Transcription factor Sp3 represses expression of p21CIP¹ via inhibition of productive elongation by RNA polymerase II.

scientific article published on 11 February 2013

Transcription factor Sp3 represses expression of p21CIP¹ via inhibition of productive elongation by RNA polymerase II. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/MCB.00323-12
P932PMC publication ID3624253
P698PubMed publication ID23401853
P5875ResearchGate publication ID235524715

P2093author name stringJian Ouyang
Grace Gill
Alvaro Valin
P2860cites workEvidence that P-TEFb alleviates the negative effect of DSIF on RNA polymerase II-dependent transcription in vitroQ22008559
Mitotic phosphorylation of histone H3 is governed by Ipl1/aurora kinase and Glc7/PP1 phosphatase in budding yeast and nematodesQ24290197
A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cellsQ24297079
CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1Q24303611
CDK9 directs H2B monoubiquitination and controls replication-dependent histone mRNA 3'-end processingQ24310547
Histone crosstalk between H3S10ph and H4K16ac generates a histone code that mediates transcription elongationQ24317522
The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expressionQ24318500
Transcription factor Sp3 is silenced through SUMO modification by PIAS1Q24534887
Dephosphorylation of CDK9 by protein phosphatase 2A and protein phosphatase-1 in Tat-activated HIV-1 transcriptionQ24535568
Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profilesQ24536351
Attenuation of estrogen receptor alpha-mediated transcription through estrogen-stimulated recruitment of a negative elongation factorQ24562734
Different members of the Sp1 multigene family exert opposite transcriptional regulation of the long terminal repeat of HIV-1Q24562924
c-Myc regulates transcriptional pause releaseQ24629119
WAF1, a potential mediator of p53 tumor suppressionQ27861121
NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongationQ28141291
A highly purified RNA polymerase II elongation control systemQ28216031
A positive feedback loop links opposing functions of P-TEFb/Cdk9 and histone H2B ubiquitylation to regulate transcript elongation in fission yeastQ28481750
Impaired hematopoiesis in mice lacking the transcription factor Sp3Q28589241
p53 Functions through Stress- and Promoter-Specific Recruitment of Transcription Initiation Components before and after DNA DamageQ28609701
SUMO-1 modification represses Sp3 transcriptional activation and modulates its subnuclear localizationQ28612080
Regulating RNA polymerase pausing and transcription elongation in embryonic stem cellsQ29392187
A chromatin landmark and transcription initiation at most promoters in human cellsQ29547180
Methylation of histone H3 by Set2 in Saccharomyces cerevisiae is linked to transcriptional elongation by RNA polymerase IIQ29614679
RNA polymerase is poised for activation across the genomeQ29615047
A DNA vector-based RNAi technology to suppress gene expression in mammalian cellsQ29616551
Molecular cloning and functional analysis of Drosophila TAF110 reveal properties expected of coactivatorsQ29620376
p21 in cancer: intricate networks and multiple activitiesQ30436015
Regulation of the p53 transcriptional response by structurally diverse core promotersQ33594126
Epigenetic silencing of spermatocyte-specific and neuronal genes by SUMO modification of the transcription factor Sp3.Q33750227
The glucocorticoid receptor blocks P-TEFb recruitment by NFkappaB to effect promoter-specific transcriptional repression.Q33780734
Global analysis of the relationship between JIL-1 kinase and transcription.Q33851456
RNA polymerase II pauses and associates with pre-mRNA processing factors at both ends of genes.Q34009055
Gene-specific requirement for P-TEFb activity and RNA polymerase II phosphorylation within the p53 transcriptional programQ34471112
Breaking barriers to transcription elongationQ34561019
Properties of RNA polymerase II elongation complexes before and after the P-TEFb-mediated transition into productive elongation.Q34654219
ATP-dependent nucleosome disruption at a heat-shock promoter mediated by binding of GAGA transcription factor.Q34727012
A glutamine-rich hydrophobic patch in transcription factor Sp1 contacts the dTAFII110 component of the Drosophila TFIID complex and mediates transcriptional activationQ34920038
The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3.Q35096586
Ubiquitylation of histone H2B controls RNA polymerase II transcription elongation independently of histone H3 methylationQ35720902
Phosphorylation of histone H3 at Ser10 facilitates RNA polymerase II release from promoter-proximal pausing in DrosophilaQ36098251
