Macrophages and Their Role in Atherosclerosis: Pathophysiology and Transcriptome Analysis

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Macrophages and Their Role in Atherosclerosis: Pathophysiology and Transcriptome Analysis is …
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review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1155/2016/9582430
P3181OpenCitations bibliographic resource ID4522440
P932PMC publication ID4967433
P698PubMed publication ID27493969

P50authorYuri V BobryshevQ88065781
Ekaterina IvanovaQ88065783
Alexander OrekhovQ51464003
P2093author name stringDimitry A Chistiakov
Nikita G Nikiforov
P2860cites workCombined Inhibition of CCL2, CX3CR1, and CCR5 Abrogates Ly6C hi and Ly6C lo Monocytosis and Almost Abolishes Atherosclerosis in Hypercholesterolemic MiceQ58149069
Macrophage Activation: Glancing into DiversityQ58862445
Distribution of macrophage polarization markers in human atherosclerosisQ63916276
Multiple-modified desialylated low density lipoproteins that cause intracellular lipid accumulation. Isolation, fractionation and characterizationQ67930751
Cholesteryl ester hydroperoxides increase macrophage CD36 gene expression via PPARalphaQ79329017
Mphi1 and Mphi2 can be re-polarized by Th2 or Th1 cytokines, respectively, and respond to exogenous danger signalsQ80141341
Oxidized LDL enhances pro-inflammatory responses of alternatively activated M2 macrophages: a crucial role for Krüppel-like factor 2Q82937913
Nrf2 is essential for cholesterol crystal-induced inflammasome activation and exacerbation of atherosclerosisQ83836296
Oxidized low-density lipoprotein induces secretion of interleukin-1β by macrophages via reactive oxygen species-dependent NLRP3 inflammasome activationQ84573835
Native LDL promotes differentiation of human monocytes to macrophages with an inflammatory phenotypeQ86925854
Monocytes in atherosclerosis: subsets and functionsQ22251045
Scavenger receptors class A-I/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophagesQ24310677
Identification of a novel macrophage phenotype that develops in response to atherogenic phospholipids via Nrf2.Q24606271
Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responsesQ24631052
CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimerQ24642646
G2A deficiency in mice promotes macrophage activation and atherosclerosisQ24643942
Atherosclerosis — An Inflammatory DiseaseQ26776972
Macrophage-mediated cholesterol handling in atherosclerosisQ26780405
LDL electronegativity index: a potential novel index for predicting cardiovascular diseaseQ26781851
Autophagy regulates lipid metabolismQ29547421
Blood monocytes consist of two principal subsets with distinct migratory propertiesQ29614286
Alternative activation of macrophages: mechanism and functionsQ29614350
Nonresolving inflammationQ29616352
Macrophage activation and polarizationQ29616353
Macrophages in the pathogenesis of atherosclerosisQ29617765
Macrophage activation and polarization: nomenclature and experimental guidelinesQ29620642
Vascular adhesion molecules in atherosclerosisQ30444182
Receptor-independent fluid-phase pinocytosis mechanisms for induction of foam cell formation with native low-density lipoprotein particlesQ30587665
HDL induces the expression of the M2 macrophage markers arginase 1 and Fizz-1 in a STAT6-dependent processQ31134072
Expression of chemokine (C-C motif) ligand 18 in human macrophages and atherosclerotic plaquesQ33387481
Cholesterol crystals activate the NLRP3 inflammasome in human macrophages: a novel link between cholesterol metabolism and inflammationQ33644572
Electrophilic nitro-fatty acids: anti-inflammatory mediators in the vascular compartmentQ33746493
Mechanisms that regulate macrophage burden in atherosclerosisQ33761114
Bioactive products generated by group V sPLA(2) hydrolysis of LDL activate macrophages to secrete pro-inflammatory cytokinesQ33771533
Covalent peroxisome proliferator-activated receptor gamma adduction by nitro-fatty acids: selective ligand activity and anti-diabetic signaling actionsQ33782620
HDL promotes rapid atherosclerosis regression in mice and alters inflammatory properties of plaque monocyte-derived cellsQ33868782
Lipoprotein subfractions and cardiovascular disease riskQ34119636
Nomenclature of monocytes and dendritic cells in blood.Q34125860
Macrophage ABCA1 reduces MyD88-dependent Toll-like receptor trafficking to lipid rafts by reduction of lipid raft cholesterol.Q34188006
Macrophages in atherosclerosis: a dynamic balance.Q34368005
Alternatively activated macrophages differentially express fibronectin and its splice variants and the extracellular matrix protein betaIG-H3.Q52965268
Susceptibility of monocytes to activation correlates with atherogenic mitochondrial DNA mutations.Q53440904
Activating transcription factor 1 directs Mhem atheroprotective macrophages through coordinated iron handling and foam cell protection.Q55055144
PPARγ Activation Primes Human Monocytes into Alternative M2 Macrophages with Anti-inflammatory PropertiesQ57244208
Macrophages and immune cells in atherosclerosis: recent advances and novel conceptsQ38462573
Study of the activated macrophage transcriptomeQ38599909
Effect of natural genetic variation on enhancer selection and function.Q38866012
Specificity of action of colony-stimulating factors in the differentiation of granulocytes and macrophagesQ39503471
7-ketocholesteryl-9-carboxynonanoate induced nuclear factor-kappa B activation in J774A.1 macrophagesQ39646631
Palmitic acid enhances lectin-like oxidized LDL receptor (LOX-1) expression and promotes uptake of oxidized LDL in macrophage cellsQ39794807
