Transcriptome-based network analysis reveals a spectrum model of human macrophage activation.

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Transcriptome-based network analysis reveals a spectrum model of human macrophage activation. is …
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scholarly articleQ13442814

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P356DOI10.1016/J.IMMUNI.2014.01.006
P932PMC publication ID3991396
P698PubMed publication ID24530056
P5875ResearchGate publication ID260217931

P50authorJoachim SchultzeQ1690457
Thomas FreemanQ42611926
Dominic De NardoQ56437411
Larisa I LabzinQ56994724
Andrea Nino-CastroQ59549464
P2093author name stringWolfgang Krebs
Eicke Latz
Michael Kraut
Jia Xue
Jil Sander
Marc Beyer
Michael R Mallmann
Susanne V Schmidt
Thomas Ulas
Lisa Schmidleithner
Astrid Draffehn
Martina Emde
Heidi Theis
Hariharasudan Ganesan
Inga Quester
Trupti D Gohel
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Exploring the full spectrum of macrophage activationQ24653754
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A validated regulatory network for Th17 cell specificationQ28586624
Transcriptional profiling of the human monocyte-to-macrophage differentiation and polarization: new molecules and patterns of gene expressionQ28646286
Integration of biological networks and gene expression data using CytoscapeQ28681323
TFCat: the curated catalog of mouse and human transcription factorsQ28752619
Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigmQ29614349
Alternative activation of macrophages: an immunologic functional perspectiveQ29614353
Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophagesQ29620142
Protective and pathogenic functions of macrophage subsetsQ29620351
Reverse engineering of regulatory networks in human B cellsQ30004211
ENDEAVOUR update: a web resource for gene prioritization in multiple speciesQ30482616
Uncovering a macrophage transcriptional program by integrating evidence from motif scanning and expression dynamicsQ33325887
Network visualization and analysis of gene expression data using BioLayout Express(3D).Q33508084
ExprEssence--revealing the essence of differential experimental data in the context of an interaction/regulation net-workQ33758941
Controlling the response: predictive modeling of a highly central, pathogen-targeted core response module in macrophage activationQ33826113
Smoking-dependent reprogramming of alveolar macrophage polarization: implication for pathogenesis of chronic obstructive pulmonary diseaseQ33865189
The role of the transcription factor CREB in immune functionQ33920635
Human macrophage activation programs induced by bacterial pathogensQ34009967
Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophagesQ34263905
The distribution of macrophages with a M1 or M2 phenotype in relation to prognosis and the molecular characteristics of colorectal cancerQ34450525
Mixed-polarization phenotype of ascites-associated macrophages in human ovarian carcinoma: correlation of CD163 expression, cytokine levels and early relapseQ34516665
The Immunological Genome Project: networks of gene expression in immune cells.Q34830433
ToppGene Suite for gene list enrichment analysis and candidate gene prioritizationQ34982758
Anti-inflammatory protein TSG-6 secreted by activated MSCs attenuates zymosan-induced mouse peritonitis by decreasing TLR2/NF-κB signaling in resident macrophages.Q35112231
Indoleamine 2,3-dioxygenase-expressing dendritic cells form suppurative granulomas following Listeria monocytogenes infectionQ35131219
InnateDB: systems biology of innate immunity and beyond--recent updates and continuing curationQ36491232
Macrophage polarization in metabolic disorders: functions and regulationQ36591717
Conservation and divergence in the transcriptional programs of the human and mouse immune systemsQ36637283
Reverse engineering and analysis of large genome-scale gene networksQ36668797
Macrophage heterogeneity in respiratory diseasesQ36692041
Dynamic regulatory network controlling TH17 cell differentiationQ36799525
Transcriptional insights into the CD8(+) T cell response to infection and memory T cell formationQ36947052
Integrated regulation of Toll-like receptor responses by Notch and interferon-gamma pathwaysQ36977850
Shared and distinct transcriptional programs underlie the hybrid nature of iNKT cellsQ37150584
Deciphering the transcriptional network of the dendritic cell lineageQ37700905
Transcriptional regulation of macrophage polarization: enabling diversity with identityQ37949245
Studying the mononuclear phagocyte system in the molecular age.Q37949247
Hypoxia-inducible factors: crosstalk between inflammation and metabolismQ38004672
New anti-inflammatory targets for chronic obstructive pulmonary disease.Q38131512
Reverse engineering cellular networks.Q38303089
Functional clustering and lineage markers: insights into cellular differentiation and gene function from large-scale microarray studies of purified primary cell populationsQ38345973
Molecular definition of the identity and activation of natural killer cellsQ38430881
Lipid chaperones and metabolic inflammationQ38908903
Infection of myeloid dendritic cells with Listeria monocytogenes leads to the suppression of T cell function by multiple inhibitory mechanismsQ39938261
Understanding the human immune system in the 21st century: the Human Immunology Project ConsortiumQ44236779
Cutting edge: Toll-like receptor (TLR)2- and TLR4-mediated pathogen recognition in resistance to airborne infection with Mycobacterium tuberculosisQ44281901
Meta-analysis of lineage-specific gene expression signatures in mouse leukocyte populationsQ56879947
Cigarette smoke-induced changes to alveolar macrophage phenotype and function are improved by treatment with procysteineQ84512676
P4510describes a project that usesCytoscapeQ3699942
WGCNAQ102537983
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectmacrophageQ184204
transcriptomeQ252857
P304page(s)274-288
P577publication date2014-02-13
P1433published inImmunityQ6005457
P1476titleTranscriptome-based network analysis reveals a spectrum model of human macrophage activation
P478volume40

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Q49720453Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing.
