Addition of cetuximab to chemotherapy as first-line treatment for KRAS wild-type metastatic colorectal cancer: pooled analysis of the CRYSTAL and OPUS randomised clinical trials

scientific article

Addition of cetuximab to chemotherapy as first-line treatment for KRAS wild-type metastatic colorectal cancer: pooled analysis of the CRYSTAL and OPUS randomised clinical trials is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.EJCA.2012.02.057
P698PubMed publication ID22446022

P50authorCarsten BokemeyerQ1045499
Eric Van CutsemQ37068027
Claus-Henning KöhneQ37068153
Fortunato CiardielloQ43184447
P2093author name stringIlhan Celik
Philippe Rougier
Michael Schlichting
Steffen Heeger
P433issue10
P921main subjectcetuximabQ420296
chemotherapyQ974135
colorectal cancerQ188874
colorectal carcinomaQ25493920
metastatic colon cancerQ108566365
P304page(s)1466-1475
P577publication date2012-03-23
P1433published inEuropean Journal of CancerQ332260
P1476titleAddition of cetuximab to chemotherapy as first-line treatment for KRAS wild-type metastatic colorectal cancer: pooled analysis of the CRYSTAL and OPUS randomised clinical trials
P478volume48

Reverse relations

cites work (P2860)
Q38584379A 2015 update on predictive molecular pathology and its role in targeted cancer therapy: a review focussing on clinical relevance
Q26775711A Comprehensive Review of Clinical Trials on EGFR Inhibitors Such as Cetuximab and Panitumumab as Monotherapy and in Combination for Treatment of Metastatic Colorectal Cancer
Q38674714A Review of Clinical Studies and Practical Guide for the Administration of Triplet Chemotherapy Regimens with Bevacizumab in First-line Metastatic Colorectal Cancer
Q35187723A mutant BRAF V600E-specific immunohistochemical assay: correlation with molecular mutation status and clinical outcome in colorectal cancer
Q90843197A practical guide to biomarkers for the evaluation of colorectal cancer
Q34580450A prospective multicenter phase II study evaluating multimodality treatment of patients with peritoneal carcinomatosis arising from appendiceal and colorectal cancer: the COMBATAC trial
Q38943220Advances in Biomarkers: Going Beyond the Carcinoembryonic Antigen.
Q26751344Advances in targeted and immunobased therapies for colorectal cancer in the genomic era
Q53490424An Unusual Combination: KRAS and BRAF Co-mutated Metastatic Colorectal Cancer.
Q38650454Anti-EGFR monoclonal antibody panitumumab for the treatment of patients with metastatic colorectal cancer: an overview of current practice and future perspectives.
Q97525750Anti-EGFR therapy in metastatic colorectal cancer: mechanisms and potential regimens of drug resistance
Q37611840Anti-tumor effects of an oncolytic adenovirus expressing hemagglutinin-neuraminidase of Newcastle disease virus in vitro and in vivo
Q38214511Antibodies directed against receptor tyrosine kinases: current and future strategies to fight cancer
Q36321184Antiepidermal growth factor receptor monoclonal antibodies: applications in colorectal cancer
Q58053523Are Gene Signatures Ready for Use in the Selection of Patients for Adjuvant Treatment?
Q36334196Assessment of frequency and severity of hypomagnesemia in patients with metastatic colorectal cancer treated with cetuximab, with a review of the literature.
Q59329181Association Between c-Myc and Colorectal Cancer Prognosis: A Meta-Analysis
Q34759064Association between molecular subtypes of colorectal cancer and patient survival
Q39703372Association of CpG island methylator phenotype and EREG/AREG methylation and expression in colorectal cancer.
Q55090775BRAF Inhibitors for BRAF V600E Mutant Colorectal Cancers: Literature Survey and Case Report.
Q97525759BRAF and KRAS mutations in metastatic colorectal cancer: future perspectives for personalized therapy
Q38652005BRAF in metastatic colorectal cancer: the future starts now.
