The Iws1:Spt6:CTD complex controls cotranscriptional mRNA biosynthesis and HYPB/Setd2-mediated histone H3K36 methylation

scientific article

The Iws1:Spt6:CTD complex controls cotranscriptional mRNA biosynthesis and HYPB/Setd2-mediated histone H3K36 methylation is …
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scholarly articleQ13442814

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P356DOI10.1101/GAD.1720008
P3181OpenCitations bibliographic resource ID2929316
P932PMC publication ID2607075
P698PubMed publication ID19141475
P5875ResearchGate publication ID23784997

P2093author name stringKatherine A Jones
Joseph S Lucas
Sunnie M Yoh
P2860cites workThe Spt6 SH2 domain binds Ser2-P RNAPII to direct Iws1-dependent mRNA splicing and exportQ24293507
TREX is a conserved complex coupling transcription with messenger RNA exportQ24295211
A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencingQ24307408
The putative cancer stem cell marker USP22 is a subunit of the human SAGA complex required for activated transcription and cell-cycle progressionQ24307439
USP22, an hSAGA subunit and potential cancer stem cell marker, reverses the polycomb-catalyzed ubiquitylation of histone H2AQ24311562
Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase IIQ24337471
Human mRNA export machinery recruited to the 5' end of mRNAQ24338302
Set2 is a nucleosomal histone H3-selective methyltransferase that mediates transcriptional repression.Q24537640
Solution structure of the Set2-Rpb1 interacting domain of human Set2 and its interaction with the hyperphosphorylated C-terminal domain of Rpb1Q24538939
Capping, splicing, and 3' processing are independently stimulated by RNA polymerase II: different functions for different segments of the CTDQ24601077
Crystal Structure and RNA Binding of the Tex Protein from Pseudomonas aeruginosaQ27649998
The role of chromatin during transcriptionQ27860995
RNA polymerase II elongation factors of Saccharomyces cerevisiae: a targeted proteomics approachQ27931237
Evidence that Spt6p controls chromatin structure by a direct interaction with histonesQ27931346
Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcriptionQ27932406
Transcriptional activators are dispensable for transcription in the absence of Spt6-mediated chromatin reassembly of promoter regionsQ27934442
Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complexQ27935315
Yeast Ataxin-7 links histone deubiquitination with gene gating and mRNA exportQ27936733
SAGA interacting factors confine sub-diffusion of transcribed genes to the nuclear envelopeQ27937982
Spn1 regulates the recruitment of Spt6 and the Swi/Snf complex during transcriptional activation by RNA polymerase IIQ27939723
Roles for Ctk1 and Spt6 in regulating the different methylation states of histone H3 lysine 36.Q27939763
The yeast hnRNP-Like proteins Yra1p and Yra2p participate in mRNA export through interaction with Mex67pQ27939919
The mRNA export factor Sus1 is involved in Spt/Ada/Gcn5 acetyltransferase-mediated H2B deubiquitinylation through its interaction with Ubp8 and Sgf11.Q27940177
Three RNA polymerase II carboxyl-terminal domain kinases display distinct substrate preferencesQ28208318
Controlling the elongation phase of transcription with P-TEFbQ28255518
A putative transcriptional elongation factor hIws1 is essential for mammalian cell proliferationQ28280169
Dynamic histone H3 methylation during gene induction: HYPB/Setd2 mediates all H3K36 trimethylationQ28593817
Methylation of histone H3 by Set2 in Saccharomyces cerevisiae is linked to transcriptional elongation by RNA polymerase IIQ29614679
Phosphorylation and functions of the RNA polymerase II CTDQ29614764
Nap1 links transcription elongation, chromatin assembly, and messenger RNP complex biogenesisQ30441325
A novel domain in Set2 mediates RNA polymerase II interaction and couples histone H3 K36 methylation with transcript elongationQ30448402