Q38837265Inflammation and Fibrosis in Polycystic Kidney Disease
Q49788145Inflammatory macrophage-associated 3-gene signature predicts subclinical allograft injury and graft survival.
Q94476088Influence of the Hippo-YAP signalling pathway on tumor associated macrophages (TAMs) and its implications on cancer immunosuppressive microenvironment
Q39314130Innate immunity in Alzheimer's disease: the relevance of animal models?
Q36984213Insulin-Like Growth Factor-1 Receptor Deficiency in Macrophages Accelerates Atherosclerosis and Induces an Unstable Plaque Phenotype in Apolipoprotein E-Deficient Mice
Q40142055Integrated Transcriptomics Establish Macrophage Polarization Signatures and have Potential Applications for Clinical Health and Disease
Q34202948Integrated multi-cohort transcriptional meta-analysis of neurodegenerative diseases.
Q37576503Interaction of biomedical nanoparticles with the pulmonary immune system
Q42513727Interferon-γ Represses M2 Gene Expression in Human Macrophages by Disassembling Enhancers Bound by the Transcription Factor MAF.
Q91973636Intestinal Macrophages Balance Inflammatory Expression Profiles via Vitamin A and Dectin-1-Mediated Signaling
Q36754839Intrinsic Gastrointestinal Macrophages: Their Phenotype and Role in Gastrointestinal Motility
Q37742749Intrinsic Properties of Brown and White Adipocytes Have Differential Effects on Macrophage Inflammatory Responses.
Q30700375Invariant NKT Cell Activation Induces Late Preterm Birth That Is Attenuated by Rosiglitazone
Q47161414Iron Induces Anti-tumor Activity in Tumor-Associated Macrophages.
Q54192665Isoniazid-induced control of Mycobacterium tuberculosis by primary human cells requires interleukin-1 receptor and tumor necrosis factor.
Q33940685IκB kinase activity drives fetal lung macrophage maturation along a non-M1/M2 paradigm.
Q39084316JUNB is a key transcriptional modulator of macrophage activation
Q58734434Kidney-resident macrophages promote a proangiogenic environment in the normal and chronically ischemic mouse kidney
Q51551641Killing Is Not Enough: How Apoptosis Hijacks Tumor-Associated Macrophages to Promote Cancer Progression.
Q86870693Krüppel-like factor 4 is a transcriptional regulator of M1/M2 macrophage polarization in alcoholic liver disease
Q92284345LSECtin on tumor-associated macrophages enhances breast cancer stemness via interaction with its receptor BTN3A3
Q39155573Latest perspectives on macrophages in bone homeostasis.
Q90439358Leukocyte Isolation from Brain, Spinal Cord, and Meninges for Flow Cytometric Analysis
Q90626648Linking innate immunity and chronic antibody-mediated allograft rejection
Q46302267Lipid homeostasis and inflammatory activation are disturbed in classically activated macrophages with peroxisomal β-oxidation deficiency
Q40441909Lipid profiling of polarized human monocyte-derived macrophages
Q88459661Lipidomic Profiling of Murine Macrophages Treated with Fatty Acids of Varying Chain Length and Saturation Status
Q64946007Liver Macrophages: Old Dogmas and New Insights.
Q39065620Liver inflammation and fibrosis
Q39187324Liver macrophages in tissue homeostasis and disease
Q90691528Loss of Nucleobindin-2 Causes Insulin Resistance in Obesity without Impacting Satiety or Adiposity
Q37241568Lung Macrophage Diversity and Asthma
Q89510732Lung Macrophage Functional Properties in Chronic Obstructive Pulmonary Disease
Q48108723Lung macrophages: old hands required rather than new blood?
Q88451456M1 Macrophages but Not M2 Macrophages Are Characterized by Upregulation of CRP Expression via Activation of NFκB: a Possible Role for Ox-LDL in Macrophage Polarization
Q90601875Macrophage Activation and Functions during Helminth Infection: Recent Advances from the Laboratory Mouse
Q58592685Macrophage Biology, Classification, and Phenotype in Cardiovascular Disease: JACC Macrophage in CVD Series (Part 1)
Q98290075Macrophage Immunometabolism and Inflammaging: Roles of Mitochondrial Dysfunction, Cellular Senescence, CD38, and NAD
Q38891314Macrophage Kdm6b controls the pro-fibrotic transcriptome signature of foam cells
Q39210018Macrophage Metabolism As Therapeutic Target for Cancer, Atherosclerosis, and Obesity.