Q26772276BRAF mutant colorectal cancer as a distinct subset of colorectal cancer: clinical characteristics, clinical behavior, and response to targeted therapies
Q47767987BRAF mutant colorectal cancer: prognosis, treatment, and new perspectives
Q40823445BRAF mutation may have different prognostic implications in early- and late-stage colorectal cancer
Q36807082BRAF mutations in colorectal cancer: clinical relevance and role in targeted therapy
Q38953687BRAF-Mutated Colorectal Cancer: What Is the Optimal Strategy for Treatment?
Q89736584Be Active or Not: the Relative Contribution of Active and Passive Tumor Targeting of Nanomaterials
Q38238740Beyond KRAS: Predictive factors of the efficacy of anti-EGFR monoclonal antibodies in the treatment of metastatic colorectal cancer.
Q55518414Biologic Response of Colorectal Cancer Xenograft Tumors to Sequential Treatment with Panitumumab and Bevacizumab.
Q37114675Biomarker in Colorectal Cancer.
Q91754859Biomarker-guided therapy for colorectal cancer: strength in complexity
Q60046390Biomarkers in colorectal cancer: Current clinical utility and future perspectives
Q37609130Biomarkers in precision therapy in colorectal cancer.
Q26766535Biomarkers predicting resistance to epidermal growth factor receptor-targeted therapy in metastatic colorectal cancer with wild-type KRAS
Q34052270Biweekly cetuximab and first-line chemotherapy in chinese patients with k-ras wild-type colorectal cancers
Q37706705Building personalized treatment plans for early-stage colorectal cancer patients
Q27010961Cancer concepts and principles: primer for the interventional oncologist-part II
Q33580500Cetuximab-induced MET activation acts as a novel resistance mechanism in colon cancer cells
Q47164059Challenges and future of biomarker tests in the era of precision oncology: Can we rely on immunohistochemistry (IHC) or fluorescence in situ hybridization (FISH) to select the optimal patients for matched therapy?
Q92451360Characteristics of BRAF V600E Mutant, Deficient Mismatch Repair/Proficient Mismatch Repair, Metastatic Colorectal Cancer: A Multicenter Series of 287 Patients
Q37530472Chemotherapy plus bevacizumab versus chemotherapy plus cetuximab as first-line treatment for patients with metastatic colorectal cancer: Results of a registry-based cohort analysis.
Q54288887Circulating tumor cells as a longitudinal biomarker in patients with advanced chemorefractory, RAS-BRAF wild-type colorectal cancer receiving cetuximab or panitumumab.
Q38800475Clinical Applications of Liquid Biopsies in Gastrointestinal Oncology
Q55385744Clinical activity and tolerability of FOLFIRI and cetuximab in elderly patients with metastatic colorectal cancer in the CAPRI-GOIM first-line trial.
Q97884672Clinical complete regression after local radiotherapy combined with chemotherapy for stage IV rectal cancer: A case report
Q92514791Clinicopathologic features and prognostic value of KRAS, NRAS and BRAF mutations and DNA mismatch repair status: A single-center retrospective study of 1,834 Chinese patients with Stage I-IV colorectal cancer
Q42690646Clinicopathologic features and treatment efficacy of Chinese patients with BRAF-mutated metastatic colorectal cancer: a retrospective observational study
Q28647615Colorectal Cancer Classification and Cell Heterogeneity: A Systems Oncology Approach
Q57178427Colorectal Liver Metastases: Does the Future of Precision Medicine Lie in Genetic Testing?
Q90834049Colorectal cancer
Q38124901Colorectal cancer diagnostics: biomarkers, cell-free DNA, circulating tumor cells and defining heterogeneous populations by single-cell analysis
Q26768427Colorectal cancer tumour markers and biomarkers: Recent therapeutic advances
Q47303076Combination Cancer Therapy Can Confer Benefit via Patient-to-Patient Variability without Drug Additivity or Synergy
Q27853216Combined BRAF and MEK Inhibition With Dabrafenib and Trametinib in BRAF V600-Mutant Colorectal Cancer.
