| P50 | author | José Miguel Vela | Q56947146 |
| | Enrique Portillo-Salido | Q57071330 |
| | Javier Burgueno | Q114780783 |
| P2093 | author name string | Manuel Merlos | |
| | Carlos Ramón Plata-Salamán | |
| P2860 | cites work | In vivo evaluation of (+)-MR200 as a new selective sigma ligand modulating MOP, DOP and KOP supraspinal analgesia. | Q46833076 |
| | Neurosteroid dehydroepiandrosterone sulphate inhibits persistent sodium currents in rat medial prefrontal cortex via activation of sigma-1 receptors | Q46884723 |
| | Potentiation of morphine-induced mechanical antinociception by σ₁ receptor inhibition: role of peripheral σ₁ receptors. | Q48112821 |
| | Modulation of brainstem opiate analgesia in the rat by sigma 1 receptors: a microinjection study | Q48148180 |
| | The induction of pain: an integrative review | Q48284194 |
| | Chronic activation of sigma-1 receptor evokes nociceptive activation of trigeminal nucleus caudalis in rats | Q48679547 |
| | Possible involvement of the Sigma-1 receptor chaperone in chemotherapeutic-induced neuropathic pain. | Q51741747 |
| | The calcium-sensitive Sigma-1 receptor prevents cannabinoids from provoking glutamate NMDA receptor hypofunction: implications in antinociception and psychotic diseases. | Q51750311 |
| | The classification of orofacial pains. | Q51892774 |
| | Effects of centrally acting analgesics on spinal segmental reflexes and wind-up. | Q52996667 |
| | Sigma-1 receptor antagonist, BD1047 reduces nociceptive responses and phosphorylation of p38 MAPK in mice orofacial formalin model. | Q54401247 |
| | The antagonistic effect of the sigma 1 receptor ligand (+)-MR200 on persistent pain induced by inflammation. | Q54473836 |
| | Sigma-1 receptors regulate activity-induced spinal sensitization and neuropathic pain after peripheral nerve injury | Q60713091 |
| | (-)-Pentazocine analgesia in mice: interactions with a sigma receptor system | Q71489821 |
| | Effects of streptozotocin-induced diabetes on neuronal sigma receptors in the rat brain | Q73326968 |
| | Identification of regions of the sigma-1 receptor ligand binding site using a novel photoprobe | Q80593514 |
| | Formalin-induced pain is reduced in sigma(1) receptor knockout mice | Q81545494 |
| | Effects of a selective sigma 1 antagonist compound on inflammatory pain | Q85949364 |
| | Antinociceptive effects of a new sigma-1 receptor antagonist (N-(2-morpholin-4-yl-ethyl)-2-(1-naphthyloxy)acetamide) in two types of nociception | Q86938185 |
| | Sigma-1 receptor inhibition reverses acute inflammatory hyperalgesia in mice: role of peripheral sigma-1 receptors | Q87462009 |
| | S1RA, a selective sigma-1 receptor antagonist, inhibits inflammatory pain in the carrageenan and complete Freund's adjuvant models in mice | Q87772697 |
| | Cloning and functional expression of the human type 1 sigma receptor (hSigmaR1) | Q24336165 |
| | Regulating ankyrin dynamics: Roles of sigma-1 receptors | Q24548145 |
| | Antagonist action of progesterone at σ-receptors in the modulation of voltage-gated sodium channels | Q24616403 |
| | Purification, molecular cloning, and expression of the mammalian sigma1-binding site | Q24619317 |
| | Sigma-1 receptor chaperones at the ER-mitochondrion interface regulate Ca(2+) signaling and cell survival | Q28255981 |
| | Sigma receptors: biology and therapeutic potential | Q28266963 |
| | Calcium-activated potassium channels | Q28278153 |
| | Dynamic interaction between sigma-1 receptor and Kv1.2 shapes neuronal and behavioral responses to cocaine | Q28506354 |
