Microglia responses to interleukin-6 and type I interferons in neuroinflammatory disease

scientific article published on 29 April 2019

Microglia responses to interleukin-6 and type I interferons in neuroinflammatory disease is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/GLIA.23634
P698PubMed publication ID31033014

P50authorMarkus J HoferQ89305070
P2093author name stringIain L Campbell
Barney Viengkhou
Phillip K West
P2860cites workInterferon-β-related tumefactive brain lesion in a Caucasian patient with neuromyelitis optica and clinical stabilization with tocilizumabQ21146701
Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune responseQ24338296
Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathwayQ24531184
Aicardi-Goutières syndrome displays genetic heterogeneity with one locus (AGS1) on chromosome 3p21.Q24538729
NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 miceQ24604235
IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channelQ24646531
Trex1 prevents cell-intrinsic initiation of autoimmunityQ24648757
Aicardi-Goutieres syndrome and related phenotypes: linking nucleic acid metabolism with autoimmunityQ24655886
Cree encephalitis is allelic with Aicardi-Goutiéres syndrome: implications for the pathogenesis of disorders of interferon alpha metabolismQ24678063
Immune phenotypes of microglia in human neurodegenerative disease: challenges to detecting microglial polarization in human brainsQ26796857
Depletion of microglia and inhibition of exosome synthesis halt tau propagationQ27311815
β2-microglobulin is a systemic pro-aging factor that impairs cognitive function and neurogenesisQ27315300
Microglia protect against brain injury and their selective elimination dysregulates neuronal network activity after stroke.Q27317371
Microglial interactions with synapses are modulated by visual experienceQ27322943
How cells respond to interferonsQ27861006
Mechanisms of type-I- and type-II-interferon-mediated signallingQ28247893
Patients with systemic lupus erythematosus, myositis, rheumatoid arthritis and scleroderma share activation of a common type I interferon pathwayQ84626226
Repopulated microglia are solely derived from the proliferation of residual microglia after acute depletionQ87855537
Microglial immune checkpoint mechanismsQ88596803
Disease-Associated Microglia: A Universal Immune Sensor of NeurodegenerationQ88727264
Csf1R inhibition attenuates experimental autoimmune encephalomyelitis and promotes recoveryQ88872669
A Combination of Ontogeny and CNS Environment Establishes Microglial IdentityQ88964912
Structural and visual functional deficits in a rat model of neuromyelitis optica spectrum disorders related optic neuritisQ89138153
Microglia have a more extensive and divergent response to interferon-α compared with astrocytesQ90562923
The Kaleidoscope of Microglial PhenotypesQ90948484
Chronic neurodegeneration induces type I interferon synthesis via STING, shaping microglial phenotype and accelerating disease progressionQ91215987
Lupus antibodies induce behavioral changes mediated by microglia and blocked by ACE inhibitorsQ91303656
Microglia in neurodegenerationQ91786444
Deletion of the type-1 interferon receptor in APPSWE/PS1ΔE9 mice preserves cognitive function and alters glial phenotypeQ37084675
Elimination of microglia improves cognitive function following cranial irradiationQ37168968
Intrastriatal injection of interleukin-1 beta triggers the formation of neuromyelitis optica-like lesions in NMO-IgG seropositive ratsQ37180238
Nucleic acid-mediated inflammatory diseasesQ37240752
Presence of an acid-labile alpha-interferon in sera from fetuses and children with congenital rubellaQ37280856
The microglial sensome revealed by direct RNA sequencingQ37341692
Interferon alpha association with neuromyelitis opticaQ37375268
Complement and microglia mediate early synapse loss in Alzheimer mouse models.Q37391481
Type I interferon causes thrombotic microangiopathy by a dose-dependent toxic effect on the microvasculature.Q37508060
Astrocyte barriers to neurotoxic inflammationQ37597818
IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microgliaQ37615661
Expression of an anti-RNA autoantibody in a mouse model of SLE increases neutrophil and monocyte numbers as well as IFN-I expressionQ37625812
Assessment of Type I Interferon Signaling in Pediatric Inflammatory DiseaseQ37666293
Pathogenic implications of cerebrospinal fluid barrier pathology in neuromyelitis optica.Q37697480
Efficacy of the anti-IL-6 receptor antibody tocilizumab in neuromyelitis optica: a pilot studyQ37725870
