The contribution of the programmed cell death machinery in innate immune cells to lupus nephritis

scientific article

The contribution of the programmed cell death machinery in innate immune cells to lupus nephritis is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1016/J.CLIM.2016.10.007
P932PMC publication ID5401656
P698PubMed publication ID27780774

P50authorCarla M CudaQ79912675
P2093author name stringHarris Perlman
FuNien Tsai
P2860cites workTreatment for lupus nephritisQ24202572
Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptorsQ24310559
Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascadeQ24311006
cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoformsQ24311676
TNF-alpha induces two distinct caspase-8 activation pathwaysQ24313656
Outcomes of children with proliferative lupus nephritis: the role of protocol renal biopsyQ79864046
Glomerular accumulation of plasmacytoid dendritic cells in active lupus nephritis: role of interleukin-18Q80419619
Immature myeloid and plasmacytoid dendritic cells infiltrate renal tubulointerstitium in patients with lupus nephritisQ80481438
Combined deficiency of proapoptotic regulators Bim and Fas results in the early onset of systemic autoimmunityQ80703822
Sialic acid-binding Ig-like lectin 1 expression in inflammatory and resident monocytes is a potential biomarker for monitoring disease activity and success of therapy in systemic lupus erythematosusQ81000909
Genomic view of systemic autoimmunity in MRLlpr miceQ82689901
Critical comparative analyses of anti-alpha-actinin and glomerulus-bound antibodies in human and murine lupus nephritisQ82691122
The landscape after LUNAR: rituximab's crater-filled pathQ83200527
Macrophages in kidney repair and regenerationQ83356478
DNase1 activity in systemic lupus erythematosus patients with and without nephropathyQ84756756
X-linked IAP is a direct inhibitor of cell-death proteasesQ24318710
BID: a novel BH3 domain-only death agonistQ24320091
IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspasesQ24533214
Impairment of neutrophil extracellular trap degradation is associated with lupus nephritisQ24606320
Therapeutic targeting of macrophages in lupus nephritisQ26796277
Phagocytosis of apoptotic cells in homeostasisQ28081044
BH3-only proteins: a 20-year stock-takeQ28085220
Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibitionQ28115131
Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteinsQ28117928
Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunityQ28138855
Marginal-zone B cellsQ28201000
The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complexQ28221276
Fas ligation on macrophages enhances IL-1R1-Toll-like receptor 4 signaling and promotes chronic inflammationQ28248826
Dietary modulation of the microbiome affects autoinflammatory diseaseQ28249017
Siglecs and their roles in the immune systemQ28294469
Cells in the marginal zone of the spleenQ28294678
Apoptotic cell responses in the splenic marginal zone: a paradigm for immunologic reactions to apoptotic antigens with implications for autoimmunityQ28385358
Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosisQ28584976
Survival function of the FADD-CASPASE-8-cFLIP(L) complexQ28589465
BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosisQ28594183
Alternative activation of macrophages: mechanism and functionsQ29614350
Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptorsQ29615065
Fcgamma receptors as regulators of immune responsesQ29615584
The M1 and M2 paradigm of macrophage activation: time for reassessmentQ29615845
Nonresolving inflammationQ29616352
Development of monocytes, macrophages, and dendritic cellsQ29616446
RIP3 mediates the embryonic lethality of caspase-8-deficient miceQ29617723
The Bcl-2 protein family: arbiters of cell survivalQ29618158
Macrophage activation and polarization: nomenclature and experimental guidelinesQ29620642
Follicular shuttling of marginal zone B cells facilitates antigen transportQ30441344
The pathogenesis, diagnosis and treatment of lupus nephritisQ30596968
RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKLQ30623992
Intramolecular epitope spreading among anti-caspase-8 autoantibodies in patients with silicosis, systemic sclerosis and systemic lupus erythematosus, as well as in healthy individualsQ30713693
Splenectomy may improve the glomerulopathy of type II mixed cryoglobulinemiaQ33332715
