review article | Q7318358 |
scholarly article | Q13442814 |
P356 | DOI | 10.1146/ANNUREV.BIOCHEM.70.1.341 |
P698 | PubMed publication ID | 11395411 |
P2093 | author name string | Willson TM | |
Kliewer SA | |||
Lambert MH | |||
P2860 | cites work | Dominant negative mutations in human PPARgamma associated with severe insulin resistance, diabetes mellitus and hypertension | Q22011018 |
P1104 | number of pages | 27 | |
P304 | page(s) | 341-367 | |
P577 | publication date | 2001-01-01 | |
P1433 | published in | Annual Review of Biochemistry | Q567356 |
P1476 | title | Peroxisome proliferator-activated receptor gamma and metabolic disease. | |
P478 | volume | 70 |
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Q40226575 | 15-deoxy-(Delta12,14)-prostaglandin J2 (15d-PGJ2) induces cell death through caspase-independent mechanism in A172 human glioma cells |
Q40810593 | 15d-Prostaglandin J2 induced reactive oxygen species-mediated apoptosis during experimental visceral leishmaniasis |
Q100495857 | A New Series of Ferulic Acid Amides Reveals an Unexpected Peroxiredoxin 1 Inhibition Activity With In Vivo Antidiabetic and Hypolipidemic Effects |
Q28593737 | A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma |
Q36763993 | A consideration of PPAR-gamma ligands with respect to lipophilicity: current trends and perspectives |
Q34249161 | A novel non-agonist peroxisome proliferator-activated receptor γ (PPARγ) ligand UHC1 blocks PPARγ phosphorylation by cyclin-dependent kinase 5 (CDK5) and improves insulin sensitivity |
Q36536205 | A review of pioglitazone HCL and glimepiride in the treatment of type 2 diabetes |
Q39121562 | A systems perspective on brown adipogenesis and metabolic activation. |
Q38361567 | AZ 242, a novel PPARalpha/gamma agonist with beneficial effects on insulin resistance and carbohydrate and lipid metabolism in ob/ob mice and obese Zucker rats |
Q44980680 | Actions of PPARgamma agonism on adipose tissue remodeling, insulin sensitivity, and lipemia in absence of glucocorticoids. |
Q37149978 | Activation of PPARγ by a Natural Flavonoid Modulator, Apigenin Ameliorates Obesity-Related Inflammation Via Regulation of Macrophage Polarization |
Q44022379 | Activation of peroxisome proliferator-activated receptor gamma inhibits osteoprotegerin gene expression in human aortic smooth muscle cells |
Q34838292 | Adipogenesis and fat-cell function in obesity and diabetes |
Q42814976 | Ahnak stimulates BMP2-mediated adipocyte differentiation through Smad1 activation |
Q40461294 | Alpha,beta-unsaturated ketone is a core moiety of natural ligands for covalent binding to peroxisome proliferator-activated receptor gamma. |
Q35195941 | Alterations in TCF7L2 expression define its role as a key regulator of glucose metabolism |
Q35639785 | Alternative mRNA splicing of corepressors generates variants that play opposing roles in adipocyte differentiation. |
Q28086892 | Alzheimer's disease and type 2 diabetes via chronic inflammatory mechanisms |
Q42469480 | An angiotensin II AT1 receptor antagonist, telmisartan augments glucose uptake and GLUT4 protein expression in 3T3-L1 adipocytes. |
Q39835267 | Anandamide increases the differentiation of rat adipocytes and causes PPARgamma and CB1 receptor upregulation |
Q42491731 | Anti-angiogenic action of PPARγ ligand in human umbilical vein endothelial cells is mediated by PTEN upregulation and VEGFR-2 downregulation |
Q37686356 | Anti-apoptotic actions of PPAR-gamma against ischemic stroke |
Q34330155 | Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5. |
Q46983586 | Antiangiogenic effect of rosiglitazone is mediated via peroxisome proliferator-activated receptor gamma-activated maxi-K channel opening in human umbilical vein endothelial cells |
Q35230678 | Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation |
