Attenuation of estrogen receptor alpha-mediated transcription through estrogen-stimulated recruitment of a negative elongation factor

scientific article

Attenuation of estrogen receptor alpha-mediated transcription through estrogen-stimulated recruitment of a negative elongation factor is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1101/GAD.1214104
P3181OpenCitations bibliographic resource ID894819
P932PMC publication ID515291
P698PubMed publication ID15342491
P5875ResearchGate publication ID8371077

P50authorChristopher MoskalukQ57441216
P2093author name stringYuki Yamaguchi
Hiroshi Handa
Rong Li
Sarah E Aiyar
Amitava Mukherjee
Da-ming Ren
Qi-Nong Ye
Jian-long Sun
Ashley L Blair
Yun-zhe Lu
P2860cites workBRCA1-induced large-scale chromatin unfolding and allele-specific effects of cancer-predisposing mutationsQ24291985
ERAP140, a conserved tissue-specific nuclear receptor coactivatorQ24295032
Human transcription elongation factor NELF: identification of novel subunits and reconstitution of the functionally active complexQ24296462
Disassembly of transcriptional regulatory complexes by molecular chaperonesQ24300055
Evidence that negative elongation factor represses transcription elongation through binding to a DRB sensitivity-inducing factor/RNA polymerase II complex and RNA.Q24537283
BRCA1 mediates ligand-independent transcriptional repression of the estrogen receptorQ24555775
Functional interactions of RNA-capping enzyme with factors that positively and negatively regulate promoter escape by RNA polymerase IIQ24562164
JunB potentiates function of BRCA1 activation domain 1 (AD1) through a coiled-coil-mediated interactionQ24675100
Transcription elongation factors repress transcription initiation from cryptic sites.Q27931897
Evidence that Spt4, Spt5, and Spt6 control transcription elongation by RNA polymerase II in Saccharomyces cerevisiaeQ27937704
The coregulator exchange in transcriptional functions of nuclear receptorsQ28131759
NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongationQ28141291
Synergistic coupling of histone H3 phosphorylation and acetylation in response to epidermal growth factor stimulationQ28141828
FACT relieves DSIF/NELF-mediated inhibition of transcriptional elongation and reveals functional differences between P-TEFb and TFIIHQ28141838
Transcriptional repression of oestrogen receptor by metastasis-associated protein 1 corepressorQ28142019
Role of direct interaction in BRCA1 inhibition of estrogen receptor activityQ28204456
Putting tumours in contextQ28207789
Combinatorial control of gene expression by nuclear receptors and coregulatorsQ28209095
Structure-function analysis of the estrogen receptor alpha corepressor scaffold attachment factor-B1: identification of a potent transcriptional repression domainQ28254928
Cloning, chromosomal localization, and functional analysis of the murine estrogen receptor betaQ28587815
CoCoA, a nuclear receptor coactivator which acts through an N-terminal activation domain of p160 coactivatorsQ28594257
An extensive network of coupling among gene expression machinesQ29547273
Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane culturesQ29547700
Cofactor dynamics and sufficiency in estrogen receptor-regulated transcriptionQ29547846
A unified theory of gene expressionQ29615022
Estrogen receptor-alpha directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoterQ29616537
SH3-mediated Hck tyrosine kinase activation and fibroblast transformation by the Nef protein of HIV-1.Q30176471
Muscarinic receptors transform NIH 3T3 cells through a Ras-dependent signalling pathway inhibited by the Ras-GTPase-activating protein SH3 domainQ30193837
Characterization of a novel trans-activation domain of BRCA1 that functions in concert with the BRCA1 C-terminal (BRCT) domainQ30306336
Identification and characterization of estrogen receptor variants in prostate cancer cell linesQ30306798
Estrogen-responsive element of the human pS2 gene is an imperfectly palindromic sequenceQ33837377
Destruction of Myc by ubiquitin-mediated proteolysis: cancer-associated and transforming mutations stabilize Myc.Q33890400
The 26S proteasome is required for estrogen receptor-alpha and coactivator turnover and for efficient estrogen receptor-alpha transactivationQ33911291
Estrogens in the causation of breast, endometrial and ovarian cancers - evidence and hypotheses from epidemiological findingsQ33932063
RNA polymerase II elongation through chromatinQ34058567
Mechanisms of estrogen actionQ34093297
Estrogen receptor pathways to AP-1.Q34132667
Ligand-dependent nuclear receptor corepressor LCoR functions by histone deacetylase-dependent and -independent mechanismsQ34171522
Transcription elongation: the 'Foggy' is liftingellipsis.Q34183941
Tracking FACT and the RNA polymerase II elongation complex through chromatin in vivoQ34224771
Estrogens and cell-cycle regulation in breast cancerQ34336956
The mRNA assembly line: transcription and processing machines in the same factoryQ34688409
Taking the study of cancer cell survival to a new dimensionQ35036517
Endocrine-responsive breast cancer and strategies for combating resistanceQ35084786
High-resolution localization of Drosophila Spt5 and Spt6 at heat shock genes in vivo: roles in promoter proximal pausing and transcription elongationQ35205005
NELF and DSIF cause promoter proximal pausing on the hsp70 promoter in DrosophilaQ35965503
Spt5 and spt6 are associated with active transcription and have characteristics of general elongation factors in D. melanogasterQ40445025
A slow RNA polymerase II affects alternative splicing in vivoQ40627617
Elongation inhibition by DRB sensitivity-inducing factor is regulated by the A20 promoter via a novel negative element and NF-kappaB.Q40633614
Cellular changes involved in conversion of normal to malignant breast: importance of the stromal reactionQ40964604
Potential role for cathepsin D in p53-dependent tumor suppression and chemosensitivity.Q41035943
Enhancement of human estrogen receptor activity by SPT6: a potential coactivatorQ41393826
Direct interaction between Sp1 and the BPV enhancer E2 protein mediates synergistic activation of transcriptionQ41684614
A regulator of transcriptional elongation controls vertebrate neuronal developmentQ46382831
Ligand-independent activation of steroid hormone receptorsQ47862014
Characterization of the proximal estrogen-responsive element of human cathepsin D geneQ48082268
Carcinogenesis: A superfamily of potentially oncogenic hormone receptorsQ59077092
BRCA1 Inhibition of Estrogen Receptor Signaling in Transfected CellsQ60568779
Identification of the sequences within the human complement 3 promoter required for estrogen responsiveness provides insight into the mechanism of tamoxifen mixed agonist activityQ71877215
The human estrogen receptor-alpha is a ubiquitinated protein whose stability is affected differentially by agonists, antagonists, and selective estrogen receptor modulatorsQ74265958
P433issue17
P407language of work or nameEnglishQ1860
P921main subjectestrogenQ277954
P304page(s)2134-2146
P577publication date2004-09-01
P1433published inGenes & DevelopmentQ1524533
P1476titleAttenuation of estrogen receptor alpha-mediated transcription through estrogen-stimulated recruitment of a negative elongation factor
P478volume18