Q90447987Macrophage Mineralocorticoid Receptor Is a Pleiotropic Modulator of Myocardial Infarct Healing
Q33744534Macrophage Ontogeny Underlies Differences in Tumor-Specific Education in Brain Malignancies
Q89666166Macrophage Phenotype and Function in Liver Disorder
Q52874552Macrophage Regulation during Vascular Remodeling: Implications for Pulmonary Hypertension Therapy.
Q29620642Macrophage activation and polarization: nomenclature and experimental guidelines
Q38893448Macrophage form, function, and phenotype in mycobacterial infection: lessons from tuberculosis and other diseases
Q38844780Macrophage heterogeneity in the context of rheumatoid arthritis.
Q26861223Macrophage heterogeneity in tissues: phenotypic diversity and functions
Q64067626Macrophage nuclear receptors: Emerging key players in infectious diseases
Q47891136Macrophage polarization and function: new prospects for fibrotic disease
Q26765298Macrophage polarization in nerve injury: do Schwann cells play a role?
Q38554081Macrophage polarization in pathology
Q64261899Macrophage proliferation distinguishes 2 subgroups of knee osteoarthritis patients
Q38804011Macrophage response to oncolytic paramyxoviruses potentiates virus-mediated tumor cell killing
Q28084850Macrophage responses to implants: prospects for personalized medicine
Q93063710Macrophage spatial heterogeneity in gastric cancer defined by multiplex immunohistochemistry
Q49108693Macrophage, a long-distance middleman.
Q54225686Macrophage-Derived Extracellular Vesicles Induce Long-Lasting Immunity Against Hepatitis C Virus Which Is Blunted by Polyunsaturated Fatty Acids.
Q92800362Macrophage-Derived Extracellular Vesicles as Carriers of Alarmins and Their Potential Involvement in Bone Homeostasis
Q39319066Macrophage-based therapeutic strategies in regenerative medicine
Q92511732Macrophages Are Key Regulators of Stem Cells during Skeletal Muscle Regeneration and Diseases
Q64067981Macrophages Do Not Express the Phagocytic Receptor BAI1/ADGRB1
Q63915886Macrophages and Cardiovascular Health
Q26738772Macrophages and Their Role in Atherosclerosis: Pathophysiology and Transcriptome Analysis
Q34627838Macrophages and dendritic cells as actors in the immune reaction of classical Hodgkin lymphoma
Q37624909Macrophages as Key Drivers of Cancer Progression and Metastasis.
Q89701276Macrophages employ quorum licensing to regulate collective activation
Q38820074Macrophages in Vascular Inflammation: Origins and Functions
Q90153652Macrophages in obesity and non-alcoholic fatty liver disease: Crosstalk with metabolism
Q38194688Macrophages in solid organ transplantation
Q26765377Macrophages: Regulators of the Inflammatory Microenvironment during Mammary Gland Development and Breast Cancer
Q38734834Macrophages: sentinels and regulators of the immune system
Q52881850Mass cytometry deep phenotyping of human mononuclear phagocytes and myeloid-derived suppressor cells from human blood and bone marrow.
Q38299898Master and commander: epigenetic regulation of macrophages
Q50184676Matrix metalloproteinases in emphysema.
Q90685522Mechanisms of Insulin Action and Insulin Resistance
Q30353324Membrane-Tethered MUC1 Mucin Counter-Regulates the Phagocytic Activity of Macrophages.
Q36347294Mer receptor tyrosine kinase mediates both tethering and phagocytosis of apoptotic cells.
Q51024048Mesenchymal stem cells maintain the microenvironment of central nervous system by regulating the polarization of macrophages/microglia after traumatic brain injury.
Q92538680Meta-Analysis of in vitro-Differentiated Macrophages Identifies Transcriptomic Signatures That Classify Disease Macrophages in vivo
Q52665600Metabolic Modulation in Macrophage Effector Function.
Q64100293Metabolic programming of macrophage functions and pathogens control
Q99583883Metabolic programming of tumor associated macrophages in the context of cancer treatment
Q50062519Metabolic regulation of macrophage phenotype and function.
Q39337536Metabolic regulation of macrophages during tissue repair: insights from skeletal muscle regeneration.
Q99583885Metabolic reprograming of tumor-associated macrophages
Q91142796Metabolic rewiring of macrophages by CpG potentiates clearance of cancer cells and overcomes tumor-expressed CD47-mediated 'don't-eat-me' signal
Q54256083Metabolomic profiling of macrophages determines the discrete metabolomic signature and metabolomic interactome triggered by polarising immune stimuli.
Q93336495Meteorin-like/Meteorin-β Is a Novel Immunoregulatory Cytokine Associated with Inflammation
Q92408379MicroRNA Regulated Macrophage Activation in Obesity
Q49977551MicroRNA networks associated with active systemic juvenile idiopathic arthritis regulate CD163 expression and anti-inflammatory functions in macrophages through two distinct mechanisms.
Q38823315MicroRNA regulation of macrophages in human pathologies
Q53392184Microglia in Alzheimer's disease.
