Killing Is Not Enough: How Apoptosis Hijacks Tumor-Associated Macrophages to Promote Cancer Progression.

scientific article published in January 2016

Killing Is Not Enough: How Apoptosis Hijacks Tumor-Associated Macrophages to Promote Cancer Progression. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1007/978-3-319-39406-0_9
P698PubMed publication ID27558823

P50authorBernhard BrüneQ84836238
Divya SekarQ114979937
Shahzad N SyedQ41644029
Andreas WeigertQ48297787
Javier MoraQ51551699
P2860cites workMicrovesicles secreted by macrophages shuttle invasion-potentiating microRNAs into breast cancer cellsQ21245767
Hallmarks of Cancer: The Next GenerationQ22252312
HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGFQ24329023
Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue KineticsQ24564912
The CD47-SIRPα pathway in cancer immune evasion and potential therapeutic implicationsQ24605052
Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identitiesQ24617969
The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumorsQ24631515
Tumor-associated macrophages in breast cancer: distinct subsets, distinct functionsQ26827662
Macrophages in intestinal homeostasis and inflammationQ26851960
Macrophages: gatekeepers of tissue integrityQ27007092
Sensing of cell death by myeloid C-type lectin receptorsQ27010313
Old, new and emerging functions of caspasesQ27686885
Targeting tumor-associated macrophages with anti-CSF-1R antibody reveals a strategy for cancer therapyQ27690653
Oncomirs - microRNAs with a role in cancerQ27860773
Cancer-related inflammationQ27860907
Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healingQ28131793
IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responsesQ28303437
Orchestration of metabolism by macrophagesQ38000642
Tissue microenvironments define and get reinforced by macrophage phenotypes in homeostasis or during inflammation, repair and fibrosis.Q38003021
Recruitment of monocytes/macrophages in different tumor microenvironmentsQ38071483
Tumor-associated macrophages: functional diversity, clinical significance, and open questionsQ38105286
Monocytes and macrophages: developmental pathways and tissue homeostasisQ38214042
Origin and functions of tissue macrophages.Q38230878
Tumor-associated macrophages: from mechanisms to therapyQ38230880
Homeostasis in the mononuclear phagocyte systemQ38232291
Sinister self-sacrifice: the contribution of apoptosis to malignancyQ38234939
Macrophage iron homeostasis and polarization in the context of cancerQ38254678
Redirecting in vivo elicited tumor infiltrating macrophages and dendritic cells towards tumor rejection.Q38327926
Biocompatible mannosylated endosomal-escape nanoparticles enhance selective delivery of short nucleotide sequences to tumor associated macrophagesQ38939381
Targeted depletion of tumour-associated macrophages by an alendronate-glucomannan conjugate for cancer immunotherapyQ38954212
In situ proliferation contributes to accumulation of tumor-associated macrophages in spontaneous mammary tumorsQ38998613
Depletion of M2-like tumor-associated macrophages delays cutaneous T-cell lymphoma development in vivoQ39000247
Phosphatidylserine-targeting antibody induces M1 macrophage polarization and promotes myeloid-derived suppressor cell differentiationQ39000553
Enhancement of anticancer effect of interferon-γ gene transfer against interferon-γ-resistant tumor by depletion of tumor-associated macrophages.Q39007021
5-Lipoxygenase contributes to PPARγ activation in macrophages in response to apoptotic cellsQ39096052
MicroRNA-19a-3p inhibits breast cancer progression and metastasis by inducing macrophage polarization through downregulated expression of Fra-1 proto-oncogeneQ39129449
miR-142-3p prevents macrophage differentiation during cancer-induced myelopoiesisQ39133794
The resolution of inflammationQ61053463
Evaluation of antitumor effect of zoledronic acid entrapped in folate-linked liposome for targeting to tumor-associated macrophagesQ61864573
Apoptotic cells, through transforming growth factor-beta, coordinately induce anti-inflammatory and suppress pro-inflammatory eicosanoid and NO synthesis in murine macrophagesQ79287661
Requirements for apoptotic cell contact in regulation of macrophage responsesQ80209354
Apoptotic cells induce arginase II in macrophages, thereby attenuating NO productionQ80210979
Expression of Tie-2 by human monocytes and their responses to angiopoietin-2Q80358599
Apoptotic cells quench reactive oxygen and nitrogen species and modulate TNF-alpha/TGF-beta1 balance in activated macrophages: involvement of phosphatidylserine-dependent and -independent pathwaysQ81699209
