Apoptotic cell responses in the splenic marginal zone: a paradigm for immunologic reactions to apoptotic antigens with implications for autoimmunity

scientific article

Apoptotic cell responses in the splenic marginal zone: a paradigm for immunologic reactions to apoptotic antigens with implications for autoimmunity is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1111/IMR.12382
P932PMC publication ID4732741
P698PubMed publication ID26683143
P5875ResearchGate publication ID287520485

P50authorTracy L. McGahaQ50541592
Mikael KarlssonQ61883911
P2860cites workOxidatively modified phosphatidylserines on the surface of apoptotic cells are essential phagocytic 'eat-me' signals: cleavage and inhibition of phagocytosis by Lp-PLA2Q23923069
Xk-related protein 8 and CED-8 promote phosphatidylserine exposure in apoptotic cellsQ24307778
Clonal nature of the immune response to phosphocholine. VII. Evidence throughout inbred mice for molecular similarities among antibodies bearing the T15 idiotypeQ71243420
Isotypes and specificities of immunoglobulins produced by germ-free mice fed chemically defined ultrafiltered “antigen-free” dietQ72379399
Phenotypic characteristics and significance of reticular meshwork surrounding splenic white pulp of miceQ73092040
Apoptotic thymocyte clearance in scavenger receptor class A-deficient mice is apparently normalQ73709129
Impaired uptake of apoptotic cells into tingible body macrophages in germinal centers of patients with systemic lupus erythematosusQ77567399
Cellular death in morphogenesis of the avian wingQ79071157
Development of Autoantibodies before the Clinical Onset of Systemic Lupus ErythematosusQ79171865
A novel B cell-mediated transport of IgE-immune complexes to the follicle of the spleenQ81206525
Dendritic cell apoptosis in the maintenance of immune toleranceQ82647177
Extracorporeal photopheresis after lung transplantation: a 10-year single-center experienceQ82942027
Oral nickel tolerance: Fas ligand-expressing invariant NK T cells promote tolerance induction by eliciting apoptotic death of antigen-carrying, effete B cellsQ83059265
Naturally occurring IgM antibodies to oxidation-specific epitopesQ84823605
Calcium-dependent phospholipid scrambling by TMEM16FQ24308774
Induction of immunological tolerance by apoptotic cells requires caspase-dependent oxidation of high-mobility group box-1 proteinQ24314282
Human macrophage-derived chemokine (MDC), a novel chemoattractant for monocytes, monocyte-derived dendritic cells, and natural killer cellsQ24321607
Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue KineticsQ24564912
Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunityQ24643886
Follicular dendritic cells control engulfment of apoptotic bodies by secreting Mfge8Q24644725
Trex1 prevents cell-intrinsic initiation of autoimmunityQ24648757
Identification of splenic reservoir monocytes and their deployment to inflammatory sitesQ24649151
Immune tolerance after delivery of dying cells to dendritic cells in situQ24673068
Human immunoglobulin M memory B cells controlling Streptococcus pneumoniae infections are generated in the spleenQ24673510
Apoptosis, oncosis, and necrosis. An overview of cell deathQ24684007
Translating transitions - how to decipher peripheral human B cell developmentQ26799037
Uncharged tRNA activates GCN2 by displacing the protein kinase moiety from a bipartite tRNA-binding domainQ27936337
Human spleen microanatomy: why mice do not sufficeQ28081182
Protective natural autoantibodies to apoptotic cells: evidence of convergent selection of recurrent innate-like clonesQ28081863
The splenic marginal zone in humans and rodents: an enigmatic compartment and its inhabitantsQ28249961
B cell-helper neutrophils stimulate the diversification and production of immunoglobulin in the marginal zone of the spleenQ28256100
Complement System Part II: Role in ImmunityQ28263460
Structure and function of the spleenQ28264813
C3d of complement as a molecular adjuvant: bridging innate and acquired immunityQ28272810
HMGB1 and RAGE in inflammation and cancerQ28274621
Molecular organization and function of the complement systemQ28289114
B-cell tolerance checkpoints in health and autoimmunityQ28296605
Natural antibodies with the T15 idiotype may act in atherosclerosis, apoptotic clearance, and protective immunityQ28344371
Contribution of Defective PS Recognition and Efferocytosis to Chronic Inflammation and AutoimmunityQ28397407