Q91592211Microglia responses to interleukin-6 and type I interferons in neuroinflammatory disease
Q33843373Microglial Activation in Traumatic Brain Injury
Q33711718Microglial depletion alters the brain neuroimmune response to acute binge ethanol withdrawal
Q36348184Microglial malfunction: the third rail in the development of Alzheimer's disease
Q90638768Mitochondrial Membrane Potential Regulates Nuclear Gene Expression in Macrophages Exposed to Prostaglandin E2
Q33558314Models of global gene expression define major domains of cell type and tissue identity
Q34019783Modulating neurotoxicity through CX3CL1/CX3CR1 signaling
Q39249384Modulation of innate immunity of patients with Alzheimer's disease by omega-3 fatty acids
Q30354884Modulation of macrophage antitumor potential by apoptotic lymphoma cells.
Q45829514Molecular Mechanisms Modulating the Phenotype of Macrophages and Microglia
Q38339473Molecular pathogenesis of cigarette smoking-induced stable COPD.
Q38588001Molecular studies of lupus nephritis kidneys
Q55420715Monoacylglycerol lipase regulates cannabinoid receptor 2-dependent macrophage activation and cancer progression.
Q37027092Monocyte Differentiation towards Protumor Activity Does Not Correlate with M1 or M2 Phenotypes
Q36840151Monocyte and macrophage contributions to cardiac remodeling.
Q48265798Monocyte and macrophage immunometabolism in atherosclerosis.
Q33805166Monocyte differentiation and macrophage priming are regulated differentially by pentraxins and their ligands
Q47939968Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span.
Q93104909Monocyte/Macrophage Abnormalities Specific to Rheumatoid Arthritis Are Linked to miR-155 and Are Differentially Modulated by Different TNF Inhibitors
Q90050688More Than Suppression: Glucocorticoid Action on Monocytes and Macrophages
Q38640912Morphologic, phenotypic, and transcriptomic characterization of classically and alternatively activated canine blood-derived macrophages in vitro
Q89472896Multidimensional communication in the microenvirons of glioblastoma
Q26770661Multiple Sclerosis between Genetics and Infections: Human Endogenous Retroviruses in Monocytes and Macrophages
Q38962283Multitasking Microglia and Alzheimer's Disease: Diversity, Tools and Therapeutic Targets
Q57073314Multivalent nanosystems: targeting monocytes/macrophages
Q38924828Myeloid cells - targets of medication in multiple sclerosis.
Q38284909Myeloid colony-stimulating factors as regulators of macrophage polarization
Q41106752Myeloid expression of the AP-1 transcription factor JUNB modulates outcomes of type 1 and type 2 parasitic infections.
Q58800964Myeloid-Derived Suppressor Cells and Pulmonary Hypertension
Q38925162Myofibroblasts and inflammatory cells as players of cardiac fibrosis
Q40885164NFATc1 releases BCL6-dependent repression of CCR2 agonist expression in peritoneal macrophages from Saccharomyces cerevisiae infected mice.
Q92637629Navigating metabolic pathways to enhance antitumour immunity and immunotherapy
Q37153681Network Analysis Identifies Proinflammatory Plasma Cell Polarization for Secretion of ISG15 in Human Autoimmunity.
Q35118812Network representations of immune system complexity
Q47748697Neural precursor cell-secreted TGF-β2 redirects inflammatory monocyte-derived cells in CNS autoimmunity.
Q55490082Neuroendocrine Control of Macrophage Development and Function.
Q28259238Neuroinflammation in Alzheimer's disease
Q27014919Neuroinflammation in Alzheimer's disease; A source of heterogeneity and target for personalized therapy
Q89896307Neurons, Glia, Extracellular Matrix and Neurovascular Unit: A Systems Biology Approach to the Complexity of Synaptic Plasticity in Health and Disease
Q39129257New "programmers" in tissue macrophage activation
Q26786785New Insights Into Tissue Macrophages: From Their Origin to the Development of Memory
Q38834168New insights into basophil heterogeneity
Q40866271New insights into the multidimensional concept of macrophage ontogeny, activation and function.
Q38514940Next generation transcriptomics and genomics elucidate biological complexity of microglia in health and disease.
Q51739890Nintedanib reduces pulmonary fibrosis in a model of rheumatoid arthritis-associated interstitial lung disease.
Q42984890Nonclassical Ly6C(-) monocytes drive the development of inflammatory arthritis in mice.
Q98157902Notch and TLR signaling coordinate monocyte cell fate and inflammation
Q35877268Novel Markers to Delineate Murine M1 and M2 Macrophages
Q49226484Novel mechanisms of Collagenase Santyl Ointment (CSO) in wound macrophage polarization and resolution of wound inflammation.
Q58579613Obesity and dysregulated central and peripheral Macrophage-neuron crosstalk
Q39011826One microenvironment does not fit all: heterogeneity beyond cancer cells
Q34147513Ontogeny and functions of central nervous system macrophages.
