Deactylase inhibitors disrupt cellular complexes containing protein phosphatases and deacetylases

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Deactylase inhibitors disrupt cellular complexes containing protein phosphatases and deacetylases is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M310997200
P698PubMed publication ID14670976
P5875ResearchGate publication ID5665885

P50authorJohn ConnorQ37368402
P2093author name stringTso-Pang Yao
Shirish Shenolikar
Amaris Guardiola
Matthew H Brush
P2860cites workThree proteins define a class of human histone deacetylases related to yeast Hda1pQ22009464
Requirement of Rsk-2 for epidermal growth factor-activated phosphorylation of histone H3Q22010472
Mitotic phosphorylation of histone H3 is governed by Ipl1/aurora kinase and Glc7/PP1 phosphatase in budding yeast and nematodesQ24290197
Molecular cloning and characterization of a novel histone deacetylase HDAC10Q24291945
Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2Q24293501
Cloning and functional characterization of HDAC11, a novel member of the human histone deacetylase familyQ24294179
Histone deacetylase 1 phosphorylation promotes enzymatic activity and complex formationQ43767926
Site-specific loss of acetylation upon phosphorylation of histone H3.Q44012132
Transcriptional attenuation following cAMP induction requires PP-1-mediated dephosphorylation of CREB.Q46127758
Preparation of low-molecular-weight forms of rabbit muscle protein phosphataseQ47187783
Protein phosphatase 1 is targeted to microtubules by the microtubule-associated protein Tau.Q47681968
Chromatin-associated Protein Phosphatase 1 Regulates Aurora-B and Histone H3 PhosphorylationQ57412269
HDAC6 is a microtubule-associated deacetylaseQ24298013
Association of a protein phosphatase 1 activity with the human factor C1 (HCF) complexQ24515330
Structural basis for the recognition of regulatory subunits by the catalytic subunit of protein phosphatase 1Q24532150
The nucleosomal response associated with immediate-early gene induction is mediated via alternative MAP kinase cascades: MSK1 as a potential histone H3/HMG-14 kinaseQ24534365
Histone deacetylase 6 binds polyubiquitin through its zinc finger (PAZ domain) and copurifies with deubiquitinating enzymesQ24536045
Mitotic phosphorylation of histone H3: spatio-temporal regulation by mammalian Aurora kinasesQ24537111
Targeting protein phosphatase 1 (PP1) to the actin cytoskeleton: the neurabin I/PP1 complex regulates cell morphologyQ24537519
Runx2 (Cbfa1, AML-3) interacts with histone deacetylase 6 and represses the p21(CIP1/WAF1) promoterQ24537942
Identification of components of the murine histone deacetylase 6 complex: link between acetylation and ubiquitination signaling pathwaysQ24548256
Mitogen-regulated RSK2-CBP interaction controls their kinase and acetylase activitiesQ24548307
A role for histone deacetylase activity in HDAC1-mediated transcriptional repressionQ24682567
Three-dimensional structure of the catalytic subunit of protein serine/threonine phosphatase-1Q27729832
Synergistic coupling of histone H3 phosphorylation and acetylation in response to epidermal growth factor stimulationQ28141828
Signaling to chromatin through histone modificationsQ28142598
The protein phosphatase-1 (PP1) regulator, nuclear inhibitor of PP1 (NIPP1), interacts with the polycomb group protein, embryonic ectoderm development (EED), and functions as a transcriptional repressorQ28177142
Interaction and feedback regulation between STK15/BTAK/Aurora-A kinase and protein phosphatase 1 through mitotic cell division cycleQ28215986
HDAC-6 interacts with and deacetylates tubulin and microtubules in vivoQ28510434
In vivo destabilization of dynamic microtubules by HDAC6-mediated deacetylationQ28585062
Mechanism for nucleocytoplasmic shuttling of histone deacetylase 7Q28594917
Acetylation: a regulatory modification to rival phosphorylation?Q29614886
Identification of protein phosphatase-1-binding proteins by microcystin-biotin affinity chromatographyQ30469609
Phosphorylation of serine 10 in histone H3 is functionally linked in vitro and in vivo to Gcn5-mediated acetylation at lysine 14.Q33911284
The modular nature of histone deacetylase HDAC4 confers phosphorylation-dependent intracellular trafficking.Q34084949
Transcriptional control at regulatory checkpoints by histone deacetylases: molecular connections between cancer and chromatinQ34188997
Interaction of histone acetylases and deacetylases in vivoQ34463350
Potent histone deacetylase inhibitors built from trichostatin A and cyclic tetrapeptide antibiotics including trapoxinQ34584029
Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylationQ34956085
Phosphatase inhibition leads to histone deacetylases 1 and 2 phosphorylation and disruption of corepressor interactionsQ39408797
Trichostatin A-induced detransformation correlates with decreased focal adhesion kinase phosphorylation at tyrosine 861 in ras-transformed fibroblastsQ40753402
Active maintenance of mHDA2/mHDAC6 histone-deacetylase in the cytoplasmQ42629017
Increased Ser-10 phosphorylation of histone H3 in mitogen-stimulated and oncogene-transformed mouse fibroblastsQ42811761
Attenuation of a phosphorylation-dependent activator by an HDAC-PP1 complexQ43521641
Follicle-stimulating hormone stimulates protein kinase A-mediated histone H3 phosphorylation and acetylation leading to select gene activation in ovarian granulosa cellsQ43703036
P433issue9
P407language of work or nameEnglishQ1860
P1104number of pages7
P304page(s)7685-7691
P577publication date2003-12-10
P1433published inJournal of Biological ChemistryQ867727
P1476titleDeactylase inhibitors disrupt cellular complexes containing protein phosphatases and deacetylases
P478volume279