Re-polarization of tumor-associated macrophages to pro-inflammatory M1 macrophages by microRNA-155Q84620188
Sumoylation of peroxisome proliferator-activated receptor gamma by apoptotic cells prevents lipopolysaccharide-induced NCoR removal from kappaB binding sites mediating transrepression of proinflammatory cytokinesQ37185721
A novel chemoimmunomodulating property of docetaxel: suppression of myeloid-derived suppressor cells in tumor bearers.Q37418671
Microenvironmental influences of apoptosis in vivo and in vitroQ37711148
Mycobacterium bovis bacillus Calmette-Guérin-induced macrophage cytotoxicity against bladder cancer cellsQ37791443
Cell death in the neighbourhood: direct microenvironmental effects of apoptosis in normal and neoplastic tissuesQ37815130
Histone deacetylases as regulators of inflammation and immunityQ37875468
Tumor promotion via injury- and death-induced inflammationQ37950602
Cancer-related inflammation: common themes and therapeutic opportunitiesQ37972525
Identification of a unique TGF-β-dependent molecular and functional signature in microgliaQ28303557
A novel copper chelate modulates tumor associated macrophages to promote anti-tumor response of T cellsQ28476155
miR-511-3p modulates genetic programs of tumor-associated macrophagesQ28504706
12/15-lipoxygenase orchestrates the clearance of apoptotic cells and maintains immunologic toleranceQ28510985
Macrophage depletion by free bisphosphonates and zoledronate-loaded red blood cellsQ28540086
Shigella mediated depletion of macrophages in a murine breast cancer model is associated with tumor regressionQ28748638
Macrophage plasticity and polarization: in vivo veritasQ29547620
Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytesQ29547633
The chemokine system in diverse forms of macrophage activation and polarizationQ29547719
Colony-stimulating factor 1 promotes progression of mammary tumors to malignancyQ29614312
The two NF-kappaB activation pathways and their role in innate and adaptive immunityQ29614355
Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAFQ29615685
Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infectionQ29615959
LNA-mediated microRNA silencing in non-human primatesQ29615962
Fate mapping analysis reveals that adult microglia derive from primitive macrophagesQ29616177
Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapyQ29619961
Immunogenic cell death in cancer therapyQ29620118
A lineage of myeloid cells independent of Myb and hematopoietic stem cellsQ29620147
Macrophage biology in development, homeostasis and diseaseQ29620350
Protective and pathogenic functions of macrophage subsetsQ29620351
Macrophage activation and polarization: nomenclature and experimental guidelinesQ29620642
Apoptotic human cells inhibit migration of granulocytes via release of lactoferrinQ30485290
S1PR1-STAT3 signaling is crucial for myeloid cell colonization at future metastatic sites.Q30514214
M2-like macrophages are responsible for collagen degradation through a mannose receptor-mediated pathwayQ30544968
Therapeutic effects of anti-CD115 monoclonal antibody in mouse cancer models through dual inhibition of tumor-associated macrophages and osteoclastsQ31137466
Heme-mediated SPI-C induction promotes monocyte differentiation into iron-recycling macrophagesQ33570011
Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetesQ33731729
Targeted imaging of tumor-associated M2 macrophages using a macromolecular contrast agent PG-Gd-NIR813.Q33976776
Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathwaysQ34035175
Tissue-specific signals control reversible program of localization and functional polarization of macrophagesQ34065482
Inducible microRNA-155 feedback promotes type I IFN signaling in antiviral innate immunity by targeting suppressor of cytokine signaling 1.Q34142942
Human dermal CD14⁺ cells are a transient population of monocyte-derived macrophagesQ34244161
Chemokine receptor CX3CR1 contributes to macrophage survival in tumor metastasisQ34248596
CSF1/CSF1R blockade reprograms tumor-infiltrating macrophages and improves response to T-cell checkpoint immunotherapy in pancreatic cancer models.Q34279134
Tumor associated macrophages and neutrophils in tumor progressionQ34306107
Immunogenic cell death and DAMPs in cancer therapyQ34311701
The cellular and molecular origin of tumor-associated macrophagesQ34378833
Environment drives selection and function of enhancers controlling tissue-specific macrophage identitiesQ34452301
Necrosis in DU145 prostate cancer spheroids induces COX-2/mPGES-1-derived PGE2 to promote tumor growth and to inhibit T cell activationQ39174587