| | Single Doses up to 800 mg of E-52862 Do Not Prolong the QTc Interval--A Retrospective Validation by Pharmacokinetic-Pharmacodynamic Modelling of Electrocardiography Data Utilising the Effects of a Meal on QTc to Demonstrate ECG Assay Sensitivity | Q28547388 |
| | Orofacial pain management: current perspectives | Q30442178 |
| | Immunocytochemical localization of the sigma(1) receptor in the adult rat central nervous system | Q30859681 |
| | Cloning and characterization of a mouse sigma1 receptor. | Q32062674 |
| | SK channels and NMDA receptors form a Ca2+-mediated feedback loop in dendritic spines. | Q33214394 |
| | The Antinociceptive Effect of Sigma-1 Receptor Antagonist, BD1047, in a Capsaicin Induced Headache Model in Rats | Q33574129 |
| | Opiate pharmacology and relief of pain | Q33650564 |
| | Visceral pain | Q33670399 |
| | Impact of lifetime opioid exposure on arterial stiffness and vascular age: cross-sectional and longitudinal studies in men and women | Q33744915 |
| | Sigma 1 receptor modulation of G-protein-coupled receptor signaling: potentiation of opioid transduction independent from receptor binding | Q33754837 |
| | The oligomeric states of the purified sigma-1 receptor are stabilized by ligands | Q33931257 |
| | Sigma-1 receptor antagonism restores injury-induced decrease of voltage-gated Ca2+ current in sensory neurons | Q33943977 |
| | Distinct potassium channels on pain-sensing neurons | Q33949400 |
| | Learning and memory in pain pathways | Q34069657 |
| | Selective sigma-1 (sigma1) receptor antagonists: emerging target for the treatment of neuropathic pain | Q34088951 |
| | Protein kinase C-dependent potentiation of intracellular calcium influx by sigma1 receptor agonists in rat hippocampal neurons. | Q34230679 |
| | Pharmacological properties of S1RA, a new sigma-1 receptor antagonist that inhibits neuropathic pain and activity-induced spinal sensitization | Q34260033 |
| | Safety, tolerability and pharmacokinetics of single and multiple doses of a novel sigma-1 receptor antagonist in three randomized phase I studies | Q34275887 |
| | Synthesis and biological evaluation of the 1-arylpyrazole class of σ(1) receptor antagonists: identification of 4-{2-[5-methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-yloxy]ethyl}morpholine (S1RA, E-52862). | Q34287318 |
| | Sigma antagonists potentiate opioid analgesia in rats | Q34302841 |
| | Role of sigma-1 receptors in paclitaxel-induced neuropathic pain in mice | Q34305923 |
| | Operant self-administration of a sigma ligand improves nociceptive and emotional manifestations of neuropathic pain. | Q34313161 |
| | σ1 receptors are involved in the visceral pain induced by intracolonic administration of capsaicin in mice | Q34321544 |
| | Acid-sensing ion channels and their modulators. | Q34466126 |
| | Sigma-1 Receptor Antagonist BD1047 Reduces Allodynia and Spinal ERK Phosphorylation Following Chronic Compression of Dorsal Root Ganglion in Rats | Q34554003 |
| | The pain interactome: connecting pain-specific protein interactions | Q34585717 |
| | Cellular memory in spinal nociceptive circuitry | Q34634092 |
| | The cannabinoid receptor 1 associates with NMDA receptors to produce glutamatergic hypofunction: implications in psychosis and schizophrenia. | Q34659000 |
| | Sigma-1 receptor and inflammatory pain. | Q34669463 |
| | Intrathecal injection of the sigma(1) receptor antagonist BD1047 blocks both mechanical allodynia and increases in spinal NR1 expression during the induction phase of rodent neuropathic pain | Q34863848 |
| | σ1 receptors activate astrocytes via p38 MAPK phosphorylation leading to the development of mechanical allodynia in a mouse model of neuropathic pain | Q34914351 |
