Cdk9 regulates a promoter-proximal checkpoint to modulate RNA polymerase II elongation rate in fission yeast.

scientific article published on 7 February 2018

Cdk9 regulates a promoter-proximal checkpoint to modulate RNA polymerase II elongation rate in fission yeast. is …
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scholarly articleQ13442814

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P819ADS bibcode2018NatCo...9..543B
P6179Dimensions Publication ID1100780743
P356DOI10.1038/S41467-018-03006-4
P932PMC publication ID5803247
P698PubMed publication ID29416031

P50authorRobert FisherQ59751014
Miriam SansóQ79252345
P2093author name stringJohn T Lis
Gregory T Booth
Pabitra K Parua
P2860cites workUltrafast and memory-efficient alignment of short DNA sequences to the human genomeQ21183894
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DSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologsQ24328838
Pause sites promote transcriptional termination of mammalian RNA polymerase IIQ24548945
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Bur1 kinase is required for efficient transcription elongation by RNA polymerase II.Q27930313
Uniform transitions of the general RNA polymerase II transcription complexQ27931804
Control of transcriptional elongation and cotranscriptional histone modification by the yeast BUR kinase substrate Spt5.Q27932002
SPT5, an essential gene important for normal transcription in Saccharomyces cerevisiae, encodes an acidic nuclear protein with a carboxy-terminal repeatQ27933970
TFIIH kinase places bivalent marks on the carboxy-terminal domain of RNA polymerase II.Q27936533
Evidence that Spt4, Spt5, and Spt6 control transcription elongation by RNA polymerase II in Saccharomyces cerevisiaeQ27937704
Kin28, the TFIIH-associated carboxy-terminal domain kinase, facilitates the recruitment of mRNA processing machinery to RNA polymerase II.Q27940303
Engineered Covalent Inactivation of TFIIH-Kinase Reveals an Elongation Checkpoint and Results in Widespread mRNA StabilizationQ28114321
NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongationQ28141291
A positive feedback loop links opposing functions of P-TEFb/Cdk9 and histone H2B ubiquitylation to regulate transcript elongation in fission yeastQ28481750
Dynamics of human immunodeficiency virus transcription: P-TEFb phosphorylates RD and dissociates negative effectors from the transactivation response elementQ28646726
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A cyclin-dependent kinase that promotes cytokinesis through modulating phosphorylation of the carboxy terminal domain of the RNA Pol II Rpb1p sub-unitQ33284612
TFIIH phosphorylation of the Pol II CTD stimulates mediator dissociation from the preinitiation complex and promoter escape.Q33671365
Separable functions of the fission yeast Spt5 carboxyl-terminal domain (CTD) in capping enzyme binding and transcription elongation overlap with those of the RNA polymerase II CTDQ33826564
Base-pair-resolution genome-wide mapping of active RNA polymerases using precision nuclear run-on (PRO-seq).Q33886781
Drosophila Paf1 modulates chromatin structure at actively transcribed genes.Q34233474
The RNA polymerase II CTD coordinates transcription and RNA processing.Q34303212
Coupling mRNA processing with transcription in time and space.Q35006630
Genome-wide dynamics of Pol II elongation and its interplay with promoter proximal pausing, chromatin, and exonsQ35171354
The elongation rate of RNA polymerase determines the fate of transcribed nucleosomes.Q35756522
Cloning and sequence determination of the Schizosaccharomyces pombe rpb1 gene encoding the largest subunit of RNA polymerase II.Q35912302
NELF and DSIF cause promoter proximal pausing on the hsp70 promoter in DrosophilaQ35965503
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Divergence of a conserved elongation factor and transcription regulation in budding and fission yeastQ36959177
Cyclin-dependent kinase control of the initiation-to-elongation switch of RNA polymerase IIQ37103512
Spt6 enhances the elongation rate of RNA polymerase II in vivoQ37196147
TFIIH and P-TEFb coordinate transcription with capping enzyme recruitment at specific genes in fission yeastQ37218934
Phosphorylation of the transcription elongation factor Spt5 by yeast Bur1 kinase stimulates recruitment of the PAF complex.Q37302219
Inhibiting eukaryotic transcription: Which compound to choose? How to evaluate its activity?Q37933073
Generation of a set of conditional analog-sensitive alleles of essential protein kinases in the fission yeast Schizosaccharomyces pombeQ38330788
Effects of Transcription Elongation Rate and Xrn2 Exonuclease Activity on RNA Polymerase II Termination Suggest Widespread Kinetic Competition.Q38827412
A rapid, extensive, and transient transcriptional response to estrogen signaling in breast cancer cellsQ39546838
TFIIH-associated Cdk7 kinase functions in phosphorylation of C-terminal domain Ser7 residues, promoter-proximal pausing, and termination by RNA polymerase IIQ39814573
Signaling pathways differentially affect RNA polymerase II initiation, pausing, and elongation rate in cellsQ40264121
Chemical genetic discovery of PARP targets reveals a role for PARP-1 in transcription elongationQ41218811
Human TFIIH Kinase CDK7 Regulates Transcription-Associated Chromatin ModificationsQ41468789
P-TEFb is critical for the maturation of RNA polymerase II into productive elongation in vivoQ41911078
Interactions between fission yeast mRNA capping enzymes and elongation factor Spt5.Q43917514
Characterization of the Schizosaccharomyces pombe Cdk9/Pch1 protein kinase: Spt5 phosphorylation, autophosphorylation, and mutational analysisQ44540450
Preparation of yeast RNA.Q46761146
P-TEFb-mediated phosphorylation of hSpt5 C-terminal repeats is critical for processive transcription elongationQ46904254
Structure of the complete elongation complex of RNA polymerase II with basal factors.Q48294585
Spt5 Plays Vital Roles in the Control of Sense and Antisense Transcription Elongation.Q50758067
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Purification of P-TEFb, a transcription factor required for the transition into productive elongation.Q52539193
The CTD code.Q53963724
In vivo assays to study histone ubiquitylationQ73739336
Interactions between fission yeast Cdk9, its cyclin partner Pch1, and mRNA capping enzyme Pct1 suggest an elongation checkpoint for mRNA quality controlQ78639812
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)543
P577publication date2018-02-07
P1433published inNature CommunicationsQ573880
P1476titleCdk9 regulates a promoter-proximal checkpoint to modulate RNA polymerase II elongation rate in fission yeast
P478volume9