Splenectomy increases the subsequent risk of systemic lupus erythematosusQ33427267
Association between SLE nephritis and polymorphic variants of the CRP and Fc RIIIa genesQ58190252
The CD95 Receptor: Apoptosis RevisitedQ62734296
Bcl-2 Antagonists Kill Plasmacytoid Dendritic Cells From Lupus-Prone Mice and Dampen Interferon-α ProductionQ62817627
cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1- and RIPK3-dependent mannerQ62817637
Anti-DNA antibodies form immune deposits at distinct glomerular and vascular sitesQ68013717
Studies of lymphoproliferation in MRL-lpr/lpr miceQ70223568
Diffuse proliferative lupus nephritis: identification of specific pathologic features affecting renal outcomeQ70624757
Effect of a specific endothelin A receptor antagonist on murine lupus nephritisQ72171798
Reduced macrophage recruitment, proliferation, and activation in colony-stimulating factor-1-deficient mice results in decreased tubular apoptosis during renal inflammationQ73100858
Rheumatic diseases in an MRL strain of mice with a deficit in the functional Fas ligandQ73414181
Dominant expression of a novel splice variant of caspase-8 in human peripheral blood lymphocytesQ73910439
Spontaneous autoimmune disease in Fc(gamma)RIIB-deficient mice results from strain-specific epistasisQ74301355
Role of the Fcgamma receptor IIa polymorphism in susceptibility to systemic lupus erythematosus and lupus nephritis: a meta-analysisQ74455224
Bcl-2 controls dendritic cell longevity in vivoQ74754628
The role of autoantibodies in the pathogenesis of lupus nephritisQ78024285
FcR-bearing myeloid cells are responsible for triggering murine lupus nephritisQ79326796
Pathogenic profiles and molecular signatures of antinuclear autoantibodies rescued from NZM2410 lupus miceQ36399144
Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosusQ36403653
Attacking cancer's Achilles heel: antagonism of anti-apoptotic BCL-2 family membersQ36601134
SIGN-R1, a C-type lectin, enhances apoptotic cell clearance through the complement deposition pathway by interacting with C1q in the spleenQ36678337
What is damaging the kidney in lupus nephritis?Q36765221
Constitutive Bcl-2 expression throughout the hematopoietic compartment affects multiple lineages and enhances progenitor cell survivalQ36776853
Role of chemokines for the localization of leukocyte subsets in the kidneyQ36833384
Apoptotic Debris Accumulates on Hematopoietic Cells and Promotes Disease in Murine and Human Systemic Lupus ErythematosusQ36905990
Both cIAP1 and cIAP2 regulate TNFalpha-mediated NF-kappaB activationQ36954601
Elimination of antigen-presenting cells and autoreactive T cells by Fas contributes to prevention of autoimmunityQ36955782
Kidney dendritic cell activation is required for progression of renal disease in a mouse model of glomerular injuryQ37170815
Progression of murine lupus nephritis is linked to acquired renal Dnase1 deficiency and not to up-regulated apoptosisQ37257125
Cutting edge: Primary and secondary effects of CD19 deficiency on cells of the marginal zoneQ37353933
Cross-regulation of signaling by ITAM-associated receptorsQ37366524
Anti-C1q autoantibodies deposit in glomeruli but are only pathogenic in combination with glomerular C1q-containing immune complexes.Q37486571
FADD and caspase-8 mediate priming and activation of the canonical and noncanonical Nlrp3 inflammasomes.Q37601031
Cutting edge: Endoplasmic reticulum stress licenses macrophages to produce mature IL-1β in response to TLR4 stimulation through a caspase-8- and TRIF-dependent pathwayQ37604958
Sialoadhesin deficiency does not influence the severity of lupus nephritis in New Zealand black x New Zealand white F1 mice.Q37690188
The distribution and function of phosphatidylserine in cellular membranesQ37700664
Regulation of the immune system by the resident intestinal bacteria.Q37716899
Deregulated cell death and lymphocyte homeostasis cause premature lethality in mice lacking the BH3-only proteins Bim and Bmf.Q37723472
The role of defective clearance of apoptotic cells in systemic autoimmunity.Q37739807
Role for toll-like receptors in autoimmune disease: The example of systemic lupus erythematosusQ37801738
Alternative Macrophage Activation and MetabolismQ37804862
Homeostatic and pathogenic role of renal dendritic cellsQ37879906
