Human Intestinal Mononuclear Phagocytes in Health and Inflammatory Bowel Disease

scientific article published on 18 March 2020

Human Intestinal Mononuclear Phagocytes in Health and Inflammatory Bowel Disease is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.3389/FIMMU.2020.00410
P932PMC publication ID7093381
P698PubMed publication ID32256490

P2093author name stringMary Jo Wick
Charles Caër
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Resident and pro-inflammatory macrophages in the colon represent alternative context-dependent fates of the same Ly6Chi monocyte precursorsQ36775202
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Disordered macrophage cytokine secretion underlies impaired acute inflammation and bacterial clearance in Crohn's diseaseQ37331540
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Transcriptional Control of Dendritic Cell Development.Q37468541
Pro-inflammatory human Th17 cells selectively express P-glycoprotein and are refractory to glucocorticoids.Q37483138
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The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibitionQ37587618
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Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8alpha+ conventional dendritic cellsQ28591976
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Crohn's diseaseQ30240201
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Small intestinal CD103+ dendritic cells display unique functional properties that are conserved between mice and humans.Q33361113
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Phenotype, function, and differentiation potential of human monocyte subsets.Q33606028
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Inflammatory cues enhance TGFβ activation by distinct subsets of human intestinal dendritic cells via integrin αvβ8.Q33712534
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Inflammation anergy in human intestinal macrophages is due to Smad-induced IkappaBalpha expression and NF-kappaB inactivationQ33911451
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Anatomical basis of tolerance and immunity to intestinal antigensQ33965210
Role of the gut microbiota in immunity and inflammatory diseaseQ34036490
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Intestinal macrophages lack CD14 and CD89 and consequently are down-regulated for LPS- and IgA-mediated activitiesQ34087190
Crosstalk between muscularis macrophages and enteric neurons regulates gastrointestinal motility.Q34109011
Nomenclature of monocytes and dendritic cells in blood.Q34125860
Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor-neutralizing therapy in patients with inflammatory bowel disease.Q41846031
Cutting Edge: identification of neutrophil PGLYRP1 as a ligand for TREM-1.Q41986614
Origin of the lamina propria dendritic cell networkQ42117974
Intestinal CD103+, but not CX3CR1+, antigen sampling cells migrate in lymph and serve classical dendritic cell functions.Q42138485
CD47 fusion protein targets CD172a+ cells in Crohn's disease and dampens the production of IL-1β and TNFQ42142744
Increased production of retinoic acid by intestinal macrophages contributes to their inflammatory phenotype in patients with Crohn's disease.Q42229506
Functional heterogeneity of gut-resident regulatory T cellsQ42279415
The Peyer's Patch Mononuclear Phagocyte System at Steady State and during InfectionQ42371903
IL-36R signalling activates intestinal epithelial cells and fibroblasts and promotes mucosal healing in vivoQ42772715
Skin-draining lymph nodes contain dermis-derived CD103(-) dendritic cells that constitutively produce retinoic acid and induce Foxp3(+) regulatory T cellsQ42830424
Gut CD103+ dendritic cells express indoleamine 2,3-dioxygenase which influences T regulatory/T effector cell balance and oral tolerance induction.Q43081763
Phagocytosis imprints heterogeneity in tissue-resident macrophages.Q43097066
An Antibody Against Triggering Receptor Expressed on Myeloid Cells 1 (TREM-1) Dampens Proinflammatory Cytokine Secretion by Lamina Propria Cells from Patients with IBD.Q43754792