Reverse relations

cites work (P2860)
Q37244303A Role of CREB in BRCA1 Constitutive Promoter Activity and Aromatase Basal Expression
Q37333813A conserved protein motif is required for full modulatory activity of negative elongation factor subunits NELF-A and NELF-B in modifying glucocorticoid receptor-regulated gene induction properties
Q37095266A global view of transcriptional regulation by nuclear receptors: gene expression, factor localization, and DNA sequence analysis
Q24536049A negative elongation factor for human RNA polymerase II inhibits the anti-arrest transcript-cleavage factor TFIIS.
Q33944154A phosphotyrosine switch determines the antitumor activity of ERβ.
Q42426276Architecture and RNA binding of the human negative elongation factor.
Q33850983Attenuation of RNA polymerase II pausing mitigates BRCA1-associated R-loop accumulation and tumorigenesis.
Q26853262BRCA1, a 'complex' protein involved in the maintenance of genomic stability
Q36978246BRD4 coordinates recruitment of pause release factor P-TEFb and the pausing complex NELF/DSIF to regulate transcription elongation of interferon-stimulated genes
Q36561822Bromodomain protein BRD4 is required for estrogen receptor-dependent enhancer activation and gene transcription
Q39999414Cellular dynamics of the negative transcription elongation factor NELF.
Q30439381Cofactor of BRCA1 modulates androgen-dependent transcription and alternative splicing
Q30444129Concerted transcriptional regulation by BRCA1 and COBRA1 in breast cancer cells
Q39958759Cotranscriptional splicing potentiates the mRNA production from a subset of estradiol-stimulated genes.
Q37075889Enforcing the pause: transcription factor Sp3 limits productive elongation by RNA polymerase II.
Q89845940Estrogen receptor alpha (ERα)-mediated coregulator binding and gene expression discriminates the toxic ERα agonist diethylstilbestrol (DES) from the endogenous ERα agonist 17β-estradiol (E2)
Q79756268Expression and distribution of trihydrophobin 1 in postnatal developing mouse testis
Q37293773FHL1 interacts with oestrogen receptors and regulates breast cancer cell growth
Q49936294Gene-Specific Genetic Complementation between Brca1 and Cobra1 During Mouse Mammary Gland Development.
Q50101639Gene-specific mechanisms direct Glucocorticoid Receptor-driven repression of inflammatory response genes in macrophages
Q35658278Gene-specific recruitment of positive and negative elongation factors during stimulated transcription of the MKP-1 gene in neuroendocrine cells.
Q35378348Genetic and genomic analyses of RNA polymerase II-pausing factor in regulation of mammalian transcription and cell growth
Q36670266Genetic suppression reveals DNA repair-independent antagonism between BRCA1 and COBRA1 in mammary gland development.
Q33355172Genome-wide analysis of alternative promoters of human genes using a custom promoter tiling array
Q40130067Genomic analyses of transcription factor binding, histone acetylation, and gene expression reveal mechanistically distinct classes of estrogen-regulated promoters
Q37157412Glucocorticoid receptor represses proinflammatory genes at distinct steps of the transcription cycle
Q33702169HEXIM1 regulates 17beta-estradiol/estrogen receptor-alpha-mediated expression of cyclin D1 in mammary cells via modulation of P-TEFb
Q34666783Hepatitis B virus X protein and the estrogen receptor variant lacking exon 5 inhibit estrogen receptor signaling in hepatoma cells
Q37351081Hormone-regulated transcriptomes: lessons learned from estrogen signaling pathways in breast cancer cells
Q37073709Human four-and-a-half LIM family members suppress tumor cell growth through a TGF-beta-like signaling pathway.
Q33673701Human negative elongation factor activates transcription and regulates alternative transcription initiation
Q37416607Immediate mediators of the inflammatory response are poised for gene activation through RNA polymerase II stalling.
