RNA polymerase II pausing downstream of core histone genes is different from genes producing polyadenylated transcripts

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RNA polymerase II pausing downstream of core histone genes is different from genes producing polyadenylated transcripts is …
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P819ADS bibcode2012PLoSO...738769A
P356DOI10.1371/JOURNAL.PONE.0038769
P932PMC publication ID3372504
P698PubMed publication ID22701709
P5875ResearchGate publication ID225372578

P2093author name stringOlivier Poch
Laetitia Poidevin
Làszlò Tora
Krishanpal Anamika
Àkos Gyenis
P2860cites workEvolutionarily conserved interaction between CstF-64 and PC4 links transcription, polyadenylation, and terminationQ24291290
Human senataxin resolves RNA/DNA hybrids formed at transcriptional pause sites to promote Xrn2-dependent terminationQ24307617
Human 5' --> 3' exonuclease Xrn2 promotes transcription termination at co-transcriptional cleavage sitesQ24317135
Pause sites promote transcriptional termination of mammalian RNA polymerase IIQ24548945
NCBI Reference Sequence (RefSeq): a curated non-redundant sequence database of genomes, transcripts and proteinsQ24558592
c-Myc regulates transcriptional pause releaseQ24629119
RNA polymerase stalling at developmental control genes in the Drosophila melanogaster embryoQ24645367
Poly(A) signal-dependent degradation of unprocessed nascent transcripts accompanies poly(A) signal-dependent transcriptional pausing in vitroQ24650853
The multifunctional protein p54nrb/PSF recruits the exonuclease XRN2 to facilitate pre-mRNA 3' processing and transcription terminationQ24671920
WebGestalt: an integrated system for exploring gene sets in various biological contextsQ24813284
The yeast Rat1 exonuclease promotes transcription termination by RNA polymerase II.Q27934493
Promoter-associated pausing in promoter architecture and postinitiation transcriptional regulationQ28138307
Multiple transcript cleavage precedes polymerase release in termination by RNA polymerase IIQ28199201
Diversified transcription initiation complexes expand promoter selectivity and tissue-specific gene expressionQ28208297
Transcription factor TFIID recruits factor CPSF for formation of 3' end of mRNAQ28249862
Metabolism and regulation of canonical histone mRNAs: life without a poly(A) tailQ28297786
The general transcription factors of RNA polymerase IIQ28298663
Formation of the 3' end of histone mRNAQ28610112
Integrating mRNA processing with transcriptionQ28610124
Formation of the 3' end of histone mRNA: getting closer to the endQ28751417
Transcription termination by nuclear RNA polymerasesQ29541446
A chromatin landmark and transcription initiation at most promoters in human cellsQ29547180
Divergent transcription from active promotersQ29614332
RNA polymerase is poised for activation across the genomeQ29615047
Transcriptional activation by recruitmentQ29615048
seqMINER: an integrated ChIP-seq data interpretation platformQ33777909
The RNA polymerase II molecule at the 5' end of the uninduced hsp70 gene of D. melanogaster is transcriptionally engaged.Q52459657
An ending is a new beginning: transcription termination supports re-initiation.Q53267577
A functional mRNA polyadenylation signal is required for transcription termination by RNA polymerase IIQ69827439
Compensatory mutations suggest that base-pairing with a small nuclear RNA is required to form the 3' end of H3 messenger RNAQ70151935
Termination of transcription in the mouse alpha-amylase gene Amy-2a occurs at multiple sites downstream of the polyadenylation siteQ72396715
Terminal exon definition occurs cotranscriptionally and promotes termination of RNA polymerase IIQ77308193
The polyadenylation inhibitor cordycepin (3'dA) causes a decline in c-MYC mRNA levels without affecting c-MYC protein levelsQ77931499
Generation of histone mRNA 3' ends by endonucleolytic cleavage of the pre-mRNA in a snRNP-dependent in vitro reactionQ33879922
RNA polymerase II pauses and associates with pre-mRNA processing factors at both ends of genes.Q34009055
On the importance of being co-transcriptionalQ34150533
Ending the message: poly(A) signals then and nowQ34213955
A poly(A) addition site and a downstream termination region are required for efficient cessation of transcription by RNA polymerase II in the mouse beta maj-globin geneQ34369553
Rules of engagement: co-transcriptional recruitment of pre-mRNA processing factorsQ34419716
The role of Rat1 in coupling mRNA 3'-end processing to transcription termination: implications for a unified allosteric-torpedo modelQ34511126