A receptor for phosphatidylserine-specific clearance of apoptotic cellsQ28586441
Absence of marginal zone B cells in Pyk-2-deficient mice defines their role in the humoral responseQ28590125
Notch-RBP-J signaling is involved in cell fate determination of marginal zone B cellsQ28594415
Recruitment of Foxp3+ T regulatory cells mediating allograft tolerance depends on the CCR4 chemokine receptorQ28595009
Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptorsQ29615065
Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAFQ29615685
Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophagesQ29616355
Sphingosine 1-Phosphate Receptor 3-Deficient Dendritic Cells Modulate Splenic Responses to Ischemia-Reperfusion InjuryQ30278837
Interferon-induced mechanosensing defects impede apoptotic cell clearance in lupusQ36040281
Cognate interaction with iNKT cells expands IL-10-producing B regulatory cellsQ36155364
Repopulation of cancer cells during therapy: an important cause of treatment failureQ36167592
Alterations in marginal zone macrophages and marginal zone B cells in old miceQ36168169
Endogenous ligands of natural killer T cells are alpha-linked glycosylceramidesQ36218250
Oxidized phosphatidylserine-CD36 interactions play an essential role in macrophage-dependent phagocytosis of apoptotic cellsQ36228153
Class A scavenger receptors regulate tolerance against apoptotic cells, and autoantibodies against these receptors are predictive of systemic lupusQ36228965
Anti-phosphorylcholine antibodies of the T15 idiotype are optimally protective against Streptococcus pneumoniaeQ36346976
Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytesQ36363024
Analysis of mutations in immunoglobulin heavy chain variable region genes of microdissected marginal zone (MGZ) B cells suggests that the MGZ of human spleen is a reservoir of memory B cellsQ36365247
The CD8+ dendritic cell subset selectively endocytoses dying cells in culture and in vivoQ36370304
Delayed apoptotic cell clearance and lupus-like autoimmunity in mice lacking the c-mer membrane tyrosine kinaseQ36371130
Macrophages control the retention and trafficking of B lymphocytes in the splenic marginal zoneQ36371307
Characteristics of natural antibody-secreting cellsQ36373409
CD1-reactive natural killer T cells are required for development of systemic tolerance through an immune-privileged site.Q36375489
Phosphatidylserine (PS) induces PS receptor-mediated macropinocytosis and promotes clearance of apoptotic cellsQ36380062
The sphingosine-1-phosphate (S1P) lysophospholipid receptor S1P3 regulates MAdCAM-1+ endothelial cells in splenic marginal sinus organizationQ36399632
Efficient presentation of phagocytosed cellular fragments on the major histocompatibility complex class II products of dendritic cellsQ36401207
Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupusQ36403146
STING manifests self DNA-dependent inflammatory diseaseQ36436812
MAPK phosphatase-1 is required for regulatory natural autoantibody-mediated inhibition of TLR responsesQ36438414
New insights into the cell biology of the marginal zone of the spleenQ36544048
SIGN-R1, a C-type lectin, enhances apoptotic cell clearance through the complement deposition pathway by interacting with C1q in the spleenQ36678337
Exacerbated autoimmunity in the absence of TLR9 in MRL.Fas(lpr) mice depends on Ifnar1Q36754420
In silico identified CCR4 antagonists target regulatory T cells and exert adjuvant activity in vaccinationQ36786874
Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a "come-and-get-me" signalQ36804936
Eukaryotic initiation factor 2 phosphorylation and translational control in metabolism.Q36830383
HIV-activated human plasmacytoid DCs induce Tregs through an indoleamine 2,3-dioxygenase-dependent mechanismQ36861242
Innate lymphoid cells in the initiation, regulation and resolution of inflammationQ36908615
Complement receptors CD21 and CD35 in humoral immunityQ36938627
NADPH oxidase-dependent generation of lysophosphatidylserine enhances clearance of activated and dying neutrophils via G2AQ36981038
The scavenger receptor SCARF1 mediates the clearance of apoptotic cells and prevents autoimmunityQ37119247
Development of CD27+ marginal zone B cells requires GALTQ37132998
Marginal zone macrophages suppress innate and adaptive immunity to apoptotic cells in the spleen.Q50541519
Plasmacytoid dendritic cells play a major role in apoptotic leukocyte-induced immune modulation.Q50635314