Gain-of-function mutations in IFIH1 cause a spectrum of human disease phenotypes associated with upregulated type I interferon signalingQ37732141
Interleukin-6, a mental cytokine.Q37828952
The pro- and anti-inflammatory properties of the cytokine interleukin-6.Q37836084
Pathology of demyelinating diseasesQ37982130
The interferons and their receptors--distribution and regulationQ37992849
IL-6 trans-signaling via the soluble IL-6 receptor: importance for the pro-inflammatory activities of IL-6.Q38058509
Interleukin-6, a major cytokine in the central nervous systemQ38058511
Interferons in the central nervous system: a few instruments play many tunes.Q38192651
IL-6 as a keystone cytokine in health and diseaseQ38433045
Type I interferon dysregulation and neurological diseaseQ38573095
The soluble interleukin-6 receptor and related proteinsQ38621814
Microglial brain region-dependent diversity and selective regional sensitivities to aging.Q38642851
A Unique Microglia Type Associated with Restricting Development of Alzheimer's DiseaseQ38672340
Microglia contribute to normal myelinogenesis and to oligodendrocyte progenitor maintenance during adulthood.Q38690047
Alpha and Beta Type 1 Interferon Signaling: Passage for Diverse Biologic Outcomes.Q38715891
Retracted article: Microglia-dependent synapse loss in type I interferon-mediated lupusQ38725841
Microglial Interferon Signaling and White Matter.Q38765964
Diverse Requirements for Microglial Survival, Specification, and Function Revealed by Defined-Medium CulturesQ38776867
The role of interleukin-6 signaling in nervous tissueQ38789542
Type I interferon signature is high in lupus and neuromyelitis optica but low in multiple sclerosisQ28251763
Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 cause Aicardi-Goutières syndrome at the AGS1 locusQ28252435
Neuroinflammation in Alzheimer's diseaseQ28259238
Association of increased interferon-inducible gene expression with disease activity and lupus nephritis in patients with systemic lupus erythematosusQ28261358
Microglia sculpt postnatal neural circuits in an activity and complement-dependent mannerQ28267444
Mutations in ADAR1 cause Aicardi-Goutières syndrome associated with a type I interferon signatureQ28275605
Interleukin 6 receptor blockade in patients with neuromyelitis optica nonresponsive to anti-CD20 therapyQ28284465
Aicardi-Goutières syndrome: an update and results of interferon-alpha studiesQ28291222
Identification of a unique TGF-β-dependent molecular and functional signature in microgliaQ28303557
Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responsesQ28634282
Synaptic pruning by microglia is necessary for normal brain developmentQ29615591
A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosisQ29615952
Fate mapping analysis reveals that adult microglia derive from primitive macrophagesQ29616177
Human USP18 deficiency underlies type 1 interferonopathy leading to severe pseudo-TORCH syndromeQ30090228
Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with MouseQ30696856
Eliminating microglia in Alzheimer's mice prevents neuronal loss without modulating amyloid-β pathology.Q30805627
Colony-stimulating factor 1 receptor blockade prevents fractionated whole-brain irradiation-induced memory deficitsQ30805782
Microglia mediate postoperative hippocampal inflammation and cognitive decline in miceQ30843381
Clinical findings and adverse outcome in neonates with symptomatic congenital cytomegalovirus (SCCMV) infectionQ31048548
Glial contributions to neurodegeneration in tauopathiesQ32173558
Microglia shape adult hippocampal neurogenesis through apoptosis-coupled phagocytosisQ33560182
Neurotoxic reactive astrocytes are induced by activated microgliaQ33602850
Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor.Q33662701
Microglial depletion alters the brain neuroimmune response to acute binge ethanol withdrawalQ33711718
A role for humoral mechanisms in the pathogenesis of Devic's neuromyelitis opticaQ33727402
Depletion of microglia exacerbates postischemic inflammation and brain injuryQ33727629
Inhibition of colony-stimulating factor 1 receptor early in disease ameliorates motor deficits in SCA1 miceQ33730419
Colony stimulating factor 1 receptor inhibition eliminates microglia and attenuates brain injury after intracerebral hemorrhageQ33828692
Innate STAT1-dependent genomic response of neurons to the antiviral cytokine alpha interferonQ33843404
Aicardi-Goutières syndrome is caused by IFIH1 mutations.Q33858615
Transgenic models for cytokine-induced neurological diseaseQ33926168
IL-6 induces regionally selective spinal cord injury in patients with the neuroinflammatory disorder transverse myelitisQ34014515