Q36051757Comet assay measures of DNA damage as biomarkers of irinotecan response in colorectal cancer in vitro and in vivo
Q44193651Comparison of COBAS 4800 KRAS, TaqMan PCR and high resolution melting PCR assays for the detection of KRAS somatic mutations in formalin-fixed paraffin embedded colorectal carcinomas.
Q48272442Comparison of cetuximab to bevacizumab as the first-line bio-chemotherapy for patients with metastatic colorectal cancer: superior progression-free survival is restricted to patients with measurable tumors and objective tumor response--a retrospecti
Q41918653Conversion Therapy Using mFOLFOX6 With Panitumumab for Unresectable Liver Metastases From Multiple Colorectal Cancers With Familial Adenomatous Polyposis
Q41116981Conversion to resection of liver metastases from colorectal cancer with hepatic artery infusion of combined chemotherapy and systemic cetuximab in multicenter trial OPTILIV.
Q38810330Cost-effectiveness of cetuximab for colorectal cancer
Q38117718Cure for peritoneal metastases? An evidence-based review
Q93039741Current Development of Monoclonal Antibodies in Cancer Therapy
Q43492228Current and future biomarkers in colorectal cancer
Q90437250Current challenges in the implementation of precision oncology for the management of metastatic colorectal cancer
Q38538213Current controversies in the management of metastatic colorectal cancer
Q38241395Current opinion on optimal systemic treatment for metastatic colorectal cancer: outcome of the ACTG/AGITG expert meeting ECCO 2013.
Q38101612Current opinion on optimal treatment for colorectal cancer.
Q26740067Current targeted therapies in the treatment of advanced colorectal cancer: a review
Q34819493Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy improves survival of patients with peritoneal carcinomatosis from colorectal cancer: a case-control study from a Chinese center
Q40428222Differential Radiographic Appearance of BRAF V600E-Mutant Metastatic Colorectal Cancer in Patients Matched by Primary Tumor Location
Q35773077Distinct gene expression profiles of proximal and distal colorectal cancer: implications for cytotoxic and targeted therapy.
Q43626555Does a higher response rate to systemic chemotherapy result in a higher resection rate in patients with initially unresectable colorectal liver metastases?
Q90190600EGFR Protein Expression in KRAS Wild-Type Metastatic Colorectal Cancer Is Another Negative Predictive Factor of the Cetuximab Therapy
Q35107670EGFR-directed antibodies increase the risk of severe infection in cancer patients
Q57758061ESMO Consensus Guidelines for management of patients with colon and rectal cancer. A personalized approach to clinical decision making
Q38175833Effect of BRAF V600E mutation on tumor response of anti-EGFR monoclonal antibodies for first-line metastatic colorectal cancer treatment: a meta-analysis of randomized studies
Q37005364Effect of RAS status on anti-EGFR monoclonal antibodies + 5-FU infusion-based chemotherapy in first-line treatment of metastatic colorectal cancer: A meta-analysis
Q26777704Effectiveness and safety of monoclonal antibodies for metastatic colorectal cancer treatment: systematic review and meta-analysis
Q47870743Effects of metformin on colorectal cancer stem cells depend on alterations in glutamine metabolism
Q92088491Efficacy and safety of bevacizumab-based maintenance therapy in metastatic colorectal cancer: A meta-analysis
Q39694235Efficacy of cetuximab-based chemotherapy in metastatic colorectal cancer according to RAS and BRAF mutation subgroups: A meta-analysis
Q53548338Elucidating the prognostic significance of KRAS, NRAS, BRAF and PIK3CA mutations in Chinese patients with metastatic colorectal cancer.
Q52599786Emerging treatment options for BRAF-mutant colorectal cancer.
Q35828499Epidermal growth factor receptor mutation mediates cross-resistance to panitumumab and cetuximab in gastrointestinal cancer.
