Vitamin D-dependent induction of cathelicidin in human macrophages results in cytotoxicity against high-grade B cell lymphoma.

scientific article published on April 2015

Vitamin D-dependent induction of cathelicidin in human macrophages results in cytotoxicity against high-grade B cell lymphoma. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1126/SCITRANSLMED.AAA3230
P8608Fatcat IDrelease_3wkz36ssi5bgvfgfihih6vcb4y
P698PubMed publication ID25855493
P5875ResearchGate publication ID274725802

P50authorChristoph DanielQ47813115
P2093author name stringKerstin Amann
Andreas Mackensen
Bettina Kempkes
Mario Fabri
Dimitrios Mougiakakos
Markus H Hoffmann
Frank Neumann
Fabian Beier
Armin Gerbitz
Maike Büttner
Heiko Bruns
Regina Jitschin
Anna Maurberger
Jörg T Bittenbring
Andreas D Hofmann
Shirin Pasemann
P2860cites workThe 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to knowQ22306208
Human cathelicidin, hCAP-18, is processed to the antimicrobial peptide LL-37 by extracellular cleavage with proteinase 3Q28117302
Cathelicidins, multifunctional peptides of the innate immunityQ28205494
Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3Q28258765
Toll-like receptor triggering of a vitamin D-mediated human antimicrobial responseQ28298985
Tumour-educated macrophages promote tumour progression and metastasisQ29614307
CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humansQ29614348
The pro-inflammatory peptide LL-37 promotes ovarian tumor progression through recruitment of multipotent mesenchymal stromal cells.Q30486489
Real-time attack on single Escherichia coli cells by the human antimicrobial peptide LL-37.Q30499787
Macrophages eliminate circulating tumor cells after monoclonal antibody therapyQ30569758
The host defense peptide cathelicidin is required for NK cell-mediated suppression of tumor growthQ30933550
Alterations in Vitamin D signalling and metabolic pathways in breast cancer progression: a study of VDR, CYP27B1 and CYP24A1 expression in benign and malignant breast lesions.Q33690078
Anti-CD47 antibody synergizes with rituximab to promote phagocytosis and eradicate non-Hodgkin lymphomaQ34144940
Vitamin D insufficiency and prognosis in non-Hodgkin's lymphoma.Q34193968
Transcriptome-based network analysis reveals a spectrum model of human macrophage activation.Q34659689
Osteosarcoma: the addition of muramyl tripeptide to chemotherapy improves overall survival--a report from the Children's Oncology GroupQ34743615
Mitochondrial metabolism and cancerQ35008848
Vitamin D is required for IFN-gamma-mediated antimicrobial activity of human macrophagesQ35715983
Function and therapeutic potential of host defence peptides.Q36231828
The altered tumoricidal capacity of macrophages isolated from tumor-bearing mice is related to reduce expression of the inducible nitric oxide synthase geneQ36366553
The innate mononuclear phagocyte network depletes B lymphocytes through Fc receptor-dependent mechanisms during anti-CD20 antibody immunotherapyQ36402637
Tumour-associated macrophages are a distinct M2 polarised population promoting tumour progression: potential targets of anti-cancer therapyQ36414978
Macrophages as mediators of tumor immunosurveillanceQ36823555
NK cells impede glioblastoma virotherapy through NKp30 and NKp46 natural cytotoxicity receptorsQ36890816
Divergence of macrophage phagocytic and antimicrobial programs in leprosyQ37393776
RNA extraction from archival formalin-fixed paraffin-embedded tissue: a comparison of manual, semiautomated, and fully automated purification methodsQ38420708
Transformations in plasma membranes of cancerous cells and resulting consequences for cation insertion studied with molecular dynamicsQ39121077
Resistance against natural killer cell cytotoxicity: analysis of mechanismsQ40232562
Interleukin-13-regulated M2 macrophages in combination with myeloid suppressor cells block immune surveillance against metastasisQ40339595
Enhanced apoptotic cell clearance capacity and B cell survival factor production by IL-10-activated macrophages: implications for Burkitt's lymphoma.Q40455024
Differential effect of cytokine treatment on Fc alpha receptor I- and Fc gamma receptor I-mediated tumor cytotoxicity by monocyte-derived macrophagesQ40878586
Control of cell growth by c-Myc in the absence of cell divisionQ40919064
Cytotoxicity and apoptosis mediated by two peptides of innate immunityQ40999708
Bacillus Calmette-Guerin (BCG) enhances monocyte- and lymphocyte-mediated bladder tumour cell killing.Q41354177
Molecular profiling reveals a tumor-promoting phenotype of monocytes and macrophages in human cancer progressionQ41750524
CD40 ligand and interferon-γ induce an antimicrobial response against Mycobacterium tuberculosis in human monocytesQ44743430
Analysis of multiple biomarkers shows that lymphoma-associated macrophage (LAM) content is an independent predictor of survival in follicular lymphoma (FL).Q46525283
High numbers of tumor-associated macrophages have an adverse prognostic value that can be circumvented by rituximab in patients with follicular lymphoma enrolled onto the GELA-GOELAMS FL-2000 trial.Q46845329
A high tumor-associated macrophage content predicts favorable outcome in follicular lymphoma patients treated with rituximab and cyclophosphamide-doxorubicin-vincristine-prednisone.Q46972244
Vitamin D deficiency impairs rituximab-mediated cellular cytotoxicity and outcome of patients with diffuse large B-cell lymphoma treated with but not without rituximab.Q53085386
Cd4+ T-cell immune response to large B-cell non-Hodgkin's lymphoma predicts patient outcome.Q53329309
Vitamin D receptor gene polymorphisms and risk of non-Hodgkin's lymphomaQ58419129
P433issue282
P407language of work or nameEnglishQ1860
P921main subjectvitamin DQ175621
P304page(s)282ra47
P577publication date2015-04-01
P1433published inScience Translational MedicineQ1573955
P1476titleVitamin D-dependent induction of cathelicidin in human macrophages results in cytotoxicity against high-grade B cell lymphoma
P478volume7

Reverse relations

cites work (P2860)
Q419275661, 25(OH)2 D3 Induces Reactivation and Death of Kaposi's Sarcoma-Associated Herpesvirus of Primary Effusion Lymphoma cells
Q37406121Calcitriol stimulates gene expression of cathelicidin antimicrobial peptide in breast cancer cells with different phenotype
Q61810406Combination of lenalidomide and vitamin D enhances MOR202-mediated cytotoxicity of macrophages: It takes three to tango
Q51737061Health Risks of Hypovitaminosis D: A Review of New Molecular Insights.
Q88355804Lenalidomide enhances MOR202-dependent macrophage-mediated effector functions via the vitamin D pathway
Q39267549Progress in tumor-associated macrophage (TAM)-targeted therapeutics
Q90077233Remaining challenges in predicting patient outcomes for diffuse large B-cell lymphoma
Q39538318The PD-1/PD-L1 axis contributes to immune metabolic dysfunctions of monocytes in chronic lymphocytic leukemia.
Q90218153Vitamin D Deficiency and Janus kinase 2 V617F Mutation Status in Essential Thrombocythemia and Polycythemia Vera
Q38809673Vitamin D and patients with palliative cancer
Q47260924Vitamin D deficiency and supplementation in patients with aggressive B-cell lymphomas treated with immunochemotherapy.
Q30275725Vitamin D in hematological disorders and malignancies
Q57081044Vitamin D status contributes to the antimicrobial activity of macrophages against Mycobacterium leprae

Search more.