| scholarly article | Q13442814 |
| review article | Q7318358 |
| P50 | author | Thirumala-Devi Kanneganti | Q30003976 |
| Sarang Tartey | Q41186533 | ||
| P2860 | cites work | Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome | Q24291856 |
| Chronic infantile neurological cutaneous and articular syndrome is caused by mutations in CIAS1, a gene highly expressed in polymorphonuclear cells and chondrocytes | Q24298360 | ||
| IFI16 is an innate immune sensor for intracellular DNA | Q24301720 | ||
| The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta | Q24305136 | ||
| Cryopyrin-induced interleukin 1beta secretion in monocytic cells: enhanced activity of disease-associated mutants and requirement for ASC | Q24316380 | ||
| AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC | Q24319706 | ||
| De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of pyrin-associated autoinflammatory diseases | Q24337040 | ||
| Toll-like receptor signalling | Q24570126 | ||
| An autoinflammatory disease with deficiency of the interleukin-1-receptor antagonist | Q24606097 | ||
| Cytosolic DNA triggers inflammasome activation in keratinocytes in psoriatic lesions | Q24629755 | ||
| Horror autoinflammaticus: the molecular pathophysiology of autoinflammatory disease (*) | Q24631660 | ||
| The NLR gene family: a standard nomenclature | Q24645445 | ||
| Pyrin binds the PSTPIP1/CD2BP1 protein, defining familial Mediterranean fever and PAPA syndrome as disorders in the same pathway | Q24655872 | ||
| Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor | Q27678368 | ||
| Molecular Mechanism for p202-Mediated Specific Inhibition of AIM2 Inflammasome Activation | Q27679064 | ||
| Pathogen recognition and innate immunity | Q27861084 | ||
| Pattern recognition receptors and inflammation | Q27861115 | ||
| Mutations in CD2BP1 disrupt binding to PTP PEST and are responsible for PAPA syndrome, an autoinflammatory disorder | Q28118980 | ||
| A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes | Q28237565 | ||
| Approaching the asymptote? Evolution and revolution in immunology | Q28274344 | ||
| Critical role for Cryopyrin/Nalp3 in activation of caspase-1 in response to viral infection and double-stranded RNA | Q28504793 | ||
| Requirement of DNase II for definitive erythropoiesis in the mouse fetal liver | Q28508639 | ||
| Lethal anemia caused by interferon-beta produced in mouse embryos carrying undigested DNA | Q28587147 | ||
| Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS | Q28596027 | ||
| Toll-like receptors and their crosstalk with other innate receptors in infection and immunity | Q29547722 | ||
| Origin and physiological roles of inflammation | Q29614298 | ||
| Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3 | Q29615598 | ||
| Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity | Q29615913 | ||
| K⁺ efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter | Q29620146 | ||
| The F-BAR protein PSTPIP1 controls extracellular matrix degradation and filopodia formation in macrophages | Q30009552 | ||
| Germline NLRP1 Mutations Cause Skin Inflammatory and Cancer Susceptibility Syndromes via Inflammasome Activation | Q30090220 | ||
| Genetics of monogenic autoinflammatory diseases: past successes, future challenges | Q37897478 | ||
| Lupus neutrophils: 'NET' gain in understanding lupus pathogenesis | Q38012323 | ||
| Inflammasomes and their roles in health and disease | Q38043048 | ||
| Mechanisms and functions of inflammasomes | Q38214128 | ||
| The inflammasomes and autoinflammatory syndromes. | Q38271261 | ||
| Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling. | Q38835006 | ||
| Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death | Q38835009 | ||
| A new autoinflammatory and autoimmune syndrome associated with NLRP1 mutations: NAIAD (NLRP1-associated autoinflammation with arthritis and dyskeratosis). | Q39031146 | ||
| Pathogen recognition and Toll-like receptor targeted therapeutics in innate immune cells | Q39070506 | ||
| The NLRP3 and Pyrin Inflammasomes: Implications in the Pathophysiology of Autoinflammatory Diseases. | Q39132605 | ||
| Mechanisms governing inflammasome activation, assembly and pyroptosis induction | Q39322410 | ||
| The monogenic autoinflammatory diseases define new pathways in human innate immunity and inflammation | Q39443996 | ||
| INFEVERS: the Registry for FMF and hereditary inflammatory disorders mutations | Q39790268 | ||
| A novel Pyrin-Associated Autoinflammation with Neutrophilic Dermatosis mutation further defines 14-3-3 binding of pyrin and distinction to Familial Mediterranean Fever. | Q40042168 | ||
