Epigenetic Control of Macrophage Polarisation and Soluble Mediator Gene Expression during Inflammation

scientific article

Epigenetic Control of Macrophage Polarisation and Soluble Mediator Gene Expression during Inflammation is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1155/2016/6591703
P3181OpenCitations bibliographic resource ID2395473
P932PMC publication ID4842078
P698PubMed publication ID27143818

P50authorTheodore S KapellosQ59549362
Asif J IqbalQ47424322
P2093author name stringAsif J Iqbal
Theodore S Kapellos
P2860cites workPEP-1-SIRT2 inhibits inflammatory response and oxidative stress-induced cell death via expression of antioxidant enzymes in murine macrophages.Q50905249
Histone deacetylase inhibitors impair antibacterial defenses of macrophages.Q54352898
Myeloid SIRT1 regulates macrophage infiltration and insulin sensitivity in mice fed a high-fat diet.Q55070433
The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infectionQ57062755
More alternative activation of macrophages in lungs of asthmatic patientsQ57891628
A novel regulator of macrophage activation: miR-223 in obesity-associated adipose tissue inflammationQ84117546
Deacetylation of C/EBPβ is required for IL-4-induced arginase-1 expression in murine macrophagesQ84734296
KAP1/TRIM28: an inhibitor of IRF5 function in inflammatory macrophagesQ85006320
Transcription-related element gene expression pattern differs between microglia and macrophages during inflammationQ87173886
Anti-inflammatory effect of Trichostatin-A on murine bone marrow-derived macrophagesQ39858104
DNA methylation in cystathionine-γ-lyase (CSE) gene promoter induced by ox-LDL in macrophages and in apoE knockout mice.Q40182931
Loss of PU.1 expression following inhibition of histone deacetylasesQ40773077
Inhibition of Histone Deacetylases Permits Lipopolysaccharide-Mediated Secretion of Bioactive IL-1β via a Caspase-1-Independent Mechanism.Q40929296
Bcl-6 and NF-kappaB cistromes mediate opposing regulation of the innate immune response.Q41193370
Genome-wide methylation analyses of primary human leukocyte subsets identifies functionally important cell-type-specific hypomethylated regions.Q41786778
MicroRNA let-7c regulates macrophage polarization.Q41855099
A high-throughput chromatin immunoprecipitation approach reveals principles of dynamic gene regulation in mammalsQ42020759
A unifying model for the selective regulation of inducible transcription by CpG islands and nucleosome remodelingQ42252373
Histone deacetylase inhibitors repress macrophage migration inhibitory factor (MIF) expression by targeting MIF gene transcription through a local chromatin deacetylation.Q42459712
Roles of histone deacetylases in epigenetic regulation: emerging paradigms from studies with inhibitorsQ42555454
Remodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription.Q42972194
Identification and characterization of enhancers controlling the inflammatory gene expression program in macrophages.Q43141233
Differential effects of selective HDAC inhibitors on macrophage inflammatory responses to the Toll-like receptor 4 agonist LPS.Q43143715
Histone deacetylase inhibitors impair innate immune responses to Toll-like receptor agonists and to infectionQ44166565
Formation of distinct chromatin conformation signatures epigenetically regulate macrophage activationQ44990722
Histone deacetylase inhibitors suppress immune activation in primary mouse microgliaQ45818902
Differential Promoter Methylation of Macrophage Genes Is Associated With Impaired Vascular Growth in Ischemic Muscles of Hyperlipidemic and Type 2 Diabetic Mice: Genome-Wide Promoter Methylation StudyQ45876930
Latent enhancers activated by stimulation in differentiated cellsQ46305342
The response of secondary genes to lipopolysaccharides in macrophages depends on histone deacetylase and phosphorylation of C/EBPβ.Q46324488
The histone methyltransferase Wbp7 controls macrophage function through GPI glycolipid anchor synthesisQ47932561
EUKARYOTIC CYTOSINE METHYLTRANSFERASESQ22255656
Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2Q24306181
Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1Q24316558
HDAC2 deacetylates class II transactivator and suppresses its activity in macrophages and smooth muscle cellsQ24319104
Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosineQ24614582
Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identitiesQ24617969
Histone H3K27ac separates active from poised enhancers and predicts developmental stateQ24628758
Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNAQ24632387
Tissue-resident macrophagesQ26991488
A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage responseQ27670940
Obesity is associated with macrophage accumulation in adipose tissueQ27860976
Histone modifications at human enhancers reflect global cell-type-specific gene expressionQ28238467
Histone deacetylase 7 promotes Toll-like receptor 4-dependent proinflammatory gene expression in macrophagesQ28294510
Histone deacetylase isoforms regulate innate immune responses by deacetylating mitogen-activated protein kinase phosphatase-1Q28304803
Histone methyltransferase Ash1l suppresses interleukin-6 production and inflammatory autoimmune diseases by inducing the ubiquitin-editing enzyme A20Q28508566
SIRT1 suppresses activator protein-1 transcriptional activity and cyclooxygenase-2 expression in macrophagesQ28509650
Role of SIRT1 in regulation of LPS- or two ethanol metabolites-induced TNF-alpha production in cultured macrophage cell linesQ28568728
A chromatin landmark and transcription initiation at most promoters in human cellsQ29547180
Macrophage plasticity and polarization: in vivo veritasQ29547620
Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytesQ29547633
Obesity induces a phenotypic switch in adipose tissue macrophage polarizationQ29547686
Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigmQ29614349
The M1 and M2 paradigm of macrophage activation: time for reassessmentQ29615845
Conserved role of intragenic DNA methylation in regulating alternative promotersQ29616289
Histone acetyltransferase complexes: one size doesn't fit allQ29620006
Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophagesQ29620142
Protective and pathogenic functions of macrophage subsetsQ29620351
Loss of Tet enzymes compromises proper differentiation of embryonic stem cellsQ33673552
SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivityQ33727409
Jmjd3-mediated epigenetic regulation of inflammatory cytokine gene expression in serum amyloid A-stimulated macrophages.Q33922619
SIRT2 deficiency modulates macrophage polarization and susceptibility to experimental colitisQ33968456
Tissue-specific signals control reversible program of localization and functional polarization of macrophagesQ34065482
Mechanisms establishing TLR4-responsive activation states of inflammatory response genes.Q34102791
SIRT1 decreases Lox-1-mediated foam cell formation in atherogenesisQ34123761
Myeloid deletion of SIRT1 induces inflammatory signaling in response to environmental stress.Q34178034
A trio of microRNAs that control Toll-like receptor signallingQ34190736
Histone deacetylase 9 represses cholesterol efflux and alternatively activated macrophages in atherosclerosis developmentQ34440353
Environment drives selection and function of enhancers controlling tissue-specific macrophage identitiesQ34452301
Inhibiting DNA Methylation by 5-Aza-2'-deoxycytidine ameliorates atherosclerosis through suppressing macrophage inflammation.Q34551679
MicroRNA-124 promotes microglia quiescence and suppresses EAE by deactivating macrophages via the C/EBP-α-PU.1 pathway.Q34606028
Transcriptome-based network analysis reveals a spectrum model of human macrophage activation.Q34659689
Macrophages: development and tissue specializationQ34669239
Proteomic changes induced by histone demethylase JMJD3 in TNF alpha-treated human monocytic (THP-1) cellsQ34742280
PU.1 and C/EBP(alpha) synergistically program distinct response to NF-kappaB activation through establishing monocyte specific enhancersQ34750033
MicroRNA-155 regulates inflammatory cytokine production in tumor-associated macrophages via targeting C/EBPbetaQ35011103