Q35834442Evaluation in usual practice of the bevacizumab-FOLFIRI combination for the first-line treatment of patients with unresectable metastatic colorectal cancer treated in 2006: focus on resected patients and oncogeriatrics: AVASTIN OUEST cohort of the O
Q28074285Evaluation of Cysteinyl Leukotriene Signaling as a Therapeutic Target for Colorectal Cancer
Q35102475Expanded RAS: refining the patient population
Q92231021Exploring the best treatment options for BRAF-mutant metastatic colon cancer
Q36287075Expression of pEGFR and pAKT as response-predictive biomarkers for RAS wild-type patients to anti-EGFR monoclonal antibodies in metastatic colorectal cancers
Q26798284Extended RAS analysis for anti-epidermal growth factor therapy in patients with metastatic colorectal cancer
Q35587176Extended RAS and BRAF Mutation Analysis Using Next-Generation Sequencing
Q52666988FOLFOX plus anti-epidermal growth factor receptor (EGFR) monoclonal antibody (mAb) is an effective first-line treatment for patients with RAS-wild left-sided metastatic colorectal cancer: A meta-analysis.
Q36857518Feasibility of proposed single-nucleotide polymorphisms as predictive markers for targeted regimens in metastatic colorectal cancer
Q55154019First Biologic Drug in the Treatment of RAS Wild-Type Metastatic Colorectal Cancer: Anti-EGFR or Bevacizumab? Results From a Meta-Analysis.
Q90450020First-line molecular therapies in the treatment of metastatic colorectal cancer - a literature-based review of phases II and III trials
Q64238010G12V Mutation is an Adverse Prognostic Factor of Chinese Gastric Cancer Patients
Q35137474Gain of ALK gene copy number may predict lack of benefit from anti-EGFR treatment in patients with advanced colorectal cancer and RAS-RAF-PI3KCA wild-type status
Q47673133Gastrointestinal Malignancy: Genetic Implications to Clinical Applications
Q95818304Genetic targeting of B-RafV600E affects survival and proliferation and identifies selective agents against BRAF-mutant colorectal cancer cells
Q91743984Genomic and Transcriptomic Determinants of Therapy Resistance and Immune Landscape Evolution during Anti-EGFR Treatment in Colorectal Cancer
Q39023377Germline polymorphisms as biomarkers of tumor response in colorectal cancer patients treated with anti-EGFR monoclonal antibodies: a systematic review and meta-analysis.
Q35229101Global impact of KRAS mutation patterns in FOLFOX treated metastatic colorectal cancer
Q38894659HDAC Inhibition Overcomes Acute Resistance to MEK Inhibition in BRAF-Mutant Colorectal Cancer by Downregulation of c-FLIPL
Q33858231Heterogeneity in the colorectal primary tumor and the synchronous resected liver metastases prior to and after treatment with an anti-EGFR monoclonal antibody
Q36238965How many diseases are colorectal cancer?
Q60939319How the V600E Mutation Defines a Distinct Subgroup of Colorectal Cancer: Molecular and Clinical Implications
Q27026516How to select the optimal treatment for first line metastatic colorectal cancer
Q48034907Identification of a novel metabolic-related mutation (IDH1) in metastatic pancreatic cancer
Q27693248Identification of clinically relevant molecular subtypes in colorectal cancer: the dawning of a new era
Q35030421Identification of the angiogenic gene signature induced by EGF and hypoxia in colorectal cancer.
Q43439313Immunohistochemistry using the BRAF V600E mutation-specific monoclonal antibody VE1 is not a useful surrogate for genotyping in colorectal adenocarcinoma
Q57800147Impact of Delayed Addition of Anti-EGFR Monoclonal Antibodies on the Outcome of First-Line Therapy in Metastatic Colorectal Cancer Patients: a Retrospective Registry-Based Analysis
Q38183447Impact of cetuximab in current treatment of metastatic colorectal cancer.