| IL-1β and Caspase-1 Drive Autoinflammatory Disease Independently of IL-1α or Caspase-8 in a Mouse Model of Familial Mediterranean Fever | Q40075783 | ||
| Familial autoinflammation with neutrophilic dermatosis reveals a regulatory mechanism of pyrin activation. | Q40111903 | ||
| The SPRY domain of Pyrin, mutated in familial Mediterranean fever patients, interacts with inflammasome components and inhibits proIL-1beta processing | Q40146198 | ||
| Increased NLRP3-dependent interleukin 1β secretion in patients with familial Mediterranean fever: correlation with MEFV genotype | Q40254261 | ||
| Hyperactivation of the NLRP3 Inflammasome in Myeloid Cells Leads to Severe Organ Damage in Experimental Lupus | Q40401297 | ||
| Cutting Edge: RIP1 kinase activity is dispensable for normal development but is a key regulator of inflammation in SHARPIN-deficient mice. | Q40416781 | ||
| Hematopoietic-specific expression of MEFV, the gene mutated in familial Mediterranean fever, and subcellular localization of its corresponding protein, pyrin. | Q40626582 | ||
| Disease activity accounts for long-term efficacy of IL-1 blockers in pyogenic sterile arthritis pyoderma gangrenosum and severe acne syndrome | Q40750904 | ||
| Inflammatory arthritis in caspase 1 gene-deficient mice: contribution of proteinase 3 to caspase 1-independent production of bioactive interleukin-1beta | Q41457693 | ||
| Long-term outcome of treating rheumatoid arthritis: results after 20 years | Q41913707 | ||
| IL-converting enzyme/caspase-1 inhibitor VX-765 blocks the hypersensitive response to an inflammatory stimulus in monocytes from familial cold autoinflammatory syndrome patients | Q42482233 | ||
| Expression profile of HIN200 in leukocytes and renal biopsy of SLE patients by real-time RT-PCR. | Q43275144 | ||
| Inhibition of P2X4 suppresses joint inflammation and damage in collagen-induced arthritis | Q43764987 | ||
| C3a modulates IL-1β secretion in human monocytes by regulating ATP efflux and subsequent NLRP3 inflammasome activation. | Q47954758 | ||
| Treatment of adult hyper-IgD syndrome with canakinumab | Q47960667 | ||
| Spontaneous mutations in the mouse Sharpin gene result in multiorgan inflammation, immune system dysregulation and dermatitis. | Q48151205 | ||
| A Disease-associated Mutant of NLRC4 Shows Enhanced Interaction with SUG1 Leading to Constitutive FADD-dependent Caspase-8 Activation and Cell Death | Q50021891 | ||
| Differential requirement of P2X7 receptor and intracellular K+ for caspase-1 activation induced by intracellular and extracellular bacteria | Q50072056 | ||
| Evidence of NLRP3-inflammasome activation in rheumatoid arthritis (RA); genetic variants within the NLRP3-inflammasome complex in relation to susceptibility to RA and response to anti-TNF treatment. | Q50980583 | ||
| Systemic lupus erythematosus. | Q51834159 | ||
| ASK1/2 signaling promotes inflammation in a mouse model of neutrophilic dermatosis. | Q52599096 | ||
| Systemic lupus erythematosus. | Q53202066 | ||
| The Inflammatory Caspases-1 and -11 Mediate the Pathogenesis of Dermatitis in Sharpin-Deficient Mice. | Q53405138 | ||
| NLRP3 and ASC suppress lupus-like autoimmunity by driving the immunosuppressive effects of TGF-β receptor signalling. | Q54194314 | ||
| NLRP1 gene polymorphism influences gene transcription and is a risk factor for rheumatoid arthritis in han chinese. | Q54345125 | ||
| Canakinumab for the cryopyrin-associated periodic syndromes | Q54806476 | ||
| Rilonacept in cryopyrin-associated periodic syndromes: the beginning of longer-acting interleukin-1 antagonism | Q54806488 | ||
| Interleukin-1-receptor antagonist in the Muckle-Wells syndrome. | Q54806497 | ||
| Germline mutations in the extracellular domains of the 55 kDa TNF receptor, TNFR1, define a family of dominantly inherited autoinflammatory syndromes. | Q54806502 | ||
| Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part I. | Q55047291 | ||
| Life-threatening NLRC4-associated hyperinflammation successfully treated with IL-18 inhibition. | Q55417340 | ||
| Ancient Missense Mutations in a New Member of the RoRet Gene Family Are Likely to Cause Familial Mediterranean Fever | Q56288694 | ||
| Rheumatoid arthritis | Q56656479 | ||
| Cutting Edge: Dysregulated CARD9 Signaling in Neutrophils Drives Inflammation in a Mouse Model of Neutrophilic Dermatoses | Q57080583 | ||
| Pannexin-1-Mediated Recognition of Bacterial Molecules Activates the Cryopyrin Inflammasome Independent of Toll-like Receptor Signaling | Q57080628 | ||
