Macrophage polarization in metabolic disorders: functions and regulation

scientific article published on October 2011

Macrophage polarization in metabolic disorders: functions and regulation is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1097/MOL.0B013E32834A77B4
P932PMC publication ID3565956
P698PubMed publication ID21825981
P5875ResearchGate publication ID51556371

P50authorBart StaelsQ28360345
Giulia ChinettiQ43169321
Giulia Chinetti-GbaguidiQ114337068
P2860cites workIdentification of a novel macrophage phenotype that develops in response to atherogenic phospholipids via Nrf2.Q24606271
Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasisQ24629044
Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco)bacteriaQ24633691
Exploring the full spectrum of macrophage activationQ24653754
Oxidative metabolism and PGC-1beta attenuate macrophage-mediated inflammationQ24682128
Obesity is associated with macrophage accumulation in adipose tissueQ27860976
Low-intensity exercise enhances expression of markers of alternative activation in circulating leukocytes: Roles of PPARγ and Th2 cytokinesQ28290989
Interleukin-4-dependent production of PPAR-gamma ligands in macrophages by 12/15-lipoxygenaseQ28587071
Transcriptional profiling of the human monocyte-to-macrophage differentiation and polarization: new molecules and patterns of gene expressionQ28646286
Obesity induces a phenotypic switch in adipose tissue macrophage polarizationQ29547686
The chemokine system in diverse forms of macrophage activation and polarizationQ29547719
Blood monocytes consist of two principal subsets with distinct migratory propertiesQ29614286
Macrophages, innate immunity and cancer: balance, tolerance, and diversityQ29614352
Macrophage-specific PPARgamma controls alternative activation and improves insulin resistanceQ29614354
The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistanceQ29616026
CXCL4 downregulates the atheroprotective hemoglobin receptor CD163 in human macrophagesQ30433527
Macrophage plasticity in experimental atherosclerosisQ33527405
Deficient CD40-TRAF6 signaling in leukocytes prevents atherosclerosis by skewing the immune response toward an antiinflammatory profileQ33656103
Dynamic, M2-like remodeling phenotypes of CD11c+ adipose tissue macrophages during high-fat diet--induced obesity in miceQ33803444
HDL promotes rapid atherosclerosis regression in mice and alters inflammatory properties of plaque monocyte-derived cellsQ33868782
Myeloid mineralocorticoid receptor controls macrophage polarization and cardiovascular hypertrophy and remodeling in mice.Q34090097
Nomenclature of monocytes and dendritic cells in blood.Q34125860
Adiponectin primes human monocytes into alternative anti-inflammatory M2 macrophagesQ34150591
Adipose tissue macrophages in insulin-resistant subjects are associated with collagen VI and fibrosis and demonstrate alternative activation.Q34426034
Differential lipid partitioning between adipocytes and tissue macrophages modulates macrophage lipotoxicity and M2/M1 polarization in obese miceQ34615417
Interleukin-33 induces protective effects in adipose tissue inflammation during obesity in miceQ34626217
STAT6 transcription factor is a facilitator of the nuclear receptor PPARγ-regulated gene expression in macrophages and dendritic cellsQ34641231
Molecular mechanism for adiponectin-dependent M2 macrophage polarization: link between the metabolic and innate immune activity of full-length adiponectinQ34787288
Angiotensin type 1 receptor modulates macrophage polarization and renal injury in obesityQ34979668
Resolvin D1 decreases adipose tissue macrophage accumulation and improves insulin sensitivity in obese-diabetic miceQ35043902
Apolipoprotein E induces antiinflammatory phenotype in macrophagesQ36486217
Heterogeneity of human macrophages in culture and in atherosclerotic plaquesQ36512340
Phenotypic switching of adipose tissue macrophages with obesity is generated by spatiotemporal differences in macrophage subtypesQ36975445
Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animalsQ37072370
Preserved glucose tolerance in high-fat-fed C57BL/6 mice transplanted with PPARgamma-/-, PPARdelta-/-, PPARgammadelta-/-, or LXRalphabeta-/- bone marrowQ37086129
Regulation of macrophage functions by PPAR-alpha, PPAR-gamma, and LXRs in mice and men.Q37103503