Reverse relations

cites work (P2860)
Q34146683A novel role for histone deacetylase 6 in the regulation of the tolerogenic STAT3/IL-10 pathway in APCs.
Q24797546Acetylation of insulin receptor substrate-1 is permissive for tyrosine phosphorylation
Q50318352Activation of ATM-dependent DNA damage signal pathway by a histone deacetylase inhibitor, trichostatin A.
Q29616624Anticancer activities of histone deacetylase inhibitors
Q38512046Anticancer potential of the histone deacetylase inhibitor-like effects of flavones, a subclass of polyphenolic compounds: a review
Q36715681Aurora A kinase (AURKA) in normal and pathological cell division
Q34797621C6-ceramide synergistically potentiates the anti-tumor effects of histone deacetylase inhibitors via AKT dephosphorylation and α-tubulin hyperacetylation both in vitro and in vivo
Q33724483Class II histone deacetylases: from sequence to function, regulation, and clinical implication
Q33636430Crosstalk in inflammation: the interplay of glucocorticoid receptor-based mechanisms and kinases and phosphatases
Q38900285Deacetylase inhibitors repress STAT5-mediated transcription by interfering with bromodomain and extra-terminal (BET) protein function
Q39861257Direct interaction between myocyte enhancer factor 2 (MEF2) and protein phosphatase 1alpha represses MEF2-dependent gene expression.
Q89865705Discovery of suppressors of CRMP2 phosphorylation reveals compounds that mimic the behavioral effects of lithium on amphetamine-induced hyperlocomotion
Q33383636Displacement affinity chromatography of protein phosphatase one (PP1) complexes
Q35597474Effect of microcystin-LR on protein phosphatase 2A and its function in human amniotic epithelial cells
Q33887501Effects of Trichostatin A on Cumulus Expansion during Mouse Oocyte Maturation
Q37075889Enforcing the pause: transcription factor Sp3 limits productive elongation by RNA polymerase II.
Q40010061Epigenetic regulation of cardiac muscle-specific genes in H9c2 cells by Interleukin-18 and histone deacetylase inhibitor m-carboxycinnamic acid bis-hydroxamide
Q38074367Epigenetic regulation of memory formation and maintenance.
Q37984815Exploiting the selectivity of protein phosphatase 1 for pharmacological intervention
Q28240437HATs and HDACs: from structure, function and regulation to novel strategies for therapy and prevention
Q53192804HDAC inhibitor sodium butyrate sensitizes E1A+Ras-transformed cells to DNA damaging agents by facilitating formation and persistence of γH2AX foci.
Q34885424HDAC-inhibitor (S)-8 disrupts HDAC6-PP1 complex prompting A375 melanoma cell growth arrest and apoptosis
Q41225033HDAC1 controls CIP2A transcription in human colorectal cancer cells
Q39829692HDAC1 in axonal degeneration: A matter of subcellular localization
Q34055727HDAC6 regulates LPS-tolerance in astrocytes
Q27326879HDAC6 regulates mitochondrial transport in hippocampal neurons
Q36908418HDAC6, at the crossroads between cytoskeleton and cell signaling by acetylation and ubiquitination
Q28290352HDACs, histone deacetylation and gene transcription: from molecular biology to cancer therapeutics
Q24647111HEF1-dependent Aurora A activation induces disassembly of the primary cilium
Q40368705Histone acetylation-independent effect of histone deacetylase inhibitors on Akt through the reshuffling of protein phosphatase 1 complexes