A CCR4 antagonist combined with vaccines induces antigen-specific CD8+ T cells and tumor immunity against self antigens.Q50993058
Regulatory T cells recruited through CCL22/CCR4 are selectively activated in lymphoid infiltrates surrounding primary breast tumors and lead to an adverse clinical outcome.Q51798642
A dominant complement fixation pathway for pneumococcal polysaccharides initiated by SIGN-R1 interacting with C1q.Q51808487
The species-specific structure of microanatomical compartments in the human spleen: strongly sialoadhesin-positive macrophages occur in the perifollicular zone, but not in the marginal zone.Q52041011
CD9 is a unique marker for marginal zone B cells, B1 cells, and plasma cells in mice.Q52119704
Internalization of circulating apoptotic cells by splenic marginal zone dendritic cells: dependence on complement receptors and effect on cytokine production.Q52547955
CCR4 dependent migration of Foxp3+ Treg cells to skin grafts and draining lymph nodes is implicated in enhanced graft survival in CD200tg recipients.Q53217292
Three-dimensional reconstruction of serial sections for analysis of the microvasculature of the white pulp and the marginal zone in the human spleen.Q53456471
Shrinkage necrosis: a distinct mode of cellular death.Q54179855
Conventional B2 B cell depletion ameliorates whereas its adoptive transfer aggravates atherosclerosis.Q54412663
DNA binds and activates complement via residues 14-26 of the human C1q A chain.Q54667444
C1q and systemic lupus erythematosusQ57089594
Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodiesQ57089602
Cutting Edge: Intravenous Soluble Antigen Is Presented to CD4 T Cells by CD8- Dendritic Cells, but Cross-Presented to CD8 T Cells by CD8+ Dendritic CellsQ57227937
Engulfment genes cooperate with ced-3 to promote cell death in Caenorhabditis elegansQ57939426
Immunosuppressive effects of apoptotic cellsQ59060221
Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophagesQ59062762
Investigations on the C1q–Calreticulin–Phosphatidylserine Interactions Yield New Insights into Apoptotic Cell RecognitionQ59343981
Feedback regulation of murine Ly-1 B cell developmentQ69737483
Impaired human antibody response to the thymus-independent antigen, DNP-Ficoll, after splenectomy. Implications for post-splenectomy infectionsQ69861077
Differential regulation of human indoleamine 2,3-dioxygenase gene expression by interferons-gamma and -alpha. Analysis of the regulatory region of the gene and identification of an interferon-gamma-inducible DNA-binding factorQ70589401
An inherently bifunctional subset of Foxp3+ T helper cells is controlled by the transcription factor eos.Q41819445
Intravenous apoptotic spleen cell infusion induces a TGF-beta-dependent regulatory T-cell expansionQ42326715
RAGE-independent autoreactive B cell activation in response to chromatin and HMGB1/DNA immune complexesQ42454979
The follicular dendritic cell network in secondary follicles of human palatine tonsils and spleensQ42485133
CD19-independent instruction of murine marginal zone B-cell development by constitutive Notch2 signaling.Q42492223
Plasmacytoid dendritic cells prime IL-10-producing T regulatory cells by inducible costimulator ligandQ42767299
Impaired Apoptotic Cell Clearance in the Germinal Center by Mer-Deficient Tingible Body Macrophages Leads to Enhanced Antibody-Forming Cell and Germinal Center ResponsesQ42856687
Fundamental roles of the innate-like repertoire of natural antibodies in immune homeostasisQ43077954
Visualization of splenic marginal zone B-cell shuttling and follicular B-cell egress.Q43118025
Extracorporeal photophoresis augments function of CD4+CD25+FoxP3+ regulatory T cells by triggering adenosine productionQ43294965
CD36 is differentially expressed on B cell subsets during development and in responses to antigenQ43976756
NADPH oxidase-dependent oxidation and externalization of phosphatidylserine during apoptosis in Me2SO-differentiated HL-60 cells. Role in phagocytic clearanceQ44177167
The frequency of phosphorylcholine-specific B cells in conventional and germfree BALB/C miceQ44473525
Milk fat globule epidermal growth factor 8 (MFG-E8) binds to oxidized phosphatidylserine: implications for macrophage clearance of apoptotic cellsQ44805868
Autoimmune disease and impaired uptake of apoptotic cells in MFG-E8-deficient miceQ44904989
Increased low-density lipoprotein levels after splenectomy: a role for the spleen in cholesterol metabolism in myeloproliferative disordersQ45105883