| Overlapping BXSB congenic intervals, in combination with microarray gene expression, reveal novel lupus candidate genes | Q57089471 | ||
| Gasdermin D mediates the pathogenesis of neonatal-onset multisystem inflammatory disease in mice | Q58617888 | ||
| Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages | Q59062762 | ||
| Anakinra Therapy for Non-cancer Inflammatory Diseases | Q59136398 | ||
| TNF/TNFR axis promotes pyrin inflammasome activation and distinctly modulates pyrin inflammasomopathy | Q63976848 | ||
| GSDMD is critical for autoinflammatory pathology in a mouse model of Familial Mediterranean Fever. | Q64905464 | ||
| Binding properties of human anti-DNA antibodies to cloned human DNA fragments | Q69742183 | ||
| Prediction of long-term mortality in patients with rheumatoid arthritis according to simple questionnaire and joint count measures | Q72631859 | ||
| Familial Mediterranean fever | Q74309346 | ||
| Anakinra for flares of pyogenic arthritis in PAPA syndrome | Q81239826 | ||
| Targeted treatment of pyoderma gangrenosum in PAPA (pyogenic arthritis, pyoderma gangrenosum and acne) syndrome with the recombinant human interleukin-1 receptor antagonist anakinra | Q84391992 | ||
| AIM2 facilitates the apoptotic DNA-induced systemic lupus erythematosus via arbitrating macrophage functional maturation | Q86348636 | ||
| The pyrin inflammasome: from sensing RhoA GTPases-inhibiting toxins to triggering autoinflammatory syndromes | Q88541042 | ||
| Innate immune adaptor MyD88 deficiency prevents skin inflammation in SHARPIN-deficient mice | Q90428539 | ||
| Differential role of the NLRP3 inflammasome in infection and tumorigenesis | Q91150755 | ||
| Rheumatoid arthritis. | Q30244019 | ||
| Tyrosine Kinase SYK Licenses MyD88 Adaptor Protein to Instigate IL-1α-Mediated Inflammatory Disease | Q30252629 | ||
| P2X7 blockade attenuates murine lupus nephritis by inhibiting activation of the NLRP3/ASC/caspase 1 pathway | Q30409205 | ||
| Aim2 Deficiency Stimulates the Expression of IFN-Inducible Ifi202, a Lupus Susceptibility Murine Gene within the Nba2 Autoimmune Susceptibility Locus | Q30429300 | ||
| An autoinflammatory disease due to homozygous deletion of the IL1RN locus | Q33577198 | ||
| Disruption of mutually negative regulatory feedback loop between interferon-inducible p202 protein and the E2F family of transcription factors in lupus-prone mice | Q33605468 | ||
| Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9. | Q33731760 | ||
| Inflammasome-independent role of apoptosis-associated speck-like protein containing a CARD (ASC) in T cell priming is critical for collagen-induced arthritis | Q33782663 | ||
| Efficacy and safety of the human anti-IL-1β monoclonal antibody canakinumab in rheumatoid arthritis: results of a 12-week, Phase II, dose-finding study | Q33953931 | ||
| TNFRSF1A mutations and autoinflammatory syndromes | Q33971049 | ||
| Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis | Q34020795 | ||
| Colchicine for familial Mediterranean fever | Q34052599 | ||
| A candidate gene for familial Mediterranean fever | Q34065122 | ||
| The inflammasome and lupus: another innate immune mechanism contributing to disease pathogenesis? | Q34127758 | ||
| Mutation of NLRC4 causes a syndrome of enterocolitis and autoinflammation | Q34254942 | ||
| An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome | Q34254955 | ||
| Constitutively activated NLRP3 inflammasome causes inflammation and abnormal skeletal development in mice | Q34257004 | ||
| Neonatal-onset multisystem inflammatory disease responsive to interleukin-1beta inhibition | Q34262569 | ||
| NOD-LRR proteins: role in host-microbial interactions and inflammatory disease | Q34426050 | ||
| An inherited mutation in NLRC4 causes autoinflammation in human and mice | Q34447217 | ||
| The C-type lectin-like domain superfamily | Q34473873 | ||
| Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis | Q34477557 | ||
| Advances in the understanding of familial Mediterranean fever and possibilities for targeted therapy | Q34608120 | ||
| TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice. | Q34729606 | ||
| Spontaneous insertion of a b2 element in the ptpn6 gene drives a systemic autoinflammatory disease in mice resembling neutrophilic dermatosis in humans | Q34805360 | ||
| Alteration in the gene encoding protein tyrosine phosphatase nonreceptor type 6 (PTPN6/SHP1) may contribute to neutrophilic dermatoses | Q34805483 | ||
| Cutting edge: AIM2 and endosomal TLRs differentially regulate arthritis and autoantibody production in DNase II-deficient mice | Q34987413 | ||