Q39950463 | Antitumor activity of a novel series of alpha-aryloxy-alpha-methylhydrocinnamic acid derivatives as PPAR gamma agonists against a panel of human cancer cell lines |
Q24318657 | Apolipoprotein C-III: understanding an emerging cardiovascular risk factor |
Q35586837 | Aromatase and cyclooxygenases: enzymes in breast cancer |
Q34470467 | Association of IL10 and other immune response- and obesity-related genes with prostate cancer in CLUE II. |
Q34490355 | Association of variants in genes related to the immune response and obesity with BPH in CLUE II |
Q27653218 | Atomic structure of mutant PPARgamma LBD complexed with 15d-PGJ2: novel modulation mechanism of PPARgamma/RXRalpha function by covalently bound ligands |
Q44349478 | Beneficial effects of β-conglycinin on renal function and nephrin expression in early streptozotocin-induced diabetic nephropathy rats |
Q64325520 | Bicyclic eremophilane-type petasite sesquiterpenes potentiate peroxisome proliferator-activated receptor γ activator-mediated inhibition of dendritic cells |
Q39224484 | C-Peptide and its intracellular signaling |
Q34540591 | C-peptide and diabetic kidney disease |
Q37302225 | C/EBPalpha and the corepressors CtBP1 and CtBP2 regulate repression of select visceral white adipose genes during induction of the brown phenotype in white adipocytes by peroxisome proliferator-activated receptor gamma agonists |
Q44780691 | CDDO induces apoptosis via the intrinsic pathway in lymphoid cells. |
Q35630715 | Circulating and dietary trans fatty acids and incident type 2 diabetes in older adults: the Cardiovascular Health Study |
Q35887411 | Combined thiazolidinedione-insulin therapy: should we be concerned about safety? |
Q33797616 | Concomitant therapy with pioglitazone and insulin for the treatment of type 2 diabetes |
Q37122445 | Consecutive positive feedback loops create a bistable switch that controls preadipocyte-to-adipocyte conversion |
Q42512618 | Coordinated transcriptional control of adipocyte triglyceride lipase (Atgl) by transcription factors Sp1 and peroxisome proliferator-activated receptor γ (PPARγ) during adipocyte differentiation. |
Q37265280 | Coordination of inflammation and metabolism by PPAR and LXR nuclear receptors |
Q46867693 | Correlation between porcine PPARGC1A mRNA expression and its downstream target genes in backfat and longissimus dorsi muscle. |
Q26824893 | Could metabolic syndrome lead to hepatocarcinoma via non-alcoholic fatty liver disease? |
Q41832154 | Current and novel therapies for the treatment of nonalcoholic steatohepatitis |
Q35611068 | Design, Synthesis, and Biological Evaluation of Thiazolidine-2,4-dione Conjugates as PPAR-γ Agonists. |
Q42806855 | Differentiation-dependent regulation of the cyclooxygenase cascade during adipogenesis suggests a complex role for prostaglandins |
Q37633561 | Dissecting the brown adipogenic regulatory network using integrative genomics |
Q36931609 | Drug insight: effects mediated by peroxisome proliferator-activated receptor-gamma in CNS disorders |
Q40739285 | Dual action of isoprenols from herbal medicines on both PPARgamma and PPARalpha in 3T3-L1 adipocytes and HepG2 hepatocytes |
Q35407199 | Early pharmacological inhibition of angiotensin-I converting enzyme activity induces obesity in adulthood |
Q30472847 | Effect of lifestyle intervention plus rosiglitazone or placebo therapy on left ventricular mass assessed with cardiovascular magnetic resonance in the metabolic syndrome |
Q43108533 | Effect of rosiglitazone on cisplatin-induced nephrotoxicity |
Q34919583 | Effects of age and dysfunction on human meibomian glands. |
Q40560414 | Effects of rosiglitazone treatment on the pentose phosphate pathway and glutathione-dependent enzymes in liver and kidney of rats fed a high-fat diet |
Q33727061 | Effects of the PPARgamma agonist pioglitazone on lipoprotein metabolism in patients with type 2 diabetes mellitus |