Q92650572Ontogeny of Tumor-Associated Macrophages
Q38597802Opposing effects of in vitro differentiated macrophages sub-type on epithelial wound healing.
Q38712433Opposing macrophage polarization programs show extensive epigenomic and transcriptional cross-talk
Q38230878Origin and functions of tissue macrophages.
Q104576046Origins and diversity of macrophages in health and disease
Q57292582Oxidative Stress and Inflammation, Key Targets of Atherosclerotic Plaque Progression and Vulnerability: Potential Impact of Physical Activity
Q90260610Oxidative Stress in Pulmonary Fibrosis
Q91874779Oxysterols provide innate immunity to bacterial infection by mobilizing cell surface accessible cholesterol
Q58669617P2X4 receptor controls microglia activation and favors remyelination in autoimmune encephalitis
Q59789508PGAM5 expression and macrophage signatures in non-small cell lung cancer associated with chronic obstructive pulmonary disease (COPD)
Q37098084PLA2G5 regulates transglutaminase activity of human IL-4-activated M2 macrophages through PGE2 generation
Q47614083Palmitate Conditions Macrophages for Enhanced Responses toward Inflammatory Stimuli via JNK Activation
Q52318985Parkin deficiency modulates NLRP3 inflammasome activation by attenuating an A20-dependent negative feedback loop.
Q38648556Pathophysiological mechanisms and therapeutic potentials of macrophages in non-alcoholic steatohepatitis
Q96128735Perspective of placenta derived mesenchymal stem cells in acute liver failure
Q38848941Petri Net computational modelling of Langerhans cell Interferon Regulatory Factor Network predicts their role in T cell activation
Q57188235Phenotype molding of stromal cells in the lung tumor microenvironment
Q27006058Phenotypic diversity and emerging new tools to study macrophage activation in bacterial infectious diseases
Q53546016Phenotypic, functional, and plasticity features of classical and alternatively activated human macrophages.
Q91935927Picturing Polarized Myeloid Phagocytes and Regulatory Cells by Mass Cytometry
Q61813270Polarization of Rheumatoid Macrophages by TNF Targeting Through an IL-10/STAT3 Mechanism
Q96304655Positive Allosteric Modulation of CD11b as a Novel Therapeutic Strategy Against Lung Cancer
Q42132875Precision attack on calcineurin in macrophages: a new anti-inflammatory weapon
Q39137327Prognostic significance of tumor-associated macrophages in endometrial adenocarcinoma
Q33832775Promotion of Tumor Invasion by Tumor-Associated Macrophages: The Role of CSF-1-Activated Phosphatidylinositol 3 Kinase and Src Family Kinase Motility Signaling
Q47831410Proteomic Signature Reveals Modulation of Human Macrophage Polarization and Functions Under Differing Environmental Oxygen Conditions.
Q26765923Purinergic Signaling to Terminate TLR Responses in Macrophages
Q61446621RAGE is a Critical Mediator of Pulmonary Oxidative Stress, Alveolar Macrophage Activation and Emphysema in Response to Cigarette Smoke
Q37733773RNA-Seq Analysis of Microglia Reveals Time-Dependent Activation of Specific Genetic Programs following Spinal Cord Injury.
Q64086915RNA-sequencing across three matched tissues reveals shared and tissue-specific gene expression and pathway signatures of COPD
Q35961926Redefining the transcriptional regulatory dynamics of classically and alternatively activated macrophages by deepCAGE transcriptomics.
Q39280710Redirecting tumor-associated macrophages to become tumoricidal effectors as a novel strategy for cancer therapy
Q36058829Reduced Leukocyte Infiltration in Absence of Eosinophils Correlates with Decreased Tissue Damage and Disease Susceptibility in ΔdblGATA Mice during Murine Neurocysticercosis
Q58576868Reduced interleukin 1A gene expression in the dorsolateral prefrontal cortex of individuals with PTSD and depression
Q26744475Regenerative Capacity of Macrophages for Remyelination
Q37629850Regulation of Epigenetic Modifiers, Including KDM6B, by Interferon-γ and Interleukin-4 in Human Macrophages.
Q41313325Regulation of Human Macrophage M1-M2 Polarization Balance by Hypoxia and the Triggering Receptor Expressed on Myeloid Cells-1.
Q28078340Regulation of Nlrp3 inflammasome by dietary metabolites
Q39523427Regulation of macrophage polarization and plasticity by complex activation signals
Q39423479Regulatory myeloid cells: an underexplored continent in B-cell lymphomas
Q47714484Renal Macrophages and Dendritic Cells in SLE Nephritis
Q44862431Response of human macrophages to wound matrices in vitro
Q106996867Reviews on Biological Activity, Clinical Trial and Synthesis Progress of Small Molecules for the Treatment of COVID-19
Q64062263Rewiring of Memory Circuits: Connecting Adult Newborn Neurons With the Help of Microglia
Q64991542Riociguat prevents hyperoxia-induced lung injury and pulmonary hypertension in neonatal rats without effects on long bone growth.