Photopheresis for the treatment of refractory renal graft rejectionQ45267792
Phosphocholine as a pattern recognition ligand for CD36.Q45275915
Phagocytosis promotes programmed cell death in C. elegansQ47069455
Nucleosomes are exposed at the cell surface in apoptosis.Q47579101
Impaired phagocytosis of apoptotic cell material by monocyte-derived macrophages from patients with systemic lupus erythematosusQ47849248
Complement Fixation on Cell Surfaces by 19 S and 7 S AntibodiesQ50260558
"Recruitment signals" from apoptotic cells: invitation to a quiet mealQ30311002
Clearing the dead: apoptotic cell sensing, recognition, engulfment, and digestionQ30408786
Pannexin 1 channels mediate 'find-me' signal release and membrane permeability during apoptosisQ30432676
Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearanceQ30436506
Follicular shuttling of marginal zone B cells facilitates antigen transportQ30441344
The open microcirculation in human spleens: a three-dimensional approach.Q30484958
Annexin V binds to positively selected B cellsQ31724311
Transcriptional suppression of interleukin-12 gene expression following phagocytosis of apoptotic cellsQ31813068
Identification of a human splenic marginal zone B cell precursor with NOTCH2-dependent differentiation propertiesQ33569820
Autoantigens as substrates for apoptotic proteases: implications for the pathogenesis of systemic autoimmune diseaseQ33592314
CD8+ CD205+ splenic dendritic cells are specialized to induce Foxp3+ regulatory T cellsQ33623556
CD8(+) but not CD8(-) dendritic cells cross-prime cytotoxic T cells in vivo.Q33928441
B cell depletion reduces the development of atherosclerosis in miceQ34044387
Do follicular dendritic cells regulate lupus-specific B cells?Q34160876
Plasmacytoid dendritic cells: recent progress and open questionsQ34162925
Apoptotic cells induce migration of phagocytes via caspase-3-mediated release of a lipid attraction signal.Q34206288
Splenectomy and subsequent mortality in veterans of the 1939-45 war.Q34273281
Cloning of a novel bacteria-binding receptor structurally related to scavenger receptors and expressed in a subset of macrophagesQ34319288
Marginal zone B cells: virtues of innate-like antibody-producing lymphocytesQ34324243
Antigen-specific cytotoxicity by invariant NKT cells in vivo is CD95/CD178-dependent and is correlated with antigenic potencyQ34338958
Complement and apoptosisQ34353040
B cell homeostasis and follicle confines are governed by fibroblastic reticular cellsQ34383642
Circulating immune complexes in the serum in systemic lupus erythematosus and in carriers of hepatitis B antigen. Quantitation by binding to radiolabeled C1q.Q34464705
Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus.Q34566135
Does aneuploidy cause cancer?Q34574496
CD40-CD40L independent Ig gene hypermutation suggests a second B cell diversification pathway in humansQ34651496
Apoptotic caspases prevent the induction of type I interferons by mitochondrial DNA.Q34745565
Protective immunity against atherosclerosis carried by B cells of hypercholesterolemic miceQ34789613
Natural antibodies of newborns recognize oxidative stress-related malondialdehyde acetaldehyde adducts on apoptotic cells and atherosclerotic plaques.Q34881734
Marginal zone B cells regulate antigen capture by marginal zone macrophagesQ34997086
Iron metabolism in the reticuloendothelial systemQ35086735
Lupus Nephritis: Animal Modeling of a Complex Disease Syndrome Pathology.Q35110038
The C-type lectin SIGN-R1 mediates uptake of the capsular polysaccharide of Streptococcus pneumoniae in the marginal zone of mouse spleen.Q35122158
Oxidation-specific epitopes are dominant targets of innate natural antibodies in mice and humansQ37170775
TLR-mediated stimulation of APC: Distinct cytokine responses of B cells and dendritic cells.Q37235039
Control of toll-like receptor 7 expression is essential to restrict autoimmunity and dendritic cell proliferationQ37252315
Invariant natural killer T cells direct B cell responses to cognate lipid antigen in an IL-21-dependent mannerQ37322505
Cutting edge: Primary and secondary effects of CD19 deficiency on cells of the marginal zoneQ37353933
Immunoglobulin M is required for protection against atherosclerosis in low-density lipoprotein receptor-deficient miceQ37385727
Extracorporeal photopheresis: from solid organs to face transplantationQ37467220
STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors.Q37502349