Human CD1c+ dendritic cells secrete high levels of IL-12 and potently prime cytotoxic T-cell responsesQ44318177
Increased Th17-inducing activity of CD14+ CD163 low myeloid cells in intestinal lamina propria of patients with Crohn's diseaseQ44369423
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Flt3-ligand and granulocyte colony-stimulating factor mobilize distinct human dendritic cell subsets in vivoQ45193405
Human CD14+ macrophages in intestinal lamina propria exhibit potent antigen-presenting ability.Q45932216
Human intestinal epithelial cells promote the differentiation of tolerogenic dendritic cells.Q45943518
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Lineage specification of human dendritic cells is marked by IRF8 expression in hematopoietic stem cells and multipotent progenitors.Q47113381
Interleukin 1β Mediates Intestinal Inflammation in Mice and Patients With Interleukin 10 Receptor Deficiency.Q47132433
Transcriptional and functional profiling defines human small intestinal macrophage subsets.Q47256407
Genetic and Pharmacological Dissection of the Role of Spleen Tyrosine Kinase (Syk) in Intestinal Inflammation and Immune Dysfunction in Inflammatory Bowel DiseasesQ47260453
High-Dimensional Phenotypic Mapping of Human Dendritic Cells Reveals Interindividual Variation and Tissue Specialization.Q47314216
Existence of CD8α-like dendritic cells with a conserved functional specialization and a common molecular signature in distant mammalian speciesQ47607521
Identification of cDC1- and cDC2-committed DC progenitors reveals early lineage priming at the common DC progenitor stage in the bone marrow.Q47687570
Human CD1c⁺ myeloid dendritic cells acquire a high level of retinoic acid-producing capacity in response to vitamin D₃.Q47727563
Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies.Q47758448
Aryl Hydrocarbon Receptor Controls Monocyte Differentiation into Dendritic Cells versus MacrophagesQ47772617
Identification of a Human Clonogenic Progenitor with Strict Monocyte Differentiation Potential: A Counterpart of Mouse cMoPsQ47841621
T Cell Zone Resident Macrophages Silently Dispose of Apoptotic Cells in the Lymph NodeQ47962765
CX3CR1+ mononuclear phagocytes control immunity to intestinal fungi.Q48257612
Yolk sac macrophage progenitors traffic to the embryo during defined stages of development.Q48293548
Macrophage Clearance of Apoptotic Cells: A Critical AssessmentQ49197192
Lymph node macrophages: Scavengers, immune sentinels and trophic effectorsQ49346577
Niche signals and transcription factors involved in tissue-resident macrophage developmentQ49793888
Dendritic Cells on the Way to GloryQ49873903
Human in vivo-differentiated monocyte-derived dendritic cellsQ49968553
Intestinal Intraepithelial Lymphocytes: Sentinels of the Mucosal BarrierQ49990746
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Human Intestinal Dendritic Cells in Inflammatory Bowel Diseases.Q50036423
IgA Function in Relation to the Intestinal Microbiota.Q50063230
Chemoreceptors in the Gut.Q50065555
Enhanced TH17 Responses in Patients with IL10 Receptor Deficiency and Infantile-onset IBD.Q50098206
Macrophage plasticity, polarization and function in health and diseaseQ50107325
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CD16+ Macrophages Mediate Fibrosis in Inflammatory Bowel Disease.Q50162390
Adjustment of dendritic cells to the breast-cancer microenvironment is subset specificQ58861966
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Cross-Talk Between Antigen Presenting Cells and T Cells Impacts Intestinal Homeostasis, Bacterial Infections, and TumorigenesisQ64056525
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Low TREM1 expression in whole blood predicts anti-TNF response in inflammatory bowel diseaseQ64261195
The Short Chain Fatty Acid Butyrate Imprints an Antimicrobial Program in MacrophagesQ64261973
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Direct evidence of monocyte recruitment to inflammatory bowel disease mucosaQ70801967