Depletion of tristetraprolin in breast cancer cells increases interleukin-16 expression and promotes tumor infiltration with monocytes/macrophagesQ39225975
Reprogramming of TAM toward proimmunogenic type through regulation of MAP kinases using a redox-active copper chelateQ39405948
Vascular endothelial growth factor-induced skin carcinogenesis depends on recruitment and alternative activation of macrophagesQ39409408
Targeted delivery of oligonucleotides into tumor-associated macrophages for cancer immunotherapyQ39436858
Macrophages programmed by apoptotic cells promote angiogenesis via prostaglandin E2.Q39568139
The interleukin 13 (IL-13) pathway in human macrophages is modulated by microRNA-155 via direct targeting of interleukin 13 receptor alpha1 (IL13Ralpha1).Q39628899
Sphingosine kinase 2 deficient tumor xenografts show impaired growth and fail to polarize macrophages towards an anti-inflammatory phenotypeQ39823174
CX3CL1/fractalkine is released from apoptotic lymphocytes to stimulate macrophage chemotaxisQ39938633
Tumor cell apoptosis polarizes macrophages role of sphingosine-1-phosphate.Q40102693
Targeting tumor-associated macrophages and inhibition of MCP-1 reduce angiogenesis and tumor growth in a human melanoma xenograftQ40140782
Apoptotic cells promote macrophage survival by releasing the antiapoptotic mediator sphingosine-1-phosphate.Q40280838
Persistence of apoptotic cells without autoimmune disease or inflammation in CD14-/- mice.Q40478439
Innate immune discrimination of apoptotic cells: repression of proinflammatory macrophage transcription is coupled directly to specific recognitionQ40602126
Development, differentiation, and phenotypic heterogeneity of murine tissue macrophages.Q40971597
Molecular profiling reveals a tumor-promoting phenotype of monocytes and macrophages in human cancer progressionQ41750524
Heme oxygenase-1 contributes to an alternative macrophage activation profile induced by apoptotic cell supernatants.Q42142782
Transient depletion of specific immune cell populations to improve adenovirus-mediated transgene expression in the liverQ42223027
The transcription factor Gata6 links tissue macrophage phenotype and proliferative renewalQ42744709
Cleavage of sphingosine kinase 2 by caspase-1 provokes its release from apoptotic cells.Q42828937
RNAi screen in apoptotic cancer cell-stimulated human macrophages reveals co-regulation of IL-6/IL-10 expressionQ43593210
A role for miR-155 in enabling tumor-infiltrating innate immune cells to mount effective antitumor responses in mice.Q43787598
Phosphatidylserine peroxidation/externalization during staurosporine-induced apoptosis in HL-60 cellsQ44075460
Sphingosine-1-phosphate signalling induces the production of Lcn-2 by macrophages to promote kidney regenerationQ44125780
The role of TRKA signaling in IL-10 production by apoptotic tumor cell-activated macrophagesQ45720263
The supernatant of apoptotic cells causes transcriptional activation of hypoxia-inducible factor-1alpha in macrophages via sphingosine-1-phosphate and transforming growth factor-beta.Q45956195
Genetic programs expressed in resting and IL-4 alternatively activated mouse and human macrophages: similarities and differencesQ46516651
Low-dose irradiation programs macrophage differentiation to an iNOS⁺/M1 phenotype that orchestrates effective T cell immunotherapyQ46817579
Apoptotic cell-derived sphingosine-1-phosphate promotes HuR-dependent cyclooxygenase-2 mRNA stabilization and protein expressionQ46820182
Recognition of apoptotic cells by macrophages activates the peroxisome proliferator-activated receptor-gamma and attenuates the oxidative burst.Q46845199
Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors.Q48425484
Induction of the nuclear receptor PPAR-γ by the cytokine GM-CSF is critical for the differentiation of fetal monocytes into alveolar macrophages.Q48509512
Liposome encapsulation of zoledronic acid results in major changes in tissue distribution and increase in toxicity.Q51830426
Genetic Studies of the Relationship of Tumour–Host Cells: Effect of Tumour Cells killed by X-rays upon the Growth of Admixed Viable CellsQ56656024
Uptake of apoptotic cells drives the growth of a pathogenic trypanosome in macrophagesQ56798121
Role of Macrophage Targeting in the Antitumor Activity of TrabectedinQ56942258
p50 Nuclear Factor- B Overexpression in Tumor-Associated Macrophages Inhibits M1 Inflammatory Responses and Antitumor ResistanceQ56942931
The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infectionQ57062755
Prediction of Survival in Follicular Lymphoma Based on Molecular Features of Tumor-Infiltrating Immune CellsQ57279527
Expression of vascular endothelial growth factor by macrophages is up-regulated in poorly vascularized areas of breast carcinomasQ58212133
