| scholarly article | Q13442814 |
| P50 | author | Kira Glover-Cutter | Q42177120 |
| Stéphane Larochelle | Q42444562 | ||
| David L Bentley | Q55137036 | ||
| P2093 | author name string | Chao Zhang | |
| Kevan Shokat | |||
| Robert P Fisher | |||
| Stéphane Larochelle | |||
| Benjamin Erickson | |||
| P2860 | cites work | NELF-mediated stalling of Pol II can enhance gene expression by blocking promoter-proximal nucleosome assembly | Q36802956 |
| Distinct activation pathways confer cyclin-binding specificity on Cdk1 and Cdk2 in human cells | Q37098110 | ||
| Cracking the RNA polymerase II CTD code | Q37155088 | ||
| Transcription regulation through promoter-proximal pausing of RNA polymerase II. | Q39442921 | ||
| RNA polymerase II carboxy-terminal domain phosphorylation is required for cotranscriptional pre-mRNA splicing and 3'-end formation | Q40025884 | ||
| Transcribing RNA polymerase II is phosphorylated at CTD residue serine-7. | Q40035560 | ||
| Serine-7 of the RNA polymerase II CTD is specifically required for snRNA gene expression | Q40035566 | ||
| Promoter-proximal pausing of RNA polymerase II defines a general rate-limiting step after transcription initiation | Q41365790 | ||
| Dichotomous but stringent substrate selection by the dual-function Cdk7 complex revealed by chemical genetics | Q41792419 | ||
| Impairment of the TFIIH-associated CDK-activating kinase selectively affects cell cycle-regulated gene expression in fission yeast | Q41836407 | ||
| Altered nucleosome occupancy and histone H3K4 methylation in response to 'transcriptional stress'. | Q42178186 | ||
| Stalled Hox promoters as chromosomal boundaries | Q42241186 | ||
| The MO15 cell cycle kinase is associated with the TFIIH transcription-DNA repair factor | Q42494377 | ||
| Phosphorylation of C-terminal domain of RNA polymerase II is not required in basal transcription | Q42512020 | ||
| Coordination of transcription, RNA processing, and surveillance by P-TEFb kinase on heat shock genes | Q44734152 | ||
| Chemical genetics: where genetics and pharmacology meet | Q46192463 | ||
| Cdk9 is an essential kinase in Drosophila that is required for heat shock gene expression, histone methylation and elongation factor recruitment. | Q52672671 | ||
| Evidence that P-TEFb alleviates the negative effect of DSIF on RNA polymerase II-dependent transcription in vitro | Q22008559 | ||
| Cdk-activating kinase complex is a component of human transcription factor TFIIH | Q24306759 | ||
| The Iws1:Spt6:CTD complex controls cotranscriptional mRNA biosynthesis and HYPB/Setd2-mediated histone H3K36 methylation | Q24316355 | ||
| Pause sites promote transcriptional termination of mammalian RNA polymerase II | Q24548945 | ||
| The ERCC2/DNA repair protein is associated with the class II BTF2/TFIIH transcription factor | Q24595611 | ||
| The role of chromatin during transcription | Q27860995 | ||
| TFIIH kinase places bivalent marks on the carboxy-terminal domain of RNA polymerase II. | Q27936533 | ||
| Different phosphorylated forms of RNA polymerase II and associated mRNA processing factors during transcription | Q28131686 | ||
| NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation | Q28141291 | ||
| Controlling the elongation phase of transcription with P-TEFb | Q28255518 | ||
| Requirement for TFIIH kinase activity in transcription by RNA polymerase II | Q28289887 | ||
| Reconstitution of the transcription factor TFIIH: assignment of functions for the three enzymatic subunits, XPB, XPD, and cdk7 | Q28646653 | ||
| A chromatin landmark and transcription initiation at most promoters in human cells | Q29547180 | ||
| Phosphorylation and functions of the RNA polymerase II CTD | Q29614764 | ||
| Phosphorylation of serine 2 within the RNA polymerase II C-terminal domain couples transcription and 3' end processing | Q29614768 | ||
| Dynamic association of capping enzymes with transcribing RNA polymerase II | Q29614771 | ||
| Control of RNA polymerase II elongation potential by a novel carboxyl-terminal domain kinase | Q29614789 | ||
| Chromatin modifications by methylation and ubiquitination: implications in the regulation of gene expression | Q29619380 | ||
| Distinct roles for CTD Ser-2 and Ser-5 phosphorylation in the recruitment and allosteric activation of mammalian mRNA capping enzyme | Q33858428 | ||