Protein serine/threonine phosphatases in neuronal plasticity and disorders of learning and memoryQ36644538
PP2B and PP1alpha cooperatively disrupt 7SK snRNP to release P-TEFb for transcription in response to Ca2+ signalingQ36649160
NELF and GAGA factor are linked to promoter-proximal pausing at many genes in DrosophilaQ36710845
Emerging roles of nuclear protein phosphatasesQ36743535
A site to remember: H3K36 methylation a mark for histone deacetylationQ36754994
NELF-mediated stalling of Pol II can enhance gene expression by blocking promoter-proximal nucleosome assemblyQ36802956
RNA polymerase II-mediated transcription at active loci does not require histone H3S10 phosphorylation in DrosophilaQ36982863
Regulation of the dual-function transcription factor Sp3 by SUMO.Q37010203
Protein phosphatase PP1 is required for normal DNA methylation in NeurosporaQ37023608
Poised polymerases: on your mark...get set...go!Q37136094
The multi-tasking P-TEFb complexQ37177846
"Cotranscriptionality": the transcription elongation complex as a nexus for nuclear transactionsQ37620941
CYCLINg through transcription: posttranslational modifications of P-TEFb regulate transcription elongationQ37740906
Sp1 plays a critical role in the transcriptional activation of the human cyclin-dependent kinase inhibitor p21(WAF1/Cip1) gene by the p53 tumor suppressor proteinQ38300297
Sp3 represses transcription when tethered to promoter DNA or targeted to promoter proximal RNA.Q38359173
Transcriptional pausing caused by NELF plays a dual role in regulating immediate-early expression of the junB geneQ38408801
Cohesin selectively binds and regulates genes with paused RNA polymeraseQ38708191
A novel evolutionarily conserved element is a general transcriptional repressor of p21WAF¹/CIP¹.Q39259178
An inhibitor domain in Sp3 regulates its glutamine-rich activation domains.Q39461480
TFIIH-associated Cdk7 kinase functions in phosphorylation of C-terminal domain Ser7 residues, promoter-proximal pausing, and termination by RNA polymerase IIQ39814573
Phosphorylation of RNA polymerase II CTD regulates H3 methylation in yeastQ39895202
SUMO-modified Sp3 represses transcription by provoking local heterochromatic gene silencingQ39962765
Sumoylation of internally initiated Sp3 isoforms regulates transcriptional repression via a Trichostatin A-insensitive mechanismQ40502178
Impaired ossification in mice lacking the transcription factor Sp3.Q40789957
Sp1 and Sp3 activate p21 (WAF1/CIP1) gene transcription in the Caco-2 colon adenocarcinoma cell lineQ40844112
A phosphorylation switch regulates the transcriptional activation of cell cycle regulator p21 by histone deacetylase inhibitors.Q41198504
P-TEFb-mediated phosphorylation of hSpt5 C-terminal repeats is critical for processive transcription elongationQ46904254
The JIL-1 histone H3S10 kinase regulates dimethyl H3K9 modifications and heterochromatic spreading in DrosophilaQ47072197
Protein phosphatase 1 regulates the histone code for long-term memoryQ48434211
NELF interacts with CBC and participates in 3' end processing of replication-dependent histone mRNAsQ50336087
Identification of SUMO-dependent chromatin-associated transcriptional repression components by a genome-wide RNAi screen.Q50336137
Short transcripts of the ternary complex provide insight into RNA polymerase II elongational pausing.Q52536804
Human general transcription factor IIH phosphorylates the C-terminal domain of RNA polymerase IIQ59098636
Transcriptional Regulation of the p21(WAF1/CIP1)GeneQ59119133
P433issue8
P407language of work or nameEnglishQ1860
P304page(s)1582-1593
P577publication date2013-02-11
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleTranscription factor Sp3 represses expression of p21CIP¹ via inhibition of productive elongation by RNA polymerase II.
P478volume33

Reverse relations

cites work (P2860)
Q42544809A role for p38 in transcriptional elongation of p21 (CIP1) in response to Aurora B inhibition
Q37075889Enforcing the pause: transcription factor Sp3 limits productive elongation by RNA polymerase II.
Q40922556Genome-wide promoter binding profiling of protein phosphatase-1 and its major nuclear targeting subunits.
Q42703854HDAC8 and STAT3 repress BMF gene activity in colon cancer cells
Q39000130Induction of p21CIP1 protein and cell cycle arrest after inhibition of Aurora B kinase is attributed to aneuploidy and reactive oxygen species.
Q34365546Overexpression of histone deacetylases in cancer cells is controlled by interplay of transcription factors and epigenetic modulators
Q60922491Protein phosphatases in chromatin structure and function

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