Cytokine induced phenotypic and epigenetic signatures are key to establishing specific macrophage phenotypesQ35035956
Genome-wide analysis of antiviral signature genes in porcine macrophages at different activation statusesQ35088187
The histone methyltransferase Smyd2 is a negative regulator of macrophage activation by suppressing interleukin 6 (IL-6) and tumor necrosis factor α (TNF-α) productionQ35126599
HDAC inhibition prevents white matter injury by modulating microglia/macrophage polarization through the GSK3β/PTEN/Akt axis.Q35157022
Epigenetic changes in bone marrow progenitor cells influence the inflammatory phenotype and alter wound healing in type 2 diabetes.Q35220547
Differential requirement of histone acetylase and deacetylase activities for IRF5-mediated proinflammatory cytokine expressionQ35599579
Tissue-resident macrophage enhancer landscapes are shaped by the local microenvironment.Q35623089
Histone deacetylase 3 is an epigenomic brake in macrophage alternative activation.Q35624730
Epigenetic Control of Macrophage Shape Transition towards an Atypical Elongated Phenotype by Histone Deacetylase ActivityQ35702406
Alternatively activated macrophages during parasite infectionsQ35702740
Histone H3 lysine 9 di-methylation as an epigenetic signature of the interferon responseQ35894144
Regulation of monocyte functional heterogeneity by miR-146a and RelbQ35906690
Epigenetic Modulation of Microglial Inflammatory Gene Loci in Helminth-Induced Immune Suppression: Implications for Immune Regulation in NeurocysticercosisQ36003478
Identifying functional microRNAs in macrophages with polarized phenotypesQ36052406
Requirement for the histone deacetylase Hdac3 for the inflammatory gene expression program in macrophagesQ36342694
Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6Q36420383
MicroRNAs in immune response and macrophage polarization.Q36547119
The NAD-dependent deacetylase sirtuin 2 is a suppressor of microglial activation and brain inflammation.Q37217396
TETonic shift: biological roles of TET proteins in DNA demethylation and transcriptionQ37244379
Jmjd3 contributes to the control of gene expression in LPS-activated macrophagesQ37362954
Epigenetic regulation of the alternatively activated macrophage phenotypeQ37381695
Immediate mediators of the inflammatory response are poised for gene activation through RNA polymerase II stalling.Q37416607
Jmjd3 is essential for the epigenetic modulation of microglia phenotypes in the immune pathogenesis of Parkinson's diseaseQ37578801
The histone deacetylase HDAC11 regulates the expression of interleukin 10 and immune toleranceQ37586967
The signal transducers Stat1 and Stat3 and their novel target Jmjd3 drive the expression of inflammatory genes in microgliaQ37614513
Transcriptional control of the inflammatory responseQ37622051
Epigenetic regulation of macrophage polarization by DNA methyltransferase 3b.Q37670092
Selective transcription in response to an inflammatory stimulusQ37715321
Histone deacetylase inhibitor LAQ824 augments inflammatory responses in macrophages through transcriptional regulation of IL-10.Q37721519
Specialized chromatin patterns in the control of inflammatory gene expressionQ37790646
Histone arginine methylationQ37809211
Transcriptional control of macrophage diversity and specializationQ37939620
Lysine methylation: beyond histonesQ37970950
Transcriptional control of macrophage polarizationQ38103800
Deciphering cis-regulatory control in inflammatory cellsQ38104721
Epigenomic control of the innate immune responseQ38118486
Macrophage polarization and function with emphasis on the evolving roles of coordinated regulation of cellular signaling pathwaysQ38162005
Inhibiting epigenetic enzymes to improve atherogenic macrophage functions.Q38935747
SOCS1 hypermethylation mediated by DNMT1 is associated with lipopolysaccharide-induced inflammatory cytokines in macrophagesQ39033223
Targeting macrophage Histone deacetylase 3 stabilizes atherosclerotic lesions.Q39162364
Control of inducible gene expression by signal-dependent transcriptional elongationQ39285490