Drosophila Kismet regulates histone H3 lysine 27 methylation and early elongation by RNA polymerase IIQ33375061
The Set2 histone methyltransferase functions through the phosphorylated carboxyl-terminal domain of RNA polymerase II.Q34168365
Rules of engagement: co-transcriptional recruitment of pre-mRNA processing factorsQ34419716
Role of the mammalian RNA polymerase II C-terminal domain (CTD) nonconsensus repeats in CTD stability and cell proliferationQ34443898
Molecular evolution of the RNA polymerase II CTD.Q34778014
Tails of intrigue: phosphorylation of RNA polymerase II mediates histone methylationQ35131664
Nuclear mRNA surveillanceQ35145841
A 10 residue motif at the C-terminus of the RNA pol II CTD is required for transcription, splicing and 3' end processing.Q35561598
Facts about FACT and transcript elongation through chromatinQ35804601
Cotranscriptional mRNP assembly: from the DNA to the nuclear poreQ36131482
Histone H3 variants and modifications on transcribed genesQ36158492
A structural perspective of CTD functionQ36167411
Drosophila UTX is a histone H3 Lys27 demethylase that colocalizes with the elongating form of RNA polymerase II.Q36421310
Reciprocal patterns of methylation of H3K36 and H3K27 on proximal vs. distal IgVH genes are modulated by IL-7 and Pax5.Q36735246
Transcriptional regulation at the nuclear pore complexQ36743038
A site to remember: H3K36 methylation a mark for histone deacetylationQ36754994
Epigenetic signatures of stem-cell identity.Q36761192
Sus1 is recruited to coding regions and functions during transcription elongation in association with SAGA and TREX2.Q36942429
H3K27 demethylases, at long lastQ36965110
Poised polymerases: on your mark...get set...go!Q37136094
Biogenesis of mRNPs: integrating different processes in the eukaryotic nucleusQ37144184
The CTD role in cotranscriptional RNA processing and surveillanceQ37147259
Cracking the RNA polymerase II CTD codeQ37155088
Genome-wide mRNA surveillance is coupled to mRNA exportQ37598853
Transcription regulation through promoter-proximal pausing of RNA polymerase II.Q39442921
Splicing- and cleavage-independent requirement of RNA polymerase II CTD for mRNA release from the transcription siteQ39751851
Phosphorylation of RNA polymerase II CTD regulates H3 methylation in yeastQ39895202
Monoubiquitinated H2B is associated with the transcribed region of highly expressed genes in human cellsQ40001798
Yra1p, a conserved nuclear RNA-binding protein, interacts directly with Mex67p and is required for mRNA exportQ40386970
The RNA processing exosome is linked to elongating RNA polymerase II in DrosophilaQ40682391
The Drosophila trithorax group protein Kismet facilitates an early step in transcriptional elongation by RNA Polymerase II.Q46486956
H2B ubiquitylation plays a role in nucleosome dynamics during transcription elongationQ46493188
Structure and carboxyl-terminal domain (CTD) binding of the Set2 SRI domain that couples histone H3 Lys36 methylation to transcriptionQ46802691
Gcn5 promotes acetylation, eviction, and methylation of nucleosomes in transcribed coding regions.Q53577981
The interaction between cap-binding complex and RNA export factor is required for intronless mRNA exportQ79960783
P433issue24
P407language of work or nameEnglishQ1860
P921main subjectPolymerase (RNA) II (DNA directed) polypeptide AQ15335024
histone H3-K36 trimethylationQ21118251
SET domain containing 2, histone lysine methyltransferaseQ21118252
Interacts with SUPT6H, CTD assembly factor 1Q21118500
SPT6, histone chaperone and transcription elongation factorQ21991476
P304page(s)3422-34
P577publication date2008-12-15
P1433published inGenes & DevelopmentQ1524533
P1476titleThe Iws1:Spt6:CTD complex controls cotranscriptional mRNA biosynthesis and HYPB/Setd2-mediated histone H3K36 methylation
P478volume22

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