Q33953149Interactions between DSIF (DRB sensitivity inducing factor), NELF (negative elongation factor), and the Drosophila RNA polymerase II transcription elongation complex
Q36964490Kinetic competition between elongation rate and binding of NELF controls promoter-proximal pausing
Q36419269Kinetically Defined Mechanisms and Positions of Action of Two New Modulators of Glucocorticoid Receptor-regulated Gene Induction
Q33737855Module Discovery by Exhaustive Search for Densely Connected, Co-Expressed Regions in Biomolecular Interaction Networks
Q24798796Molecular characterization of Drosophila NELF
Q28475186Mouse cofactor of BRCA1 (Cobra1) is required for early embryogenesis.
Q90187891NELF Regulates a Promoter-Proximal Step Distinct from RNA Pol II Pause-Release
Q36710845NELF and GAGA factor are linked to promoter-proximal pausing at many genes in Drosophila
Q28474810NELF potentiates gene transcription in the Drosophila embryo
Q36802956NELF-mediated stalling of Pol II can enhance gene expression by blocking promoter-proximal nucleosome assembly
Q37151045Negative elongation factor (NELF) coordinates RNA polymerase II pausing, premature termination, and chromatin remodeling to regulate HIV transcription
Q45405018Negative elongation factor NELF represses human immunodeficiency virus transcription by pausing the RNA polymerase II complex
Q38629873Negative elongation factor accelerates the rate at which heat shock genes are shut off by facilitating dissociation of heat shock factor
Q39663904Negative role of trihydrophobin 1 in breast cancer growth and migration
Q36974098Pausing for thought: disrupting the early transcription elongation checkpoint leads to developmental defects and tumourigenesis.
Q34494012Pol II waiting in the starting gates: Regulating the transition from transcription initiation into productive elongation.
Q37099958Postrecruitment regulation of RNA polymerase II directs rapid signaling responses at the promoters of estrogen target genes
Q36237484Promoter proximal pausing and the control of gene expression
Q37284766Promoter proximal pausing on genes in metazoans
Q36505626RNA polymerase II pausing as a context-dependent reader of the genome
Q29615047RNA polymerase is poised for activation across the genome
Q24645367RNA polymerase stalling at developmental control genes in the Drosophila melanogaster embryo
Q38562823Ready, pause, go: regulation of RNA polymerase II pausing and release by cellular signaling pathways
Q30441905Regulation of clustered gene expression by cofactor of BRCA1 (COBRA1) in breast cancer cells
Q40362927Stimulatory cross-talk between NFAT3 and estrogen receptor in breast cancer cells
Q40273664The BRCA1 COOH-terminal region acts as an RNA polymerase II carboxyl-terminal domain kinase inhibitor that modulates p21WAF1/CIP1 expression
Q36602565The role of BRCA1 in transcriptional regulation and cell cycle control
Q36759836Transcription factor Sp3 represses expression of p21CIP¹ via inhibition of productive elongation by RNA polymerase II.
Q35855656Transcription termination factor Pcf11 limits the processivity of Pol II on an HIV provirus to repress gene expression
Q38408801Transcriptional pausing caused by NELF plays a dual role in regulating immediate-early expression of the junB gene
Q24307973Transcriptional regulation of BRCA1 expression by a metabolic switch
Q35641521Translational Initiation at a Non-AUG Start Codon for Human and Mouse Negative Elongation Factor-B
Q34125340Trihydrophobin 1 phosphorylation by c-Src regulates MAPK/ERK signaling and cell migration
Q35812718Tumor therapy mediated by lentiviral expression of shBcl-2 and S-TRAIL.
Q37520630Tyrosine phosphorylation regulates ERβ ubiquitination, protein turnover, and inhibition of breast cancer
Q34795516What goes on behind closed doors: physiological versus pharmacological steroid hormone actions

Search more.