Peroxisome proliferator-activated receptor gamma and metabolic disease.

scientific article

Peroxisome proliferator-activated receptor gamma and metabolic disease. is …
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review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1146/ANNUREV.BIOCHEM.70.1.341
P698PubMed publication ID11395411

P2093author name stringWillson TM
Kliewer SA
Lambert MH
P2860cites workDominant negative mutations in human PPARgamma associated with severe insulin resistance, diabetes mellitus and hypertensionQ22011018
P1104number of pages27
P304page(s)341-367
P577publication date2001-01-01
P1433published inAnnual Review of BiochemistryQ567356
P1476titlePeroxisome proliferator-activated receptor gamma and metabolic disease.
P478volume70

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cites work (P2860)
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Q79745372Expression of ectonucleotide pyrophosphate phosphodiesterase and peroxisome proliferator activated receptor gamma in morbidly obese patients
Q44471149Fatty acids modulate the effect of darglitazone on macrophage CD36 expression.
Q40895648Fibroblast growth factor-21 regulates PPARγ activity and the antidiabetic actions of thiazolidinediones.
Q38408437Functional interaction between peroxisome proliferator-activated receptor gamma and beta-catenin
Q38022356Functional role of peroxisome-proliferator-activated receptor γ in hepatocellular carcinoma
Q27679090GQ-16, a Novel Peroxisome Proliferator-activated Receptor   (PPAR ) Ligand, Promotes Insulin Sensitization without Weight Gain
Q36267948Genes involved in obesity: Adipocytes, brain and microflora
Q37408562Genetic variations in peroxisome proliferator-activated receptor gamma expression affect blood pressure
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Q46479941Human dendritic cell activities are modulated by the omega-3 fatty acid, docosahexaenoic acid, mainly through PPAR(gamma):RXR heterodimers: comparison with other polyunsaturated fatty acids
Q36447407Human immunodeficiency virus (HIV)-1 viral protein R suppresses transcriptional activity of peroxisome proliferator-activated receptor {gamma} and inhibits adipocyte differentiation: implications for HIV-associated lipodystrophy
Q39772693IL-10 mediates rosiglitazone-induced kidney protection in cisplatin nephrotoxicity
Q90073276Identification and Characterization of Cannabimovone, a Cannabinoid from Cannabis sativa, as a Novel PPARγ Agonist via a Combined Computational and Functional Study
Q90448406Identification and structural insight of an effective PPARγ modulator with improved therapeutic index for anti-diabetic drug discovery
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Q35237706Identification of a novel selective agonist of PPARγ with no promotion of adipogenesis and less inhibition of osteoblastogenesis
Q40576825Impact and Therapeutic Potential of PPARs in Alzheimer's Disease
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Q26866480Inflammation and oxidative stress in diabetic nephropathy: new insights on its inhibition as new therapeutic targets
Q38471509Influence of quercetin-rich onion peel extracts on adipokine expression in the visceral adipose tissue of rats
Q34315365Inhibition of cancer cell proliferation by PPARγ is mediated by a metabolic switch that increases reactive oxygen species levels
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Q36512559Investigational PPAR-gamma agonists for the treatment of Type 2 diabetes
Q36695847Lack of efficacy of troglitazone at clinically achievable concentrations, with or without 9-cis retinoic acid or cytotoxic agents, for hepatocellular carcinoma cell lines
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Q34671576Lipid management in diabetic patients: lessons from prevention trials
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Q24529989Mechanisms of phthalate ester toxicity in the female reproductive system
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Q44776756Metabolic effects of Troglitazone in patients with diet-controlled type 2 diabetes
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Q45247890Nuclear receptor peroxisome proliferator-activated receptor-gamma is activated in rat microglial cells by the anti-inflammatory drug HCT1026, a derivative of flurbiprofen
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Q26825692Nuclear receptors and their selective pharmacologic modulators
Q42125206PPAR Could Contribute to the Pathogenesis of Hepatocellular Carcinoma
Q37553185PPAR and Pain
Q36426786PPAR-gamma in the Cardiovascular System
Q41938308PPAR-gamma, Microglial Cells, and Ocular Inflammation: New Venues for Potential Therapeutic Approaches
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Q35458969PPARgamma activation by thiazolidinediones (TZDs) may modulate breast carcinoma outcome: the importance of interplay with TGFbeta signalling.