| Regulation of CDK7 substrate specificity by MAT1 and TFIIH. | Q33886335 | ||
| RNA polymerase II pauses and associates with pre-mRNA processing factors at both ends of genes. | Q34009055 | ||
| A kinase-deficient transcription factor TFIIH is functional in basal and activated transcription | Q34295542 | ||
| Rules of engagement: co-transcriptional recruitment of pre-mRNA processing factors | Q34419716 | ||
| Gene-specific requirement for P-TEFb activity and RNA polymerase II phosphorylation within the p53 transcriptional program | Q34471112 | ||
| Breaking barriers to transcription elongation | Q34561019 | ||
| Chemical inhibition of the TFIIH-associated kinase Cdk7/Kin28 does not impair global mRNA synthesis. | Q35749517 | ||
| Requirements for Cdk7 in the assembly of Cdk1/cyclin B and activation of Cdk2 revealed by chemical genetics in human cells. | Q35765888 | ||
| Cdk7 is required for full activation of Drosophila heat shock genes and RNA polymerase II phosphorylation in vivo | Q35924027 | ||
| NELF and DSIF cause promoter proximal pausing on the hsp70 promoter in Drosophila | Q35965503 | ||
| P433 | issue | 20 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | phosphorylation | Q242736 |
| P304 | page(s) | 5455-5464 | |
| P577 | publication date | 2009-08-10 | |
| P1433 | published in | Molecular and Cellular Biology | Q3319478 |
| P1476 | title | TFIIH-associated Cdk7 kinase functions in phosphorylation of C-terminal domain Ser7 residues, promoter-proximal pausing, and termination by RNA polymerase II | |
| P478 | volume | 29 |
| Q52430605 | A CRISPR screen identifies CDK7 as a therapeutic target in hepatocellular carcinoma. |
| Q27308081 | A Conserved Nuclear Cyclophilin Is Required for Both RNA Polymerase II Elongation and Co-transcriptional Splicing in Caenorhabditis elegans |
| Q91558288 | A high-throughput screen identifies that CDK7 activates glucose consumption in lung cancer cells |
| Q42119642 | A novel TBP-TAF complex on RNA polymerase II-transcribed snRNA genes |
| Q28481750 | A positive feedback loop links opposing functions of P-TEFb/Cdk9 and histone H2B ubiquitylation to regulate transcript elongation in fission yeast |
| Q36637485 | ARCH domain of XPD, an anchoring platform for CAK that conditions TFIIH DNA repair and transcription activities |
| Q46006387 | Activation of the p53 Transcriptional Program Sensitizes Cancer Cells to Cdk7 Inhibitors. |
| Q50040433 | Allele-Specific Chromatin Recruitment and Therapeutic Vulnerabilities of ESR1 Activating Mutations |
| Q27674553 | An unexpected binding mode for a Pol II CTD peptide phosphorylated at Ser7 in the active site of the CTD phosphatase Ssu72 |
| Q34503750 | B2 RNA represses TFIIH phosphorylation of RNA polymerase II. |
| Q36978246 | BRD4 coordinates recruitment of pause release factor P-TEFb and the pausing complex NELF/DSIF to regulate transcription elongation of interferon-stimulated genes |
| Q39078385 | Bio-molecular architects: a scaffold provided by the C-terminal domain of eukaryotic RNA polymerase II |
| Q88609298 | Born to run: control of transcription elongation by RNA polymerase II |
| Q50015077 | CDK regulation of transcription by RNAP II: Not over 'til it's over? |
| Q28533417 | CDK4 T172 phosphorylation is central in a CDK7-dependent bidirectional CDK4/CDK2 interplay mediated by p21 phosphorylation at the restriction point |
| Q92641658 | CDK7 inhibition suppresses aberrant hedgehog pathway and overcomes resistance to smoothened antagonists |
| Q34449062 | CDK7 inhibition suppresses super-enhancer-linked oncogenic transcription in MYCN-driven cancer. |
| Q50290873 | CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter |
| Q34495729 | CDK7-dependent transcriptional addiction in triple-negative breast cancer. |
| Q34094495 | CDK8 is a positive regulator of transcriptional elongation within the serum response network |
| Q34558375 | CDK8: a positive regulator of transcription |
| Q51788132 | CDKF;1 and CDKD protein kinases regulate phosphorylation of serine residues in the C-terminal domain of Arabidopsis RNA polymerase II. |
| Q27936808 | Cdc28 kinase activity regulates the basal transcription machinery at a subset of genes |
