Full Spectrum of LPS Activation in Alveolar Macrophages of Healthy Volunteers by Whole Transcriptomic Profiling.

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Full Spectrum of LPS Activation in Alveolar Macrophages of Healthy Volunteers by Whole Transcriptomic Profiling. is …
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scholarly articleQ13442814

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P819ADS bibcode2016PLoSO..1159329P
P356DOI10.1371/JOURNAL.PONE.0159329
P932PMC publication ID4951018
P698PubMed publication ID27434537

P50authorRobert M TigheQ63386802
Miguel Pinilla-VeraQ63562505
Janet S. LeeQ86796403
P2093author name stringJohn Hollingsworth
Jing Zhao
Prabir Ray
Jay K Kolls
Bryan J McVerry
Yutong Zhao
Anuradha Ray
W Michael Foster
Michael P Donahoe
William T Horne
Zeyu Xiong
Suchitra Barge
Anastasiya Birukova
Rama Mallampalli
P2860cites workTLR4 mutations are associated with endotoxin hyporesponsiveness in humansQ22254186
Type I interferon [corrected] gene induction by the interferon regulatory factor family of transcription factorsQ24303448
Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteasesQ24304224
UBP43 is a novel regulator of interferon signaling independent of its ISG15 isopeptidase activityQ24337310
Immune responsive gene 1 (IRG1) promotes endotoxin tolerance by increasing A20 expression in macrophages through reactive oxygen speciesQ24338871
Type I IFNs mediate development of postinfluenza bacterial pneumonia in miceQ37241332
Transcriptional re-programming of primary macrophages reveals distinct apoptotic and anti-tumoral functions of IRF-3 and IRF-7.Q37411480
CD14 mediates binding of high doses of LPS but is dispensable for TNF-α productionQ37481749
Scavenger receptors in homeostasis and immunityQ38127564
RNA degradation in antiviral immunity and autoimmunityQ38364656
The effects of cetuximab alone and in combination with radiation and/or chemotherapy in lung cancer.Q40460294
Mycobacterium tuberculosis-induced CXCR4 and chemokine expression leads to preferential X4 HIV-1 replication in human macrophagesQ40558726
CD91 is a common receptor for heat shock proteins gp96, hsp90, hsp70, and calreticulinQ43566795
Characterization of viable autofluorescent macrophages among cultured peripheral blood mononuclear cellsQ43579967
Differential gene expression analysis in human monocyte-derived macrophages: impact of cigarette smoke on host defenceQ44423945
Cutting edge: involvement of the type I IFN production and signaling pathway in lipopolysaccharide-induced IL-10 productionQ46543293
Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathwaysQ48219736
The role of innate immunity in acute allograft rejection after lung transplantation.Q54770843
Expression of CCR5 Is Increased in Human Monocyte-Derived Macrophages and Alveolar Macrophages in the Course of in Vivo and in Vitro Mycobacterium tuberculosis InfectionQ56839542
Toll-like Receptor 4 Polymorphisms and AtherogenesisQ59273869
Neutralization of IL-10 increases survival in a murine model of Klebsiella pneumoniaQ71870349
CD91: a receptor for heat shock protein gp96Q73615235
Bacterial pneumonia. Managing a deadly complication of influenza in older adults with comorbid diseaseQ77781485
Two-colour flow-cytometric analysis of pulmonary alveolar macrophages from smokersQ77853233
IL-6 and maturation govern TLR2 and TLR4 induced TLR agonist tolerance and cross-tolerance in dendritic cellsQ81464256
Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid productionQ24338884
An immune basis for lung parenchymal destruction in chronic obstructive pulmonary disease and emphysemaQ24802958
Immunomodulatory functions of type I interferonsQ26823904
Regulation of type I interferon responsesQ26853177
Role of the fragility of the pulmonary blood-gas barrier in the evolution of the pulmonary circulationQ26864735
Relevance of mutations in the TLR4 receptor in patients with gram-negative septic shockQ28216899
Type I interferons in infectious diseaseQ28255842
IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptorsQ28260114
Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathwayQ28592087
By Binding SIRPα or Calreticulin/CD91, Lung Collectins Act as Dual Function Surveillance Molecules to Suppress or Enhance InflammationQ28609700