An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex.Q34123789
Interleukin-6, age, and corpus callosum integrityQ34133815
Role of interleukin-6 and soluble IL-6 receptor in region-specific induction of astrocytic differentiation and neurotrophin expressionQ48201154
Astrocyte-derived TGF-β1 accelerates disease progression in ALS mice by interfering with the neuroprotective functions of microglia and T cellsQ48221138
Sall1 is a transcriptional regulator defining microglia identity and function.Q48264747
Reciprocal regulation between resting microglial dynamics and neuronal activity in vivo.Q48271496
Inhibition of RGMa alleviates symptoms in a rat model of neuromyelitis optica.Q48293438
Investigation Into the Effects of Tenilsetam on Markers of Neuroinflammation in GFAP-IL6 Mice.Q48300482
Intracranial calcification with congenital rubella syndrome in a mother with serologic immunity.Q48304304
Increased cerebrospinal fluid metalloproteinase-2 and interleukin-6 are associated with albumin quotient in neuromyelitis optica: Their possible role on blood-brain barrier disruption.Q48493417
Site-specific production of IL-6 in the central nervous system retargets and enhances the inflammatory response in experimental autoimmune encephalomyelitis.Q48524409
Microglia modulate wiring of the embryonic forebrain.Q48583475
Neuroradiographic abnormalities in congenital cytomegalovirus infection.Q48585880
Chronic complement C3 gene expression in the CNS of transgenic mice with astrocyte-targeted interleukin-6 expression.Q48901153
Intrathecal synthesis of different alpha-interferons in patients with various neurological diseases.Q49183237
A transcriptomic atlas of aged human microglia.Q49578602
Microglia-mediated recovery from ALS-relevant motor neuron degeneration in a mouse model of TDP-43 proteinopathy.Q49789449
An open-label trial of JAK 1/2 blockade in progressive IFIH1-associated neuroinflammation.Q50102108
Early long-term administration of the CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in 5XFAD mouse model of Alzheimer's disease.Q50533712
Interleukin-6 analysis of 572 consecutive CSF samples from neurological disorders: A special focus on neuromyelitis optica.Q51102172
CSF cytokine and chemokine profiles in acute disseminated encephalomyelitis.Q51982590
Development of a Validated Interferon Score Using NanoString Technology.Q52594390
In Utero Administration of Drugs Targeting Microglia Improves the Neurodevelopmental Outcome Following Cytomegalovirus Infection of the Rat Fetal Brain.Q52645969
Immunohistochemistry using antibodies to alpha-interferon and its induced protein, MxA, in Alzheimer's and Parkinson's disease brain tissues.Q53204231
Reduced long-term potentiation in the dentate gyrus of transgenic mice with cerebral overexpression of interleukin-6.Q53778368
Targeting macrophage and microglia activation with colony stimulating factor 1 receptor inhibitor is an effective strategy to treat injury-triggered neuropathic pain.Q53824229
Characterization of human disease phenotypes associated with mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, ADAR, and IFIH1.Q54295783
A potential role for interferon-alpha in the pathogenesis of HIV-associated dementia.Q54713181
Depletion of microglia augments the dopaminergic neurotoxicity of MPTP.Q55395566
Aquaporin-4 Autoantibodies From Neuromyelitis Optica Spectrum Disorder Patients Induce Complement-Independent Immunopathologies in Mice.Q55498468
JAK1/2 inhibition with baricitinib in the treatment of autoinflammatory interferonopathies.Q55548365
Cytokine and chemokine profiles in neuromyelitis optica: significance of interleukin-6Q56771952
Different responses to interferon beta-1b treatment in patients with neuromyelitis optica and multiple sclerosisQ56771955
Markedly increased CSF interleukin-6 levels in neuromyelitis optica, but not in multiple sclerosisQ56772014
Microglia in Alzheimer's diseaseQ56922819
Type I interferonopathies: a novel set of inborn errors of immunityQ56923635
TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal DystrophyQ57265227
Effects of astrocyte-targeted production of interleukin-6 in the mouse on the host response to nerve injuryQ58027329
Trans-Signaling Is a Dominant Mechanism for the Pathogenic Actions of Interleukin-6 in the BrainQ58027335
Enforced microglial depletion and repopulation as a promising strategy for the treatment of neurological disordersQ58095253
Neuropsychiatric systemic lupus erythematosusQ59924786
Analysis of IL-6/gp130 family receptor expression reveals that in contrast to astroglia, microglia lack the oncostatin M receptor and functional responses to oncostatin MQ62658810