Contributions of dendritic cells and macrophages to intestinal homeostasis and immune defenseQ38080684
Current management of lupus nephritisQ38163138
Monocytes and macrophages: developmental pathways and tissue homeostasisQ38214042
The effect of cell death in the initiation of lupus nephritis.Q38231647
Necroptosis and its role in inflammationQ38319916
Efficacy and safety of rituximab in patients with active proliferative lupus nephritis: the Lupus Nephritis Assessment with Rituximab studyQ38466691
Nephritogenic lupus antibodies recognize glomerular basement membrane-associated chromatin fragments released from apoptotic intraglomerular cellsQ38623614
The Kidney Biopsy in Lupus Nephritis: Past, Present, and FutureQ38634789
Biologics for the treatment of autoimmune renal diseases.Q38763327
Ro52/SSA sensitizes cells to death receptor-induced apoptosis by down-regulating c-FLIP(L).Q39404426
RIG-I RNA helicase activation of IRF3 transcription factor is negatively regulated by caspase-8-mediated cleavage of the RIP1 proteinQ39573761
Microparticles as antigenic targets of antibodies to DNA and nucleosomes in systemic lupus erythematosusQ39581032
Bim-Bcl-2 homology 3 mimetic therapy is effective at suppressing inflammatory arthritis through the activation of myeloid cell apoptosisQ39885694
The Sjogren's syndrome-associated autoantigen Ro52 is an E3 ligase that regulates proliferation and cell deathQ40284365
Caspase-8 promotes cell motility and calpain activity under nonapoptotic conditionsQ40291610
The human anti-apoptotic proteins cIAP1 and cIAP2 bind but do not inhibit caspasesQ40341729
Antagonist of fractalkine (CX3CL1) delays the initiation and ameliorates the progression of lupus nephritis in MRL/lpr mice.Q40425124
Cellular FLIP (long form) regulates CD8+ T cell activation through caspase-8-dependent NF-kappa B activationQ40432682
Cutting Edge: defective follicular exclusion of apoptotic antigens due to marginal zone macrophage defects in autoimmune BXD2 mice.Q40773152
Caspase-8 deficiency in epidermal keratinocytes triggers an inflammatory skin diseaseQ42459225
Prospective observational single-centre cohort study to evaluate the effectiveness of treating lupus nephritis with rituximab and mycophenolate mofetil but no oral steroids.Q43472878
Predictive power of the second renal biopsy in lupus nephritis: significance of macrophagesQ43514448
Increased tubulointerstitial recruitment of human CD141(hi) CLEC9A(+) and CD1c(+) myeloid dendritic cell subsets in renal fibrosis and chronic kidney diseaseQ43855997
Macrophages and fibrosis: How resident and infiltrating mononuclear phagocytes orchestrate all phases of tissue injury and repairQ44163378
Fc receptorsQ44298973
Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikisQ44502162
Up-regulation of cellular FLICE-inhibitory protein in peripheral blood B lymphocytes in patients with systemic lupus erythematosus is associated with clinical characteristicsQ44598743
Murine monoclonal anti-DNA antibodies bind directly to glomerular antigens and form immune depositsQ45008271
Phosphocholine as a pattern recognition ligand for CD36.Q45275915
Q222R polymorphism in DNAse I gene is a risk factor for nephritis in South Indian SLE patientsQ45693668
The Bcl-2 family antagonist ABT-737 significantly inhibits multiple animal models of autoimmunity.Q45983884
Differential expression of factors involved in the intrinsic and extrinsic apoptotic pathways in juvenile systemic lupus erythematosusQ46130093
Apoptotic cell recognition: will the real phosphatidylserine receptor(s) please stand up?Q46796831
Factors associated with poor outcomes in patients with lupus nephritisQ46840865
Accelerated macrophage apoptosis induces autoantibody formation and organ damage in systemic lupus erythematosusQ46925835
Nucleosomes are exposed at the cell surface in apoptosis.Q47579101
A Bcl-2-dependent molecular timer regulates the lifespan and immunogenicity of dendritic cellsQ47631638
Splenectomy increases the subsequent risk of systemic lupus erythematosus: a word of cautionQ48089976
Cellular FLIP Inhibits Myeloid Cell Activation by Suppressing Selective Innate Signaling.Q48151091
Non-apoptotic role of BID in inflammation and innate immunityQ50521157
Sialoadhesin deficiency ameliorates myelin degeneration and axonopathic changes in the CNS of PLP overexpressing mice.Q52003587
Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation.Q53183279
Bone marrow Ly6Chigh monocytes are selectively recruited to injured kidney and differentiate into functionally distinct populations.Q53363185
MCL1 transgenic mice exhibit a high incidence of B-cell lymphoma manifested as a spectrum of histologic subtypes.Q53398443
Polymorphism of the FcgammaRIIalpha IgG receptor in patients with lupus nephritis and glomerulopathy.Q53634333
Association of FAS and FAS ligand genes polymorphism and risk of systemic lupus erythematosus.Q54231271
Caspase-8 blocks kinase RIPK3-mediated activation of the NLRP3 inflammasome.Q54464120
Enhanced dendritic cell survival attenuates lipopolysaccharide-induced immunosuppression and increases resistance to lethal endotoxic shock.Q54534377
Decreased expressions of the TNF-alpha signaling adapters in peripheral blood mononuclear cells (PBMCs) are correlated with disease activity in patients with systemic lupus erythematosus.Q54561488
Dendritic cells in renal biopsies of patients with acute tubulointerstitial nephritis.Q54568887
Chemokine receptor Ccr2 deficiency reduces renal disease and prolongs survival in MRL/lpr lupus-prone mice.Q54632752
Mycophenolate versus Azathioprine as Maintenance Therapy for Lupus NephritisQ56335982
VavP-Bcl2 transgenic mice develop follicular lymphoma preceded by germinal center hyperplasiaQ56963014
C1q and systemic lupus erythematosusQ57089594
Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodiesQ57089602
Development of autoimmune nephritis in genetically asplenic and splenectomized BAFF transgenic miceQ57212152
The FcγRIIIA-F158 allele is a risk factor for the development of lupus nephritis: A meta-analysisQ57332141
Loss of function of a lupus-associated FcγRIIb polymorphism through exclusion from lipid raftsQ57369625
Genetic Segregation of Spontaneous Erosive Arthritis and Generalized Autoimmune Disease in the BXD2 Recombinant Inbred Strain of MiceQ57982623
Requirement of myeloid cell-specific Fas expression for prevention of systemic autoimmunity in miceQ35791280
Deficiency of Bim in dendritic cells contributes to overactivation of lymphocytes and autoimmunity.Q35828628
Critical role of macrophages in the marginal zone in the suppression of immune responses to apoptotic cell-associated antigensQ35901015
Dendritic cell and macrophage heterogeneity in vivoQ35903971
BIM deficiency differentially impacts the function of kidney endothelial and epithelial cells through modulation of their local microenvironmentQ35924542
Rheumatoid arthritis subtypes identified by genomic profiling of peripheral blood cells: assignment of a type I interferon signature in a subpopulation of patients.Q35953527
Structure and function of renal macrophages and dendritic cells from lupus-prone miceQ35991361
Identification of stage-specific genes associated with lupus nephritis and response to remission induction in (NZB × NZW)F1 and NZM2410 mice.Q36010662
Bcl-2 as a Therapeutic Target in Human Tubulointerstitial Inflammation.Q36012345
Interferon-induced mechanosensing defects impede apoptotic cell clearance in lupusQ36040281
The BCL-2 protein family, BH3-mimetics and cancer therapyQ36067778
Cross-species transcriptional network analysis defines shared inflammatory responses in murine and human lupus nephritisQ36083938
Atacicept in combination with MMF and corticosteroids in lupus nephritis: results of a prematurely terminated trial.Q36085018
Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophilsQ36141195
Conditional deletion of caspase-8 in macrophages alters macrophage activation in a RIPK-dependent manner.Q36168991
Oxidized phosphatidylserine-CD36 interactions play an essential role in macrophage-dependent phagocytosis of apoptotic cellsQ36228153
Class A scavenger receptors regulate tolerance against apoptotic cells, and autoantibodies against these receptors are predictive of systemic lupusQ36228965
Kinase RIP3 is dispensable for normal NF-kappa Bs, signaling by the B-cell and T-cell receptors, tumor necrosis factor receptor 1, and Toll-like receptors 2 and 4.Q36233089
Sialoadhesin promotes rapid proinflammatory and type I IFN responses to a sialylated pathogen, Campylobacter jejuniQ36233954
The Pathogenesis and Therapeutic Implications of Tubulointerstitial Inflammation in Human Lupus NephritisQ36299959
