Mammary Gland Involution Provides a Unique Model to Study the TGF-β Cancer Paradox

scientific article published on 13 January 2017

Mammary Gland Involution Provides a Unique Model to Study the TGF-β Cancer Paradox is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.3390/JCM6010010
P932PMC publication ID5294963
P698PubMed publication ID28098775

P50authorNathan PennockQ42771253
Pepper J SchedinQ59160451
P2093author name stringElizabeth Mitchell
Courtney Betts
Qiuchen Guo
P2860cites workTransforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanismQ24600173
Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesisQ24610450
Mammary gland developmentQ24629797
Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestineQ24648636
A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1)Q24677007
Proteolytic activation of latent transforming growth factor-beta from fibroblast-conditioned mediumQ24679838
Involution of the mouse mammary gland is associated with an immune cascade and an acute-phase response, involving LBP, CD14 and STAT3Q24794211
Gene expression profiling of mammary gland development reveals putative roles for death receptors and immune mediators in post-lactational regressionQ24794250
Clinical development of galunisertib (LY2157299 monohydrate), a small molecule inhibitor of transforming growth factor-beta signaling pathwayQ26797238
Platelet-derived CXCL12 regulates monocyte function, survival, differentiation into macrophages and foam cells through differential involvement of CXCR4-CXCR7Q27329947
Complexities of TGF-β targeted cancer therapyQ27693607
The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cellsQ27860620
Mechanisms of TGF-beta signaling from cell membrane to the nucleusQ27860785
Induction of intestinal Th17 cells by segmented filamentous bacteriaQ28131638
IL-13 and TH2 cytokine exposure triggers matrix metalloproteinase 7-mediated Fas ligand cleavage from bronchial epithelial cellsQ39681261
The immune tolerance of cancer is mediated by IDO that is inhibited by COX-2 inhibitors through regulatory T cellsQ39869179
DAP-kinase is a mediator of endoplasmic reticulum stress-induced caspase activation and autophagic cell death.Q39937447
IKKbeta/2 induces TWEAK and apoptosis in mammary epithelial cellsQ40300890
Celecoxib Alters the Intestinal Microbiota and Metabolome in Association with Reducing Polyp BurdenQ40608521
TGF-beta1-mediated fibroblast-myofibroblast terminal differentiation-the role of Smad proteinsQ40676876
Th2 cell membrane factors in association with IL-4 enhance matrix metalloproteinase-1 (MMP-1) while decreasing MMP-9 production by granulocyte-macrophage colony-stimulating factor-differentiated human monocytes.Q40878546
Fibronectin fragments induce MMP activity in mouse mammary epithelial cells: evidence for a role in mammary tissue remodeling.Q40900586
DAP-kinase participates in TNF-alpha- and Fas-induced apoptosis and its function requires the death domainQ40942632
The tumor suppressor Smad4/DPC 4 as a central mediator of Smad functionQ41119639
A phase III study of belagenpumatucel-L, an allogeneic tumour cell vaccine, as maintenance therapy for non-small cell lung cancer.Q41474859
Mechanisms of TGF-beta-induced cell cycle arrestQ41731272
Apoptotic cell death and tissue remodelling during mouse mammary gland involutionQ42462200
Immunosuppression induced by immature dendritic cells is mediated by TGF-beta/IL-10 double-positive CD4+ regulatory T cellsQ42915023
Mechanoregulation of the Myofibroblast in Wound Contraction, Scarring, and Fibrosis: Opportunities for New Therapeutic InterventionQ43159830
Quantitative extracellular matrix proteomics to study mammary and liver tissue microenvironments.Q44638329
CXCL12-CXCR4 promotes proliferation and invasion of pancreatic cancer cellsQ45412550
Transforming growth factor-beta regulates human retinal pigment epithelial cell phagocytosis by influencing a protein kinase C-dependent pathway.Q45937155
Epithelial cells remove apoptotic epithelial cells during post-lactation involution of the mouse mammary glandQ46868007
Transforming growth factor beta3 induces cell death during the first stage of mammary gland involution.Q52167469
Cell death by apoptosis during involution of the lactating breast in mice and rats.Q52487735
Leukemia inhibitory factor induces apoptosis of the mammary epithelial cells and participates in mouse mammary gland involution.Q54096126
Macrophages are crucial for epithelial cell death and adipocyte repopulation during mammary gland involution.Q54336220
Smad4 signalling in T cells is required for suppression of gastrointestinal cancer.Q54462818
Divergent effects of interleukin-4 and interferon-gamma on macrophage-derived chemokine production: an amplification circuit of polarized T helper 2 responsesQ59713952
Programmed cell death during mammary tissue involution induced by weaning, litter removal, and milk stasisQ71556998
Transforming growth factor beta 1 functions in monocytic differentiation of hematopoietic cells through autocrine and paracrine mechanismsQ71804661
Abrogation of TGFbeta signaling in T cells leads to spontaneous T cell differentiation and autoimmune diseaseQ73542905