Activation of gp 130 by IL-6/soluble IL-6 receptor induces neuronal differentiationQ62658913
Epigenetic regulation of brain region-specific microglia clearance activity.Q64985968
Reactive gliosis as a consequence of interleukin-6 expression in the brain: studies in transgenic miceQ71686282
Microglial localization of α-interferon receptor in human brain tissuesQ71874807
Expression of cytokine receptors in cultured neuronal and glial cellsQ72624819
Soluble interleukin 6 receptor in biological fluids from human originQ72775784
Intrathecal cytokines in systemic lupus erythematosus with central nervous system involvementQ73086927
Development of extensive brain lesions following interferon beta therapy in relapsing neuromyelitis optica and longitudinally extensive myelitisQ79838192
Cytokine-mediated inflammation, tumorigenesis, and disease-associated JAK/STAT/SOCS signaling circuits in the CNSQ81683770
Does interferon beta treatment exacerbate neuromyelitis optica spectrum disorder?Q83485788
Astrocyte-targeted production of interleukin-6 reduces astroglial and microglial activation in the cuprizone demyelination model: Implications for myelin clearance and oligodendrocyte maturation.Q38809608
DNA damage primes the type I interferon system via the cytosolic DNA sensor STING to promote anti-microbial innate immunityQ38908391
Microglia Priming with Aging and StressQ38948754
Type-1 interferon signaling mediates neuro-inflammatory events in models of Alzheimer's diseaseQ39059270
Intracellular Nucleic Acid Detection in Autoimmunity.Q39112112
Type I interferon pathway in CNS homeostasis and neurological disorders.Q39315038
Cerebrospinal fluid interleukin 6 in amyotrophic lateral sclerosis: immunological parameter and comparison with inflammatory and non-inflammatory central nervous system diseasesQ39444706
IL-1β potently stabilizes IL-6 mRNA in human astrocytesQ39596628
Predictors of clinical outcomes in patients with neuropsychiatric systemic lupus erythematosus.Q40129046
Toll-like receptor 7-dependent loss of B cell tolerance in pathogenic autoantibody knockin miceQ40231922
Central inhibition of interleukin-6 trans-signaling during peripheral infection reduced neuroinflammation and sickness in aged miceQ40282211
A Common Variant of IL-6R is Associated with Elevated IL-6 Pathway Activity in Alzheimer's Disease BrainsQ40371888
Loss of Trex1 in Dendritic Cells Is Sufficient To Trigger Systemic Autoimmunity.Q40580578
Targeting the colony stimulating factor 1 receptor alleviates two forms of Charcot-Marie-Tooth disease in miceQ40617443
Reexamination of the role of ubiquitin-like modifier ISG15 in the phenotype of UBP43-deficient miceQ40701351
IL-6, IL-8, IP-10, MCP-1 and G-CSF are significantly increased in cerebrospinal fluid but not in sera of patients with central neuropsychiatric lupus erythematosusQ40804722
Shared receptor components but distinct complexes for alpha and beta interferonsQ41008873
Interferon-alpha in lupus psychosisQ41092098
Cytokines and matrix metalloproteinases in the cerebrospinal fluid of patients with acute transverse myelitis: an outcome analysisQ41095945
The Lifespan and Turnover of Microglia in the Human BrainQ41217922
Long-term Therapy With Interleukin 6 Receptor Blockade in Highly Active Neuromyelitis Optica Spectrum DisorderQ41222751
Cytomegalovirus-induced brain malformations in fetusesQ41930828
Interferon-α and the calcifying microangiopathy in Aicardi-Goutières syndrome.Q42072565
Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell ResolutionQ42252166
Mef2C restrains microglial inflammatory response and is lost in brain ageing in an IFN-I-dependent manner.Q42366438
Localization of metallothionein-I and -III expression in the CNS of transgenic mice with astrocyte-targeted expression of interleukin 6.Q42462809
Local Cues Establish and Maintain Region-Specific Phenotypes of Basal Ganglia MicrogliaQ42512130
Regulation of microglial proliferation during chronic neurodegenerationQ42713015
Interferon Beta treatment in neuromyelitis optica: increase in relapses and aquaporin 4 antibody titersQ42942128
Cytomegalovirus induces interferon-stimulated gene expression and is attenuated by interferon in the developing brain.Q42957459
Astrocytic damage is far more severe than demyelination in NMO: a clinical CSF biomarker studyQ42965338
Context-dependent IL-6 potentiation of interferon- gamma-induced IL-12 secretion and CD40 expression in murine microglia.Q43284924
Amyloidogenic role of cytokine TGF-beta1 in transgenic mice and in Alzheimer's diseaseQ43736405