Marginal zone CD169+ macrophages coordinate apoptotic cell-driven cellular recruitment and toleranceQ37659828
Antigen-specific tolerance by autologous myelin peptide-coupled cells: a phase 1 trial in multiple sclerosisQ37679881
The distribution and function of phosphatidylserine in cellular membranesQ37700664
Subsets, expansion and activation of myeloid-derived suppressor cellsQ37727050
Innate lymphoid cells integrate stromal and immunological signals to enhance antibody production by splenic marginal zone B cells.Q37734578
Regulatory T cells in tumor immunityQ37762224
New insights into the molecular mechanisms of classical complement activationQ37764573
Secondary necrosis: The natural outcome of the complete apoptotic programQ37802938
Scavenger receptors as regulators of natural antibody responses and B cell activation in autoimmunity.Q37844731
Regulation of indoleamine 2,3-dioxygenase gene expression in human fibroblasts by interferon-gamma. Upstream control region discriminates between interferon-gamma and interferon-alphaQ37895881
Innate immune functions of macrophage subpopulations in the spleen.Q37983386
Stromal cells of the mouse spleenQ38027148
Nineteenth century research on cell death.Q38052376
Sialoadhesin - a macrophage-restricted marker of immunoregulation and inflammationQ38062551
DNA recognition in immunity and diseaseQ38073511
Autoreactive B cell responses to RNA-related antigens due to TLR7 gene duplicationQ38313174
Novel subset of CD8{alpha}+ dendritic cells localized in the marginal zone is responsible for tolerance to cell-associated antigens.Q38355730
Sheepish B cells: evidence for antigen-independent antibody diversification in humans and mice.Q38845506
Induction of type I IFN is a physiological immune reaction to apoptotic cell-derived membrane microparticles.Q39587713
iC3b-opsonized apoptotic cells mediate a distinct anti-inflammatory response and transcriptional NF-kappaB-dependent blockadeQ39758134
Organizer-like reticular stromal cell layer common to adult secondary lymphoid organsQ39926763
CX3CL1/fractalkine is released from apoptotic lymphocytes to stimulate macrophage chemotaxisQ39938633
Methods to detect and quantitate complement activationQ40108324
CD46 plays a key role in tailoring innate immune recognition of apoptotic and necrotic cellsQ40387246
Invariant NKT cells limit activation of autoreactive CD1d-positive B cells.Q40463756
Response to self antigen imprints regulatory memory in tissuesQ40573313
Phospholipid flip-flop and phospholipid scramblase 1 (PLSCR1) co-localize to uropod rafts in formylated Met-Leu-Phe-stimulated neutrophilsQ40591748
Hereditary C1q deficiency and systemic lupus erythematosus.Q40629807
Macrophage recognition of externalized phosphatidylserine and phagocytosis of apoptotic Jurkat cells--existence of a thresholdQ40653519
Circulating immune complexes in systemic lupus erythematosusQ40657247
A role for oxidative stress in apoptosis: oxidation and externalization of phosphatidylserine is required for macrophage clearance of cells undergoing Fas-mediated apoptosisQ40723230
Cutting Edge: defective follicular exclusion of apoptotic antigens due to marginal zone macrophage defects in autoimmune BXD2 mice.Q40773152
Annexin V binds to viable B cells and colocalizes with a marker of lipid rafts upon B cell receptor activationQ40905062
Predominance of the prototypic T15 anti-phosphorylcholine junctional sequence in neonatal pre-B cellsQ41144622
Conduits mediate transport of low-molecular-weight antigen to lymph node folliclesQ41291427
CD4+ natural killer T cells potently augment aortic root atherosclerosis by perforin- and granzyme B-dependent cytotoxicityQ41660866
Cutting edge: DNA sensing via the STING adaptor in myeloid dendritic cells induces potent tolerogenic responsesQ41770853
Suppression of systemic autoimmunity by the innate immune adaptor STING.Q35128992
Prevention of murine autoimmune diabetes by CCL22-mediated Treg recruitment to the pancreatic isletsQ35142798
Neutrophil clearance: when the party is over, clean-up beginsQ35151051
Transitional B cells: step by step towards immune competenceQ35155960
Follicular dendritic cells: dynamic antigen libraries.Q35191870
CD103+ pulmonary dendritic cells preferentially acquire and present apoptotic cell-associated antigenQ35208349
Complement protein C1q bound to apoptotic cells suppresses human macrophage and dendritic cell-mediated Th17 and Th1 T cell subset proliferation.Q35227723
