Synthesis and biological evaluation of the 1-arylpyrazole class of σ(1) receptor antagonists: identification of 4-{2-[5-methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-yloxy]ethyl}morpholine (S1RA, E-52862).

scientific article

Synthesis and biological evaluation of the 1-arylpyrazole class of σ(1) receptor antagonists: identification of 4-{2-[5-methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-yloxy]ethyl}morpholine (S1RA, E-52862). is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1021/JM3007323
P698PubMed publication ID22784008

P50authorChristian LaggnerQ114451963
Javier BurguenoQ114780783
Daniel ZamanilloQ122981817
P2093author name stringManuel Merlos
José Luis Díaz
José Miguel Vela
Adriana Port
Ariadna Fernández
Carmen Almansa
Helmut Buschmann
Joana Berrocal
Jörg Holenz
Maria Teresa Serafini
Montserrat Contijoch
Rosa Cuberes
Ute Christmann
P433issue19
P407language of work or nameEnglishQ1860
P304page(s)8211-8224
P577publication date2012-07-27
P1433published inJournal of Medicinal ChemistryQ900316
P1476titleSynthesis and biological evaluation of the 1-arylpyrazole class of σ(1) receptor antagonists: identification of 4-{2-[5-methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-yloxy]ethyl}morpholine (S1RA, E-52862).
P478volume55

Reverse relations

cites work (P2860)
Q64922722A New Pharmacophore Model for the Design of Sigma-1 Ligands Validated on a Large Experimental Dataset.
Q30400072A Review of the Human Sigma-1 Receptor Structure
Q91031402A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing
Q51420967A systematic exploration of the effects of flexibility and basicity on sigma (σ) receptor binding in a series of substituted diamines.
Q92572737Discovery of a novel class of potent and selective tetrahydroindazole-based sigma-1 receptor ligands
Q52996667Effects of centrally acting analgesics on spinal segmental reflexes and wind-up.
Q48258075Fluorinated PET Tracers for Molecular Imaging of σ1 Receptors in the Central Nervous System
Q38513640Investigational sigma-1 receptor antagonists for the treatment of pain.
Q38723014Medicinal Chemistry of σ1 Receptor Ligands: Pharmacophore Models, Synthesis, Structure Affinity Relationships, and Pharmacological Applications
Q89525831Morpholine As a Scaffold in Medicinal Chemistry: An Update on Synthetic Strategies
Q52478636New consensus multivariate models based on PLS and ANN studies of sigma-1 receptor antagonists.
Q47353437Novel Sigma-1 receptor antagonists: from opioids to small molecules: what is new?
Q38896666Pharmacological Modulation of the Sigma 1 Receptor and the Treatment of Pain
Q38235503Selective sigma-1 receptor antagonists for the treatment of pain.
Q39153819Sigma 2 Receptor/Tmem97 Agonists Produce Long Lasting Antineuropathic Pain Effects in Mice
Q37439130Sigma-1 Receptor Agonism Promotes Mechanical Allodynia After Priming the Nociceptive System with Capsaicin
Q39158236Sigma-1 Receptor Antagonists: A New Class of Neuromodulatory Analgesics
Q53647635Sigma-1 Receptor and Pain.
Q87462009Sigma-1 receptor inhibition reverses acute inflammatory hyperalgesia in mice: role of peripheral sigma-1 receptors
Q55437025Sigma-1 receptor: a new player in neuroprotection against chemotherapy-induced peripheral neuropathy.
Q34670217Sigma-1 receptors and animal studies centered on pain and analgesia
Q48142973Solid-phase organic synthesis of chiral, non-racemic 1,2,4-trisubstituted 1,4-diazepanes with high σ1 receptor affinity.
Q47756273Structure-Activity Relationships within a Series of σ1 and σ2 Receptor Ligands: Identification of a σ2 Receptor Agonist (BS148) with Selective Toxicity against Metastatic Melanoma.
Q64093881Supraspinal and Peripheral, but Not Intrathecal, σR Blockade by S1RA Enhances Morphine Antinociception
Q46466603Synthesis and pharmacological evaluation of like- and unlike-configured tetrahydro-2-benzazepines with the α-substituted benzyl moiety in the 5-position
Q51076938Synthesis, σ receptor affinity, and pharmacological evaluation of 5-phenylsulfanyl- and 5-benzyl-substituted tetrahydro-2-benzazepines.
Q38639528The Sigma-1 Receptor Antagonist, S1RA, Reduces Stroke Damage, Ameliorates Post-Stroke Neurological Deficits and Suppresses the Overexpression of MMP-9.
Q51750311The calcium-sensitive Sigma-1 receptor prevents cannabinoids from provoking glutamate NMDA receptor hypofunction: implications in antinociception and psychotic diseases.

Search more.