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Toll-like receptors 2 and 4 are up-regulated during intestinal inflammationQ74262578
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Macrophages expressing triggering receptor expressed on myeloid cells-1 are underrepresented in the human intestineQ81178366
Relationship between human intestinal dendritic cells, gut microbiota, and disease activity in Crohn's diseaseQ84936754
Differential accumulation and function of proinflammatory 6-sulfo LacNAc dendritic cells in lymph node and colon of Crohn's versus ulcerative colitis patientsQ85570375
Ly6C hi monocytes in the inflamed colon give rise to proinflammatory effector cells and migratory antigen-presenting cellsQ85634389
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Critical Role for the Microbiota in CX3CR1+ Intestinal Mononuclear Phagocyte Regulation of Intestinal T Cell ResponsesQ89448413
Intestinal macrophages and their interaction with the enteric nervous system in health and inflammatory bowel diseaseQ89585472
Transcriptomic Analysis and High-dimensional Phenotypic Mapping of Mononuclear Phagocytes in Mesenteric Lymph Nodes Reveal Differences Between Ulcerative Colitis and Crohn's DiseaseQ90197813
TREM-1, the ideal predictive biomarker for endoscopic healing in anti-TNF-treated Crohn's disease patients?Q90214239
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Gut microbiome structure and metabolic activity in inflammatory bowel diseaseQ90371831
Transcriptional profiling reveals monocyte-related macrophages phenotypically resembling DC in human intestineQ90427375
Two distinct colonic CD14+ subsets characterized by single-cell RNA profiling in Crohn's diseaseQ91168567
Immunometabolism at the interface between macrophages and pathogensQ91212060
Mucosal Profiling of Pediatric-Onset Colitis and IBD Reveals Common Pathogenics and Therapeutic PathwaysQ91296899
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Macrophages in intestinal inflammation and resolution: a potential therapeutic target in IBDQ91937728
Novel Pharmacological Therapy in Inflammatory Bowel Diseases: Beyond Anti-Tumor Necrosis FactorQ91970764
Inflammation triggers immediate rather than progressive changes in monocyte differentiation in the small intestineQ92034675
Development and functional specialization of CD103+ dendritic cells.Q37700854
Mucosal macrophages in intestinal homeostasis and inflammationQ37949275
How vitamin A metabolizing dendritic cells are generated in the gut mucosaQ37955483
The three human monocyte subsets: implications for health and diseaseQ37995036
Sargramostim (GM-CSF) for induction of remission in Crohn's disease: a cochrane inflammatory bowel disease and functional bowel disorders systematic review of randomized trialsQ38007115
Paneth cells: maestros of the small intestinal cryptsQ38080558
The interaction between signal regulatory protein alpha (SIRPα) and CD47: structure, function, and therapeutic targetQ38161542
Intestinal epithelial cells: regulators of barrier function and immune homeostasisQ38190874
Intestinal macrophages and dendritic cells: what's the difference?Q38209216
Intestinal dendritic cells in the regulation of mucosal immunityQ38221347
Origin and functions of tissue macrophages.Q38230878
Dendritic cells and monocyte-derived cells: Two complementary and integrated functional systemsQ38468896
SuperSAGE evidence for CD14++CD16+ monocytes as a third monocyte subsetQ38487146
IL-12 and IL-23 cytokines: from discovery to targeted therapies for immune-mediated inflammatory diseases.Q38539817
A Comparative Study of the T Cell Stimulatory and Polarizing Capacity of Human Primary Blood Dendritic Cell Subsets.Q38576179
Human lymphoid organ dendritic cell identity is predominantly dictated by ontogeny, not tissue microenvironmentQ38636864
Role of Intestinal HIF-2α in Health and DiseaseQ38669208
CCR2-dependent monocyte-derived macrophages resolve inflammation and restore gut motility in postoperative ileusQ38671025
Genetics and Pathogenesis of Inflammatory Bowel DiseaseQ38747192