Q39686417 | Effects of the insulin sensitizing drug, pioglitazone, and lipopolysaccharide administration on markers of systemic inflammation and clinical parameters in horses |
Q36905154 | Effects of thiazolidinediones on blood pressure |
Q35578270 | Enzymology and Molecular Biology of Glucocorticoid Metabolism in Humans |
Q79745372 | Expression of ectonucleotide pyrophosphate phosphodiesterase and peroxisome proliferator activated receptor gamma in morbidly obese patients |
Q44471149 | Fatty acids modulate the effect of darglitazone on macrophage CD36 expression. |
Q40895648 | Fibroblast growth factor-21 regulates PPARγ activity and the antidiabetic actions of thiazolidinediones. |
Q38408437 | Functional interaction between peroxisome proliferator-activated receptor gamma and beta-catenin |
Q38022356 | Functional role of peroxisome-proliferator-activated receptor γ in hepatocellular carcinoma |
Q27679090 | GQ-16, a Novel Peroxisome Proliferator-activated Receptor (PPAR ) Ligand, Promotes Insulin Sensitization without Weight Gain |
Q36267948 | Genes involved in obesity: Adipocytes, brain and microflora |
Q37408562 | Genetic variations in peroxisome proliferator-activated receptor gamma expression affect blood pressure |
Q91339440 | How to reprogram microglia toward beneficial functions |
Q46479941 | Human dendritic cell activities are modulated by the omega-3 fatty acid, docosahexaenoic acid, mainly through PPAR(gamma):RXR heterodimers: comparison with other polyunsaturated fatty acids |
Q36447407 | Human immunodeficiency virus (HIV)-1 viral protein R suppresses transcriptional activity of peroxisome proliferator-activated receptor {gamma} and inhibits adipocyte differentiation: implications for HIV-associated lipodystrophy |
Q39772693 | IL-10 mediates rosiglitazone-induced kidney protection in cisplatin nephrotoxicity |
Q90073276 | Identification and Characterization of Cannabimovone, a Cannabinoid from Cannabis sativa, as a Novel PPARγ Agonist via a Combined Computational and Functional Study |
Q90448406 | Identification and structural insight of an effective PPARγ modulator with improved therapeutic index for anti-diabetic drug discovery |
Q41910885 | Identification of a domain within peroxisome proliferator-activated receptor gamma regulating expression of a group of genes containing fibroblast growth factor 21 that are selectively repressed by SIRT1 in adipocytes |
Q37609686 | Identification of a novel selective PPARγ ligand with a unique binding mode and improved therapeutic profile in vitro. |
Q35237706 | Identification of a novel selective agonist of PPARγ with no promotion of adipogenesis and less inhibition of osteoblastogenesis |
Q40576825 | Impact and Therapeutic Potential of PPARs in Alzheimer's Disease |
Q46503090 | Improvement in psoriasis with rosiglitazone in a diabetic and a nondiabetic patient |
Q26866480 | Inflammation and oxidative stress in diabetic nephropathy: new insights on its inhibition as new therapeutic targets |
Q38471509 | Influence of quercetin-rich onion peel extracts on adipokine expression in the visceral adipose tissue of rats |
Q34315365 | Inhibition of cancer cell proliferation by PPARγ is mediated by a metabolic switch that increases reactive oxygen species levels |
Q37225357 | Integration of metabolism and inflammation by lipid-activated nuclear receptors |
Q42513731 | Interferon-gamma-mediated activation and ubiquitin-proteasome-dependent degradation of PPARgamma in adipocytes |
Q21342827 | Intracellular signalling by C-peptide |
Q36512559 | Investigational PPAR-gamma agonists for the treatment of Type 2 diabetes |
Q36695847 | Lack of efficacy of troglitazone at clinically achievable concentrations, with or without 9-cis retinoic acid or cytotoxic agents, for hepatocellular carcinoma cell lines |
