Complement protein C1q directs macrophage polarization and limits inflammasome activity during the uptake of apoptotic cells.

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Complement protein C1q directs macrophage polarization and limits inflammasome activity during the uptake of apoptotic cells. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.4049/JIMMUNOL.1103760
P932PMC publication ID3358549
P698PubMed publication ID22523386
P5875ResearchGate publication ID224811876

P50authorElizabeth V ClarkeQ59684151
P2093author name stringAndrea J Tenner
Deborah A Fraser
Pedro Morgado
Marie E Benoit
P2860cites workThe PAAD/PYRIN-only protein POP1/ASC2 is a modulator of ASC-mediated nuclear-factor-kappa B and pro-caspase-1 regulationQ24298443
IL-33 amplifies the polarization of alternatively activated macrophages that contribute to airway inflammationQ24309034
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C1q and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cellsQ24670661
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Characterization of C1q receptor expression on human phagocytic cells: effects of PDBu and fMLPQ68798810
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Expression of C1q, a subcomponent of the rat complement system, is dramatically enhanced in brains of rats with either Borna disease or experimental allergic encephalomyelitisQ71707145
C1q binds directly and specifically to surface blebs of apoptotic human keratinocytes: complement deficiency and systemic lupus erythematosus revisitedQ73326011
The globular heads of C1q specifically recognize surface blebs of apoptotic vascular endothelial cellsQ73509925
Complement receptor type 1 (CR1, CD35) is a receptor for C1qQ73767610
Maturation of dendritic cells abrogates C1q production in vivo and in vitroQ75272880
Opsonization with C1q and mannose-binding lectin targets apoptotic cells to dendritic cellsQ80475635
Minimum information about a microarray experiment (MIAME)-toward standards for microarray dataQ27860569
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resourcesQ27860739
Analyzing real-time PCR data by the comparative C(T) methodQ28131831
IL-37 is a fundamental inhibitor of innate immunityQ28295265
COPs and POPs: modulators of inflammasome activityQ28387485
Integration of biological networks and gene expression data using CytoscapeQ28681323
Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigmQ29614349
How dying cells alert the immune system to dangerQ29615501
TM4 microarray software suiteQ29618829
Gene expression of the A- and B-chain of mouse C1q in different tissues and the characterization of the recombinant A-chainQ33436583
C1q enhances microglial clearance of apoptotic neurons and neuronal blebs, and modulates subsequent inflammatory cytokine productionQ33601747
The complement cascade: Yin-Yang in neuroinflammation--neuro-protection and -degenerationQ33685823
C1q differentially modulates phagocytosis and cytokine responses during ingestion of apoptotic cells by human monocytes, macrophages, and dendritic cells.Q33745559
A hierarchical role for classical pathway complement proteins in the clearance of apoptotic cells in vivoQ33912964
Lipopolysaccharide-Mediated IL-10 Transcriptional Regulation Requires Sequential Induction of Type I IFNs and IL-27 in MacrophagesQ33919041
Systemic lupus erythematosus, complement deficiency, and apoptosisQ34082803
The inflammatory response to cell deathQ34718276
C1q deficiency leads to the defective suppression of IFN-alpha in response to nucleoprotein containing immune complexesQ34729450
The role of complement in the development of systemic lupus erythematosusQ35698485
Complement proteins C1q and MBL are pattern recognition molecules that signal immediate and long-term protective immune functionsQ36565247
The complement protein properdin binds apoptotic T cells and promotes complement activation and phagocytosis.Q36752476
Clearance of apoptotic cells by phagocytesQ36850155
Complement activation and inhibition: a delicate balance.Q37368654
Systemic lupus erythematosus and C1q: A quantitative ELISA for determining C1q levels in serumQ39327756
Direct demonstration and quantitation of the first complement component in human serumQ39477585
Role of surfactant proteins A, D, and C1q in the clearance of apoptotic cells in vivo and in vitro: calreticulin and CD91 as a common collectin receptor complexQ39750562
Acquisition of chemiluminescent signals from immunoblots with a digital single-lens reflex cameraQ39902264
Properdin binds to late apoptotic and necrotic cells independently of C3b and regulates alternative pathway complement activationQ39980543
Complement subcomponent C1q stimulates Ig production by human B lymphocytesQ41683610
Biosynthesis in vitro of complement subcomponents C1q, C1s and C1̅ inhibitor by resting and stimulated human monocytesQ41843990
Complement subcomponent C1q secreted by cultured human monocytes has subunit structure identical with that of serum C1q.Q41940468
Complement protein C1q-mediated neuroprotection is correlated with regulation of neuronal gene and microRNA expressionQ42719812
Phagocytic cell molecules that bind the collagen-like region of C1q. Involvement in the C1q-mediated enhancement of phagocytosisQ43788310
Janus kinase 3 down-regulates lipopolysaccharide-induced IL-1 beta-converting enzyme activation by autocrine IL-10.Q44832283
C1q and MBL, components of the innate immune system, influence monocyte cytokine expression.Q45973916
Kainic acid and decorticating lesions stimulate the synthesis of C1q protein in adult rat brain.Q46138240
Infiltrating dendritic cells contribute to local synthesis of C1q in murine and human lupus nephritisQ46189746
Murine CD93 (C1qRp) contributes to the removal of apoptotic cells in vivo but is not required for C1q-mediated enhancement of phagocytosisQ47992020
Complement C1q regulates LPS-induced cytokine production in bone marrow-derived dendritic cells.Q51030802
The dissociation properties of native C1Q52717945
Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodiesQ57089602
P4510describes a project that usesImageJQ1659584
CytoscapeQ3699942
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectmacrophageQ184204
inflammasome complexQ412405
apoptotic processQ14599311
P304page(s)5682-5693
P577publication date2012-04-20
P1433published inJournal of ImmunologyQ3521441
P1476titleComplement protein C1q directs macrophage polarization and limits inflammasome activity during the uptake of apoptotic cells
P478volume188

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