Serum Hepcidin Levels, Iron Dyshomeostasis and Cognitive Loss in Alzheimer's Disease

scientific article published on April 2017

Serum Hepcidin Levels, Iron Dyshomeostasis and Cognitive Loss in Alzheimer's Disease is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.14336/AD.2016.0811
P932PMC publication ID5362180
P698PubMed publication ID28400987

P50authorShayan WasehQ57476631
Michael D. GarrickQ47796123
P2093author name stringLin Zhao
Joseph F Quinn
Zihua Hu
Daniel Sternberg
Zohara Sternberg
Kaye Jeffrey
Katharine Wild
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Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalizationQ24310115
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Iron and the translation of the amyloid precursor protein (APP) and ferritin mRNAs: riboregulation against neural oxidative damage in Alzheimer's diseaseQ24651822
Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporterQ28145559
Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammationQ28186993
Assignment of human ferritin genes to chromosomes 11 and 19q13.3----19qterQ28305793
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Ferritin and ferritin isoforms II: protection against uncontrolled cellular proliferation, oxidative damage and inflammatory processes.Q30362213
Core candidate neurochemical and imaging biomarkers of Alzheimer's diseaseQ31162752
Increased iron and free radical generation in preclinical Alzheimer disease and mild cognitive impairmentQ33740552
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Coordinate transcriptional and translational regulation of ferritin in response to oxidative stressQ33964988
Selective translational control of the Alzheimer amyloid precursor protein transcript by iron regulatory protein-1.Q34181256
Body fluid cytokine levels in mild cognitive impairment and Alzheimer's disease: a comparative overviewQ34277859
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Serum ferritin is an important inflammatory disease marker, as it is mainly a leakage product from damaged cellsQ56974269
Selective Reductions in Plasma A 1-42 in Healthy Elderly Subjects During Longitudinal Follow-Up: A Preliminary ReportQ57317953
Ferritin Heavy Chain Upregulation by NF-κB Inhibits TNFα-Induced Apoptosis by Suppressing Reactive Oxygen SpeciesQ58419541
The iron content of serum ferritin: physiological importance and diagnostic valueQ73349406
Serum ferritin iron, a new test, measures human body iron stores unconfounded by inflammationQ73577498
Plasma A[beta]40 and A[beta]42 and Alzheimer's disease: relation to age, mortality, and riskQ79279445
Glucose acts as a regulator of serum iron by increasing serum hepcidin concentrationsQ84595476
Body iron stores in relation to risk of type 2 diabetes in apparently healthy womenQ34297017
A quantitative analysis of isoferritins in select regions of aged, parkinsonian, and Alzheimer's diseased brainsQ34300345
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Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer's disease: implications for sequence of pathological events in Alzheimer's diseaseQ37181302
Ventricular enlargement as a possible measure of Alzheimer's disease progression validated using the Alzheimer's disease neuroimaging initiative databaseQ37300216
Alzheimer's disease and the Blood-Brain Barrier: Past, Present and FutureQ37422795
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The interplay between iron accumulation, mitochondrial dysfunction, and inflammation during the execution step of neurodegenerative disordersQ38198015
Role for NF-kappa B in the regulation of ferritin H by tumor necrosis factor-alphaQ38294141
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Multifunctional iron-chelators with protective roles against neurodegenerative diseases.Q39181472
Structural and immunological relationships of isoferritins in normal and malignant cellsQ39379847
How Do Scores on the ADAS-Cog, MMSE, and CDR-SOB Correspond?Q40263591
The effect of iron in MRI and transverse relaxation of amyloid-beta plaques in Alzheimer's diseaseQ41661825
Effect of iron overload on glucose metabolism in patients with hereditary hemochromatosis.Q42461077
Importance of hypoglycemia on the risk of Alzheimer's disease in elderly subjects with diabetes mellitusQ43182104
An iron-responsive element type II in the 5'-untranslated region of the Alzheimer's amyloid precursor protein transcriptQ44116151
Pancreatic beta-cells express hepcidin, an iron-uptake regulatory peptide.Q46628661
Serum ferritin is derived primarily from macrophages through a nonclassical secretory pathway.Q46645329
Decreased plasma iron in Alzheimer's disease is due to transferrin desaturationQ46686159
A complex proinflammatory role for peripheral monocytes in Alzheimer's disease.Q46827803
Macrophages function as a ferritin iron source for cultured human erythroid precursorsQ46976742
Relationship between brain R(2) and liver and serum iron concentrations in elderly men.Q48334368
Apolipoprotein E-dependent accumulation of Alzheimer disease-related lesions begins in middle age.Q48552163
Transferrin receptor on endothelium of brain capillariesQ48602638
Modest amyloid deposition is associated with iron dysregulation, microglial activation, and oxidative stress.Q48861931
Ferritin H is a novel marker of early erythroid precursors and macrophages.Q50492019
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Association of low plasma Abeta42/Abeta40 ratios with increased imminent risk for mild cognitive impairment and Alzheimer disease.Q51762261
P433issue2
P921main subjectAlzheimer's diseaseQ11081
P304page(s)215-227
P577publication date2017-04-01
P1433published inAging and DiseaseQ20312700
P1476titleSerum Hepcidin Levels, Iron Dyshomeostasis and Cognitive Loss in Alzheimer's Disease
P478volume8

Reverse relations

cites work (P2860)
Q64981447DMT1 Expression and Iron Levels at the Crossroads Between Aging and Neurodegeneration.
Q49885816Hepcidin, an emerging and important player in brain iron homeostasis.
Q58754278Iron and Alzheimer's Disease: From Pathogenesis to Therapeutic Implications
Q53698735No effects without causes: the Iron Dysregulation and Dormant Microbes hypothesis for chronic, inflammatory diseases.
Q92801350Plasma Lipoprotein-associated Phospholipase A2 and Superoxide Dismutase are Independent Predicators of Cognitive Impairment in Cerebral Small Vessel Disease Patients: Diagnosis and Assessment
Q60046944Rusty Microglia: Trainers of Innate Immunity in Alzheimer's Disease
Q60949622Vitamin B12 Levels in Methamphetamine Addicts

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