Q33602487 | Leptin revisited: its mechanism of action and potential for treating diabetes |
Q81422309 | Ligand-escape pathways from the ligand-binding domain of PPARgamma receptor as probed by molecular dynamics simulations |
Q34671576 | Lipid management in diabetic patients: lessons from prevention trials |
Q27013011 | Liver X receptor and peroxisome proliferator-activated receptor as integrators of lipid homeostasis and immunity |
Q41064444 | Lotus Leaf Aqueous Extract Reduces Visceral Fat Mass and Ameliorates Insulin Resistance in HFD-Induced Obese Rats by Regulating PPARγ2 Expression |
Q35794061 | Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones |
Q35222047 | Macrophage-specific expression of human lysosomal acid lipase corrects inflammation and pathogenic phenotypes in lal-/- mice. |
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Q27679376 | Medium Chain Fatty Acids Are Selective Peroxisome Proliferator Activated Receptor (PPAR) γ Activators and Pan-PPAR Partial Agonists |
Q36622931 | Metabolic control of the Treg/Th17 axis |
Q44776756 | Metabolic effects of Troglitazone in patients with diet-controlled type 2 diabetes |
Q26770105 | Molecular Regulation of Adipogenesis and Potential Anti-Adipogenic Bioactive Molecules |
Q37338210 | Moringin activates Wnt canonical pathway by inhibiting GSK3β in a mouse model of experimental autoimmune encephalomyelitis |
Q35745608 | Netoglitazone is a PPAR-gamma ligand with selective effects on bone and fat. |
Q42728024 | Neuroprotection by rosiglitazone in transient focal cerebral ischemia might not be mediated by glutamate transporter-1. |
Q33935032 | Novel PPARγ partial agonists with weak activity and no cytotoxicity; identified by a simple PPARγ ligand screening system |
Q45247890 | Nuclear receptor peroxisome proliferator-activated receptor-gamma is activated in rat microglial cells by the anti-inflammatory drug HCT1026, a derivative of flurbiprofen |
Q36852547 | Nuclear receptor signalling in dendritic cells connects lipids, the genome and immune function |
Q26825692 | Nuclear receptors and their selective pharmacologic modulators |
Q42125206 | PPAR Could Contribute to the Pathogenesis of Hepatocellular Carcinoma |
Q37553185 | PPAR and Pain |
Q36426786 | PPAR-gamma in the Cardiovascular System |
Q41938308 | PPAR-gamma, Microglial Cells, and Ocular Inflammation: New Venues for Potential Therapeutic Approaches |
Q46314621 | PPAR-gamma-independent inhibitory effect of rosiglitazone on glucose synthesis in primary cultured rabbit kidney-cortex tubules. |
Q51491070 | PPAR-gamma2 Pro12Ala variant, insulin resistance and plasma long-chain polyunsaturated fatty acids in childhood obesity. |
Q26863678 | PPAR-γ -- a possible drug target for complicated pregnancies |
Q33572403 | PPAR-γ2 and PTPRD gene polymorphisms influence type 2 diabetes patients' response to pioglitazone in China |
Q35458969 | PPARgamma activation by thiazolidinediones (TZDs) may modulate breast carcinoma outcome: the importance of interplay with TGFbeta signalling. |
Q28574968 | PPARgamma agonism increases rat adipose tissue lipolysis, expression of glyceride lipases, and the response of lipolysis to hormonal control |
Q37215869 | PPARgamma agonists as therapeutics for the treatment of Alzheimer's disease |
Q40371669 | PPARgamma agonists do not directly enhance basal or insulin-stimulated Na(+) transport via the epithelial Na(+) channel |
Q72999922 | PPARgamma agonists in the treatment of type II diabetes: is increased fatness commensurate with long-term efficacy? |
Q35144057 | PPARgamma and PPARdelta negatively regulate specific subsets of lipopolysaccharide and IFN-gamma target genes in macrophages |
Q37764531 | PPARgamma in adipocyte differentiation and metabolism--novel insights from genome-wide studies |
Q36693982 | PPARgamma, a lipid-activated transcription factor as a regulator of dendritic cell function |