Q38329556Role of innate and adaptive immune mechanisms in cardiac injury and repair
Q57055334Roles of the immune system in cancer: from tumor initiation to metastatic progression
Q52901372SIK inhibition in human myeloid cells modulates TLR and IL-1R signaling and induces an anti-inflammatory phenotype.
Q47122380STING Activation Reverses Lymphoma-Mediated Resistance to Antibody Immunotherapy
Q42627854SaVanT: a web-based tool for the sample-level visualization of molecular signatures in gene expression profiles
Q41876369Saturated Fatty Acids Engage an IRE1α-Dependent Pathway to Activate the NLRP3 Inflammasome in Myeloid Cells
Q59296342Schwann cell-derived periostin promotes autoimmune peripheral polyneuropathy via macrophage recruitment
Q64115863Sequential conditioning-stimulation reveals distinct gene- and stimulus-specific effects of Type I and II IFN on human macrophage functions
Q92913990SerpinB2 inhibits migration and promotes a resolution phase signature in large peritoneal macrophages
Q42234796Serum exosomes and cytokines promote a T-helper cell type 2 environment in the peripheral blood of glioblastoma patients
Q48966773Shifts in macrophage phenotype at the biomaterial interface via IL-4 eluting coatings are associated with improved implant integration.
Q92075092Short-term fish oil supplementation applied in presymptomatic stage of Alzheimer's disease enhances microglial/macrophage barrier and prevents neuritic dystrophy in parietal cortex of 5xFAD mouse model
Q38645730Similarities in the Metabolic Reprogramming of Immune System and Endothelium
Q64122294Single cell RNA sequencing identifies unique inflammatory airspace macrophage subsets
Q93125442Single cell transcriptomics based-MacSpectrum reveals novel macrophage activation signatures in diseases
Q65001289Sjogren's Syndrome and TAM Receptors: A Possible Contribution to Disease Onset.
Q35252669Small-molecule control of cytokine function: new opportunities for treating immune disorders
Q26862356Spatial, Temporal, and Functional Aspects of Macrophages during "The Good, the Bad, and the Ugly" Phases of Inflammation
Q89351708Strategically Altering the Balance of Macrophage Subpopulations to Inhibit Chronic Rejection
Q40792746Streptococci Engage TLR13 on Myeloid Cells in a Site-Specific Fashion.
Q90370791Stromal Gas6 promotes the progression of premalignant mammary cells
Q98224728Susceptibility to Intracellular Infections: Contributions of TNF to Immune Defense
Q39301702Synovial cellular and molecular markers in rheumatoid arthritis
Q40961556System xC- is a mediator of microglial function and its deletion slows symptoms in amyotrophic lateral sclerosis mice
Q38996594Systematic Pan-Cancer Analysis Reveals Immune Cell Interactions in the Tumor Microenvironment.
Q89723169Systemic administration of pentoxifylline attenuates the development of hypertension in renovascular hypertensive rats
Q52870062Systemic depletion of macrophages in the subacute phase of wound healing reduces hypertrophic scar formation.
Q42189381T-cell-restricted T-bet overexpression induces aberrant hematopoiesis of myeloid cells and impairs function of macrophages in the lung
Q35819380TAM receptor signaling in immune homeostasis
Q47096116TAMeless traitors: macrophages in cancer progression and metastasis
Q90725991TLR-3 Stimulation Skews M2 Macrophages to M1 Through IFN-αβ Signaling and Restricts Tumor Progression
Q26776492TNF biology, pathogenic mechanisms and emerging therapeutic strategies
Q36212734Targeting CD64 mediates elimination of M1 but not M2 macrophages in vitro and in cutaneous inflammation in mice and patient biopsies
Q52784518Targeting Notch-Activated M1 Macrophages Attenuates Joint Tissue Damage in a Mouse Model of Inflammatory Arthritis.
Q26744219Targeting innate immunity for neurodegenerative disorders of the central nervous system
Q53376999Targeting microglia for the treatment of Alzheimer's Disease.
Q41935730Targeting myeloid derived suppressor cells with all-trans retinoic acid is highly time-dependent in therapeutic tumor vaccination
Q30988184Teaching 'big data' analysis to young immunologists
Q42569323Temporal and spatial distribution of macrophage phenotype markers in the foreign body response to glutaraldehyde-crosslinked gelatin hydrogels
Q55429076Temporal changes in macrophage phenotype after peripheral nerve injury.
Q38435899The AP-1 Transcription Factor c-Jun Promotes Arthritis by Regulating Cyclooxygenase-2 and Arginase-1 Expression in Macrophages.
Q92783389The Adaptive and Innate Immune Cell Landscape of Uterine Leiomyosarcomas
Q92307792The Gastrointestinal Tumor Microenvironment: An Updated Biological and Clinical Perspective
Q37599443The Heme Connection: Linking Erythrocytes and Macrophage Biology
Q61803782The Immunology of Macrophage Activation Syndrome
Q26774681The Interplay Between Monocytes/Macrophages and CD4(+) T Cell Subsets in Rheumatoid Arthritis
Q89621213The Interplay Between Tissue Niche and Macrophage Cellular Metabolism in Obesity
Q26800142The Many Alternative Faces of Macrophage Activation
Q38646389The Mononuclear Phagocyte System in Organ Transplantation.
