Conditional deletion of caspase-8 in macrophages alters macrophage activation in a RIPK-dependent manner.

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Conditional deletion of caspase-8 in macrophages alters macrophage activation in a RIPK-dependent manner. is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1010711215
P356DOI10.1186/S13075-015-0794-Z
P932PMC publication ID4608154
P698PubMed publication ID26471282

P50authorJack HutchesonQ47504174
Carla M CudaQ79912675
P2093author name stringG Kenneth Haines
Alexander V Misharin
Andrea Dorfleutner
Christian Stehlik
G R Scott Budinger
Harris Perlman
Sonal Khare
Philip J Homan
Amy M Archer
FuNien Tsai
Rana Saber
P2860cites workCaspase-8 prevents sustained activation of NF-kappaB in monocytes undergoing macrophagic differentiationQ24307493
cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoformsQ24311676
Specific involvement of caspases in the differentiation of monocytes into macrophagesQ24312229
Caspase-8 serves both apoptotic and nonapoptotic rolesQ28507001
Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosisQ28584976
BH3-only proteins in rheumatoid arthritis: potential targets for therapeutic intervention.Q33727248
Caspase-8 acts as a molecular rheostat to limit RIPK1- and MyD88-mediated dendritic cell activationQ33819040
Microbiota and autoimmune disease: the hosted selfQ34054052
Lpr and gld: single gene models of systemic autoimmunity and lymphoproliferative diseaseQ34602392
Commensal microbiota are required for systemic inflammation triggered by necrotic dendritic cells.Q34751838
Caspase-8-mediated cleavage inhibits IRF-3 protein by facilitating its proteasome-mediated degradationQ35311960
Deletion of FADD in macrophages and granulocytes results in RIP3- and MyD88-dependent systemic inflammationQ35393485
Role of the commensal microbiota in normal and pathogenic host immune responsesQ35448732
Requirement of myeloid cell-specific Fas expression for prevention of systemic autoimmunity in miceQ35791280
Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunityQ35964742
FADD and caspase-8 mediate priming and activation of the canonical and noncanonical Nlrp3 inflammasomes.Q37601031
A novel Ly6C/Ly6G-based strategy to analyze the mouse splenic myeloid compartment.Q38769761
RIG-I RNA helicase activation of IRF3 transcription factor is negatively regulated by caspase-8-mediated cleavage of the RIP1 proteinQ39573761
Defective signal-transduction pathways in T-cells from autoimmune MRL-lpr/lpr mice are associated with increased polyamine concentrationsQ42822466
Nonclassical Ly6C(-) monocytes drive the development of inflammatory arthritis in mice.Q42984890
Cutting edge: innate immunity conferred by B cells is regulated by caspase-8.Q43523380
Tipping the balance between necrosis and apoptosis in human and murine cells treated with interferon and dsRNA.Q44104456
Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation.Q53183279
Caspase-8 blocks kinase RIPK3-mediated activation of the NLRP3 inflammasome.Q54464120
Inhibition of Toll-like receptor-7 (TLR-7) or TLR-7 plus TLR-9 attenuates glomerulonephritis and lung injury in experimental lupusQ80219157
Combined deficiency of proapoptotic regulators Bim and Fas results in the early onset of systemic autoimmunityQ80703822
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P921main subjectmacrophageQ184204
P304page(s)291
P577publication date2015-10-16
P1433published inArthritis Research and TherapyQ15757229
P1476titleConditional deletion of caspase-8 in macrophages alters macrophage activation in a RIPK-dependent manner
P478volume17

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cites work (P2860)
Q36162984Activity of Uncleaved Caspase-8 Controls Anti-bacterial Immune Defense and TLR-Induced Cytokine Production Independent of Cell Death
Q26751108An outline of necrosome triggers
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Q94451657Caspase-1 cleaves Bid to release mitochondrial SMAC and drive secondary necrosis in the absence of GSDMD
Q37625431Caspase-8: not so silently deadly
Q39277461Caspase-8: regulating life and death
Q61808775Early Protection by Resveratrol in Rat Lung Transplantation
Q41355621Enhanced Macrophage M1 Polarization and Resistance to Apoptosis Enable Resistance to Plague
Q47939968Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span.
Q52609972Necrosulfonamide Attenuates Spinal Cord Injury via Necroptosis Inhibition.
Q36477467New insights into the regulation of innate immunity by caspase-8.
Q91644625Pan-caspase inhibitors induce necroptosis via ROS-mediated activation of mixed lineage kinase domain-like protein and p38 in classically activated macrophages
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Q47557102The Effects of Dendritic Cell Hypersensitivity on Persistent Viral Infection.
Q42278840The caspase-8/RIPK3 signaling axis in antigen presenting cells controls the inflammatory arthritic response.
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Q28274739The intersection of cell death and inflammasome activation

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