Reduced hippocampal neurogenesis in adult transgenic mice with chronic astrocytic production of interleukin-6.Q43850180
Cytokines and other markers of intrathecal immune response in patients with herpes simplex encephalitisQ44060297
Cerebrospinal fluid interleukin-6 and glial fibrillary acidic protein levels are increased during initial neuromyelitis optica attacksQ44312623
Synaptic changes characterize early behavioural signs in the ME7 model of murine prion diseaseQ44465591
Astrocytes produce interferon-alpha and CXCL10, but not IL-6 or CXCL8, in Aicardi-Goutières syndromeQ44815605
Layer V cortical neurons require microglial support for survival during postnatal development.Q45205743
A novel microglial subset plays a key role in myelinogenesis in developing brainQ45248956
Prognostic value of cerebrospinal fluid cytokine changes in herpes simplex virus encephalitisQ45386195
CD4+ and CD8+ cells accumulate in the brains of acquired immunodeficiency syndrome patients with human immunodeficiency virus encephalitisQ45729143
TGF-beta1 promotes microglial amyloid-beta clearance and reduces plaque burden in transgenic mice.Q45972218
A new fate mapping system reveals context-dependent random or clonal expansion of microgliaQ46046152
ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathyQ46160288
Evolution of Neuropathologic Abnormalities Associated with Blood-Brain Barrier Breakdown in Transgenic Mice Expressing lnterleukin-6 in AstrocytesQ46191027
Microglia and macrophages in brain homeostasis and diseaseQ46461757
Age-related myelin degradation burdens the clearance function of microglia during aging.Q46707647
Minimal role for STAT1 in interleukin-6 signaling and actions in the murine brainQ46893501
The role of microglia and their CX3CR1 signaling in adult neurogenesis in the olfactory bulbQ47141465
Alzheimer's Disease: The Role of Microglia in Brain Homeostasis and ProteopathyQ47175712
A progressive familial encephalopathy in infancy with calcifications of the basal ganglia and chronic cerebrospinal fluid lymphocytosisQ34267120
Identification and validation of Ifit1 as an important innate immune bottleneckQ34321053
Genome-wide association study of CSF levels of 59 alzheimer's disease candidate proteins: significant associations with proteins involved in amyloid processing and inflammationQ34394932
Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment.Q34419957
Directing transition from innate to acquired immunity: defining a role for IL-6.Q34449051
Brain MRI in patients with diffuse psychiatric/neuropsychological syndromes in systemic lupus erythematosusQ34478835
Mutations in genes encoding ribonuclease H2 subunits cause Aicardi-Goutières syndrome and mimic congenital viral brain infectionQ34548112
Interleukin 6 signaling promotes anti-aquaporin 4 autoantibody production from plasmablasts in neuromyelitis optica.Q34621516
Type I interferon receptors: biochemistry and biological functions.Q34628239
Microglia regulate the number of neural precursor cells in the developing cerebral cortexQ34649089
Transcriptome-based network analysis reveals a spectrum model of human macrophage activation.Q34659689
Elimination of Microglia Improves Functional Outcomes Following Extensive Neuronal Loss in the Hippocampus.Q34671403
Characteristic cerebrospinal fluid cytokine/chemokine profiles in neuromyelitis optica, relapsing remitting or primary progressive multiple sclerosisQ34700673
Neuromyelitis optica unique area postrema lesions: nausea, vomiting, and pathogenic implicationsQ34743150
Massive gliosis induced by interleukin-6 suppresses Abeta deposition in vivo: evidence against inflammation as a driving force for amyloid depositionQ34878224
Stroma-derived interleukin-34 controls the development and maintenance of langerhans cells and the maintenance of microgliaQ34918881
Microglia as a source and target of cytokinesQ34963658
Cerebrospinal fluid interleukin-6 in central nervous system inflammatory diseasesQ34981487
Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaquesQ35030015
Inhibition of interleukin-6 trans-signaling in the brain facilitates recovery from lipopolysaccharide-induced sickness behaviorQ35040208
Assessment of interferon-related biomarkers in Aicardi-Goutières syndrome associated with mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, and ADAR: a case-control study.Q35147055
Activation of neuronal NMDA receptors triggers transient ATP-mediated microglial process outgrowth.Q35220649
Tissue-resident macrophage enhancer landscapes are shaped by the local microenvironment.Q35623089
Gene-targeted mice lacking the Trex1 (DNase III) 3'-->5' DNA exonuclease develop inflammatory myocarditisQ35663520