Macrophages generate reactive oxygen species in response to minimally oxidized low-density lipoprotein: toll-like receptor 4- and spleen tyrosine kinase-dependent activation of NADPH oxidase 2.Q39903564
Oxysterol-induced up-regulation of MCP-1 expression and synthesis in macrophage cellsQ40363965
Phenomenon of individual difference in human monocyte activationQ40802228
ATP-binding cassette transporters and HDL suppress hematopoietic stem cell proliferationQ41789790
Autophagy links inflammasomes to atherosclerotic progression.Q41825615
CXC chemokine ligand 4 induces a unique transcriptome in monocyte-derived macrophagesQ41859211
Human CD14dim monocytes patrol and sense nucleic acids and viruses via TLR7 and TLR8 receptorsQ42101285
The adenosine-dependent angiogenic switch of macrophages to an M2-like phenotype is independent of interleukin-4 receptor alpha (IL-4Rα) signalingQ42234391
Human atherosclerotic plaque alternative macrophages display low cholesterol handling but high phagocytosis because of distinct activities of the PPARγ and LXRα pathways.Q42557215
Molecular signaling operated by a diet-compatible mixture of oxysterols in up-regulating CD36 receptor in CD68 positive cellsQ43120227
Low density lipoprotein-containing circulating immune complexes and coronary atherosclerosisQ43566437
The proinflammatory CD14+CD16+DR++ monocytes are a major source of TNF.Q43925988
Oxidized cholesteryl linoleates stimulate endothelial cells to bind monocytes via the extracellular signal-regulated kinase 1/2 pathwayQ43957606
The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophagesQ44542540
Latent enhancers activated by stimulation in differentiated cellsQ46305342
Free fatty acids in the presence of high glucose amplify monocyte inflammation via Toll-like receptorsQ34501763
The CD14+ CD16+ blood monocytes: their role in infection and inflammationQ34585882
Transcriptome-based network analysis reveals a spectrum model of human macrophage activation.Q34659689
αMβ₂ integrin activation prevents alternative activation of human and murine macrophages and impedes foam cell formationQ34822654
Electrophilic fatty acids regulate matrix metalloproteinase activity and expression.Q34963415
Molecular regulation of HDL metabolism and function: implications for novel therapiesQ35191066
Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromataQ35251005
Macrophages in immunopathology of atherosclerosis: a target for diagnostics and therapy.Q35595537
Macrophage autophagy plays a protective role in advanced atherosclerosisQ35877886
The origin and kinetics of mononuclear phagocytesQ36269269
Efficient clearance of early apoptotic cells by human macrophages requires M2c polarization and MerTK inductionQ36301713
Role of cholesterol and lipid organization in diseaseQ36327808
Scavenger receptors in atherosclerosis: beyond lipid uptakeQ36489900
High-density lipoprotein inhibits human M1 macrophage polarization through redistribution of caveolin-1.Q36546975
Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR.Q36683297
Cholesteryl ester hydroperoxides are biologically active components of minimally oxidized low density lipoproteinQ36749185
Atherosclerosis: evidence for impairment of resolution of vascular inflammation governed by specific lipid mediatorsQ36879456
Coronary intraplaque hemorrhage evokes a novel atheroprotective macrophage phenotypeQ37150841
Loss of SR-A and CD36 activity reduces atherosclerotic lesion complexity without abrogating foam cell formation in hyperlipidemic miceQ37151524
Emigration of monocyte-derived cells to lymph nodes during resolution of inflammation and its failure in atherosclerosisQ37260168
Mechanisms and consequences of macrophage apoptosis in atherosclerosisQ37308942
Heterogeneous in vivo behavior of monocyte subsets in atherosclerosisQ37446568
Role of HDL, ABCA1, and ABCG1 transporters in cholesterol efflux and immune responsesQ37606964
Activation of liver X receptor decreases atherosclerosis in Ldlr⁻/⁻ mice in the absence of ATP-binding cassette transporters A1 and G1 in myeloid cellsQ37615062
Pyrin critical to macrophage IL-1beta response to Francisella challengeQ37661273
Oxidation-specific epitopes are danger-associated molecular patterns recognized by pattern recognition receptors of innate immunityQ37830940
Macrophage Phenotype Modulation by CXCL4 in AtherosclerosisQ37978620
Heme and haemoglobin direct macrophage Mhem phenotype and counter foam cell formation in areas of intraplaque haemorrhageQ38024990
Monocytes and macrophages: developmental pathways and tissue homeostasisQ38214042
Macrophage phenotypes and their modulation in atherosclerosisQ38226669
The complexity of cell composition of the intima of large arteries: focus on pericyte-like cellsQ38228732
The transcriptional regulator network of human inflammatory macrophages is defined by open chromatin.Q38299850
Macrophage phenotypic plasticity in atherosclerosis: The associated features and the peculiarities of the expression of inflammatory genesQ38371352
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectmacrophageQ184204
transcriptomeQ252857
cellQ7868
pathophysiologyQ1135939
atherosclerosisQ12252367
biomedical investigative techniqueQ66648976
hemic and immune systemsQ70202933
macromolecular substanceQ75174158
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)9582430
P577publication date2016-07-17
P1433published inBioMed Research InternationalQ17509958
P1476titleMacrophages and Their Role in Atherosclerosis: Pathophysiology and Transcriptome Analysis
P478volume2016

Reverse relations

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