Q64905994The Notch ligand DNER regulates macrophage IFNγ release in chronic obstructive pulmonary disease.
Q58122550The Pathophysiological Relevance of the iNKT Cell/Mononuclear Phagocyte Crosstalk in Tissues
Q39134471The Role of Inflammation in Cardiovascular Outcome.
Q59132980The Role of Leukocytes in Diabetic Cardiomyopathy
Q60954887The Role of Monocytes and Macrophages in Acute and Acute-on-Chronic Liver Failure
Q64093135The Role of Myeloid-Derived Cells in the Progression of Liver Disease
Q30834373The Role of Neuromodulators in Cortical Plasticity. A Computational Perspective
Q39099711The Role of Tissue Macrophage-Mediated Inflammation on NAFLD Pathogenesis and Its Clinical Implications.
Q57816901The Role of the Extracellular Matrix and Its Molecular and Cellular Regulators in Cancer Cell Plasticity
Q52641713The cellular metabolic landscape in the tumor milieu regulates the activity of myeloid infiltrates.
Q38990736The contribution of the programmed cell death machinery in innate immune cells to lupus nephritis
Q38964911The contributions of lung macrophage and monocyte heterogeneity to influenza pathogenesis
Q35338729The emerging understanding of myeloid cells as partners and targets in tumor rejection
Q35970492The generation of macrophages with anti-inflammatory activity in the absence of STAT6 signaling
Q26853435The ground state of innate immune responsiveness is determined at the interface of genetic, epigenetic, and environmental influences
Q26795639The heterogeneity of lung macrophages in the susceptibility to disease
Q89070227The human heart contains distinct macrophage subsets with divergent origins and functions
Q98205361The immune contexture and Immunoscore in cancer prognosis and therapeutic efficacy
Q42656251The immune system in cancer metastasis: friend or foe?
Q41678839The impact of hypoxia on tumor-associated macrophages
Q37631369The inflammatory role of phagocyte apoptotic pathways in rheumatic diseases.
Q52760295The influence of vitamin D on M1 and M2 macrophages in patients with Crohn's disease.
Q89507027The metabolic axis of macrophage and immune cell polarization
Q93132600The pro-remyelination properties of microglia in the central nervous system
Q90621963The regulation of sequence specific NF-κB DNA binding and transcription by IKKβ phosphorylation of NF-κB p50 at serine 80
Q49634844The role of macrophage phenotype in regulating the response to radiation therapy.
Q39442839The role of microglia in multiple sclerosis.
Q49192854The role of microglia in the progression of glaucomatous neurodegeneration- a review.
Q39118808The role of neuroimmune signaling in alcoholism
Q38673089The role of the local environment and epigenetics in shaping macrophage identity and their effect on tissue homeostasis.
Q49684254The roles of CSFs on the functional polarization of tumor-associated macrophages.
Q36944484The significance of macrophage phenotype in cancer and biomaterials
Q39211384The significance of macrophage polarization subtypes for animal models of tissue fibrosis and human fibrotic diseases
Q41024271The transcription factor ATF7 mediates lipopolysaccharide-induced epigenetic changes in macrophages involved in innate immunological memory.
Q38879903The transcriptional PPARβ/δ network in human macrophages defines a unique agonist-induced activation state
Q37153637The transcriptional coregulator GRIP1 controls macrophage polarization and metabolic homeostasis
Q38299850The transcriptional regulator network of human inflammatory macrophages is defined by open chromatin.
Q42317468The transcriptional signature of human ovarian carcinoma macrophages is associated with extracellular matrix reorganization.
Q45872331Therapeutic Inhibition of Inflammatory Monocyte Recruitment Reduces Steatohepatitis and Liver Fibrosis
Q27000074Therapeutic targeting of liver inflammation and fibrosis by nanomedicine
Q92799419Time-Dependent Changes in Microglia Transcriptional Networks Following Traumatic Brain Injury
Q90735583Tissue Resident CCR2- and CCR2+ Cardiac Macrophages Differentially Orchestrate Monocyte Recruitment and Fate Specification Following Myocardial Injury
Q38260567Tissue macrophage identity and self-renewal.
Q38983414Tissue-resident macrophages - how to humanize our knowledge
Q35201949Tissue-resident macrophages: then and now.
Q26786973To Extinguish the Fire from Outside the Cell or to Shutdown the Gas Valve Inside? Novel Trends in Anti-Inflammatory Therapies
Q45395222Toll-Like Receptor Ligands and Interferon-γ Synergize for Induction of Antitumor M1 Macrophages.
Q93127395Transcription factor Fra-1 targets arginase-1 to enhance macrophage-mediated inflammation in arthritis
Q35824601Transcriptional and Linkage Analyses Identify Loci that Mediate the Differential Macrophage Response to Inflammatory Stimuli and Infection
Q90442064Transcriptional and epigenetic regulation of macrophages in atherosclerosis
Q47256407Transcriptional and functional profiling defines human small intestinal macrophage subsets.