| Q47108063 | Cdk7 Is Required for Activity-Dependent Neuronal Gene Expression, Long-Lasting Synaptic Plasticity and Long-Term Memory |
| Q37348799 | Cdk7 mediates RPB1-driven mRNA synthesis in Toxoplasma gondii |
| Q93388181 | Cdk7: a kinase at the core of transcription and in the crosshairs of cancer drug discovery |
| Q42410146 | Cdk7: open questions beyond the prevailing model |
| Q49163645 | Cdk9 regulates a promoter-proximal checkpoint to modulate RNA polymerase II elongation rate in fission yeast. |
| Q38064457 | Cell cycle-related kinase in carcinogenesis |
| Q39975943 | Chemical-genomic dissection of the CTD code. |
| Q38286121 | Chromatin modification by the RNA Polymerase II elongation complex |
| Q36019901 | Co-transcriptional regulation of alternative pre-mRNA splicing |
| Q51513312 | Co-transcriptional splicing and the CTD code. |
| Q24301475 | Control of the RNA polymerase II phosphorylation state in promoter regions by CTD interaction domain-containing proteins RPRD1A and RPRD1B |
| Q34592670 | Coupling mRNA synthesis and decay |
| Q27024720 | Coupling pre-mRNA processing to transcription on the RNA factory assembly line |
| Q59042587 | Cross Talk between Cellular Regulatory Networks Mediated by Shared Proteins |
| Q36015334 | Cyclin Dependent Kinase 9 Inhibitors for Cancer Therapy |
| Q38003504 | Cyclin K goes with Cdk12 and Cdk13 |
| Q38973176 | Cyclin-dependent kinase 7 controls mRNA synthesis by affecting stability of preinitiation complexes, leading to altered gene expression, cell cycle progression, and survival of tumor cells. |
| Q92347514 | Cyclin-dependent kinase 7 inhibitor THZ1 in cancer therapy |
| Q37103512 | Cyclin-dependent kinase control of the initiation-to-elongation switch of RNA polymerase II |
| Q41138339 | DDX6 transfers P-TEFb kinase to the AF4/AF4N (AFF1) super elongation complex |
| Q36600950 | Dephosphorylating eukaryotic RNA polymerase II |
| Q38120534 | Deregulations in the cyclin-dependent kinase-9-related pathway in cancer: implications for drug discovery and development |
| Q96641354 | Dissecting the Pol II transcription cycle and derailing cancer with CDK inhibitors |
| Q98784809 | Distinct Cdk9-phosphatase switches act at the beginning and end of elongation by RNA polymerase II |
| Q64059258 | Efficacy of the novel CDK7 inhibitor QS1189 in mantle cell lymphoma |
| Q35910114 | Emerging Views on the CTD Code |
| Q28114321 | Engineered Covalent Inactivation of TFIIH-Kinase Reveals an Elongation Checkpoint and Results in Widespread mRNA Stabilization |
| Q39002232 | Function and control of RNA polymerase II C-terminal domain phosphorylation in vertebrate transcription and RNA processing |
| Q33832604 | Functional analysis of the Cdk7.cyclin H.Mat1 complex in mouse embryonic stem cells and embryos |
| Q36676600 | Functional interaction of Rpb1 and Spt5 C-terminal domains in co-transcriptional histone modification |
| Q52848985 | Functional interplay between MSL1 and CDK7 controls RNA polymerase II Ser5 phosphorylation. |
| Q35126559 | Functional role of RNA polymerase II and P70 S6 kinase in KCl withdrawal-induced cerebellar granule neuron apoptosis |
| Q97886082 | Functions and Clinical Significance of Super-Enhancers in Bone-Related Diseases |
| Q42576807 | Gene looping facilitates TFIIH kinase-mediated termination of transcription |
| Q26863342 | Gene-specific requirement of RNA polymerase II CTD phosphorylation |
| Q50290871 | General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene |
| Q37408454 | Genetic and pharmacological inhibition of CDK9 drives neutrophil apoptosis to resolve inflammation in zebrafish in vivo |
| Q93335194 | HDAC stimulates gene expression through BRD4 availability in response to IFN and in interferonopathies |
| Q35261303 | Herpes Simplex Virus 1 (HSV-1) ICP22 protein directly interacts with cyclin-dependent kinase (CDK)9 to inhibit RNA polymerase II transcription elongation |
| Q48510616 | High MITF Expression is Associated with Super-enhancers and Suppressed by CDK7 Inhibition in Melanoma. |
| Q41468789 | Human TFIIH Kinase CDK7 Regulates Transcription-Associated Chromatin Modifications |
| Q24310867 | Human mediator subunit MED26 functions as a docking site for transcription elongation factors |