Characterising the immune profile of the kidney biopsy at lupus nephritis flare differentiates early treatment responders from non-respondersQ36302345
Delayed apoptotic cell clearance and lupus-like autoimmunity in mice lacking the c-mer membrane tyrosine kinaseQ36371130
Monocyte chemoattractant protein 1-dependent leukocytic infiltrates are responsible for autoimmune disease in MRL-Fas(lpr) miceQ36375621
BH3-only proteins in rheumatoid arthritis: potential targets for therapeutic intervention.Q33727248
Proliferative lesions and metalloproteinase activity in murine lupus nephritis mediated by type I interferons and macrophagesQ33733803
Autoreactive marginal zone B cells enter the follicles and interact with CD4+ T cells in lupus-prone miceQ33798580
Caspase-8 acts as a molecular rheostat to limit RIPK1- and MyD88-mediated dendritic cell activationQ33819040
Type I interferons produced by resident renal cells may promote end-organ disease in autoantibody-mediated glomerulonephritis.Q33877996
Activation of NF-kappaB by FADD, Casper, and caspase-8.Q33897301
Bid, a widely expressed proapoptotic protein of the Bcl-2 family, displays lipid transfer activity.Q34012615
Efficacy of rituximab in 164 patients with biopsy-proven lupus nephritis: pooled data from European cohortsQ34060110
Immunologic characteristics of intrarenal T cells: trafficking of expanded CD8+ T cell β-chain clonotypes in progressive lupus nephritisQ34087313
Lupus nephritis: a critical reviewQ34299943
Cloning of a novel bacteria-binding receptor structurally related to scavenger receptors and expressed in a subset of macrophagesQ34319288
Activation of caspases-8 and -10 by FLIP(L).Q34328223
Dendritic cells in lupus are not required for activation of T and B cells but promote their expansion, resulting in tissue damageQ34443260
FLIP: a novel regulator of macrophage differentiation and granulocyte homeostasisQ34450721
Regulation of steady-state neutrophil homeostasis by macrophages.Q34542130
Lpr and gld: single gene models of systemic autoimmunity and lymphoproliferative diseaseQ34602392
Soluble fas and the -670 polymorphism of fas in lupus nephritisQ34611175
Transcriptome-based network analysis reveals a spectrum model of human macrophage activation.Q34659689
Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 miceQ34729932
Commensal microbiota are required for systemic inflammation triggered by necrotic dendritic cells.Q34751838
Apoptotic pathways: the roads to ruinQ34753431
Functional complementation between FADD and RIP1 in embryos and lymphocytesQ34768810
The natural interferon-alpha producing cells in systemic lupus erythematosusQ35024789
Proapoptotic activity of a monomeric smac mimetic on human fibroblast-like synoviocytes from patients with rheumatoid arthritis.Q35033204
A unique hybrid renal mononuclear phagocyte activation phenotype in murine systemic lupus erythematosus nephritisQ35174510
Modulation of immune development and function by intestinal microbiota.Q35235355
Caspase-8-mediated cleavage inhibits IRF-3 protein by facilitating its proteasome-mediated degradationQ35311960
Vimentin is a dominant target of in situ humoral immunity in human lupus tubulointerstitial nephritisQ35324023
Deletion of FADD in macrophages and granulocytes results in RIP3- and MyD88-dependent systemic inflammationQ35393485
CD11c-mediated deletion of Flip promotes autoreactivity and inflammatory arthritisQ35601082
Reduced uptake of apoptotic cells by macrophages in systemic lupus erythematosus: correlates with decreased serum levels of complementQ35636552
Understanding the Mysterious M2 Macrophage through Activation Markers and Effector MechanismsQ35674290
The Spleen Plays No Role in Nephrotoxic Serum Nephritis, but Constitutes a Place of Compensatory HaematopoiesisQ35738747
P921main subjectcell deathQ2383867
P304page(s)74-85
P577publication date2016-10-22
P1433published inClinical ImmunologyQ15752921
P1476titleThe contribution of the programmed cell death machinery in innate immune cells to lupus nephritis
P478volume185

Reverse relations

cites work (P2860)
Q92618002MicroRNA-124 represents a novel diagnostic marker in human lupus nephritis and plays an inhibitory effect on the growth and inflammation of renal mesangial cells by targeting TRAF6
Q92222878Programmed Cell Death Pathways in the Pathogenesis of Systemic Lupus Erythematosus

Search more.