Coronary intraplaque hemorrhage evokes a novel atheroprotective macrophage phenotypeQ37150841
Regulatory mechanisms for adipose tissue M1 and M2 macrophages in diet-induced obese mice.Q37400710
Glucocorticoids and thiazolidinediones interfere with adipocyte-mediated macrophage chemotaxis and recruitmentQ37431494
A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathwaysQ38297619
Activin A skews macrophage polarization by promoting a proinflammatory phenotype and inhibiting the acquisition of anti-inflammatory macrophage markersQ39578612
Adipocyte-derived lipids increase angiotensin-converting enzyme (ACE) expression and modulate macrophage phenotypeQ39626014
Peroxisome proliferator-activated receptor gamma activation promotes infiltration of alternatively activated macrophages into adipose tissue.Q39973799
Alternative M2 activation of Kupffer cells by PPARdelta ameliorates obesity-induced insulin resistance.Q41644055
CXC chemokine ligand 4 induces a unique transcriptome in monocyte-derived macrophagesQ41859211
Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity.Q41912120
C-reactive protein polarizes human macrophages to an M1 phenotype and inhibits transformation to the M2 phenotypeQ42042963
Human adipose tissue macrophages are of an anti-inflammatory phenotype but capable of excessive pro-inflammatory mediator production.Q42514705
Human atherosclerotic plaque alternative macrophages display low cholesterol handling but high phagocytosis because of distinct activities of the PPARγ and LXRα pathways.Q42557215
Reversal of hyperlipidemia with a genetic switch favorably affects the content and inflammatory state of macrophages in atherosclerotic plaquesQ42789505
Newly identified adipose tissue macrophage populations in obesity with distinct chemokine and chemokine receptor expression.Q43049709
Human adipose tissue macrophages: m1 and m2 cell surface markers in subcutaneous and omental depots and after weight lossQ43259519
Antagonistic regulation of macrophage phenotype by M-CSF and GM-CSF: implication in atherosclerosisQ45774913
Dietary intervention-induced weight loss decreases macrophage content in adipose tissue of obese women.Q47429190
Glucocorticoids induce differentiation of a specifically activated, anti-inflammatory subtype of human monocytes.Q52767154
Modulating macrophage function with IgG immune complexes.Q53656585
Unlike PPARγ, PPARα or PPARβ/δ activation does not promote human monocyte differentiation toward alternative macrophagesQ57244153
PPARγ Activation Primes Human Monocytes into Alternative M2 Macrophages with Anti-inflammatory PropertiesQ57244208
Remodeling Phenotype of Human Subcutaneous Adipose Tissue MacrophagesQ57321396
Increased Inflammatory Properties of Adipose Tissue Macrophages Recruited During Diet-Induced ObesityQ58197140
Macrophages in human visceral adipose tissue: increased accumulation in obesity and a source of resistin and visfatinQ82639139
Telmisartan improves insulin resistance and modulates adipose tissue macrophage polarization in high-fat-fed miceQ83682804
Telmisartan exerts antiatherosclerotic effects by activating peroxisome proliferator-activated receptor-γ in macrophagesQ83809430
Glucocorticoid treatment skews human monocyte differentiation into a hemoglobin-clearance phenotype with enhanced heme-iron recycling and antioxidant capacityQ84806018
Exercise training inhibits inflammation in adipose tissue via both suppression of macrophage infiltration and acceleration of phenotypic switching from M1 to M2 macrophages in high-fat-diet-induced obese miceQ85027038
P433issue5
P921main subjectmacrophageQ184204
P304page(s)365-372
P577publication date2011-10-01
P1433published inCurrent Opinion in LipidologyQ15758705
P1476titleMacrophage polarization in metabolic disorders: functions and regulation
P478volume22

Reverse relations

cites work (P2860)
Q42377885Activated macrophages control human adipocyte mitochondrial bioenergetics via secreted factors
Q37149978Activation of PPARγ by a Natural Flavonoid Modulator, Apigenin Ameliorates Obesity-Related Inflammation Via Regulation of Macrophage Polarization
Q89940604Adipose stromal/stem cells in regenerative medicine: Potentials and limitations
Q33829331Adipose tissue immune response: novel triggers and consequences for chronic inflammatory conditions.
Q40038383Adipose tissue infiltration in normal-weight subjects and its impact on metabolic function.