| Q28534162 | Identification and Functional Characterisation of CRK12:CYC9, a Novel Cyclin-Dependent Kinase (CDK)-Cyclin Complex in Trypanosoma brucei |
| Q36804109 | In vivo live imaging of RNA polymerase II transcription factories in primary cells |
| Q37636710 | Inhibition of cyclin dependent kinase 9 by dinaciclib suppresses cyclin B1 expression and tumor growth in triple negative breast cancer |
| Q92965686 | Inhibition of the transcriptional kinase CDK7 overcomes therapeutic resistance in HER2-positive breast cancers |
| Q38255119 | Insights into the U1 small nuclear ribonucleoprotein complex superfamily |
| Q24299038 | Interaction of cyclin-dependent kinase 12/CrkRS with cyclin K1 is required for the phosphorylation of the C-terminal domain of RNA polymerase II |
| Q42513451 | Is TFIIH the new Achilles heel of cancer cells? |
| Q38091888 | Lost in transcription: molecular mechanisms that control HIV latency |
| Q38212042 | Making a Short Story Long: Regulation of P-TEFb and HIV-1 Transcriptional Elongation in CD4+ T Lymphocytes and Macrophages. |
| Q57059661 | Mediator is essential for small nuclear and nucleolar RNA transcription in yeast |
| Q39212481 | Multiparametric cell-based assay for the evaluation of transcription inhibition by high-content imaging |
| Q26851218 | Mutual relationships between transcription and pre-mRNA processing in the synthesis of mRNA |
| Q35524345 | Non-mRNA 3' end formation: how the other half lives |
| Q39416252 | O-GlcNAcase Is an RNA Polymerase II Elongation Factor Coupled to Pausing Factors SPT5 and TIF1β. |
| Q34174006 | On the traces of XPD: cell cycle matters - untangling the genotype-phenotype relationship of XPD mutations |
| Q36432038 | P-TEFb regulation of transcription termination factor Xrn2 revealed by a chemical genetic screen for Cdk9 substrates. |
| Q51181694 | PHF13: A new player involved in RNA polymerase II transcriptional regulation and co-transcriptional splicing. |
| Q37688835 | Pause, play, repeat: CDKs push RNAP II's buttons |
| Q37874803 | Paused RNA polymerase II as a developmental checkpoint |
| Q37091672 | Phosphorylation of RNA polymerase II is independent of P-TEFb in the C. elegans germline |
| Q27932580 | Pol II CTD kinases Bur1 and Kin28 promote Spt5 CTR-independent recruitment of Paf1 complex |
| Q29614782 | Progression through the RNA polymerase II CTD cycle |
| Q92254256 | Promoter-proximal pausing of RNA polymerase II: a nexus of gene regulation |
| Q29540749 | RNA Polymerase II C-Terminal Domain: Tethering Transcription to Transcript and Template |
| Q34377487 | RNA polymerase II CTD modifications: how many tales from a single tail. |
| Q34305741 | RNA polymerase II pausing downstream of core histone genes is different from genes producing polyadenylated transcripts |
| Q46594026 | RNA polymerase II primes Polycomb-repressed developmental genes throughout terminal neuronal differentiation. |
| Q34046663 | RNA polymerase II transcription elongation and Pol II CTD Ser2 phosphorylation: A tail of two kinases |
| Q34960186 | RNA polymerase II transcription elongation control |
| Q27684567 | RPRD1A and RPRD1B are human RNA polymerase II C-terminal domain scaffolds for Ser5 dephosphorylation |
| Q38856092 | Regulation of Transcription Elongation by the XPG-TFIIH Complex Is Implicated in Cockayne Syndrome |
| Q39374135 | Regulation of expression of human RNA polymerase II-transcribed snRNA genes |
| Q47271381 | Regulation of the cohesin-loading factor NIPBL: Role of the lncRNA NIPBL-AS1 and identification of a distal enhancer element |
| Q42787982 | Requirement of TFIIH kinase subunit Mat1 for RNA Pol II C-terminal domain Ser5 phosphorylation, transcription and mRNA turnover |
| Q41886305 | Role of Ser7 phosphorylation of the CTD during transcription of snRNA genes |
| Q34712027 | Rpb4/7 facilitates RNA polymerase II CTD dephosphorylation |
| Q91996384 | Selective Kinase Inhibition Shows That Bur1 (Cdk9) Phosphorylates the Rpb1 Linker In Vivo |
| Q36210855 | Separate domains of fission yeast Cdk9 (P-TEFb) are required for capping enzyme recruitment and primed (Ser7-phosphorylated) Rpb1 carboxyl-terminal domain substrate recognition. |
| Q24298880 | Ser7 phosphorylation of the CTD recruits the RPAP2 Ser5 phosphatase to snRNA genes |