Q24794438 | PPARgamma, neuroinflammation, and disease |
Q36791361 | PPARs and molecular mechanisms of transrepression |
Q40288794 | PPARs in Alzheimer's Disease |
Q37738780 | PPARs in bone: the role in bone cell differentiation and regulation of energy metabolism |
Q30006155 | PPARγ Agonists Attenuate Trigeminal Neuropathic Pain |
Q37649336 | PPARγ Antagonist Gleevec Improves Insulin Sensitivity and Promotes the Browning of White Adipose Tissue |
Q38227702 | PPARγ and PGC-1α as therapeutic targets in Parkinson's |
Q28069549 | PPARγ as a therapeutic target to rescue mitochondrial function in neurological disease |
Q89552798 | PPM1A Controls Diabetic Gene Programming through Directly Dephosphorylating PPARγ at Ser273 |
Q35955186 | PTPRD silencing by DNA hypermethylation decreases insulin receptor signaling and leads to type 2 diabetes |
Q42574886 | Paracrine Regulation of Angiogenesis and Adipocyte Differentiation During In Vivo Adipogenesis |
Q24685818 | Parallel SUMOylation-dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARgamma |
Q42397418 | Peroxisome Proliferator-Activated Receptors (PPARs) as Potential Inducers of Antineoplastic Effects in CNS Tumors. |
Q34271250 | Peroxisome proliferator activated receptor-γ and traumatic brain injury. |
Q37995569 | Peroxisome proliferator-activated receptor gamma (PPAR-γ) and neurodegenerative disorders |
Q40298113 | Peroxisome proliferator-activated receptor gamma ligands stimulate myeloid differentiation and lipogenensis in human leukemia NB4 cells. |
Q33247258 | Peroxisome proliferator-activated receptor gamma-regulated ABCG2 expression confers cytoprotection to human dendritic cells |
Q36918509 | Peroxisome proliferator-activated receptor targets for the treatment of metabolic diseases |
Q44848225 | Peroxisome proliferator-activated receptor-gamma down-regulates chondrocyte matrix metalloproteinase-1 via a novel composite element |
Q35688221 | Peroxisome proliferator-activated receptor-gamma: therapeutic target for diseases beyond diabetes: quo vadis? |
Q37412297 | Peroxisome proliferator-activated receptors in diabetic nephropathy |
Q35212744 | Peroxisome proliferator-activated receptors: are they involved in atherosclerosis progression? |
Q35039274 | Pharmacogenomics and pharmacogenetics of thiazolidinediones: role in diabetes and cardiovascular risk factors |
Q44965022 | Pharmacokinetics of pioglitazone after multiple oral dose administration in horses |
Q33744181 | Pharmacophore-driven identification of PPARγ agonists from natural sources. |
Q80525197 | Pioglitazone and nonalcoholic steatohepatitis |
Q28580246 | Pioglitazone attenuates diabetic nephropathy through an anti-inflammatory mechanism in type 2 diabetic rats |
Q34309135 | Pioglitazone modulates the proliferation and apoptosis of vascular smooth muscle cells via peroxisome proliferators-activated receptor-gamma |
Q46982956 | Pioglitazone. Review of its metabolic and systemic effects |
Q46883819 | Pioglitazone: a review of its use in type 2 diabetes mellitus |
Q37142044 | Pleiotropic effects of thiazolidinediones |
Q38272127 | Pleiotropic role of PPARγ in intracerebral hemorrhage: an intricate system involving Nrf2, RXR, and NF-κB. |
Q35842790 | Post-translational modifications of nuclear receptors and human disease |
Q38809165 | Potent PPARγ Ligands from Swietenia macrophylla Are Capable of Stimulating Glucose Uptake in Muscle Cells. |
Q28066552 | Potential of Natural Products in the Inhibition of Adipogenesis through Regulation of PPARγ Expression and/or Its Transcriptional Activity |
Q36444597 | Preferential PPAR-α activation reduces neuroinflammation, and blocks neurodegeneration in vivo |
Q44414175 | Prevention of autoimmune diabetes in NOD mice by troglitazone is associated with modulation of ICAM-1 expression on pancreatic islet cells and IFN-γ expression in splenic T cells |
