Curcumin blocks small cell lung cancer cells migration, invasion, angiogenesis, cell cycle and neoplasia through Janus kinase-STAT3 signalling pathway

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Curcumin blocks small cell lung cancer cells migration, invasion, angiogenesis, cell cycle and neoplasia through Janus kinase-STAT3 signalling pathway is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2012PLoSO...737960Y
P356DOI10.1371/JOURNAL.PONE.0037960
P932PMC publication ID3360669
P698PubMed publication ID22662257
P5875ResearchGate publication ID225098294

P50authorYong-Yu LiuQ38546585
P2093author name stringYi Ren
Zhen Li
Yao Li
Yi-Xue Xue
Cheng-Liang Yang
Ye-Gang Ma
Xiao-Bai Liu
De-Gui Liu
P2860cites workLung cancerQ73858423
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Differential expression of STAT5 and Bcl-xL, and high expression of Neu and STAT3 in non-small-cell lung carcinomaQ80228054
Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomasQ24669579
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Clinical significances of preoperative serum interleukin-6 and C-reactive protein level in operable gastric cancerQ33448971
The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumorsQ33613105
Disorders in cell circuitry during multistage carcinogenesis: the role of homeostasisQ33900139
Inhibitors of cyclo-oxygenase 2: a new class of anticancer agents?Q35557450
Cancer risk and diet in IndiaQ35575541
Role of chemopreventive agents in cancer therapyQ35920265
Nerve growth factor abrogates the tumorigenicity of human small cell lung cancer cell linesQ36070435
Constitutive activation of signal transducer and activator of transcription 5 contributes to tumor growth, epithelial-mesenchymal transition, and resistance to epidermal growth factor receptor targetingQ36175369
Sustained suppression of Bcr-Abl-driven lymphoid leukemia by microRNA mimics.Q36300062
STAT3 as a central mediator of neoplastic cellular transformationQ36665485
Regulation of metastases by signal transducer and activator of transcription 3 signaling pathway: clinical implicationsQ36749049
Molecular approaches towards the inhibition of the signal transducer and activator of transcription 3 (Stat3) proteinQ37015696
Interleukin-6 in the bone marrow microenvironment promotes the growth and survival of neuroblastoma cellsQ37385705
Guggulsterone enhances head and neck cancer therapies via inhibition of signal transducer and activator of transcription-3Q37437236
Bioactive natural products derived from the East African floraQ37638288
Activation of Stat3 by receptor tyrosine kinases and cytokines regulates survival in human non-small cell carcinoma cellsQ38353138
Curcumin induces small cell lung cancer NCI-H446 cell apoptosis via the reactive oxygen species-mediated mitochondrial pathway and not the cell death receptor pathwayQ39516612
Curcumin suppresses constitutive activation of STAT-3 by up-regulating protein inhibitor of activated STAT-3 (PIAS-3) in ovarian and endometrial cancer cells.Q39726725
Constitutively activated STAT3 frequently coexpresses with epidermal growth factor receptor in high-grade gliomas and targeting STAT3 sensitizes them to Iressa and alkylatorsQ39933616
Dasatinib (BMS-354825) tyrosine kinase inhibitor suppresses invasion and induces cell cycle arrest and apoptosis of head and neck squamous cell carcinoma and non-small cell lung cancer cellsQ40366043
Alternative implication of CXCR4 in JAK2/STAT3 activation in small cell lung cancerQ42277237
Organ heterogeneity of host-derived matrix metalloproteinase expression and its involvement in multiple-organ metastasis by lung cancer cell lines.Q44183141
Curcumin-induced suppression of cell proliferation correlates with down-regulation of cyclin D1 expression and CDK4-mediated retinoblastoma protein phosphorylationQ44250309
Anti-invasive gene expression profile of curcumin in lung adenocarcinoma based on a high throughput microarray analysis.Q44727251
Chemopreventive efficacy of ginger, a naturally occurring anticarcinogen during the initiation, post-initiation stages of 1,2 dimethylhydrazine-induced colon cancerQ46599915
Activated epidermal growth factor receptor-Stat-3 signaling promotes tumor survival in vivo in non-small cell lung cancerQ46831080
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectcell migrationQ189092
curcuminQ312266
angiogenesisQ539568
lung cancerQ47912
P304page(s)e37960
P577publication date2012-05-25
P1433published inPLOS OneQ564954
P1476titleCurcumin blocks small cell lung cancer cells migration, invasion, angiogenesis, cell cycle and neoplasia through Janus kinase-STAT3 signalling pathway
P478volume7

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