| Q33716938 | Site-specific regulation of histone H1 phosphorylation in pluripotent cell differentiation |
| Q27936613 | Ssu72 phosphatase-dependent erasure of phospho-Ser7 marks on the RNA polymerase II C-terminal domain is essential for viability and transcription termination. |
| Q24600535 | Structural and functional characterization of an atypical activation domain in erythroid Kruppel-like factor (EKLF) |
| Q42107719 | Sub1 globally regulates RNA polymerase II C-terminal domain phosphorylation. |
| Q64973075 | Super-enhancer-associated MEIS1 promotes transcriptional dysregulation in Ewing sarcoma in co-operation with EWS-FLI1. |
| Q47671139 | Suppression of Adaptive Responses to Targeted Cancer Therapy by Transcriptional Repression. |
| Q36414906 | TFIIB dephosphorylation links transcription inhibition with the p53-dependent DNA damage response |
| Q38008913 | TFIIH: when transcription met DNA repair. |
| Q35987692 | THZ1 Reveals Roles for Cdk7 in Co-transcriptional Capping and Pausing |
| Q59329526 | Targeting MYC dependency in ovarian cancer through inhibition of CDK7 and CDK12/13 |
| Q90069521 | Targeting transcription factors in cancer - from undruggable to reality |
| Q34429918 | Targeting transcription regulation in cancer with a covalent CDK7 inhibitor |
| Q37407640 | Termination of Transcription of Short Noncoding RNAs by RNA Polymerase II. |
| Q48170699 | The 7SK snRNP associates with the little elongation complex to promote snRNA gene expression. |
| Q42044526 | The C-terminal domain of Rpb1 functions on other RNA polymerase II subunits |
| Q36796443 | The CDK Network: Linking Cycles of Cell Division and Gene Expression |
| Q64102425 | The CDK7 inhibitor THZ1 alters RNA polymerase dynamics at the 5' and 3' ends of genes |
| Q34303212 | The RNA polymerase II CTD coordinates transcription and RNA processing. |
| Q53831437 | The anti-human cytomegalovirus drug tricin inhibits cyclin-dependent kinase 9. |
| Q36107018 | The chromatin remodeling and mRNA splicing functions of the Brahma (SWI/SNF) complex are mediated by the SNR1/SNF5 regulatory subunit |
| Q34769498 | The elongation complex components BRD4 and MLLT3/AF9 are transcriptional coactivators of nuclear retinoid receptors |
| Q39005055 | The emerging picture of CDK9/P-TEFb: more than 20 years of advances since PITALRE. |
| Q52319133 | The essential and multi-functional TFIIH complex. |
| Q41951178 | The integrator complex recognizes a new double mark on the RNA polymerase II carboxyl-terminal domain |
| Q40090160 | The point of no return: The poly(A)-associated elongation checkpoint |
| Q38948938 | The pol II CTD: new twists in the tail |
| Q27682428 | The structure and substrate specificity of human Cdk12/Cyclin K |
| Q27670698 | The yeast regulator of transcription protein Rtr1 lacks an active site and phosphatase activity |
| Q90344497 | Therapeutic Targeting of CDK7 Suppresses Tumor Progression in Intrahepatic Cholangiocarcinoma |
| Q58572303 | Therapeutic targeting of transcriptional cyclin-dependent kinases |
| Q28728197 | Threonine-4 of mammalian RNA polymerase II CTD is targeted by Polo-like kinase 3 and required for transcriptional elongation |
| Q36759836 | Transcription factor Sp3 represses expression of p21CIP¹ via inhibition of productive elongation by RNA polymerase II. |
| Q38161381 | Transcription inhibition as a therapeutic target for cancer |
| Q46985603 | Transcriptional Dependencies in Diffuse Intrinsic Pontine Glioma |
| Q36826839 | Trypanosome cdc2-related kinase 9 controls spliced leader RNA cap4 methylation and phosphorylation of RNA polymerase II subunit RPB1 |
| Q90043715 | Tumors with TSC mutations are sensitive to CDK7 inhibition through NRF2 and glutathione depletion |
| Q37864536 | Unravelling the means to an end: RNA polymerase II transcription termination. |
| Q42133715 | Updating the CTD Story: From Tail to Epic. |
| Q35233598 | Vertebrate Ssu72 regulates and coordinates 3'-end formation of RNAs transcribed by RNA polymerase II. |
| Q35939852 | Yeast Swd2 is essential because of antagonism between Set1 histone methyltransferase complex and APT (associated with Pta1) termination factor |
| Q36174000 | snRNA 3' End Processing by a CPSF73-Containing Complex Essential for Development in Arabidopsis |
Search more.