Enforcing the pause: transcription factor Sp3 limits productive elongation by RNA polymerase II.

scientific article published on 15 May 2013

Enforcing the pause: transcription factor Sp3 limits productive elongation by RNA polymerase II. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.4161/CC.24992
P932PMC publication ID3735696
P698PubMed publication ID23676218
P5875ResearchGate publication ID236910988

P2093author name stringGrace Gill
Alvaro Valin
P2860cites workBRCA1-induced large-scale chromatin unfolding and allele-specific effects of cancer-predisposing mutationsQ24291985
Human transcription elongation factor NELF: identification of novel subunits and reconstitution of the functionally active complexQ24296462
Histone crosstalk between H3S10ph and H4K16ac generates a histone code that mediates transcription elongationQ24317522
The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylationQ24323313
Transcription factor Sp3 is silenced through SUMO modification by PIAS1Q24534887
CDK9 autophosphorylation regulates high-affinity binding of the human immunodeficiency virus type 1 tat-P-TEFb complex to TAR RNAQ24550765
Relief of two built-In autoinhibitory mechanisms in P-TEFb is required for assembly of a multicomponent transcription elongation complex at the human immunodeficiency virus type 1 promoterQ24552532
Attenuation of estrogen receptor alpha-mediated transcription through estrogen-stimulated recruitment of a negative elongation factorQ24562734
c-Myc regulates transcriptional pause releaseQ24629119
Three functional classes of transcriptional activation domainQ24649917
Molecular cloning and analysis of two subunits of the human TFIID complex: hTAFII130 and hTAFII100Q24682969
Protein phosphatase 1--targeted in many directionsQ28200684
Controlling the elongation phase of transcription with P-TEFbQ28255518
Analysis of the large inactive P-TEFb complex indicates that it contains one 7SK molecule, a dimer of HEXIM1 or HEXIM2, and two P-TEFb molecules containing Cdk9 phosphorylated at threonine 186Q28257440
COBRA1 inhibits AP-1 transcriptional activity in transfected cellsQ28292004
Nascent RNA sequencing reveals widespread pausing and divergent initiation at human promotersQ28302903
Impaired hematopoiesis in mice lacking the transcription factor Sp3Q28589241
p53 Functions through Stress- and Promoter-Specific Recruitment of Transcription Initiation Components before and after DNA DamageQ28609701
SUMO-1 modification represses Sp3 transcriptional activation and modulates its subnuclear localizationQ28612080
Regulating RNA polymerase pausing and transcription elongation in embryonic stem cellsQ29392187
A chromatin landmark and transcription initiation at most promoters in human cellsQ29547180
RNA polymerase is poised for activation across the genomeQ29615047
Molecular cloning and functional analysis of Drosophila TAF110 reveal properties expected of coactivatorsQ29620376
Epigenetic silencing of spermatocyte-specific and neuronal genes by SUMO modification of the transcription factor Sp3.Q33750227
Identification in vivo of different rate-limiting steps associated with transcriptional activators in the presence and absence of a GAGA elementQ33758271
The glucocorticoid receptor blocks P-TEFb recruitment by NFkappaB to effect promoter-specific transcriptional repression.Q33780734
Global analysis of the relationship between JIL-1 kinase and transcription.Q33851456
AFF4, a component of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemiaQ33857407
Control of inducible gene expression by signal-dependent transcriptional elongationQ39285490
Stepwise recruitment of components of the preinitiation complex by upstream activators in vivoQ39583958
Mechanism of rapid transcriptional induction of tumor necrosis factor alpha-responsive genes by NF-kappaB.Q39681517
HIV-1 Tat assembles a multifunctional transcription elongation complex and stably associates with the 7SK snRNPQ39703646
SUMO-modified Sp3 represses transcription by provoking local heterochromatic gene silencingQ39962765
Nuclear targeting of protein phosphatase-1 by HIV-1 Tat proteinQ40379930
Elongation inhibition by DRB sensitivity-inducing factor is regulated by the A20 promoter via a novel negative element and NF-kappaB.Q40633614
Impaired ossification in mice lacking the transcription factor Sp3.Q40789957
A phosphorylation switch regulates the transcriptional activation of cell cycle regulator p21 by histone deacetylase inhibitors.Q41198504
Promoter-proximal pausing of RNA polymerase II defines a general rate-limiting step after transcription initiationQ41365790
Chromatin remodeling and transcriptionQ41441673
Attenuation of a phosphorylation-dependent activator by an HDAC-PP1 complexQ43521641
NF-kappaB binds P-TEFb to stimulate transcriptional elongation by RNA polymerase II.Q43730164
Transcription factors that activate the Ultrabithorax promoter in developmentally staged extractsQ46523598
Phosphorylated positive transcription elongation factor b (P-TEFb) is tagged for inhibition through association with 7SK snRNA.Q46675052