Amino acid catabolism: a pivotal regulator of innate and adaptive immunity.Q35261125
STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors.Q35263440
Sterile inflammation in the spleen during atherosclerosis provides oxidation-specific epitopes that induce a protective B-cell responseQ35549073
Constitutive exposure of phosphatidylserine on viable cellsQ35585909
IgM antibodies to apoptosis-associated determinants recruit C1q and enhance dendritic cell phagocytosis of apoptotic cellsQ35597401
Prevention of life-threatening infections due to encapsulated bacteria in children with hyposplenia or asplenia: a brief review of current recommendations for practical purposesQ35604607
The inflammatory cytokine IL-18 induces self-reactive innate antibody responses regulated by natural killer T cellsQ35651114
Regulatory B10 cells differentiate into antibody-secreting cells after transient IL-10 production in vivoQ35685566
Autoimmunity initiates in nonhematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune diseaseQ35717955
A tolerogenic role for Toll-like receptor 9 is revealed by B-cell interaction with DNA complexes expressed on apoptotic cellsQ35735423
The perifollicular and marginal zones of the human splenic white pulp : do fibroblasts guide lymphocyte immigration?Q35747070
Clearance of apoptotic cells: getting rid of the corpses.Q35763978
Expression of the mucosal vascular addressin, MAdCAM-1, on sinus-lining cells in the spleenQ35798382
Tolerance to apoptotic cells is regulated by indoleamine 2,3-dioxygenase.Q35844935
CC chemokine receptor 4 is required for experimental autoimmune encephalomyelitis by regulating GM-CSF and IL-23 production in dendritic cells.Q35844943
Critical role of macrophages in the marginal zone in the suppression of immune responses to apoptotic cell-associated antigensQ35901015
Apoptotic caspases suppress mtDNA-induced STING-mediated type I IFN productionQ35903465
Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2,3-dioxygenaseQ35925641
Engineering DNA nanoparticles as immunomodulatory reagents that activate regulatory T cellsQ35949475
Complement protein C1q directs macrophage polarization and limits inflammasome activity during the uptake of apoptotic cells.Q35981460
The amino acid sensor GCN2 inhibits inflammatory responses to apoptotic cells promoting tolerance and suppressing systemic autoimmunityQ36008229
Apoptosis in the ovary: molecular mechanismsQ36038018
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectapoptotic processQ14599311
P304page(s)26-43
P577publication date2016-01-01
P1433published inImmunological ReviewsQ15724582
P1476titleApoptotic cell responses in the splenic marginal zone: a paradigm for immunologic reactions to apoptotic antigens with implications for autoimmunity
P478volume269

Reverse relations

cites work (P2860)
Q88671353Apoptotic cell-induced AhR activity is required for immunological tolerance and suppression of systemic lupus erythematosus in mice and humans
Q57176332Autoantigen-Harboring Apoptotic Cells Hijack the Coinhibitory Pathway of T Cell Activation
Q47371480Bim suppresses the development of SLE by limiting myeloid inflammatory responses.
Q38790504Concise Review: Apoptotic Cell-Based Therapies-Rationale, Preclinical Results and Future Clinical Developments.
Q49967408Development of novel fluorescent particles applicable for phagocytosis assays with human macrophages
Q90763949Dialysis therapy is associated with peripheral marginal zone B-cell augmentation
Q90284182How macrophages deal with death
Q91765452Identification and isolation of splenic tissue-resident macrophage sub-populations by flow cytometry
Q64118720LangerinCD8 Dendritic Cells in the Splenic Marginal Zone: Not So Marginal After All
Q48666099Multipeptide-coupled nanoparticles induce tolerance in 'humanised' HLA-transgenic mice and inhibit diabetogenic CD8+ T cell responses in type 1 diabetes
Q89820601Predominant Role of Immunoglobulin G in the Pathogenesis of Splenomegaly in Murine Lupus
Q37261531Selective Memory to Apoptotic Cell-Derived Self-Antigens with Implications for Systemic Lupus Erythematosus Development
Q96171663Systemic lupus erythematosus favors the generation of IL-17 producing double negative T cells
Q48332393The Phagocytic Function of Macrophage-Enforcing Innate Immunity and Tissue Homeostasis.
Q38990736The contribution of the programmed cell death machinery in innate immune cells to lupus nephritis