Current and emerging therapeutic targets for IBD.Q38763559
Resolution of inflammation: a new therapeutic frontierQ38791244
Lessons Learned From Trials Targeting Cytokine Pathways in Patients With Inflammatory Bowel DiseasesQ38805575
Role of Monocytes and Intestinal Macrophages in Crohn's Disease and Ulcerative ColitisQ38848938
Human haematopoietic stem cell lineage commitment is a continuous processQ38893856
Macrophages in gastrointestinal homeostasis and inflammation.Q38913938
Mechanisms, Management, and Treatment of Fibrosis in Patients With Inflammatory Bowel DiseasesQ38976561
Functions of Murine Dendritic CellsQ38985483
The intestinal epithelial barrier: a therapeutic target?Q39009998
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Novel Targeted Therapies for Inflammatory Bowel DiseaseQ39028822
Genome-wide association study identifies distinct genetic contributions to prognosis and susceptibility in Crohn's disease.Q39031925
Mechanisms of Organ Injury and Repair by MacrophagesQ39037455
Retinoic Acid and Immune Homeostasis: A Balancing Act.Q39091685
Cells of the innate and adaptive immunity and their interactions in inflammatory bowel disease.Q39105607
Pathogenesis of Intestinal Fibrosis in Inflammatory Bowel Disease and Perspectives for Therapeutic ImplicationQ39113709
CD103+ Dendritic Cell Function Is Altered in the Colons of Patients with Ulcerative ColitisQ50533232
CD64 distinguishes macrophages from dendritic cells in the gut and reveals the Th1-inducing role of mesenteric lymph node macrophages during colitis.Q50787445
Human inflammatory dendritic cells induce Th17 cell differentiation.Q50917340
IRF4 transcription-factor-dependent CD103(+)CD11b(+) dendritic cells drive mucosal T helper 17 cell differentiation.Q51002504
Macrophages and the Recovery from Acute and Chronic Inflammation.Q51270292
Apoptosis and Clearance of Apoptotic Cells.Q51366322
Regulation of the Cell Biology of Antigen Cross-Presentation.Q51410365
The Complexity of alpha E beta 7 Blockade in Inflammatory Bowel Diseases.Q51471341
Long-term persistence of human donor alveolar macrophages in lung transplant recipients.Q51503858
Reprogramming of monocytes by GM-CSF contributes to regulatory immune functions during intestinal inflammation.Q51661405
Human dendritic cell subsets from spleen and blood are similar in phenotype and function but modified by donor health status.Q51869621
TL1A produced by lamina propria macrophages induces Th1 and Th17 immune responses in cooperation with IL-23 in patients with Crohn's disease.Q51889710
Translating Immunology into Therapeutic Concepts for Inflammatory Bowel Disease.Q52314229
Urbanization and the gut microbiota in health and inflammatory bowel disease.Q52579441
Imbalance of NKp44(+)NKp46(-) and NKp44(-)NKp46(+) natural killer cells in the intestinal mucosa of patients with Crohn's disease.Q52602187
Review article: nonclinical and clinical pharmacology, pharmacokinetics and pharmacodynamics of etrolizumab, an anti-β7 integrin therapy for inflammatory bowel disease.Q52618987
Rapid accumulation of CD14+CD11c+ dendritic cells in gut mucosa of celiac disease after in vivo gluten challengeQ34206293
Constant replenishment from circulating monocytes maintains the macrophage pool in the intestine of adult miceQ34214131
Human dermal CD14⁺ cells are a transient population of monocyte-derived macrophagesQ34244161
The gastrointestinal mucus system in health and diseaseQ34332180
Human intestinal macrophages display profound inflammatory anergy despite avid phagocytic and bacteriocidal activityQ34381271
Regional specialization within the intestinal immune systemQ34439411
Macrophages in Tissue Repair, Regeneration, and FibrosisQ34518415
Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitorsQ34555562
Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasisQ34646876
Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytesQ34650719
Transcriptome-based network analysis reveals a spectrum model of human macrophage activation.Q34659689
Macrophages: development and tissue specializationQ34669239