Q90428458Improving patient selection for adjuvant therapy in high-risk renal cell carcinoma
Q48585692Incorporating BEAMing technology as a liquid biopsy into clinical practice for the management of colorectal cancer patients: an expert taskforce review
Q38545768Incorporating traditional and emerging biomarkers in the clinical management of metastatic colorectal cancer.
Q44069776Interpreting the clinical utility of a pharmacogenomic marker based on observational association studies
Q96166477Intra-arterial hepatic beads loaded with irinotecan (DEBIRI) with mFOLFOX6 in unresectable liver metastases from colorectal cancer: a Phase 2 study
Q35009259Intraoperative blood loss independently predicts survival and recurrence after resection of colorectal cancer liver metastasis
Q36936979Is early response by (18)F-2-fluoro-2-deoxy-D-glucose positron emission tomography-computed tomography a predictor of long-term outcome in patients with metastatic colorectal cancer?
Q55071072KRAS and BRAF mutations in anal carcinoma.
Q41136513KRAS as a predictor of poor prognosis and benefit from postoperative FOLFOX chemotherapy in patients with stage II and III colorectal cancer
Q27852414KRAS as prognostic biomarker in metastatic colorectal cancer patients treated with bevacizumab: a pooled analysis of 12 published trials
Q37495964KRAS early testing: consensus initiative and cost-effectiveness evaluation for metastatic colorectal patients in an Italian setting
Q90279899KRAS, NRAS, BRAF, HER2 and microsatellite instability in metastatic colorectal cancer - practical implications for the clinician
Q36889656KRAS-mutation status in relation to colorectal cancer survival: the joint impact of correlated tumour markers
Q44422760Landmark study raises the bar for interventional oncology
Q38783966MGMT in colorectal cancer: a promising component of personalized treatment
Q28076490Mechanisms of resistance to anti-epidermal growth factor receptor inhibitors in metastatic colorectal cancer
Q27027648Meta-analysis of BRAF mutation as a predictive biomarker of benefit from anti-EGFR monoclonal antibody therapy for RAS wild-type metastatic colorectal cancer
Q37481713Metastatic colorectal cancer-prolonging overall survival with targeted therapies
Q33654609Microenvironmental regulation of therapeutic response in cancer
Q37471795Microsatellite instability and B-type Raf proto-oncogene mutation in colorectal cancer: Clinicopathological characteristics and effects on survival
Q41175542Microvessel density and endothelial cell proliferation levels in colorectal liver metastases from patients given neo-adjuvant cytotoxic chemotherapy and bevacizumab
Q28070038Molecular Diagnostics for Precision Medicine in Colorectal Cancer: Current Status and Future Perspective
Q91599765Molecular Profiles Guide Colorectal Cancer Treatment
Q47439465Molecular basis for necitumumab inhibition of EGFR variants associated with acquired cetuximab resistance
Q64071667Molecular biomarkers and histological parameters impact on survival and response to first- line systemic therapy of metastatic colorectal cancer patients
Q59794745Molecular characterization and biomarker identification in colorectal cancer: Toward realization of the precision medicine dream
Q37642614Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors.
Q38258269Molecular markers for colon diagnosis, prognosis and targeted therapy
Q38938329Molecular markers of prognosis and therapeutic targets in metastatic colorectal cancer.
Q26778296Molecular profiling in the treatment of colorectal cancer: focus on regorafenib
Q37525272Molecular spectrum of KRAS, NRAS, BRAF, PIK3CA, TP53, and APC somatic gene mutations in Arab patients with colorectal cancer: determination of frequency and distribution pattern.
Q64935738Molecular targeted therapy of BRAF-mutant colorectal cancer.
Q26828735Molecularly targeted drugs for metastatic colorectal cancer
Q35807573Multicenter Phase II study of FOLFOX or biweekly XELOX and Erbitux (cetuximab) as first-line therapy in patients with wild-type KRAS/BRAF metastatic colorectal cancer: The FLEET study.
