Mechanical ventilation induces IL-4 secretion in lungs and reduces the phagocytic capacity of lung macrophages

scientific article published on 13 November 2017

Mechanical ventilation induces IL-4 secretion in lungs and reduces the phagocytic capacity of lung macrophages is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/INFDIS/JIX573
P698PubMed publication ID29140452

P2093author name stringSurbhi Malhotra-Kumar
Herman Goossens
Philippe G Jorens
Samir Kumar-Singh
Christine Lammens
Kenny Bielen
Jan Boddaert
Bart 's Jongers
P2860cites workGuidelines for the Management of Adults with Hospital-acquired, Ventilator-associated, and Healthcare-associated PneumoniaQ22241905
Sterile post-traumatic immunosuppressionQ26748401
Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome NetworkQ27861021
M-1/M-2 macrophages and the Th1/Th2 paradigmQ28145893
Differentiation of effector CD4 T cell populations (*)Q29614838
Macrophage activation and polarization: nomenclature and experimental guidelinesQ29620642
Alternative activation of macrophages by IL-4 impairs phagocytosis of pathogens but potentiates microbial-induced signalling and cytokine secretionQ33597540
Increased risk of serious pneumococcal disease in patients with asthmaQ33612894
Protective mechanical ventilation in the non-injured lung: review and meta-analysisQ33751999
Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapyQ33828888
Pneumonia in the intensive care unitQ35552807
Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophilsQ36141195
Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activationQ36231523
Stroke-induced immunodeficiency promotes spontaneous bacterial infections and is mediated by sympathetic activation reversal by poststroke T helper cell type 1-like immunostimulationQ36371682
Cytokine profiles as markers of disease severity in sepsis: a multiplex analysisQ36392617
An interleukin 4 (IL-4)-independent pathway for CD4+ T cell IL-4 production is revealed in IL-4 receptor-deficient mice.Q36596732
A mouse model of Acinetobacter baumannii-associated pneumonia using a clinically isolated hypervirulent strainQ37036579
Roles of interleukin-6 in activation of STAT proteins and recruitment of neutrophils during Escherichia coli pneumoniaQ37172129
Injurious ventilatory strategies increase cytokines and c-fos m-RNA expression in an isolated rat lung modelQ37364413
Eosinophils and Th2 immunity: contemporary insightsQ37672261
The Design of Future Pediatric Mechanical Ventilation Trials for Acute Lung InjuryQ37781940
Nosocomial pneumonia in 27 ICUs in Europe: perspectives from the EU-VAP/CAP studyQ38861673
Allergic airway inflammation inhibits pulmonary antibacterial host defenseQ40254150
Type 2 Interleukin-4 Receptor Signaling in Neutrophils Antagonizes Their Expansion and Migration during Infection and Inflammation.Q40606145
Intensive care unit-acquired infections in a tertiary care hospital: An epidemiologic survey and influence on patient outcomesQ40767497
Interleukin 4 Deficiency Reverses Development of Secondary Pseudomonas aeruginosa Pneumonia During Sepsis-Associated ImmunosuppressionQ41609318
Mechanical ventilation strategies in children with acute lung injury: a survey on stated practice pattern*.Q43534233
Mechanical ventilation may increase susceptibility to the development of bacteremiaQ44311432
Dupilumab in persistent asthma with elevated eosinophil levelsQ44480181
Global prospective epidemiologic and surveillance study of ventilator-associated pneumonia due to Pseudomonas aeruginosaQ44540920
Pulmonary vascular dysfunction induced by high tidal volume mechanical ventilation.Q44672224
Mechanical ventilation of healthy rats suppresses peripheral immune functionQ47249101
Allergic airway inflammation and susceptibility to pneumococcal pneumonia in a murine model with real-time in vivo evaluationQ47811956
Mechanical ventilation alters the immune response in children without lung pathology.Q49136526
Asthma as a risk factor for invasive pneumococcal disease.Q50761639
IL-4 induces characteristic Th2 responses even in the combined absence of IL-5, IL-9, and IL-13.Q51708862
T-bet/GATA-3 ratio as a measure of the Th1/Th2 cytokine profile in mixed cell populations: predominant role of GATA-3.Q54756939
P407language of work or nameEnglishQ1860
P921main subjectmechanical ventilationQ3766250
P577publication date2017-11-13
P1433published inJournal of Infectious DiseasesQ4051141
P1476titleMechanical ventilation induces IL-4 secretion in lungs and reduces the phagocytic capacity of lung macrophages

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Q90723370Mechanical Ventilation Impairs IL-17 Cytokine Family Expression in Ventilator-Associated Pneumoniacites workP2860

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