RAGE is a Critical Mediator of Pulmonary Oxidative Stress, Alveolar Macrophage Activation and Emphysema in Response to Cigarette Smoke

scientific article published in Scientific Reports

RAGE is a Critical Mediator of Pulmonary Oxidative Stress, Alveolar Macrophage Activation and Emphysema in Response to Cigarette Smoke is …
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scholarly articleQ13442814

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P356DOI10.1038/S41598-018-36163-Z
P932PMC publication ID6338799
P698PubMed publication ID30659203

P2093author name stringDon A Delker
Yuxia Zhang
John R Hoidal
Mark W Hazel
Yuntian Chen
Tanna Wuren
Emily Beck
Karl A Sanders
Tom Huecksteadt
P2860cites workProjections of global mortality and burden of disease from 2002 to 2030Q21144688
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A multimodal RAGE-specific inhibitor reduces amyloid β-mediated brain disorder in a mouse model of Alzheimer diseaseQ28261647
The receptor for advanced glycation end products (RAGE) is a cellular binding site for amphoterin. Mediation of neurite outgrowth and co-expression of rage and amphoterin in the developing nervous systemQ28567291
Receptor for advanced glycation endproducts (RAGE) exhibits highly differential cellular and subcellular localisation in rat and human lungQ28568578
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Receptor for advanced glycation endproducts (RAGE) maintains pulmonary structure and regulates the response to cigarette smokeQ33873927
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Advanced glycation end products and its receptor (RAGE) are increased in patients with COPD.Q34152095
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Nrf2-deficient mice are highly susceptible to cigarette smoke-induced emphysemaQ47680966
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Soluble RAGE is deficient in neutrophilic asthma and COPDQ60624707
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Critical role of proteostasis-imbalance in pathogenesis of COPD and severe emphysemaQ35083187
RNA sequencing of sessile serrated colon polyps identifies differentially expressed genes and immunohistochemical markersQ35095334
The receptor for advanced glycation end products (RAGE) contributes to the progression of emphysema in miceQ35190905
Angiotensin receptor blockade attenuates cigarette smoke-induced lung injury and rescues lung architecture in miceQ35640559
Effect of five genetic variants associated with lung function on the risk of chronic obstructive lung disease, and their joint effects on lung functionQ36099476
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Oxidative stress and redox regulation of lung inflammation in COPD.Q36525624
Advanced glycation endproducts and their receptor in different body compartments in COPDQ36842527
sRAGE induces human monocyte survival and differentiationQ36900801
Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword?Q36989869
Multiple levels of regulation determine the role of the receptor for AGE (RAGE) as common soil in inflammation, immune responses and diabetes mellitus and its complicationsQ37564063
Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in miceQ37591945
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Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2Q37622629
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Receptor for advanced glycation end-products signals through Ras during tobacco smoke-induced pulmonary inflammation.Q39623825
Expression of high-mobility group box 1 and of receptor for advanced glycation end products in chronic obstructive pulmonary diseaseQ39743331
Induction of apoptosis by cigarette smoke via ROS-dependent endoplasmic reticulum stress and CCAAT/enhancer-binding protein-homologous protein (CHOP).Q39994444
RAGE: developmental expression and positive feedback regulation by Egr-1 during cigarette smoke exposure in pulmonary epithelial cells.Q39994864
Cigarette smoke induces an unfolded protein response in the human lung: a proteomic approachQ40035546
Cigarette smoke induces proinflammatory cytokine release by activation of NF-kappaB and posttranslational modifications of histone deacetylase in macrophagesQ40317523
Receptor for advanced glycation end products (RAGE) regulates sepsis but not the adaptive immune responseQ40899986
Cigarette smoke-induced Egr-1 upregulates proinflammatory cytokines in pulmonary epithelial cells.Q42053422
Activation of the alpha7 nAChR reduces acid-induced acute lung injury in mice and ratsQ42066672
Increased proinflammatory endothelial response to S100A8/A9 after preactivation through advanced glycation end productsQ42414162
Systemic soluble receptor for advanced glycation endproducts is a biomarker of emphysema and associated with AGER genetic variants in patients with chronic obstructive pulmonary diseaseQ43779676
Acute cigarette smoke exposure induces apoptosis of alveolar macrophagesQ43796594
RAGE and arthritis: the G82S polymorphism amplifies the inflammatory responseQ44032299
Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsisQ45122630
Emphysema requires the receptor for advanced glycation end-products triggering on structural cellsQ46188793
The role of interleukin-1beta in murine cigarette smoke-induced emphysema and small airway remodelingQ46309552
P4510describes a project that usesDESeq2Q113018293
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectmacrophageQ184204
pulmonary emphysemaQ188605
P304page(s)231
P577publication date2019-01-18
P1433published inScientific ReportsQ2261792
P1476titleRAGE is a Critical Mediator of Pulmonary Oxidative Stress, Alveolar Macrophage Activation and Emphysema in Response to Cigarette Smoke
P478volume9

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Q64904798Glycation of Plant Proteins: Regulatory Roles and Interplay with Sugar Signalling?cites workP2860

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