A distinct and unique transcriptional program expressed by tumor-associated macrophages (defective NF-kappaB and enhanced IRF-3/STAT1 activation).Q34465280
Dissecting the tumor myeloid compartment reveals rare activating antigen-presenting cells critical for T cell immunityQ34625640
Macrophage regulation of tumor responses to anticancer therapiesQ34649588
Transcriptome-based network analysis reveals a spectrum model of human macrophage activation.Q34659689
Immunology's foundation: the 100-year anniversary of the Nobel Prize to Paul Ehrlich and Elie MetchnikoffQ34787221
Targeting tumor-associated macrophages as a novel strategy against breast cancerQ34803221
CXCL16 suppresses liver metastasis of colorectal cancer by promoting TNF-α-induced apoptosis by tumor-associated macrophages.Q34990965
Targeted delivery of proapoptotic peptides to tumor-associated macrophages improves survivalQ34991697
CSF-1R inhibition alters macrophage polarization and blocks glioma progressionQ34993852
MicroRNA-155 regulates inflammatory cytokine production in tumor-associated macrophages via targeting C/EBPbetaQ35011103
Caspase 3-mediated stimulation of tumor cell repopulation during cancer radiotherapyQ35093740
Efferocytosis produces a prometastatic landscape during postpartum mammary gland involutionQ35140121
CSF1-ETS2-induced microRNA in myeloid cells promote metastatic tumor growthQ35205613
Interleukin-17 induces an atypical M2-like macrophage subpopulation that regulates intestinal inflammationQ35276306
Apoptotic cells induce Mer tyrosine kinase-dependent blockade of NF-kappaB activation in dendritic cellsQ35615917
Tissue-resident macrophage enhancer landscapes are shaped by the local microenvironment.Q35623089
Inflammatory signaling in macrophages: transitions from acute to tolerant and alternative activation statesQ35689569
Reprogramming tumor-associated dendritic cells in vivo using miRNA mimetics triggers protective immunity against ovarian cancerQ35871752
Depletion of tumor-associated macrophages enhances the anti-tumor immunity induced by a Toll-like receptor agonist-conjugated peptideQ35886752
Apoptotic mimicry: phosphatidylserine liposomes reduce inflammation through activation of peroxisome proliferator-activated receptors (PPARs) in vivoQ36053108
TNF-alpha induces leukemic clonal evolution ex vivo in Fanconi anemia group C murine stem cells.Q36088939
Galectin-1 deactivates classically activated microglia and protects from inflammation-induced neurodegenerationQ36191881
The origin and kinetics of mononuclear phagocytesQ36269269
Proliferating macrophages associated with high grade, hormone receptor negative breast cancer and poor clinical outcomeQ36310475
Requirement for the histone deacetylase Hdac3 for the inflammatory gene expression program in macrophagesQ36342694
MicroRNA-155 promotes atherosclerosis by repressing Bcl6 in macrophagesQ36357815
Recognition ligands on apoptotic cells: a perspectiveQ36461127
Targeting tumor-infiltrating macrophages decreases tumor-initiating cells, relieves immunosuppression, and improves chemotherapeutic responsesQ36586333
"Re-educating" tumor-associated macrophages by targeting NF-kappaB.Q36699735
Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a "come-and-get-me" signalQ36804936
Trophic macrophages in development and diseaseQ36829147
Redox control of inflammation in macrophagesQ37032282
Macrophage polarization in tumour progressionQ37158140
Nitric oxide, apoptosis and macrophage polarization during tumor progression.Q37166559
P407language of work or nameEnglishQ1860
P1104number of pages35
P304page(s)205-239
P577publication date2016-01-01
P1433published inAdvances in Experimental Medicine and BiologyQ4686385
P1476titleKilling Is Not Enough: How Apoptosis Hijacks Tumor-Associated Macrophages to Promote Cancer Progression.
P478volume930

Reverse relations

cites work (P2860)
Q52429963An apoptosis-driven 'onco-regenerative niche': roles of tumour-associated macrophages and extracellular vesicles.
Q64117034Apoptotic tumor cell-derived microRNA-375 uses CD36 to alter the tumor-associated macrophage phenotype
Q89342869Chemotherapy-generated cell debris stimulates colon carcinoma tumor growth via osteopontin
Q41902511Iron Handling in Tumor-Associated Macrophages-Is There a New Role for Lipocalin-2?
Q92333454Role of tumor-associated immune cells in prostate cancer: angel or devil?
Q38626918S1P Provokes Tumor Lymphangiogenesis via Macrophage-Derived Mediators Such as IL-1β or Lipocalin-2.
Q91981643Strategies to Interfere with Tumor Metabolism through the Interplay of Innate and Adaptive Immunity

Search more.