Regulation of macrophage development and function in peripheral tissuesQ34674559
Tissue-Resident Macrophage Ontogeny and HomeostasisQ34676333
Intestinal lamina propria dendritic cell subsets have different origin and functions.Q35001346
Recent advances in inflammatory bowel disease: mucosal immune cells in intestinal inflammationQ35012024
Origins and functional specialization of macrophages and of conventional and monocyte-derived dendritic cells in mouse skinQ35030843
Circulating precursors of human CD1c+ and CD141+ dendritic cellsQ35161496
Restricted dendritic cell and monocyte progenitors in human cord blood and bone marrowQ35161508
Monocyte and M1 Macrophage-induced Barrier Defect Contributes to Chronic Intestinal Inflammation in IBD.Q35611467
Regulatory immune cells in regulation of intestinal inflammatory response to microbiota.Q35665218
Understanding the Mysterious M2 Macrophage through Activation Markers and Effector MechanismsQ35674290
Inflammation switches the differentiation program of Ly6Chi monocytes from antiinflammatory macrophages to inflammatory dendritic cells in the colon.Q35679555
Immunopathogenesis of IBD: current state of the art.Q35857951
Batf3 maintains autoactivation of Irf8 for commitment of a CD8α(+) conventional DC clonogenic progenitor.Q35866588
Interleukin-10 receptor signaling in innate immune cells regulates mucosal immune tolerance and anti-inflammatory macrophage functionQ35884586
Reparative inflammation takes charge of tissue regenerationQ35899475
Compartment-specific immunity in the human gut: properties and functions of dendritic cells in the colon versus the ileumQ35931663
Resident CD141 (BDCA3)+ dendritic cells in human skin produce IL-10 and induce regulatory T cells that suppress skin inflammationQ35946105
Molecular and cellular mechanisms of food allergy and food tolerance.Q35984123
TREM-1--expressing intestinal macrophages crucially amplify chronic inflammation in experimental colitis and inflammatory bowel diseasesQ35987572
Development and maintenance of intestinal regulatory T cellsQ35992122
Gut microbiota, metabolites and host immunityQ36031926
Development of conventional dendritic cells: from common bone marrow progenitors to multiple subsets in peripheral tissues.Q39136220
Resident macrophages in the healthy and inflamed intestinal muscularis externa.Q39150054
TREM-1 and its potential ligands in non-infectious diseases: from biology to clinical perspectivesQ39155066
Diversity and functions of intestinal mononuclear phagocytesQ39221260
Transcriptional control of monocyte and macrophage developmentQ39221646
Cross-talk between RORγt+ innate lymphoid cells and intestinal macrophages induces mucosal IL-22 production in Crohn's diseaseQ39256177
Monocyte differentiation and antigen-presenting functionsQ39258320
Does niche competition determine the origin of tissue-resident macrophages?Q39276574
TGF-β in inflammatory bowel disease: a key regulator of immune cells, epithelium, and the intestinal microbiotaQ39324100
Roles of intestinal epithelial cells in the maintenance of gut homeostasisQ39331432
Rapid and Efficient Generation of Regulatory T Cells to Commensal Antigens in the PeripheryQ39343055
Transcriptional determination and functional specificity of myeloid cells: making sense of diversityQ39350743
Inflammation and metabolism in tissue repair and regeneration.Q39360685
DNGR-1 is a specific and universal marker of mouse and human Batf3-dependent dendritic cells in lymphoid and nonlymphoid tissuesQ39374974
IRF8 Transcription Factor Controls Survival and Function of Terminally Differentiated Conventional and Plasmacytoid Dendritic Cells, RespectivelyQ39381290
Mucosal immune system of the gastrointestinal tract: maintaining balance between the good and the bad.Q39428969
Gut microbiota and IBD: causation or correlation?Q39458190
Impaired antibacterial autophagy links granulomatous intestinal inflammation in Niemann-Pick disease type C1 and XIAP deficiency with NOD2 variants in Crohn's diseaseQ39940199
Differentiation of human monocytes and derived subsets of macrophages and dendritic cells by the HLDA10 monoclonal antibody panel.Q39979829