Q38040275Adipose triglyceride lipase in immune response, inflammation, and atherosclerosis.
Q92005929Aerosol inhalation of a hydrogen-rich solution restored septic renal function
Q36475199Age-associated changes in long-chain fatty acid profile during healthy aging promote pro-inflammatory monocyte polarization via PPARγ.
Q58088634Amygdalar Metabolic Activity Independently Associates with Progression of Visceral Adiposity
Q36201919Apolipoprotein E4 impairs macrophage efferocytosis and potentiates apoptosis by accelerating endoplasmic reticulum stress
Q64079461Association between Adipose Tissue Interleukin-33 and Immunometabolic Markers in Individuals with Varying Degrees of Glycemia
Q37978508Bone marrow transplantation as an established approach for understanding the role of macrophages in atherosclerosis and the metabolic syndrome
Q55307134Can we target CCR2 to treat osteoarthritis? The trick is in the timing!
Q36519765Carotid atherosclerotic plaque matrix metalloproteinase-12-positive macrophage subpopulation predicts adverse outcome after endarterectomy
Q52666785Cell-intrinsic sphingosine kinase 2 promotes macrophage polarization and renal inflammation in response to unilateral ureteral obstruction.
Q40761391Characteristics of alveolar macrophages from murine models of OVA-induced allergic airway inflammation and LPS-induced acute airway inflammation
Q54324008Characterization of polarized THP-1 macrophages and polarizing ability of LPS and food compounds.
Q39320915Cholinergic modulation of the immune system presents new approaches for treating inflammation
Q36065117Combined Liver X Receptor/Peroxisome Proliferator-activated Receptor γ Agonist Treatment Reduces Amyloid β Levels and Improves Behavior in Amyloid Precursor Protein/Presenilin 1 Mice
Q41342312Conjugated linoleic acid induces an atheroprotective macrophage MΦ2 phenotype and limits foam cell formation
Q33751235Critical illness induces nutrient-independent adipogenesis and accumulation of alternatively activated tissue macrophages
Q50096179Diabetic macroangiopathy: Pathogenetic insights and novel therapeutic approaches with focus on high glucose-mediated vascular damage.
Q36938464Differences in forward angular light scattering distributions between M1 and M2 macrophages.
Q27002464Distinct regulation of dengue virus-induced inflammasome activation in human macrophage subsets
Q42806842Divergent functions of endotrophin on different cell populations in adipose tissue
Q40305759Haemodynamic analysis of femoral artery bifurcation models under different physiological flow waveforms
Q38811310Hemopexin therapy reverts heme-induced proinflammatory phenotypic switching of macrophages in a mouse model of sickle cell disease
Q34113876IL-24 gene polymorphisms are associated with cardiometabolic parameters and cardiovascular risk factors but not with premature coronary artery disease: the genetics of atherosclerotic disease Mexican study.
Q38766188Identification of M2 macrophages in anterior pituitary glands of normal rats and rats with estrogen-induced prolactinoma
Q35906920Identification of polarized macrophage subsets in zebrafish
Q46328983Identifying exposition to low oxygen environment in human macrophages using secondary ion mass spectrometry and multivariate analysis.
Q39366921Immunometabolic Signaling Pathways Contribute to Macrophage and Dendritic Cell Function.
Q93204690Immunometabolism features of metabolic deregulation and cancer
Q37235370Immunometabolism in obese asthmatics: are we there yet?
Q37310434Increased atherosclerotic lesions in LDL receptor deficient mice with hematopoietic nuclear receptor Rev-erbα knock- down
Q38721837Innate Immunity and Inflammation in NAFLD/NASH.
Q42028727Interleukin-27 polymorphisms are associated with premature coronary artery disease and metabolic parameters in the Mexican population: the genetics of atherosclerotic disease (GEA) Mexican study.
Q28591246Interleukin-4 regulates lipid metabolism by inhibiting adipogenesis and promoting lipolysis
Q37231144Keap1 knockdown increases markers of metabolic syndrome after long-term high fat diet feeding
Q85529972Lactobacillus paracasei Induces M2-Dominant Kupffer Cell Polarization in a Mouse Model of Nonalcoholic Steatohepatitis
Q93008488Low-Frequency Intermittent Hypoxia Suppresses Subcutaneous Adipogenesis and Induces Macrophage Polarization in Lean Mice
Q37104535M1- and M2-Type Macrophage Responses Are Predictive of Adverse Outcomes in Human Atherosclerosis.