Novel role for mediator complex subunit Srb5/Med18 in termination of transcriptionQ35423214
Ultrastructural study of transcription factories in mouse erythroblastsQ35548402
New perspectives on connecting messenger RNA 3' end formation to transcriptionQ35774183
Connections between mRNA 3' end processing and transcription terminationQ36131487
Global analysis of short RNAs reveals widespread promoter-proximal stalling and arrest of Pol II in DrosophilaQ36214878
An intact histone 3'-processing site is required for transcription termination in a mouse histone H2a geneQ36681497
NELF and GAGA factor are linked to promoter-proximal pausing at many genes in DrosophilaQ36710845
Polycomb associates genome-wide with a specific RNA polymerase II variant, and regulates metabolic genes in ESCsQ36927892
Control of eukaryotic gene expression: gene loops and transcriptional memory.Q37805178
A genomic analysis of RNA polymerase II modification and chromatin architecture related to 3' end RNA polyadenylationQ38290836
MAZ-dependent termination between closely spaced human complement genesQ38301674
Specific transcriptional pausing activates polyadenylation in a coupled in vitro systemQ38323992
Transcription regulation through promoter-proximal pausing of RNA polymerase II.Q39442921
Mechanism of poly(A) signal transduction to RNA polymerase II in vitroQ39528777
A rapid, extensive, and transient transcriptional response to estrogen signaling in breast cancer cellsQ39546838
Multilevel regulation of replication-dependent histone genesQ39569366
TFIIH-associated Cdk7 kinase functions in phosphorylation of C-terminal domain Ser7 residues, promoter-proximal pausing, and termination by RNA polymerase IIQ39814573
Phosphorylation of TFIIB links transcription initiation and termination.Q39886347
The two steps of poly(A)-dependent termination, pausing and release, can be uncoupled by truncation of the RNA polymerase II carboxyl-terminal repeat domainQ40815653
A pause site for RNA polymerase II is associated with termination of transcriptionQ41081406
Transcriptional termination between the closely linked human complement genes C2 and factor B: common termination factor for C2 and c-myc?Q41083821
A core complex of CPSF73, CPSF100, and Symplekin may form two different cleavage factors for processing of poly(A) and histone mRNAsQ41656652
Characterization of the mouse beta maj globin transcription termination region: a spacing sequence is required between the poly(A) signal sequence and multiple downstream termination elementsQ41817304
Functional interaction of the Ess1 prolyl isomerase with components of the RNA polymerase II initiation and termination machineriesQ41837167
The conserved AAUAAA hexamer of the poly(A) signal can act alone to trigger a stable decrease in RNA polymerase II transcription velocityQ41875673
Gene looping is conferred by activator-dependent interaction of transcription initiation and termination machineriesQ42035394
Biased chromatin signatures around polyadenylation sites and exonsQ42689954
Crosstalk between mRNA 3' end processing and transcription initiationQ42821628
The poly(A) signal, without the assistance of any downstream element, directs RNA polymerase II to pause in vivo and then to release stochastically from the templateQ46370210
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue6
P407language of work or nameEnglishQ1860
P304page(s)e38769
P577publication date2012-06-11
P1433published inPLOS OneQ564954
P1476titleRNA polymerase II pausing downstream of core histone genes is different from genes producing polyadenylated transcripts
P478volume7

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cites work (P2860)
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Q38890103CDK9 inhibitors define elongation checkpoints at both ends of RNA polymerase II-transcribed genes.
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Q26798138Fail-safe transcription termination: Because one is never enough
Q89393350Heat Shock Causes a Reversible Increase in RNA Polymerase II Occupancy Downstream of mRNA Genes, Consistent with a Global Loss in Transcriptional Termination
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Q35233598Vertebrate Ssu72 regulates and coordinates 3'-end formation of RNAs transcribed by RNA polymerase II.
Q90025192Widespread Backtracking by RNA Pol II Is a Major Effector of Gene Activation, 5' Pause Release, Termination, and Transcription Elongation Rate

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