Mouse mammary gland involution is associated with cytochrome c release and caspase activationQ74014346
TGF-beta induces apoptosis through Smad-mediated expression of DAP-kinaseQ77342591
Elimination of colon cancer in germ-free transforming growth factor beta 1-deficient miceQ78532668
Janus Kinase 1 Is Essential for Inflammatory Cytokine Signaling and Mammary Gland Remodeling.Q37122579
Cancer as an overhealing wound: an old hypothesis revisitedQ37217254
The TGF-beta paradox in human cancer: an updateQ37261631
An indispensable role for the chemokine receptor CCR10 in IgA antibody-secreting cell accumulationQ37357265
TGF-beta regulates in vivo expansion of Foxp3-expressing CD4+CD25+ regulatory T cells responsible for protection against diabetesQ37358159
The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironmentQ37366259
Mechanisms by which the extracellular matrix and integrin signaling act to regulate the switch between tumor suppression and tumor promotionQ37450854
Coordinated regulation of apoptosis and cell proliferation by transforming growth factor beta 1 in cultured uterine epithelial cellsQ37486376
Th17 cytokines and host-pathogen interactions at the mucosa: dichotomies of help and harmQ37576442
Attenuation of TGF-β signaling supports tumor progression of a mesenchymal-like mammary tumor cell line in a syngeneic murine modelQ37626943
Targeting the TGFβ pathway for cancer therapy.Q38274752
Prostaglandin E2 transactivates the colony-stimulating factor-1 receptor and synergizes with colony-stimulating factor-1 in the induction of macrophage migration via the mitogen-activated protein kinase ERK1/2.Q38901572
TGF-β Signaling from Receptors to SmadsQ38906099
Non-steroidal anti-inflammatory drugs target the pro-tumorigenic extracellular matrix of the postpartum mammary glandQ39429471
Altered TGF-β signaling in a subpopulation of human stromal cells promotes prostatic carcinogenesis.Q39595827
Making sense of latent TGFbeta activationQ28217641
Transforming growth factor-beta induces development of the T(H)17 lineageQ28237370
SMAD2, SMAD3 and SMAD4 mutations in colorectal cancerQ28278952
Abnormal lung development and cleft palate in mice lacking TGF-beta 3 indicates defects of epithelial-mesenchymal interactionQ28284617
Transforming growth factor-beta regulation of immune responsesQ28303115
Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-beta1 secretion and the resolution of inflammationQ28344659
Alternatively activated macrophages and collagen remodeling characterize the postpartum involuting mammary gland across speciesQ28576808
Regulated splicing of the fibronectin EDA exon is essential for proper skin wound healing and normal lifespanQ28593378
The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cellsQ29614226
Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAFQ29615685
TGF-beta-induced epithelial to mesenchymal transitionQ29619820
Non-Smad pathways in TGF-beta signalingQ29620040
Molecular mechanism of TGF-beta1-induced apoptosis in HC11 mouse mammary epithelial cells (MEC).Q30830601
Smad3 has a critical role in TGF-beta-mediated growth inhibition and apoptosis in colonic epithelial cellsQ33200320
The miR-424(322)/503 cluster orchestrates remodeling of the epithelium in the involuting mammary gland.Q33588077
Early but not late pregnancy induces lifelong reductions in the proportion of mammary progesterone sensing cells and epithelial Wnt signalingQ33739845
IgA ASC accumulation to the lactating mammary gland is dependent on VCAM-1 and alpha4 integrinsQ33771126
Transforming growth factor beta stimulates mammary adenocarcinoma cell invasion and metastatic potentialQ33825657
Collagen density promotes mammary tumor initiation and progressionQ33845553
Transforming growth factor beta1 suppresses nonmetastatic colon cancer at an early stage of tumorigenesisQ33868837
Alpha-smooth muscle actin expression upregulates fibroblast contractile activityQ33946717
Epithelial to mesenchymal transition by TGFβ-1 induction increases stemness characteristics in primary non small cell lung cancer cell lineQ33955042
Targeted mutations of transforming growth factor-beta genes reveal important roles in mouse development and adult homeostasisQ34098867
Two distinct phases of apoptosis in mammary gland involution: proteinase-independent and -dependent pathways.Q34103424
Cyclooxygenase-2-dependent lymphangiogenesis promotes nodal metastasis of postpartum breast cancerQ34128977
Postpartum mammary gland involution drives progression of ductal carcinoma in situ through collagen and COX-2.Q34206453
TGFβ signaling plays a critical role in promoting alternative macrophage activationQ34306291
Transforming growth factor type beta induces monocyte chemotaxis and growth factor productionQ34339289
A phase I dose-escalation study to a predefined dose of a transforming growth factor-β1 monoclonal antibody (TβM1) in patients with metastatic cancerQ34432864
Stat3 controls cell death during mammary gland involution by regulating uptake of milk fat globules and lysosomal membrane permeabilizationQ34437556
Pregnancy-associated breast cancer and metastasis.Q34504760
Transforming growth factor-beta signaling through the Smad pathway: role in extracellular matrix gene expression and regulationQ34527773