| Familial cold autoinflammatory syndrome: phenotype and genotype of an autosomal dominant periodic fever | Q35064725 | ||
| The clinical continuum of cryopyrinopathies: novel CIAS1 mutations in North American patients and a new cryopyrin model | Q35064730 | ||
| Monocytes from familial cold autoinflammatory syndrome patients are activated by mild hypothermia | Q35064754 | ||
| Gain-of-function Pyrin mutations induce NLRP3 protein-independent interleukin-1β activation and severe autoinflammation in mice | Q35086225 | ||
| NLRP3 mediates osteolysis through inflammation-dependent and -independent mechanisms | Q35410664 | ||
| Regulation of inflammasome activation | Q35456425 | ||
| Cell type and gender-dependent differential regulation of the p202 and Aim2 proteins: implications for the regulation of innate immune responses in SLE. | Q35536260 | ||
| Preliminary results of safety and efficacy of the interleukin 1 receptor antagonist anakinra in patients with severe lupus arthritis. | Q35555391 | ||
| Inflammasome activation of IL-18 results in endothelial progenitor cell dysfunction in systemic lupus erythematosus | Q35566819 | ||
| The autoinflammatory syndromes | Q35643296 | ||
| AIM2 Drives Joint Inflammation in a Self-DNA Triggered Model of Chronic Polyarthritis | Q35675556 | ||
| The role of complement in the development of systemic lupus erythematosus | Q35698485 | ||
| Cryopyrin/NALP3 binds ATP/dATP, is an ATPase, and requires ATP binding to mediate inflammatory signaling | Q35808888 | ||
| Non-transcriptional regulation of NLRP3 inflammasome signaling by IL-4. | Q35832520 | ||
| A spontaneous mutation characterized by chronic proliferative dermatitis in C57BL mice | Q35833532 | ||
| U1-small nuclear ribonucleoprotein activates the NLRP3 inflammasome in human monocytes | Q35945030 | ||
| Complement protein C1q directs macrophage polarization and limits inflammasome activity during the uptake of apoptotic cells. | Q35981460 | ||
| Brief Report: Cryopyrin-Associated Periodic Syndrome Caused by a Myeloid-Restricted Somatic NLRP3 Mutation | Q36001556 | ||
| Enhanced activity of NLRP3 inflammasome in peripheral blood cells of patients with active rheumatoid arthritis | Q36073831 | ||
| Non-transcriptional priming and deubiquitination regulate NLRP3 inflammasome activation | Q36332983 | ||
| Critical roles for interleukin 1 and tumor necrosis factor alpha in antibody-induced arthritis | Q36371110 | ||
| Neutrophil extracellular trap-associated protein activation of the NLRP3 inflammasome is enhanced in lupus macrophages | Q36553792 | ||
| Self double-stranded (ds)DNA induces IL-1β production from human monocytes by activating NLRP3 inflammasome in the presence of anti-dsDNA antibodies | Q36585774 | ||
| Nonreceptor protein-tyrosine phosphatases in immune cell signaling | Q36732551 | ||
| Beneficial suicide: why neutrophils die to make NETs | Q36882473 | ||
| RIP1-driven autoinflammation targets IL-1α independently of inflammasomes and RIP3. | Q36931209 | ||
| Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger | Q36937153 | ||
| Colchicine prevents tumor necrosis factor-induced toxicity in vivo | Q36945062 | ||
| Intracellular NOD-like receptors in host defense and disease | Q36984454 | ||
| Site-specific phosphorylation and microtubule dynamics control Pyrin inflammasome activation | Q37200090 | ||
| Divergence of IL-1, IL-18, and cell death in NLRP3 inflammasomopathies | Q37259317 | ||
| Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity. | Q37382279 | ||
| A mutation in the Nlrp3 gene causing inflammasome hyperactivation potentiates Th17 cell-dominant immune responses | Q37393022 | ||
| Distinct role of IL-1β in instigating disease in Sharpincpdm mice | Q37444344 | ||
| Anakinra for rheumatoid arthritis: a systematic review | Q37485424 | ||
| Familial Mediterranean fever mutations lift the obligatory requirement for microtubules in Pyrin inflammasome activation | Q37515104 | ||
| NLRP3 and CARD8 Polymorphisms Influence Higher Disease Activity in Rheumatoid Arthritis | Q37694959 | ||
| P433 | issue | 3 | |
| P921 | main subject | pathophysiology | Q1135939 |
| P304 | page(s) | 379-391 | |
| P577 | publication date | 2019-10-14 | |
| P1433 | published in | Journal of Leukocyte Biology | Q1524048 |
| P1476 | title | Inflammasomes in the pathophysiology of autoinflammatory syndromes | |
| P478 | volume | 107 |
| Q99207751 | A comprehensive guide to studying inflammasome activation and cell death | cites work | P2860 |
Search more.