Q35224224Multicenter phase II study of FOLFIRI plus bevacizumab after discontinuation of oxaliplatin-based regimen for advanced or recurrent colorectal cancer (CR0802)
Q26796348New findings on primary and acquired resistance to anti-EGFR therapy in metastatic colorectal cancer: do all roads lead to RAS?
Q26772277New therapeutic strategies for BRAF mutant colorectal cancers
Q57739115Noninvasive Biomarkers of Colorectal Cancer: Role in Diagnosis and Personalised Treatment Perspectives
Q38800472Novel Therapies in Development for Metastatic Colorectal Cancer
Q26769884Novel cancer antigens for personalized immunotherapies: latest evidence and clinical potential
Q38799963Novel investigational therapies for treating biliary tract carcinoma
Q37429996Observational study on quality of life, safety, and effectiveness of first-line cetuximab plus chemotherapy in KRAS wild-type metastatic colorectal cancer patients: the ObservEr Study
Q37231968Optimization of routine KRAS mutation PCR-based testing procedure for rational individualized first-line-targeted therapy selection in metastatic colorectal cancer
Q30235144Overall survival of patients with KRAS wild-type tumor treated with FOLFOX/FORFIRI±cetuximab as the first-line treatment for metastatic colorectal cancer: A meta-analysis
Q61816598Overcoming Intrinsic and Acquired Cetuximab Resistance in RAS Wild-Type Colorectal Cancer: An In Vitro Study on the Expression of HER Receptors and the Potential of Afatinib
Q38084846PI3K and MEK inhibitor combinations: examining the evidence in selected tumor types
Q40235695PIK3CA Mutations Contribute to Acquired Cetuximab Resistance in Patients with Metastatic Colorectal Cancer.
Q31168985Palliative care and end-stage colorectal cancer management: the surgeon meets the oncologist
Q38167675Palliative treatment of metastatic colorectal cancer: what is the optimal approach?
Q38193195Panitumumab : leading to better overall survival in metastatic colorectal cancer?
Q38562067Panitumumab for the treatment of metastatic colorectal cancer: a review.
Q47134024Panitumumab use in metastatic colorectal cancer and patterns of RAS testing: results from a Europe-wide physician survey and medical records review
Q33947880Patient and tumor characteristics and BRAF and KRAS mutations in colon cancer, NCCTG/Alliance N0147
Q43136720Performance of a novel KRAS mutation assay for formalin-fixed paraffin embedded tissues of colorectal cancer
Q33838073Peritoneal metastases of lower gastrointestinal tract origin:a comparative study of patient outcomes following cytoreduction and intraperitoneal chemotherapy
Q39453553Personalized and precision medicine: integrating genomics into treatment decisions in gastrointestinal malignancies
Q38232150Personalized oncology: genomic screening in phase 1.
Q26822817Personalized treatment for advanced colorectal cancer: KRAS and beyond
Q38296666Personalized treatment is better than one treatment fits all in the management of patients with mCRC: a consensus statement
Q36086845Phase I study of FOLFIRI plus pimasertib as second-line treatment for KRAS-mutated metastatic colorectal cancer
Q99635705Phase II study on first-line treatment of NIVolumab in combination with folfoxiri/bevacizumab in patients with Advanced COloRectal cancer RAS or BRAF mutated - NIVACOR trial (GOIRC-03-2018)
Q27853121Pilot trial of combined BRAF and EGFR inhibition in BRAF-mutant metastatic colorectal cancer patients
Q38805790Potential biomarkers for anti-EGFR therapy in metastatic colorectal cancer
Q38271031Pragmatic issues in biomarker evaluation for targeted therapies in cancer
Q26795558Precision medicine in colorectal cancer: the molecular profile alters treatment strategies
Q26738655Predictive Biomarkers in Colorectal Cancer: From the Single Therapeutic Target to a Plethora of Options
Q37697540Predictive and prognostic biomarkers with therapeutic targets in advanced colorectal cancer.