Q99633734Transcriptional and immunohistological assessment of immune infiltration in pancreatic cancer
Q40357866Transcriptional and metabolic reprogramming induce an inflammatory phenotype in non-medullary thyroid carcinoma-induced macrophages.
Q64062767Transcriptional down-regulation of in a subset of HIV+ controllers and their family members
Q60305742Transcriptional profiling identifies novel regulators of macrophage polarization
Q42215028Transcriptional profiling predicts overwhelming homology of Schwann cells, olfactory ensheathing cells, and Schwann cell-like glia
Q38422828Transcriptional programming of human macrophages: on the way to systems immunology
Q38894121Transcriptome analysis of IL-10-stimulated (M2c) macrophages by next-generation sequencing.
Q64235758Transcriptome network analysis identifies protective role of the LXR/SREBP-1c axis in murine pulmonary fibrosis
Q98303052Transcriptome sequencing supports a conservation of macrophage polarization in fish
Q39733187Transcriptome-Wide Analysis Reveals Modulation of Human Macrophage Inflammatory Phenotype Through Alternative Splicing
Q91973462Transcriptomic Analysis of Monocyte-Derived Non-Phagocytic Macrophages Favors a Role in Limiting Tissue Repair and Fibrosis
Q92643241Transcriptomic Profiles of Monocyte-Derived Macrophages in Response to Escherichia coli is Associated with the Host Genetics
Q35584125Transcriptomic analysis of human polarized macrophages: more than one role of alternative activation?
Q38260568Transcriptomic analysis of mononuclear phagocyte differentiation and activation.
Q98611601Transcriptomics uncovers substantial variability associated with alterations in manufacturing processes of macrophage cell therapy products
Q51736303Transplantation of Normal Adipose Tissue Improves Blood Flow and Reduces Inflammation in High Fat Fed Mice With Hindlimb Ischemia.
Q52373701Treg cells limit IFN-γ production to control macrophage accrual and phenotype during skeletal muscle regeneration.
Q49544289Tumor Associated Macrophages as Therapeutic Targets for Breast Cancer.
Q98771756Tumor Microenvironment in Ovarian Cancer: Function and Therapeutic Strategy
Q50209202Tumor associated macrophages in gynecologic cancers.
Q37346644Tumor macrophages are pivotal constructors of tumor collagenous matrix.
Q55518010Tumor matrix remodeling and novel immunotherapies: the promise of matrix-derived immune biomarkers.
Q26766429Tumor-Associated Macrophages and Neutrophils in Tumor Microenvironment
Q47644033Tumor-associated macrophages (TAMs) depend on ZEB1 for their cancer-promoting roles
Q38766176Tumor-associated macrophages and anti-tumor therapies: complex links
Q39148281Tumor-associated macrophages: implications in cancer immunotherapy
Q36692838Tumor-associated macrophages: unwitting accomplices in breast cancer malignancy.
Q39239026Tuning cancer fate: the unremitting role of host immunity.
Q92556918Tuning the Tumor Myeloid Microenvironment to Fight Cancer
Q91868469Twenty Novel Disease Group-Specific and 12 New Shared Macrophage Pathways in Eight Groups of 34 Diseases Including 24 Inflammatory Organ Diseases and 10 Types of Tumors
Q55396890Underlying Causes and Therapeutic Targeting of the Inflammatory Tumor Microenvironment.
Q38260569Understanding macrophage diversity at the ontogenic and transcriptomic levels.
Q50300234Unique Immune Gene Expression Patterns in Bronchoalveolar Lavage and Tumor Adjacent Non-Neoplastic Lung Tissue in Non-Small Cell Lung Cancer.
Q50048770Unique metabolic activation of adipose tissue macrophages in obesity promotes inflammatory responses.
Q52311029Unsupervised, statistically-based systems biology approach for unraveling the genetics of complex traits: A demonstration with ethanol metabolism.
Q58801557Use of Graph Theory to Characterize Human and Arthropod Vector Cell Protein Response to Infection With
Q89821719Using toponomics to characterize phenotypic diversity in alveolar macrophages from male mice treated with exogenous SP-A1
Q40576387Vaccine-induced tumor regression requires a dynamic cooperation between T cells and myeloid cells at the tumor site.
Q36238135Validation of Immune Cell Modules in Multicellular Transcriptomic Data.
Q27002981Vascular smooth muscle cells and monocyte-macrophages accomplice in the accelerated atherosclerosis of insulin resistance states
Q35597924Vitamin D-dependent induction of cathelicidin in human macrophages results in cytotoxicity against high-grade B cell lymphoma.
Q91663580Vitamin D3-vitamin D receptor axis suppresses pulmonary emphysema by maintaining alveolar macrophage homeostasis and function
Q53795100Wound healing in Mac-1 deficient mice.
Q28068327Writ large: Genomic dissection of the effect of cellular environment on immune response
Q53214538[History and perspectives of the monocyte-macrophage system].
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