| | Opioid-induced bowel dysfunction: pathophysiology and potential new therapies | Q35091914 |
| | Spinal neuronal NOS activation mediates sigma-1 receptor-induced mechanical and thermal hypersensitivity in mice: involvement of PKC-dependent GluN1 phosphorylation | Q35195533 |
| | Human Na(v)1.8: enhanced persistent and ramp currents contribute to distinct firing properties of human DRG neurons | Q35609134 |
| | Visceral pain: the ins and outs, the ups and downs | Q35738047 |
| | The sigma-1 receptors are present in monomeric and oligomeric forms in living cells in the presence and absence of ligands | Q35846559 |
| | GABAA-receptor-mediated effects of progesterone, its ring-A-reduced metabolites and synthetic neuroactive steroids on neurogenic oedema in the rat meninges | Q35873339 |
| | Expression of a truncated form of the endoplasmic reticulum chaperone protein, σ1 receptor, promotes mitochondrial energy depletion and apoptosis. | Q36078713 |
| | The sigma-1 receptor binds to the Nav1.5 voltage-gated Na+ channel with 4-fold symmetry | Q36347732 |
| | Intracellular sigma1 receptor modulates phospholipase C and protein kinase C activities in the brainstem | Q36418374 |
| | Activation of the spinal sigma-1 receptor enhances NMDA-induced pain via PKC- and PKA-dependent phosphorylation of the NR1 subunit in mice | Q36768687 |
| | Neuroactive properties of reproductive steroids | Q36938673 |
| | Neuropathic pain: emerging treatments | Q37176898 |
| | Voltage-gated sodium channel modulation by sigma-receptors in cardiac myocytes and heterologous systems | Q37190328 |
| | Inflammatory pain: the cellular basis of heat hyperalgesia. | Q37211785 |
| | Antagonism by haloperidol and its metabolites of mechanical hypersensitivity induced by intraplantar capsaicin in mice: role of sigma-1 receptors. | Q37225259 |
| | Persistent Na-channels: origin and function. A review | Q37225805 |
| | Sigma-1 receptor expression in sensory neurons and the effect of painful peripheral nerve injury | Q37357665 |
| | Genetic inactivation and pharmacological blockade of sigma-1 receptors prevent paclitaxel-induced sensory-nerve mitochondrial abnormalities and neuropathic pain in mice | Q37583394 |
| | Targeting voltage-gated calcium channels for neuropathic pain management | Q37605352 |
| | Opening paths to novel analgesics: the role of potassium channels in chronic pain | Q37623462 |
| | Peripheral analgesia: Hitting pain where it hurts | Q37824028 |
| | Treatment of chronic non-cancer pain | Q37894414 |
| | The roles of sodium channels in nociception: implications for mechanisms of neuropathic pain | Q37900697 |
| | Adverse effects associated with non-opioid and opioid treatment in patients with chronic pain | Q37987196 |
| | Direct association of Mu-opioid and NMDA glutamate receptors supports their cross-regulation: molecular implications for opioid tolerance. | Q38037679 |
| | Primary headache disorders | Q38117782 |
| | Contributions of peripheral, spinal, and supraspinal actions to analgesia. | Q38204556 |
| | Selective sigma-1 receptor antagonists for the treatment of pain. | Q38235503 |
| | Peripheral neurosteroids enhance P2X receptor-induced mechanical allodynia via a sigma-1 receptor-mediated mechanism | Q38417171 |
| | Role of peripheral sigma-1 receptors in ischaemic pain: Potential interactions with ASIC and P2X receptors. | Q38422557 |
| | Investigational sigma-1 receptor antagonists for the treatment of pain. | Q38513640 |
| | Peripherally Restricted Cannabinoids for the Treatment of Pain | Q38615325 |
| | The σ-1 receptor interacts directly with GluN1 but not GluN2A in the GluN1/GluN2A NMDA receptor | Q39063368 |