Control of proinflammatory gene programs by regulated trimethylation and demethylation of histone H4K20.Q39291348
Cell-type-specific control of enhancer activity by H3K9 trimethylationQ39341916
IL-2 and GM-CSF are regulated by DNA demethylation during activation of T cells, B cells and macrophagesQ39386252
Gene networking and inflammatory pathway analysis in a JMJD3 knockdown human monocytic cell lineQ39410846
Histone deacetylase inhibition by sodium valproate regulates polarization of macrophage subsetsQ39447956
The interleukin 13 (IL-13) pathway in human macrophages is modulated by microRNA-155 via direct targeting of interleukin 13 receptor alpha1 (IL13Ralpha1).Q39628899
A feed-forward circuit controlling inducible NF-κB target gene activation by promoter histone demethylationQ39657007
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectinflammationQ101991
macrophageQ184204
regulation of gene expressionQ411391
cellQ7868
cell biologyQ7141
genetic epigenesisQ64443099
hemic and immune systemsQ70202933
P304page(s)6591703
P577publication date2016-01-01
2016-04-10
P1433published inMediators of InflammationQ2144494
P1476titleEpigenetic Control of Macrophage Polarisation and Soluble Mediator Gene Expression during Inflammation
P478volume2016

Reverse relations

cites work (P2860)
Q99711618Changes in H3K27ac at Gene Regulatory Regions in Porcine Alveolar Macrophages Following LPS or PolyIC Exposure
Q48194888Class I histone deacetylase inhibition improves pancreatitis outcome by limiting leukocyte recruitment and acinar-to-ductal metaplasia
Q58781713Cxxc Finger Protein 1 Positively Regulates GM-CSF-Derived Macrophage Phagocytosis Through Csf2rα-Mediated Signaling
Q55266134Epigenetic control of macrophage polarization: implications for targeting tumor-associated macrophages.
Q88453278Epigenetics of Aberrant Cardiac Wound Healing
Q28070238Extrinsic and Intrinsic Regulation of Axon Regeneration by MicroRNAs after Spinal Cord Injury
Q39271667Macrophage Differentiation in Normal and Accelerated Wound Healing
Q48598698Macrophages: Their role, activation and polarization in pulmonary diseases.
Q61449502Myosin 1F Regulates M1-Polarization by Stimulating Intercellular Adhesion in Macrophages
Q37534530Perinatal Arterial Ischemic Stroke Is Associated to Materno-Fetal Immune Activation and Intracranial Arteritis.
Q55033012Reg3β from cardiomyocytes regulated macrophage migration, proliferation and functional skewing in experimental autoimmune myocarditis.
Q38693756Regulation of Microglia and Macrophage Polarization via Apoptosis Signal-Regulating Kinase 1 Silencing after Ischemic/Hypoxic Injury.
Q38968676Regulation of Nitrogen Mustard-Induced Lung Macrophage Activation by Valproic Acid, a Histone Deacetylase Inhibitor
Q39367753Resolution of inflammation in inflammatory bowel disease
Q49352534Sodium valproate modulates immune response by alternative activation of monocyte-derived macrophages in systemic lupus erythematosus.
Q88763807TLR-activated repression of Fe-S cluster biogenesis drives a metabolic shift and alters histone and tubulin acetylation
Q64061544Targeting Microglia and Macrophages: A Potential Treatment Strategy for Multiple Sclerosis
Q94596578The Immunosuppressant Fingolimod (FTY720) for the Treatment of Mechanical Force-Induced Abnormal Scars
Q55492520The Kat in the HAT: The Histone Acetyl Transferase Kat6b (MYST4) Is Downregulated in Murine Macrophages in Response to LPS.
Q90191786The Peroxisome Proliferator-Activated Receptor α- Agonist Gemfibrozil Promotes Defense Against Mycobacterium abscessus Infections
Q60305742Transcriptional profiling identifies novel regulators of macrophage polarization
Q41684073Translational Significance for Tumor Metastasis of Tumor-Associated Macrophages and Epithelial-Mesenchymal Transition
Q91835845Tumor-associated macrophages in tumor metastasis: biological roles and clinical therapeutic applications
Q33802584World Trade Center (WTC) dust exposure in mice is associated with inflammation, oxidative stress and epigenetic changes in the lung

Search more.