Q28574968PPARgamma agonism increases rat adipose tissue lipolysis, expression of glyceride lipases, and the response of lipolysis to hormonal control
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Q72999922PPARgamma agonists in the treatment of type II diabetes: is increased fatness commensurate with long-term efficacy?
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Q36693982PPARgamma, a lipid-activated transcription factor as a regulator of dendritic cell function
Q24794438PPARgamma, neuroinflammation, and disease
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Q40288794PPARs in Alzheimer's Disease
Q37738780PPARs in bone: the role in bone cell differentiation and regulation of energy metabolism
Q30006155PPARγ Agonists Attenuate Trigeminal Neuropathic Pain
Q37649336PPARγ Antagonist Gleevec Improves Insulin Sensitivity and Promotes the Browning of White Adipose Tissue
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Q42397418Peroxisome Proliferator-Activated Receptors (PPARs) as Potential Inducers of Antineoplastic Effects in CNS Tumors.
Q34271250Peroxisome proliferator activated receptor-γ and traumatic brain injury.
Q37995569Peroxisome proliferator-activated receptor gamma (PPAR-γ) and neurodegenerative disorders
Q40298113Peroxisome proliferator-activated receptor gamma ligands stimulate myeloid differentiation and lipogenensis in human leukemia NB4 cells.
Q33247258Peroxisome proliferator-activated receptor gamma-regulated ABCG2 expression confers cytoprotection to human dendritic cells
Q36918509Peroxisome proliferator-activated receptor targets for the treatment of metabolic diseases
Q44848225Peroxisome proliferator-activated receptor-gamma down-regulates chondrocyte matrix metalloproteinase-1 via a novel composite element
Q35688221Peroxisome proliferator-activated receptor-gamma: therapeutic target for diseases beyond diabetes: quo vadis?
Q37412297Peroxisome proliferator-activated receptors in diabetic nephropathy
Q35212744Peroxisome proliferator-activated receptors: are they involved in atherosclerosis progression?
Q35039274Pharmacogenomics and pharmacogenetics of thiazolidinediones: role in diabetes and cardiovascular risk factors
Q44965022Pharmacokinetics of pioglitazone after multiple oral dose administration in horses
Q33744181Pharmacophore-driven identification of PPARγ agonists from natural sources.
Q80525197Pioglitazone and nonalcoholic steatohepatitis
Q28580246Pioglitazone attenuates diabetic nephropathy through an anti-inflammatory mechanism in type 2 diabetic rats
Q34309135Pioglitazone modulates the proliferation and apoptosis of vascular smooth muscle cells via peroxisome proliferators-activated receptor-gamma
Q46982956Pioglitazone. Review of its metabolic and systemic effects
Q46883819Pioglitazone: a review of its use in type 2 diabetes mellitus
Q37142044Pleiotropic effects of thiazolidinediones
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Q35842790Post-translational modifications of nuclear receptors and human disease
Q38809165Potent PPARγ Ligands from Swietenia macrophylla Are Capable of Stimulating Glucose Uptake in Muscle Cells.
Q28066552Potential of Natural Products in the Inhibition of Adipogenesis through Regulation of PPARγ Expression and/or Its Transcriptional Activity
Q36444597Preferential PPAR-α activation reduces neuroinflammation, and blocks neurodegeneration in vivo
Q44414175Prevention of autoimmune diabetes in NOD mice by troglitazone is associated with modulation of ICAM-1 expression on pancreatic islet cells and IFN-γ expression in splenic T cells
Q44332739Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-gamma (PPAR-gamma) gene and risk of prostate cancer among men in a large cancer prevention study
Q36554451Protection of the kidney by thiazolidinediones: an assessment from bench to bedside
Q37433259Pseudoginsenoside F11, a Novel Partial PPAR γ Agonist, Promotes Adiponectin Oligomerization and Secretion in 3T3-L1 Adipocytes
Q54946092Pulmonary Arterial Hypertension and Insulin Resistance.
Q39837073Pyrimidinyl-arylpropionic acid derivatives: viable resources in the development of new antineoplastic agents
Q34856939Rationale for and role of thiazolidinediones in type 2 diabetes mellitus
Q36407304Recent findings concerning thiazolidinediones in the treatment of diabetes
Q33420391Reducing glycosphingolipid content in adipose tissue of obese mice restores insulin sensitivity, adipogenesis and reduces inflammation
Q37157531Regulation of Glial Cell Functions by PPAR-gamma Natural and Synthetic Agonists.