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cites work (P2860)
Q59087054A Cdk9-PP1 switch regulates the elongation-termination transition of RNA polymerase II
Q92195101CDK12 controls G1/S progression by regulating RNAPII processivity at core DNA replication genes
Q93388181Cdk7: a kinase at the core of transcription and in the crosshairs of cancer drug discovery
Q96641354Dissecting the Pol II transcription cycle and derailing cancer with CDK inhibitors
Q98784809Distinct Cdk9-phosphatase switches act at the beginning and end of elongation by RNA polymerase II
Q57044797Elongation/Termination Factor Exchange Mediated by PP1 Phosphatase Orchestrates Transcription Termination
Q92204955In vitro analysis of RNA polymerase II elongation complex dynamics
Q91333274Measuring RNA polymerase activity genome-wide with high-resolution run-on-based methods
Q92535255Nascent RNA analyses: tracking transcription and its regulation
Q92254256Promoter-proximal pausing of RNA polymerase II: a nexus of gene regulation
Q91996384Selective Kinase Inhibition Shows That Bur1 (Cdk9) Phosphorylates the Rpb1 Linker In Vivo
Q91405332Transcription modulation by CDK9 regulates inflammatory genes and RIPK3-MLKL-mediated necroptosis in periodontitis progression
Q92217036Writing a wrong: Coupled RNA polymerase II transcription and RNA quality control

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