Q26780531Macrophage Heterogeneity and Plasticity: Impact of Macrophage Biomarkers on Atherosclerosis
Q33716370Macrophage polarization in inflammatory diseases
Q36494659Macrophages modulate cardiac function in lipotoxic cardiomyopathy.
Q30541876Macrophages regulate corpus luteum development during embryo implantation in mice
Q37171886Moderate-intensity exercise alters markers of alternative activation in circulating monocytes in females: a putative role for PPARγ.
Q35987094Modulation of Macrophage Polarization and HMGB1-TLR2/TLR4 Cascade Plays a Crucial Role for Cardiac Remodeling in Senescence-Accelerated Prone Mice.
Q28071265Molecular Pathogenesis of NASH
Q33569870MyD88-dependent interplay between myeloid and endothelial cells in the initiation and progression of obesity-associated inflammatory diseases
Q39364012Myeloperoxidase-Oxidized LDLs Enhance an Anti-Inflammatory M2 and Antioxidant Phenotype in Murine Macrophages.
Q36496336Nanotherapeutics for inhibition of atherogenesis and modulation of inflammation in atherosclerotic plaques
Q26741391Natural Phyto-Bioactive Compounds for the Treatment of Type 2 Diabetes: Inflammation as a Target
Q35850234Peripheral and Hepatic Vein Cytokine Levels in Correlation with Non-Alcoholic Fatty Liver Disease (NAFLD)-Related Metabolic, Histological, and Haemodynamic Features
Q42321362Peroxisome proliferator-activated receptor-γ activation induces 11β-hydroxysteroid dehydrogenase type 1 activity in human alternative macrophages.
Q35757816Prolonged Endoplasmic Reticulum-Stressed Hepatocytes Drive an Alternative Macrophage Polarization.
Q47831410Proteomic Signature Reveals Modulation of Human Macrophage Polarization and Functions Under Differing Environmental Oxygen Conditions.
Q34175955Relationship of MMP-14 and TIMP-3 expression with macrophage activation and human atherosclerotic plaque vulnerability
Q38383117Role of taurine in the pathogenesis of obesity
Q45784133Signature of subclinical femoral artery atherosclerosis in peripheral blood mononuclear cells
Q49352534Sodium valproate modulates immune response by alternative activation of monocyte-derived macrophages in systemic lupus erythematosus.
Q37100284Suppression of coronary atherosclerosis by helix B surface Peptide, a nonerythropoietic, tissue-protective compound derived from erythropoietin.
Q42408070The Secretome of Hydrogel-Coembedded Endothelial Progenitor Cells and Mesenchymal Stem Cells Instructs Macrophage Polarization in Endotoxemia
Q48150455The Upregulation of Integrin αDβ2 (CD11d/CD18) on Inflammatory Macrophages Promotes Macrophage Retention in Vascular Lesions and Development of Atherosclerosis.
Q52594157The flavonoid compound apigenin prevents colonic inflammation and motor dysfunctions associated with high fat diet-induced obesity.
Q99564846The influenza virus NS1A binding protein gene modulates macrophages response to cytokines and phagocytic potential in inflammation
Q36237960The rs7044343 Polymorphism of the Interleukin 33 Gene Is Associated with Decreased Risk of Developing Premature Coronary Artery Disease and Central Obesity, and Could Be Involved in Regulating the Production of IL-33.
Q34659689Transcriptome-based network analysis reveals a spectrum model of human macrophage activation.
Q64916342Transcriptomics Analysis Reveals New Insights into the Roles of Notch1 Signaling on Macrophage Polarization.
Q91720473Treatment of obesity-related inflammation with a novel synthetic pentacyclic oleanane triterpenoids via modulation of macrophage polarization
Q36385767Vitamin D suppression of endoplasmic reticulum stress promotes an antiatherogenic monocyte/macrophage phenotype in type 2 diabetic patients
Q38543908When fat becomes an ally of the enemy: adipose tissue as collaborator in human breast cancer

Search more.