Dual functions of largest NURF subunit NURF301 in nucleosome sliding and transcription factor interactionsQ47070476
The JIL-1 histone H3S10 kinase regulates dimethyl H3K9 modifications and heterochromatic spreading in DrosophilaQ47072197
Protein phosphatase 1 regulates the histone code for long-term memoryQ48434211
Transcriptional elongation by RNA polymerase II is stimulated by transactivators.Q49101405
Identification of SUMO-dependent chromatin-associated transcriptional repression components by a genome-wide RNAi screen.Q50336137
Short transcripts of the ternary complex provide insight into RNA polymerase II elongational pausing.Q52536804
Purification of P-TEFb, a transcription factor required for the transition into productive elongation.Q52539193
SUMO engages multiple corepressors to regulate chromatin structure and transcriptionQ84725717
Licensed to elongate: a molecular mechanism for MLL-based leukaemogenesisQ85036285
Artificial recruitment of TFIID, but not RNA polymerase II holoenzyme, activates transcription in mammalian cellsQ33963967
Deactylase inhibitors disrupt cellular complexes containing protein phosphatases and deacetylasesQ34283050
Small CTD phosphatases function in silencing neuronal gene expressionQ34389521
Gene-specific requirement for P-TEFb activity and RNA polymerase II phosphorylation within the p53 transcriptional programQ34471112
Signaling by protein phosphatases in the nucleusQ34540906
Cooperation between core promoter elements influences transcriptional activity in vivoQ34555034
Breaking barriers to transcription elongationQ34561019
Dynamics of potentiation and activation: GAGA factor and its role in heat shock gene regulationQ34639083
HIV-1 Tat and host AFF4 recruit two transcription elongation factors into a bifunctional complex for coordinated activation of HIV-1 transcriptionQ34896128
New insights into the control of HIV-1 transcription: when Tat meets the 7SK snRNP and super elongation complex (SEC).Q34919381
A glutamine-rich hydrophobic patch in transcription factor Sp1 contacts the dTAFII110 component of the Drosophila TFIID complex and mediates transcriptional activationQ34920038
Drosophila GAGA factor directs histone H3.3 replacement that prevents the heterochromatin spreadingQ35677275
Phosphorylation of histone H3 at Ser10 facilitates RNA polymerase II release from promoter-proximal pausing in DrosophilaQ36098251
The super elongation complex family of RNA polymerase II elongation factors: gene target specificity and transcriptional outputQ36210873
Global analysis of short RNAs reveals widespread promoter-proximal stalling and arrest of Pol II in DrosophilaQ36214878
Transcriptional control by chromosome-associated protein phosphatase-1.Q36295505
Protein serine/threonine phosphatases in neuronal plasticity and disorders of learning and memoryQ36644538
PP2B and PP1alpha cooperatively disrupt 7SK snRNP to release P-TEFb for transcription in response to Ca2+ signalingQ36649160
Promoter elements associated with RNA Pol II stalling in the Drosophila embryoQ36676820
NELF and GAGA factor are linked to promoter-proximal pausing at many genes in DrosophilaQ36710845
Emerging roles of nuclear protein phosphatasesQ36743535
Transcription factor Sp3 represses expression of p21CIP¹ via inhibition of productive elongation by RNA polymerase II.Q36759836
NELF-mediated stalling of Pol II can enhance gene expression by blocking promoter-proximal nucleosome assemblyQ36802956
RNA polymerase II-mediated transcription at active loci does not require histone H3S10 phosphorylation in DrosophilaQ36982863
Poised polymerases: on your mark...get set...go!Q37136094
The multi-tasking P-TEFb complexQ37177846
P-TEFb- the final frontierQ37356131
From promiscuity to precision: protein phosphatases get a makeoverQ37414833
Immediate mediators of the inflammatory response are poised for gene activation through RNA polymerase II stalling.Q37416607
CYCLINg through transcription: posttranslational modifications of P-TEFb regulate transcription elongationQ37740906
Paused RNA polymerase II as a developmental checkpointQ37874803
HSF access to heat shock elements in vivo depends critically on promoter architecture defined by GAGA factor, TFIID, and RNA polymerase II binding sitesQ38289211
Transcriptional activators differ in their responses to overexpression of TATA-box-binding proteinQ38298143
Transcriptional pausing caused by NELF plays a dual role in regulating immediate-early expression of the junB geneQ38408801
P433issue12
P304page(s)1828-1834
P577publication date2013-05-15
P1433published inCell CycleQ1254166
P1476titleEnforcing the pause: transcription factor Sp3 limits productive elongation by RNA polymerase II.
P478volume12

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cites work (P2860)
Q45857351Hypoxia inducible factor 1 alpha down-regulates type i collagen through Sp3 transcription factor in human chondrocytes
Q39062294The Robo3 receptor, a key player in the development, evolution, and function of commissural systems

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