Q44332739 | Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-gamma (PPAR-gamma) gene and risk of prostate cancer among men in a large cancer prevention study |
Q36554451 | Protection of the kidney by thiazolidinediones: an assessment from bench to bedside |
Q37433259 | Pseudoginsenoside F11, a Novel Partial PPAR γ Agonist, Promotes Adiponectin Oligomerization and Secretion in 3T3-L1 Adipocytes |
Q54946092 | Pulmonary Arterial Hypertension and Insulin Resistance. |
Q39837073 | Pyrimidinyl-arylpropionic acid derivatives: viable resources in the development of new antineoplastic agents |
Q34856939 | Rationale for and role of thiazolidinediones in type 2 diabetes mellitus |
Q36407304 | Recent findings concerning thiazolidinediones in the treatment of diabetes |
Q33420391 | Reducing glycosphingolipid content in adipose tissue of obese mice restores insulin sensitivity, adipogenesis and reduces inflammation |
Q37157531 | Regulation of Glial Cell Functions by PPAR-gamma Natural and Synthetic Agonists. |
Q36995029 | Regulation of Wnt/beta-catenin pathway by cPLA2alpha and PPARdelta |
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Q35109744 | Resistin: molecular history and prognosis |
Q35191573 | Resolving the Two "Bony" Faces of PPAR-gamma. |
Q33440398 | Role of G protein-coupled receptor kinase-2 in peroxisome proliferator-activated receptor gamma-mediated modulation of blood pressure and renal vascular reactivity in SHR. |
Q37997005 | Role of PPARs in Trypanosoma cruzi Infection: Implications for Chagas Disease Therapy |
Q35168497 | Roles of 5'-AMP-activated protein kinase (AMPK) in mammalian glucose homoeostasis |
Q47802906 | Rosiglitazone Regulates TLR4 and Rescues HO-1 and NRF2 Expression in Myometrial and Decidual Macrophages in Inflammation-Induced Preterm Birth. |
Q46611073 | Rosiglitazone and 15-deoxy-Delta12,14-prostaglandin J2 cause potent neuroprotection after experimental stroke through noncompletely overlapping mechanisms. |
Q36157326 | Rosiglitazone induces decreases in bone mass and strength that are reminiscent of aged bone |
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Q46034890 | Rosiglitazone-induced heart remodelling is associated with enhanced turnover of myofibrillar protein and mTOR activation. |
Q24535573 | SDP1 is a peroxisome-proliferator-activated receptor gamma 2 co-activator that binds through its SCAN domain |
Q36497213 | SMRT-GPS2 corepressor pathway dysregulation coincides with obesity-linked adipocyte inflammation |
Q47696944 | Screening of molecular cell targets for carcinogenic heterocyclic aromatic amines by using CALUX® reporter gene assays |
Q24793556 | Serum adiponectin as a biomarker for in vivo PPARgamma activation and PPARgamma agonist-induced efficacy on insulin sensitization/lipid lowering in rats |
Q40360288 | Spectroscopic analyses of the binding kinetics of 15d-PGJ2 to the PPARgamma ligand-binding domain by multi-wavelength global fitting |
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Q46074706 | Synthesis of lipoxin A4 by 5-lipoxygenase mediates PPARgamma-dependent, neuroprotective effects of rosiglitazone in experimental stroke. |
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Q34772498 | The peroxisome proliferator-activated receptor alpha (PPARalpha): role in hepatocarcinogenesis |
Q28585701 | The peroxisome proliferator-activated receptor gamma agonist rosiglitazone ameliorates murine lupus by induction of adiponectin |
Q34838209 | The role of PPARs in atherosclerosis |
Q45929326 | The role of peroxisome proliferator-activated receptor gamma in blood pressure regulation. |
Q37848841 | The safety of thiazolidinediones |
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Q33885244 | Zinc-chelated Vitamin C Stimulates Adipogenesis of 3T3-L1 Cells |
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