Q90448739Preoperative chemotherapy in colorectal cancer patients with synchronous liver metastasis
Q38648300Present and future of metastatic colorectal cancer treatment: A review of new candidate targets
Q27015224Primary and acquired resistance to EGFR-targeted therapies in colorectal cancer: impact on future treatment strategies
Q41410508Prognostic Value of BRAF, PI3K, PTEN, EGFR Copy Number, Amphiregulin and Epiregulin Status in Patients with KRAS Codon 12 Wild-Type Metastatic Colorectal Cancer Receiving First-Line Chemotherapy with Anti-EGFR Therapy.
Q89529095Prognostic and Predictive Molecular Biomarkers for Colorectal Cancer: Updates and Challenges
Q36115580Prognostic and predictive biomarkers in metastatic colorectal cancer anti-EGFR therapy
Q38089641Promising biomarkers for predicting the outcomes of patients with KRAS wild-type metastatic colorectal cancer treated with anti-epidermal growth factor receptor monoclonal antibodies: a systematic review with meta-analysis
Q35583697Prospective study of a molecular selection profile for RAS wild type colorectal cancer patients receiving irinotecan-cetuximab
Q33555345Protocol for Combined Analysis of FOXFIRE, SIRFLOX, and FOXFIRE-Global Randomized Phase III Trials of Chemotherapy +/- Selective Internal Radiation Therapy as First-Line Treatment for Patients With Metastatic Colorectal Cancer.
Q30967175RAS Mutations Beyond KRAS Exon 2: A Review and Discussion of Clinical Trial Data
Q28074175RAS and BRAF in metastatic colorectal cancer management
Q33648830RHBDD1 upregulates EGFR via the AP-1 pathway in colorectal cancer
Q37701607Radiolabeled novel mAb 4G1 for immunoSPECT imaging of EGFRvIII expression in preclinical glioblastoma xenografts
Q38376696Randomized Phase II Trial of Seribantumab in Combination With Paclitaxel in Patients With Advanced Platinum-Resistant or -Refractory Ovarian Cancer.
Q93040761Randomized Phase II Trial of Seribantumab in Combination with Erlotinib in Patients with EGFR Wild-Type Non-Small Cell Lung Cancer
Q39140763Rational combination of a MEK inhibitor, selumetinib, and the Wnt/calcium pathway modulator, cyclosporin A, in preclinical models of colorectal cancer
Q33624491Recent Advances in Targeting the EGFR Signaling Pathway for the Treatment of Metastatic Colorectal Cancer
Q26851075Recent applications of chemosensitivity tests for colorectal cancer treatment
Q90083939Response to Anti-EGFR Therapy in Patients with BRAF non-V600-Mutant Metastatic Colorectal Cancer
Q37542817Response to MLN8237 in pancreatic cancer is not dependent on RalA phosphorylation
Q36244599Retrospective study of RAS/PIK3CA/BRAF tumor mutations as predictors of response to first-line chemotherapy with bevacizumab in metastatic colorectal cancer patients.
Q38516244Role and mechanisms of resistance of epidermal growth factor receptor antagonists in the treatment of colorectal cancer.
Q49566155Role of Anti-Epidermal Growth Factor Receptor Therapy Compared with Anti-Vascular Endothelial Growth Factor Therapy for Metastatic Colorectal Cancer: an Update Meta-Analysis of Randomized Clinical Trials
Q37708010Role of cetuximab in first-line treatment of metastatic colorectal cancer
Q39051652Role of circulating free DNA in colorectal cancer
Q64067069SUVmax and metabolic tumor volume: surrogate image biomarkers of KRAS mutation status in colorectal cancer
Q26751035Serrated colorectal cancer: Molecular classification, prognosis, and response to chemotherapy
Q53164323Significance of FGF9 gene in resistance to anti-EGFR therapies targeting colorectal cancer: A subset of colorectal cancer patients with FGF9 upregulation may be resistant to anti-EGFR therapies.