Q24315060Histone deacetylase 6 interacts with the microtubule-associated protein tau
Q40511487Histone deacetylase inhibitors differentially mediate apoptosis in prostate cancer cells
Q36908440Histone deacetylase inhibitors: molecular mechanisms of action
Q37389553Histone deacetylases: salesmen and customers in the post-translational modification market.
Q33707775Impaired function of HDAC6 slows down axonal growth and interferes with axon initial segment development
Q43107945Increased acetylation of microtubules rescues human tau-induced microtubule defects and neuromuscular junction abnormalities in Drosophila.
Q42152675Inhibition of histone deacetylase overcomes rapamycin-mediated resistance in diffuse large B-cell lymphoma by inhibiting Akt signaling through mTORC2
Q47140652Inhibitors of the PI3K/mTOR pathway prevent STAT5 phosphorylation in JAK2V617F mutated cells through PP2A/CIP2A axis
Q80543429Irradiation modulates association of NF-Y with histone-modifying cofactors PCAF and HDAC
Q24798502Leaky ribosomal scanning in mammalian genomes: significance of histone H4 alternative translation in vivo
Q30477707Lymphocyte chemotaxis is regulated by histone deacetylase 6, independently of its deacetylase activity
Q30590712MYPT1 regulates contractility and microtubule acetylation to modulate integrin adhesions and matrix assembly
Q39941696Microtubule acetylation through HDAC6 inhibition results in increased transfection efficiency
Q53551565Mutations in SIRT2 deacetylase which regulate enzymatic activity but not its interaction with HDAC6 and tubulin.
Q47687461Oxidative stress promotes SIRT1 recruitment to the GADD34/PP1α complex to activate its deacetylase function
Q24301735PP2A regulates HDAC4 nuclear import
Q42738099Pharmacological inhibition of HDAC6 attenuates endothelial barrier dysfunction induced by thrombin
Q30440367Phosphatase inhibitor 2 promotes acetylation of tubulin in the primary cilium of human retinal epithelial cells
Q38236704Protein phosphatase 1 catalytic isoforms: specificity toward interacting proteins
Q48434211Protein phosphatase 1 regulates the histone code for long-term memory
Q24304927Protein phosphatase 1α interacting proteins in the human brain
Q64062337Pseudophosphatase MK-STYX Alters Histone Deacetylase 6 Cytoplasmic Localization, Decreases Its Phosphorylation, and Increases Detyrosination of Tubulin
Q37825437Regulating the regulators: the post-translational code of class I HDAC1 and HDAC2.
Q33929939Suppression of class I and II histone deacetylases blunts pressure-overload cardiac hypertrophy
Q24658001Targeting protein serine/threonine phosphatases for drug development
Q34984418The HDAC inhibitor LBH589 induces ERK-dependent prometaphase arrest in prostate cancer via HDAC6 inactivation and down-regulation
Q27331540The microRNA cluster miR-183/96/182 contributes to long-term memory in a protein phosphatase 1-dependent manner
Q38385900The power of the yeast two-hybrid system in the identification of novel drug targets: building and modulating PPP1 interactomes
Q34279114The role of histone acetylation in memory formation and cognitive impairments
Q37820143The tale of protein lysine acetylation in the cytoplasm.

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