Alterations in adenosine metabolism and signaling in patients with chronic obstructive pulmonary disease and idiopathic pulmonary fibrosisQ28748902
Cell-surface calreticulin initiates clearance of viable or apoptotic cells through trans-activation of LRP on the phagocyteQ29615441
The regulation of IL-10 production by immune cellsQ29615479
Uncovering a macrophage transcriptional program by integrating evidence from motif scanning and expression dynamicsQ33325887
Controlling the response: predictive modeling of a highly central, pathogen-targeted core response module in macrophage activationQ33826113
Smoking-dependent reprogramming of alveolar macrophage polarization: implication for pathogenesis of chronic obstructive pulmonary diseaseQ33865189
Aryl hydrocarbon receptor control of a disease tolerance defence pathwayQ33901562
Inflammatory caspases are innate immune receptors for intracellular LPS.Q34041730
ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin toleranceQ34303629
IRF7 regulates TLR2-mediated activation of splenic CD11c(hi) dendritic cells.Q34345575
Selective inactivation of USP18 isopeptidase activity in vivo enhances ISG15 conjugation and viral resistanceQ34458906
Infectious disease. Life-threatening influenza and impaired interferon amplification in human IRF7 deficiencyQ34468857
Aicardi-Goutières syndrome and the type I interferonopathiesQ34479620
IRF-3, IRF-5, and IRF-7 coordinately regulate the type I IFN response in myeloid dendritic cells downstream of MAVS signalingQ34539832
TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteriaQ34640637
Transcriptome-based network analysis reveals a spectrum model of human macrophage activation.Q34659689
Transcriptomic and proteomic analyses reveal key innate immune signatures in the host response to the gastrointestinal pathogen Campylobacter concisusQ34955777
Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammationQ35002436
Autoimmunity initiates in nonhematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune diseaseQ35717955
CD91-dependent programming of T-helper cell responses following heat shock protein immunizationQ35973873
Alveolar macrophages lack CCR2 expression and do not migrate to CCL2Q36177122
STAT1-regulated lung MDSC-like cells produce IL-10 and efferocytose apoptotic neutrophils with relevance in resolution of bacterial pneumoniaQ36421706
The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in miceQ36512209
Overexpression of apoptotic cell removal receptor MERTK in alveolar macrophages of cigarette smokersQ36980516
P275copyright licenseCreative Commons CC0 LicenseQ6938433
P6216copyright statuscopyrighted, dedicated to the public domain by copyright holderQ88088423
P433issue7
P407language of work or nameEnglishQ1860
P921main subjecttranscriptomeQ252857
RNA sequencingQ2542347
P304page(s)e0159329
P577publication date2016-07-19
P1433published inPLOS OneQ564954
P1476titleFull Spectrum of LPS Activation in Alveolar Macrophages of Healthy Volunteers by Whole Transcriptomic Profiling
P478volume11

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cites work (P2860)
Q57486486ADGRE1 (EMR1, F4/80) Is a Rapidly-Evolving Gene Expressed in Mammalian Monocyte-Macrophages
Q99711618Changes in H3K27ac at Gene Regulatory Regions in Porcine Alveolar Macrophages Following LPS or PolyIC Exposure
Q47684869Decidual T Cells Exhibit a Highly Differentiated Phenotype and Demonstrate Potential Fetal Specificity and a Strong Transcriptional Response to IFN.
Q92238885FOXO3a is stabilized by USP18-mediated de-ISGylation and inhibits TGF-β1-induced fibronectin expression
Q39308555Human Lung Mononuclear Phagocytes in Health and Disease.
Q64230500Iron Homeostasis in the Lungs-A Balance between Health and Disease
Q33758739RNA-sequencing Identifies Novel Pathways in Sarcoidosis Monocytes
Q55689281Respiratory Mononuclear Phagocytes in Human Influenza A Virus Infection: Their Role in Immune Protection and As Targets of the Virus.
Q44920994Structure-Function Relationships Underlying the Capacity of Bordetella Adenylate Cyclase Toxin to Disarm Host Phagocytes
Q92382430The role of deubiquitinating enzymes in gastric cancer

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