Q36995029Regulation of Wnt/beta-catenin pathway by cPLA2alpha and PPARdelta
Q36254439Regulation of small ubiquitin-like modifier-1, nuclear receptor coreceptor, histone deacetylase 3, and peroxisome proliferator-activated receptor-γ in human adipose tissue
Q34575468Relevance of TNBS-colitis in rats: a methodological study with endoscopic, histologic and Transcriptomic [corrected] characterization and correlation to IBD.
Q40455776Removal of serum factors by charcoal treatment promotes adipogenesis via a MAPK-dependent pathway.
Q35109744Resistin: molecular history and prognosis
Q35191573Resolving the Two "Bony" Faces of PPAR-gamma.
Q33440398Role of G protein-coupled receptor kinase-2 in peroxisome proliferator-activated receptor gamma-mediated modulation of blood pressure and renal vascular reactivity in SHR.
Q37997005Role of PPARs in Trypanosoma cruzi Infection: Implications for Chagas Disease Therapy
Q35168497Roles of 5'-AMP-activated protein kinase (AMPK) in mammalian glucose homoeostasis
Q47802906Rosiglitazone Regulates TLR4 and Rescues HO-1 and NRF2 Expression in Myometrial and Decidual Macrophages in Inflammation-Induced Preterm Birth.
Q46611073Rosiglitazone and 15-deoxy-Delta12,14-prostaglandin J2 cause potent neuroprotection after experimental stroke through noncompletely overlapping mechanisms.
Q36157326Rosiglitazone induces decreases in bone mass and strength that are reminiscent of aged bone
Q54311344Rosiglitazone modulates the behaviors of diabetic host-derived fibroblasts in a carboxymethyllysine-modified collagen model.
Q46034890Rosiglitazone-induced heart remodelling is associated with enhanced turnover of myofibrillar protein and mTOR activation.
Q24535573SDP1 is a peroxisome-proliferator-activated receptor gamma 2 co-activator that binds through its SCAN domain
Q36497213SMRT-GPS2 corepressor pathway dysregulation coincides with obesity-linked adipocyte inflammation
Q47696944Screening of molecular cell targets for carcinogenic heterocyclic aromatic amines by using CALUX® reporter gene assays
Q24793556Serum adiponectin as a biomarker for in vivo PPARgamma activation and PPARgamma agonist-induced efficacy on insulin sensitization/lipid lowering in rats
Q40360288Spectroscopic analyses of the binding kinetics of 15d-PGJ2 to the PPARgamma ligand-binding domain by multi-wavelength global fitting
Q42925474Stimulation of ENaC Activity by Rosiglitazone is PPARγ-Dependent and Correlates with SGK1 Expression Increase
Q61697352Structural insights for the design of new PPARgamma partial agonists with high binding affinity and low transactivation activity
Q37120932Studying arrhythmogenic right ventricular dysplasia with patient-specific iPSCs
Q64923743Sulfuretin Prevents Obesity and Metabolic Diseases in Diet Induced Obese Mice.
Q38920687Supplementation of omega 3 fatty acids improves oxidative stress in activated BV2 microglial cell line
Q44586126Synthesis of a high-affinity fluorescent PPARgamma ligand for high-throughput fluorescence polarization assays
Q41828132Synthesis of a novel thiazolidinedione and evaluation of its modulatory effect on IFN- γ , IL-6, IL-17A, and IL-22 production in PBMCs from rheumatoid arthritis patients.
Q46074706Synthesis of lipoxin A4 by 5-lipoxygenase mediates PPARgamma-dependent, neuroprotective effects of rosiglitazone in experimental stroke.
Q40747044T0070907, a selective ligand for peroxisome proliferator-activated receptor gamma, functions as an antagonist of biochemical and cellular activities
Q33809886Targeting Peroxisome Proliferator-Activated Receptors Using Thiazolidinediones: Strategy for Design of Novel Antidiabetic Drugs
Q26852726Targeting inflammation in diabetes: Newer therapeutic options
Q37570577Targeting insulin sensitivity in the treatment of polycystic ovary syndrome
Q35714622Targeting orphan nuclear receptors for treatment of metabolic diseases and autoimmunity
Q42778982Telmisartan inhibits vasoconstriction via PPARγ-dependent expression and activation of endothelial nitric oxide synthase
Q38016858The Current Knowledge of the Role of PPAR in Hepatic Ischemia-Reperfusion Injury.