TGF-beta promotes cell death and suppresses lactation during the second stage of mammary involutionQ34571586
Inflammation-mediated genetic and epigenetic alterations drive cancer development in the neighboring epithelium upon stromal abrogation of TGF-β signalingQ34585721
The microRNA 424/503 cluster reduces CDC25A expression during cell cycle arrest imposed by transforming growth factor β in mammary epithelial cellsQ34592870
Cyclooxygenase-2 inhibition blocks M2 macrophage differentiation and suppresses metastasis in murine breast cancer modelQ34718187
T helper 17-associated cytokines are produced during antigen-specific inflammation in the mammary glandQ34733857
Loss of TGF-beta type II receptor in fibroblasts promotes mammary carcinoma growth and invasion through upregulation of TGF-alpha-, MSP- and HGF-mediated signaling networksQ34781947
Rat mammary extracellular matrix composition and response to ibuprofen treatment during postpartum involution by differential GeLC-MS/MS analysis.Q34939050
Wound healing-like immune program facilitates postpartum mammary gland involution and tumor progressionQ35071581
Remodeling of the mammary microenvironment after lactation promotes breast tumor cell metastasis.Q35087966
Efferocytosis produces a prometastatic landscape during postpartum mammary gland involutionQ35140121
Mammary gland involution as an immunotherapeutic target for postpartum breast cancer.Q35186471
Phagocytosis of apoptotic cells and the resolution of inflammationQ35592696
Impaired cell death and mammary gland involution in the absence of Dock1 and Rac1 signaling.Q35679546
Molecular Phenotype of Breast Cancer According to Time Since Last Pregnancy in a Large Cohort of Young WomenQ35820514
Prostaglandin E2 restrains macrophage maturation via E prostanoid receptor 2/protein kinase A signaling.Q35849262
TGF-β promotes heterogeneity and drug resistance in squamous cell carcinomaQ35871985
Loss of one Tgfbr2 allele in fibroblasts promotes metastasis in MMTV: polyoma middle T transgenic and transplant mouse models of mammary tumor progressionQ36026081
Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity.Q36134167
Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activationQ36231523
Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblastsQ36232642
TGF-beta regulation of epithelial cell proliferationQ36351946
Stromelysin-1 regulates adipogenesis during mammary gland involutionQ36375815
Tumor cells convert immature myeloid dendritic cells into TGF-beta-secreting cells inducing CD4+CD25+ regulatory T cell proliferationQ36403539
Mammary epithelial cell phagocytosis downstream of TGF-β3 is characterized by adherens junction reorganizationQ36472463
T-bet and GATA3 orchestrate Th1 and Th2 differentiation through lineage-specific targeting of distal regulatory elements.Q36503230
Transforming growth factor-beta in cancer and metastasisQ36585129
Th17 Cell Induction by Adhesion of Microbes to Intestinal Epithelial Cells.Q36614277
Down-regulation of TGF-beta receptors in human colorectal cancer: implications for cancer developmentQ36620077
COX-2 modulates mammary tumor progression in response to collagen density.Q36715145
Postpartum diagnosis demonstrates a high risk for metastasis and merits an expanded definition of pregnancy-associated breast cancer.Q36718439
Fibroblast differentiation in wound healing and fibrosisQ36729100
Formation and function of the myofibroblast during tissue repairQ36735389
TGF-beta 1 stimulates cultured human fibroblasts to proliferate and produce tissue-like fibroplasia: a fibronectin matrix-dependent eventQ36844219
CXCL12/CXCR4 axis induces proliferation and invasion in human endometrial cancerQ36879569
Induction of apoptosis in cultured hepatocytes and in regressing liver by transforming growth factor beta 1Q37058555
Induction of TGF-β1 synthesis by macrophages in response to apoptotic cells requires activation of the scavenger receptor CD36Q37066594
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P577publication date2017-01-13
P1433published inJournal of Clinical MedicineQ27724774
P1476titleMammary Gland Involution Provides a Unique Model to Study the TGF-β Cancer Paradox
P478volume6

Reverse relations

cites work (P2860)
Q91964812Abrupt involution induces inflammation, estrogenic signaling, and hyperplasia linking lack of breastfeeding with increased risk of breast cancer
Q89714669Breast tumor tissue inflammation but not lobular involution is associated with survival among breast cancer patients in the Multiethnic Cohort
Q100752680Characterization of weaning-induced breast involution in women: implications for young women's breast cancer
Q100512247Concepts of extracellular matrix remodelling in tumour progression and metastasis
Q47839645Linking Race, Cancer Outcomes, and Tissue Repair.
Q93193962Molecular mechanism of mammary gland involution: An update
Q92005259NHERF1 Is Required for Localization of PMCA2 and Suppression of Early Involution in the Female Lactating Mammary Gland
Q64237753Studies of postpartum mammary gland involution reveal novel pro-metastatic mechanisms
Q52714767ZnT2 is critical for lysosome acidification and biogenesis during mammary gland involution.

Search more.