals no evidence for common aneuploidy in normal and Alzheimer's disease neurons
Q92772563Sleep and circadian rhythm disruption and stress intersect in Alzheimer's disease
Q91754985Sleep and inflammation: partners in sickness and in health
Q35890272Social-Biological Interactions in Oral Disease: A 'Cells to Society' View
Q37410147Soluble phospho-tau from Alzheimer's disease hippocampus drives microglial degeneration
Q91819996Sphingolipids in neuroinflammation: a potential target for diagnosis and therapy
Q57190087Stem cell factor induces polarization of microglia to the neuroprotective phenotype
Q87932936Substance P and Antagonists of the Neurokinin-1 Receptor in Neuroinflammation Associated with Infectious and Neurodegenerative Diseases of the Central Nervous System
Q92511851Suppression of Alzheimer's Disease-Like Pathology Progression by Mitochondria-Targeted Antioxidant SkQ1: A Transcriptome Profiling Study
Q37460856Surface area-dependence of gas-particle interactions influences pulmonary and neuroinflammatory outcomes.
Q59145861Synthesis of Ibuprofen Conjugated Molecular Transporter Capable of Enhanced Brain Penetration
Q38662596Systematic tissue-specific functional annotation of the human genome highlights immune-related DNA elements for late-onset Alzheimer's disease
Q37672845T Lymphocytes and Inflammatory Mediators in the Interplay between Brain and Blood in Alzheimer's Disease: Potential Pools of New Biomarkers
Q39110320T cell responses in the central nervous system
Q90320717TLR4 (toll-like receptor 4) activation suppresses autophagy through inhibition of FOXO3 and impairs phagocytic capacity of microglia
Q38845677TMEM119 marks a subset of microglia in the human brain
Q51743108TNF alpha inhibitors in Alzheimer's disease: A systematic review.
Q91895181TNF-α promotes human antibody-mediated complement-dependent cytotoxicity of porcine endothelial cells through downregulating P38-mediated Occludin expression
Q52331413TNFα and IL-1β but not IL-18 Suppresses Hippocampal Long-Term Potentiation Directly at the Synapse.
Q26785919TREM2 in CNS homeostasis and neurodegenerative disease
Q48419551Targeting CCR3 to Reduce Amyloid-β Production, Tau Hyperphosphorylation, and Synaptic Loss in a Mouse Model of Alzheimer's Disease.
Q26744219Targeting innate immunity for neurodegenerative disorders of the central nervous system
Q89011157Tau Activates Transposable Elements in Alzheimer's Disease
Q88588446Tau reduction in the presence of amyloid-β prevents tau pathology and neuronal death in vivo
Q90612341Tau-Mediated Disruption of the Spliceosome Triggers Cryptic RNA Splicing and Neurodegeneration in Alzheimer's Disease
Q42252166Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell Resolution
Q91706874Th17 and Cognitive Impairment: Possible Mechanisms of Action
Q94452114The Amyloid-beta rich CNS environment alters myeloid cell functionality independent of their origin
Q58486506The Amyloid-β Peptide in Amyloid Formation Processes: Interactions with Blood Proteins and Naturally Occurring Metal Ions
Q58122158The Dual Role of Hepcidin in Brain Iron Load and Inflammation
Q39217126The Gut Microbiota and Alzheimer's Disease
Q58757545The Gut-Brain Axis in Alzheimer's Disease and Omega-3. A Critical Overview of Clinical Trials
Q96304563The Human Body as a Super Network: Digital Methods to Analyze the Propagation of Aging
Q39324087The IL-1β phenomena in neuroinflammatory diseases
Q90552914The Involvement of NLRP3 on the Effects of Minocycline in an AD-Like Pathology Induced by β-Amyloid Oligomers Administered to Mice
Q38671719The Lipoxygenases: Their Regulation and Implication in Alzheimer's Disease.
Q52147741The Oral Iron Chelator, Deferasirox, Reverses the Age-Dependent Alterations in Iron and Amyloid-β Homeostasis in Rat Brain: Implications in the Therapy of Alzheimer's Disease.
Q41334102The P2X7 Receptor Primes IL-1β and the NLRP3 Inflammasome in Astrocytes Exposed to Mechanical Strain
Q42006096The Rag-Ragulator Complex Regulates Lysosome Function and Phagocytic Flux in Microglia
Q55381143The Role of Genetics in Advancing Precision Medicine for Alzheimer's Disease-A Narrative Review.
Q99711183The Role of Microglia in Perioperative Neurocognitive Disorders
Q38676359The Triggering Receptor Expressed on Myeloid Cells 2: A Molecular Link of Neuroinflammation and Neurodegenerative Diseases
Q63740571The Use of Pluripotent Stem Cell-Derived Organoids to Study Extracellular Matrix Development during Neural Degeneration
Q47550084The association of high sensitivity C-reactive protein and incident Alzheimer disease in patients 60 years and older: The HUNT study, Norway
Q30239749The blood brain barrier in Alzheimer's disease.
Q47122756The cargo protein MAP17 (PDZK1IP1) regulates the immune microenvironment
Q38562255The complex contribution of chemokines to neuroinflammation: switching from beneficial to detrimental effects
Q64989086The emerging risk of exposure to air pollution on cognitive decline and Alzheimer's disease - Evidence from epidemiological and animal studies.