Q34035340The Role of Peroxisome Proliferator-Activated Receptor beta/delta on the Inflammatory Basis of Metabolic Disease.
Q38254887The association between lipid metabolism gene polymorphisms and nephropathy in type 2 diabetes: a meta-analysis
Q35212543The central role of fat and effect of peroxisome proliferator-activated receptor-gamma on progression of insulin resistance and cardiovascular disease
Q38323767The effect of troglitazone on lipid accumulation and related gene expression in Hanwoo muscle satellite cell.
Q36545395The effects of thiazolidinediones on blood pressure levels - a systematic review
Q35164460The first completed genome sequence from a teleost fish (Fugu rubripes) adds significant diversity to the nuclear receptor superfamily
Q34986351The macrophage foam cell as a target for therapeutic intervention
Q34208083The orphan nuclear receptor Rev-Erbalpha is a peroxisome proliferator-activated receptor (PPAR) gamma target gene and promotes PPARgamma-induced adipocyte differentiation
Q34772498The peroxisome proliferator-activated receptor alpha (PPARalpha): role in hepatocarcinogenesis
Q28585701The peroxisome proliferator-activated receptor gamma agonist rosiglitazone ameliorates murine lupus by induction of adiponectin
Q34838209The role of PPARs in atherosclerosis
Q45929326The role of peroxisome proliferator-activated receptor gamma in blood pressure regulation.
Q37848841The safety of thiazolidinediones
Q36328530The toxicology of ligands for peroxisome proliferator-activated receptors (PPAR).
Q28742884The ε3 and ε4 alleles of human APOE differentially affect tau phosphorylation in hyperinsulinemic and pioglitazone treated mice
Q40444038Thiazolidinedione (pioglitazone) blocks P. gingivalis- and F. nucleatum, but not E. coli, lipopolysaccharide (LPS)-induced interleukin-6 (IL-6) production in adipocytes
Q37142138Thiazolidinedione derivatives in diabetes and cardiovascular disease: an update
Q38641190Thiazolidinedione drugs in the treatment of type 2 diabetes mellitus: past, present and future
Q33585657Thiazolidinedione-independent activation of peroxisome proliferator-activated receptor γ is a potential target for diabetic macrovascular complications
Q36283538Thiazolidinediones and inflammation
Q33948063Thiazolidinediones are partial agonists for the glucocorticoid receptor
Q36996294Thiazolidinediones as anti-inflammatory and anti-atherogenic agents
Q36484662Thiazolidinediones: effects on insulin resistance and the cardiovascular system
Q34430709Thrap3 docks on phosphoserine 273 of PPARγ and controls diabetic gene programming
Q24303852Transcription factors and nuclear receptors interact with the SWI/SNF complex through the BAF60c subunit
Q90231446Transcriptional Analysis of FOXO1, C/EBP-α and PPAR-γ2 Genes and Their Association with Obesity-Related Insulin Resistance
Q34637612Transcriptional regulation of hepatic stellate cell activation
Q52678882Troglitazone induces differentiation in Trypanosoma brucei.
Q40610380Tumor necrosis factor-alpha inhibits peroxisome proliferator-activated receptor gamma activity at a posttranslational level in hepatic stellate cells
Q36494764Unifying mechanisms of action of the anticancer activities of triterpenoids and synthetic analogs
Q44294516Visceral fat and liver fat are independent predictors of metabolic risk factors in men.
Q38717181WIP1 phosphatase is a critical regulator of adipogenesis through dephosphorylating PPARγ serine 112.
Q55658411Water Pharmacophore: Designing Ligands using Molecular Dynamics Simulations with Water.
Q47855337Weak bones in diabetes mellitus - an update on pharmaceutical treatment options
Q65001385Withaferin A inhibits adipogenesis in 3T3-F442A cell line, improves insulin sensitivity and promotes weight loss in high fat diet-induced obese mice.
Q33885244Zinc-chelated Vitamin C Stimulates Adipogenesis of 3T3-L1 Cells

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