Mapping the human DC lineage through the integration of high-dimensional techniques.Q40225787
Transcriptional Heterogeneity and Lineage Commitment in Myeloid ProgenitorsQ40252079
Identification of a human intestinal myeloid cell subset that regulates gut homeostasis.Q40480972
Optimal Generation of Tissue-Resident but Not Circulating Memory T Cells during Viral Infection Requires Crosspriming by DNGR-1+ Dendritic CellsQ40499828
Characterization of human blood dendritic cell subsetsQ40625943
A Frameshift in CSF2RB Predominant Among Ashkenazi Jews Increases Risk for Crohn's Disease and Reduces Monocyte Signaling via GM-CSF.Q40667799
IRF8 Transcription-Factor-Dependent Classical Dendritic Cells Are Essential for Intestinal T Cell Homeostasis.Q40719461
New insights into the multidimensional concept of macrophage ontogeny, activation and function.Q40866271
Superior antigen cross-presentation and XCR1 expression define human CD11c+CD141+ cells as homologues of mouse CD8+ dendritic cellsQ40952120
Cytokine profiles differ in newly recruited and resident subsets of mucosal macrophages from inflammatory bowel diseaseQ41459552
The macrophage transcription factor PU.1 directs tissue-specific expression of the macrophage colony-stimulating factor receptorQ41497311
Human gut dendritic cells drive aberrant gut-specific t-cell responses in ulcerative colitis, characterized by increased IL-4 production and loss of IL-22 and IFNγ.Q41661113
CD1c-Expression by Monocytes - Implications for the Use of Commercial CD1c+ Dendritic Cell Isolation KitsQ36054531
Immunological aspects of intestinal mucus and mucins.Q36096975
Monocyte and macrophage plasticity in tissue repair and regenerationQ36167571
Mucosal T-cell immunoregulation varies in early and late inflammatory bowel diseaseQ36172835
Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogenyQ36263627
Tracing the origin of adult intestinal stem cellsQ92052877
Resident memory CD8 T cells persist for years in human small intestineQ92133770
The role of macrophages in the resolution of inflammationQ92153164
Intra- and Inter-cellular Rewiring of the Human Colon during Ulcerative ColitisQ92204349
Immune cell trafficking and retention in inflammatory bowel disease: mechanistic insights and therapeutic advancesQ92281952
Multi-omics of the gut microbial ecosystem in inflammatory bowel diseasesQ92383004
IL-12 and Mucosal CD14+ Monocyte-Like Cells Induce IL-8 in Colonic Memory CD4+ T Cells of Patients With Ulcerative Colitis but not Crohn's DiseaseQ92804209
Assessment of Crohn's disease-associated small bowel strictures and fibrosis on cross-sectional imaging: a systematic reviewQ92827433
Innate lymphoid cells support regulatory T cells in the intestine through interleukin-2Q92830433
The Mononuclear Phagocytic System. Generation of DiversityQ92857858
Plasmacytoid dendritic cells develop from Ly6D+ lymphoid progenitors distinct from the myeloid lineageQ92860934
Targeting immune cell circuits and trafficking in inflammatory bowel diseaseQ93001372
Single-Cell Analysis of Crohn's Disease Lesions Identifies a Pathogenic Cellular Module Associated with Resistance to Anti-TNF TherapyQ93043721
Single-Cell Analysis of Human Mononuclear Phagocytes Reveals Subset-Defining Markers and Identifies Circulating Inflammatory Dendritic CellsQ93044640
Compartmentalization of dendritic cell and T-cell interactions in the lymph node: Anatomy of T-cell fate decisionsQ93049134
Microbial genes and pathways in inflammatory bowel diseaseQ93088941
Bridging intestinal immunity and gut microbiota by metabolitesQ93092528
Fate Mapping via Ms4a3-Expression History Traces Monocyte-Derived CellsQ93151331
Cytokine Networks in the Pathophysiology of Inflammatory Bowel DiseaseQ93158351
Inhibiting Interleukin 36 Receptor Signaling Reduces Fibrosis in Mice With Chronic Intestinal InflammationQ93212826
Dendritic cell subsets in T cell programming: location dictates functionQ93338385
Risk factors for postoperative infection after gastrointestinal surgery among adult patients with inflammatory bowel disease: Findings from a large observational US cohort studyQ93355863