| | The development of new analgesics over the past 50 years: a lack of real breakthrough drugs | Q39139329 |
| | The sigma agonist 1,3-di-o-tolyl-guanidine directly blocks SK channels in dopaminergic neurons and in cell lines | Q39693378 |
| | Demonstration of a direct interaction between sigma-1 receptors and acid-sensing ion channels | Q39718372 |
| | Sigma-1 receptor regulation of voltage-gated calcium channels involves a direct interaction | Q39959189 |
| | The spinal antinociceptive mechanism determined by systemic administration of BD1047 in zymosan-induced hyperalgesia in rats. | Q40469477 |
| | Clonidine Reduces Nociceptive Responses in Mouse Orofacial Formalin Model: Potentiation by Sigma-1 Receptor Antagonist BD1047 without Impaired Motor Coordination | Q40586321 |
| | Perspectives on the N-methyl-D-aspartate/nitric oxide cascade and opioid tolerance | Q41070625 |
| | HINT1 protein: a new therapeutic target to enhance opioid antinociception and block mechanical allodynia | Q41760609 |
| | Gα(q/11) signaling tonically modulates nociceptor function and contributes to activity-dependent sensitization | Q42497106 |
| | The sigma-1 receptor modulates NMDA receptor synaptic transmission and plasticity via SK channels in rat hippocampus. | Q42601878 |
| | Effect of acute topical application of +-pentazocine on the mechanical allodynia in diabetic mice | Q43024609 |
| | The σ1 receptor engages the redox-regulated HINT1 protein to bring opioid analgesia under NMDA receptor negative control | Q43195386 |
| | Sigma-1 receptor antagonism as opioid adjuvant strategy: enhancement of opioid antinociception without increasing adverse effects. | Q43587271 |
| | Sigma1 receptor modulation of opioid analgesia in the mouse | Q43893570 |
| | The sigma receptor as a ligand-regulated auxiliary potassium channel subunit | Q43978439 |
| | Sigma receptors inhibit high-voltage-activated calcium channels in rat sympathetic and parasympathetic neurons | Q44010643 |
| | Synthesis and binding affinity of cis-(-)- and cis-(+)-N-ethyleneamino-N-nordeoxymetazocine and cis-(-)-N-normetazocine analogues at sigma1, sigma2 and kappa opioid receptors. | Q44334102 |
| | A new sigma ligand, (+/-)-PPCC, antagonizes kappa opioid receptor-mediated antinociceptive effect | Q44337781 |
| | Functional antagonism of morphine analgesia by (+)-pentazocine: evidence for an anti-opioid sigma 1 system | Q44338331 |
| | Modulation of peripheral μ-opioid analgesia by σ1 receptors | Q44341715 |
| | Enhanced kappa-opioid receptor-mediated analgesia by antisense targeting the sigma1 receptor | Q44346672 |
| | Age-related expression of sigma1 receptors and antidepressant efficacy of a selective agonist in the senescence-accelerated (SAM) mouse | Q45213895 |
| | Sigma-1 receptor stimulation attenuates calcium influx through activated L-type Voltage Gated Calcium Channels in purified retinal ganglion cells | Q46044065 |
| | Sigma-1 receptors are essential for capsaicin-induced mechanical hypersensitivity: studies with selective sigma-1 ligands and sigma-1 knockout mice. | Q46046241 |
| | sigma-1 receptor modulation of acid-sensing ion channel a (ASIC1a) and ASIC1a-induced Ca2+ influx in rat cortical neurons | Q46413616 |
| | Antinociceptive effects of haloperidol and its metabolites in the formalin test in mice | Q46630813 |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 85-107 | |
| P577 | publication date | 2017-01-01 | |
| P1433 | published in | Advances in Experimental Medicine and Biology | Q4686385 |
| P1476 | title | Pharmacological Modulation of the Sigma 1 Receptor and the Treatment of Pain | |
| P478 | volume | 964 | |