Q61772849The identity and function of microglia in neurodegeneration
Q37085168The mixed-lineage kinase 3 inhibitor URMC-099 facilitates microglial amyloid-β degradation
Q37054759The relationship between complement factor C3, APOE ε4, amyloid and tau in Alzheimer's disease
Q40080281The role of the immunoproteasome in interferon-γ-mediated microglial activation
Q42656274The roles of inflammation and immune mechanisms in Alzheimer's disease
Q50532647The technical reliability and biotemporal stability of cerebrospinal fluid biomarkers for profiling multiple pathophysiologies in Alzheimer's disease.
Q64269112Theaflavins Improve Memory Impairment and Depression-Like Behavior by Regulating Microglial Activation
Q42135978Therapeutic effect of frankincense in a rat model of Alzheimer's disease
Q52371823Thioredoxin-Interacting Protein (TXNIP) in Cerebrovascular and Neurodegenerative Diseases: Regulation and Implication.
Q41876717Three-way interaction model to trace the mechanisms involved in Alzheimer's disease transgenic mice
Q64236740Thrombin and the in Neurotrauma, ALS, and Other Neurodegenerative Disorders
Q48182680Towards a Novel Class of Multitarget-Directed Ligands: Dual P2X7-NMDA Receptor Antagonists
Q60950945Traditional Japanese Herbal Medicine Yokukansan Targets Distinct but Overlapping Mechanisms in Aged Mice and in the 5xFAD Mouse Model of Alzheimer's Disease
Q90709364Transcriptional and Epigenetic Regulation of Microglia in Health and Disease
Q63246569Transcriptional mechanism of IRF8 and PU.1 governs microglial activation in neurodegenerative condition
Q91875027Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation
Q33635637Transcriptome sequencing study implicates immune-related genes differentially expressed in schizophrenia: new data and a meta-analysis
Q90262416Transcriptomic analysis reveals new hippocampal gene networks induced by prolactin
Q97644250Translocator Protein 18 kDa (TSPO) Deficiency Inhibits Microglial Activation and Impairs Mitochondrial Function
Q39547833Treatment for Rheumatoid Arthritis and Risk of Alzheimer's Disease: A Nested Case-Control Analysis
Q47741254Trigonelline insulates against oxidative stress, proinflammatory cytokines and restores BDNF levels in lipopolysaccharide induced cognitive impairment in adult mice
Q90383670Type 1 Interleukin-4 Signaling Obliterates Mouse Astroglia in vivo but Not in vitro
Q52328598U1 snRNP Alteration and Neuronal Cell Cycle Reentry in Alzheimer Disease.
Q47751388Understanding AMD by analogy: systematic review of lipid-related common pathogenic mechanisms in AMD, AD, AS and GN.
Q48863961Understanding the Role of miR-33 in Brain Lipid Metabolism: Implications for Alzheimer's Disease.
Q47431150Understanding the roles of mutations in the amyloid precursor protein in Alzheimer disease.
Q54944394Unique and shared inflammatory profiles of human brain endothelia and pericytes.
Q52314225Unraveling the Complex Interplay Between T Cell Metabolism and Function.
Q48183122Validating GWAS Variants from Microglial Genes Implicated in Alzheimer's Disease
Q23915139Vascular-directed responses of microglia produced by methamphetamine exposure: indirect evidence that microglia are involved in vascular repair?
Q57039750Visceral fat-related systemic inflammation and the adolescent brain: a mediating role of circulating glycerophosphocholines
Q92603728Vitamin E and Alzheimer's disease: what do we know so far?
Q42656222Vitamin E family: Role in the pathogenesis and treatment of Alzheimer's disease
Q33705067Voluntary Exercise Promotes Glymphatic Clearance of Amyloid Beta and Reduces the Activation of Astrocytes and Microglia in Aged Mice
Q55318125Von Willebrand factor and ADAMTS13 activity in relation to risk of dementia: a population-based study.
Q47268030Water Quality and Brain Function
Q92819641White matter inflammation and cognitive function in a co-morbid metabolic syndrome and prodromal Alzheimer's disease rat model
Q46302841Why are Functional Amyloids Non-Toxic in Humans?
Q92021885Why microglia kill neurons after neural disorders? The friendly fire hypothesis
Q36285113Wine Flavonoids in Health and Disease Prevention
Q33784904YKL-40 (Chitinase 3-like I) is expressed in a subset of astrocytes in Alzheimer's disease and other tauopathies
Q89014037[18F]FEPPA a TSPO Radioligand: Optimized Radiosynthesis and Evaluation as a PET Radiotracer for Brain Inflammation in a Peripheral LPS-Injected Mouse Model
Q92486776[Efficacy and safety of metformin for Behcet's disease and its effect on Treg/Th17 balance: a single-blinded, before-after study]
Q42910436iRhoms in the brain - a new frontier?
Q55338776modCHIMERA: a novel murine closed-head model of moderate traumatic brain injury.
Q47757183γ-Secretase in microglia - implications for neurodegeneration and neuroinflammation.

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