IL-12, IL-23 and IL-17 in IBD: immunobiology and therapeutic targetingQ93381993
Immunopathogenesis of inflammatory bowel disease and mechanisms of biological therapies.Q52664145
Mechanisms of Oral Tolerance.Q52682112
Integrated Single-Cell Analysis Maps the Continuous Regulatory Landscape of Human Hematopoietic Differentiation.Q52715871
Dendritic Cells Display Subset and Tissue-Specific Maturation Dynamics over Human Life.Q52780418
Effects of Mongersen (GED-0301) on Endoscopic and Clinical Outcomes in Patients With Active Crohn's Disease.Q53093762
Novel therapies for immune-mediated inflammatory diseases: What can we learn from their use in rheumatoid arthritis, spondyloarthritis, systemic lupus erythematosus, psoriasis, Crohn's disease and ulcerative colitis?Q53131122
Reduced numbers of mucosal DR(int) macrophages and increased numbers of CD103(+) dendritic cells during anti-TNF-α treatment in patients with Crohn's disease.Q53203956
CD163L1 and CLEC5A discriminate subsets of human resident and inflammatory macrophages in vivo.Q53543419
Human intestinal pro-inflammatory CD11chighCCR2+CX3CR1+ macrophages, but not their tolerogenic CD11c-CCR2-CX3CR1- counterparts, are expanded in inflammatory bowel disease.Q53819683
Tissue-resident macrophages in the intestine are long lived and defined by Tim-4 and CD4 expression.Q54201969
To respond or not to respond - a personal perspective of intestinal tolerance.Q54264589
Th1/Th17 immune response is induced by mesenteric lymph node dendritic cells in Crohn's disease.Q54471973
CD14(hi)HLA-DR(dim) macrophages, with a resemblance to classical blood monocytes, dominate inflamed mucosa in Crohn's disease.Q54629123
Human in vivo-generated monocyte-derived dendritic cells and macrophages cross-present antigens through a vacuolar pathway.Q55453765
Structural Remodeling of the Human Colonic Mesenchyme in Inflammatory Bowel DiseaseQ57025321
Self-Maintaining Gut Macrophages Are Essential for Intestinal HomeostasisQ57025360
Abnormal Small Intestinal Epithelial Microvilli in Patients With Crohn's DiseaseQ57098797
The elusive case of human intraepithelial T cells in gut homeostasis and inflammationQ57143881
Defining GM-CSF- and macrophage-CSF-dependent macrophage responses by in vitro modelsQ57149911
miR-10a inhibits dendritic cell activation and Th1/Th17 cell immune responses in IBDQ57197627
Macrophage-restricted interleukin-10 receptor deficiency, but not IL-10 deficiency, causes severe spontaneous colitisQ57339877
Intestinal Tolerance Requires Gut Homing and Expansion of FoxP3+ Regulatory T Cells in the Lamina PropriaQ57339886
Developmental and Functional Heterogeneity of MonocytesQ57457579
Human monocytes and macrophages regulate immune tolerance via integrin αvβ8-mediated TGFβ activationQ57792331
Intestinal fibrosisQ58568367
Inhibiting Inflammation with Myeloid Cell-Specific Nanobiologics Promotes Organ Transplant AcceptanceQ58592065
Malignancies in Inflammatory Bowel Disease: Frequency, Incidence and Risk Factors-Results from the Swiss IBD Cohort StudyQ58604512
Notch Signaling Facilitates In Vitro Generation of Cross-Presenting Classical Dendritic CellsQ58620994
ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS-STINGQ58700139
The Transcription Factor ZEB2 Is Required to Maintain the Tissue-Specific Identities of MacrophagesQ58730196
Mechanisms regulating intestinal barrier integrity and its pathological implicationsQ58774497
Resolution of chronic inflammatory disease: universal and tissue-specific conceptsQ58778332
Large-Scale Human Dendritic Cell Differentiation Revealing Notch-Dependent Lineage Bifurcation and HeterogeneityQ58780459
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P921main subjectinflammatory bowel diseasesQ917447
P304page(s)410
P577publication date2020-03-18
P1433published inFrontiers in ImmunologyQ27723748
P1476titleHuman Intestinal Mononuclear Phagocytes in Health and Inflammatory Bowel Disease
P478volume11

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