Transverse Myelitis: pathogenesis, diagnosis and treatmentQ35672760
USP18 lack in microglia causes destructive interferonopathy of the mouse brainQ35762623
Chronic overproduction of transforming growth factor-beta1 by astrocytes promotes Alzheimer's disease-like microvascular degeneration in transgenic miceQ35793406
Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis.Q35810427
Sustained hippocampal IL-1 beta overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathologyQ35813745
Chronic IL-1β-mediated neuroinflammation mitigates amyloid pathology in a mouse model of Alzheimer's disease without inducing overt neurodegenerationQ35827454
Ex vivo spinal cord slice model of neuromyelitis optica reveals novel immunopathogenic mechanismsQ35870397
Systemic challenge with the TLR3 agonist poly I:C induces amplified IFNalpha/beta and IL-1beta responses in the diseased brain and exacerbates chronic neurodegenerationQ35906528
Colony-stimulating factor 1 receptor inhibition prevents microglial plaque association and improves cognition in 3xTg-AD miceQ35908248
Experimental Neuromyelitis Optica Induces a Type I Interferon Signature in the Spinal CordQ35962565
A Distinct Population of Microglia Supports Adult Neurogenesis in the Subventricular ZoneQ35995933
Progressive decline in avoidance learning paralleled by inflammatory neurodegeneration in transgenic mice expressing interleukin 6 in the brainQ35998206
Microglia in the degenerating brain are capable of phagocytosis of beads and of apoptotic cells, but do not efficiently remove PrPSc, even upon LPS stimulation.Q36400800
Immunoinflammatory diseases of the central nervous system - the tale of two cytokinesQ36547012
Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6Q36631212
Principal components derived from CSF inflammatory profiles predict outcome in survivors after severe traumatic brain injuryQ36664950
Type I interferon response in the central nervous systemQ36780318
Sustained interleukin-1β overexpression exacerbates tau pathology despite reduced amyloid burden in an Alzheimer's mouse modelQ36799810
Neuropathology of early HIV-1 infectionQ36826608
TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaquesQ36863174
Aging. Aging-induced type I interferon response at the choroid plexus negatively affects brain functionQ36907335
Interleukin-6 trans-signaling in the senescent mouse brain is involved in infection-related deficits in contextual fear conditioning.Q36975857
Interleukin 6 plasma concentration associates with cognitive decline: the northern Manhattan studyQ37051184
Microglia ablation alleviates myelin-associated catatonic signs in miceQ47281583
Early intrathecal production of interleukin-6 predicts the size of brain lesion in stroke.Q47349753
Microglia are required for protection against lethal coronavirus encephalitis in miceQ47548394
Expression profiling suggests microglial impairment in HIV neuropathogenesis.Q47548985
The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative DiseasesQ47568641
Microglia Gone Rogue: Impacts on Psychiatric Disorders across the LifespanQ47642958
Diverse Brain Myeloid Expression Profiles Reveal Distinct Microglial Activation States and Aspects of Alzheimer's Disease Not Evident in Mouse ModelsQ47853785
Reduced cuprizone-induced cerebellar demyelination in mice with astrocyte-targeted production of IL-6 is associated with chronically activated, but less responsive microgliaQ47989996
Follicular Dendritic Cell Activation by TLR Ligands Promotes Autoreactive B Cell Responses.Q47995140
Site-specific hippocampal pathophysiology due to cerebral overexpression of interleukin-6 in transgenic miceQ48087469
Intrathecal synthesis of interferon-alpha in infants with progressive familial encephalopathyQ48096912
Microglia turnover with aging and in an Alzheimer's model via long-term in vivo single-cell imaging.Q48137631
Neuromyelitis optica-like pathology is dependent on type I interferon response.Q48151829
Expression of MRP14, 27E10, interferon-alpha and leukocyte common antigen by reactive microglia in postmortem human brain tissueQ48164017
Cognitive impairment and cortical degeneration in neuromyelitis opticaQ48178165
P433issue10
P921main subjectmicrogliaQ1622829
P304page(s)1821-1841
P577publication date2019-04-29
P1433published inGliaQ15716658
P1476titleMicroglia responses to interleukin-6 and type I interferons in neuroinflammatory disease
P478volume67

Reverse relations

cites work (P2860)
Q97073856Neurobiology of coronaviruses: Potential relevance for COVID-19
Q99711183The Role of Microglia in Perioperative Neurocognitive Disorders

Search more.