Q87702900Significance of KRAS, NRAS, BRAF and PIK3CA mutations in metastatic colorectal cancer patients receiving Bevacizumab: a single institution experience
Q37548830Single agent panitumumab in KRAS wild-type metastatic colorectal cancer patients following cetuximab-based regimens: Clinical outcome and biomarkers of efficacy
Q28088693Standard chemotherapy with cetuximab for treatment of colorectal cancer
Q39949794Systemic treatment of liver metastases from colorectal cancer
Q92306520Targeted Therapy in Metastatic Colorectal Cancer: Current Standards and Novel Agents in Review
Q30862367Targeted therapies in metastatic colorectal cancer: a systematic review and assessment of currently available data
Q38652294Targeting BRAF aberrations in advanced colorectal carcinoma: from bench to bedside.
Q38239612Targeting BRAF mutant metastatic colorectal cancer: clinical implications and emerging therapeutic strategies
Q38390840Targeting EGFR in metastatic colorectal cancer beyond the limitations of KRAS status: alternative biomarkers and therapeutic strategies.
Q38241190Targeting angiogenesis and tumor microenvironment in metastatic colorectal cancer: role of aflibercept.
Q41922459Temsirolimus enhances the efficacy of cetuximab in colon cancer through a CIP2A-dependent mechanism.
Q90290671The Association of Baseline Serum Tumour Markers with Outcome of Patients with Metastatic Colorectal Cancer Treated with Anti-EGFR Monoclonal Antibodies in the First Line
Q38773904The EGFR-specific antibody cetuximab combined with chemotherapy triggers immunogenic cell death.
Q92193162The Evolving Biomarker Landscape for Treatment Selection in Metastatic Colorectal Cancer
Q38825575The Multidisciplinary Management of Colorectal Cancer: Present and Future Paradigms
Q38481038The distinctive molecular, pathological and clinical characteristics of BRAF-mutant colorectal tumors
Q89520785The evolving treatment paradigm for BRAF V600 mutant colorectal cancer
Q27852988The predictive value of KRAS, NRAS, BRAF, PIK3CA and PTEN for anti-EGFR treatment in metastatic colorectal cancer: A systematic review and meta-analysis
Q34776118The prognostic role of BRAF mutation in metastatic colorectal cancer receiving anti-EGFR monoclonal antibodies: a meta-analysis
Q48266694The prognostic role of microsatellite instability, codon-specific KRAS, and BRAF mutations in colon cancer
Q37130603The role of personalized medicine in metastatic colorectal cancer: an evolving landscape
Q38181431Tissue-based biomarkers predicting outcomes in metastatic colorectal cancer: a review.
Q26827212Toward a Molecular Classification of Colorectal Cancer: The Role of BRAF
Q30239109Translating genomic profiling to gastrointestinal cancer treatment
Q34503734Treatment of colorectal liver metastases in Germany: a ten-year population-based analysis of 5772 cases of primary colorectal adenocarcinoma
Q34441837Tumor markers in colorectal cancer, gastric cancer and gastrointestinal stromal cancers: European group on tumor markers 2014 guidelines update
Q54405775Ultra-deep sequencing confirms immunohistochemistry as a highly sensitive and specific method for detecting BRAF V600E mutations in colorectal carcinoma.
Q37606696Use of a High-Throughput Genotyping Platform (OncoMap) for RAS Mutational Analysis to Predict Cetuximab Efficacy in Patients with Metastatic Colorectal Cancer.
Q48263612Using Genome Sequence to Enable the Design of Medicines and Chemical Probes.
Q36341759Using Molecular Markers to Guide Therapy of Metastatic Colorectal Cancer
Q36561520VE1 immunohistochemistry predicts BRAF V600E mutation status and clinical outcome in colorectal cancer
Q36286704Vascular endothelial growth factor D expression is a potential biomarker of bevacizumab benefit in colorectal cancer
Q53581884[Molecular pathology of colorectal cancer].

Search more.