Nanoparticle-Based Celecoxib and Plumbagin for the Synergistic Treatment of Melanoma.

scientific article published on 21 December 2016

Nanoparticle-Based Celecoxib and Plumbagin for the Synergistic Treatment of Melanoma. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1158/1535-7163.MCT-16-0285
P932PMC publication ID5821064
P698PubMed publication ID28003325

P50authorGavin P. RobertsonQ55873679
Arati SharmaQ63934950
Gregory R KardosQ87832569
Raghavendra GowdaQ88023903
P2093author name stringSanjay Singh
P2860cites workRegulation of inflammation in cancer by eicosanoidsQ24564308
Wilms' tumor 1-associating protein regulates G2/M transition through stabilization of cyclin A2 mRNAQ24675575
Pathways and therapeutic targets in melanomaQ26865736
Effects of enriched environment on COX-2, leptin and eicosanoids in a mouse model of breast cancerQ27330395
Inhibition of paclitaxel-induced apoptosis by the specific COX-2 inhibitor, NS398, in epithelial ovarian cancer cellsQ28195446
Minireview: Cyclin D1: normal and abnormal functionsQ28279069
Nanocarriers as an emerging platform for cancer therapyQ29616699
Drug combination studies and their synergy quantification using the Chou-Talalay methodQ29617422
Characterization of 9-nitrocamptothecin liposomes: anticancer properties and mechanisms on hepatocellular carcinoma in vitro and in vivoQ30475089
Targeting Akt3 signaling in malignant melanoma using isoselenocyanatesQ33408109
Resistance to Raf inhibition in cancerQ33651779
Use of Nanotechnology to Develop Multi-Drug Inhibitors For Cancer TherapyQ33859472
Clinical pharmacokinetics and pharmacodynamics of celecoxib: a selective cyclo-oxygenase-2 inhibitorQ33882627
Curcumin blocks small cell lung cancer cells migration, invasion, angiogenesis, cell cycle and neoplasia through Janus kinase-STAT3 signalling pathwayQ34291456
Leelamine mediates cancer cell death through inhibition of intracellular cholesterol transport.Q34413011
Circumventing tumor resistance to chemotherapy by nanotechnologyQ34618357
Celecoxib analogs that lack COX-2 inhibitory function: preclinical development of novel anticancer drugsQ34743086
Targeting multiple key signaling pathways in melanoma using leelamine.Q35136450
Nanolipolee-007, a novel nanoparticle-based drug containing leelamine for the treatment of melanoma.Q35225907
Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone), isolated from Plumbago zeylanica, inhibits ultraviolet radiation-induced development of squamous cell carcinomas.Q35747332
Suppressive Effects of Plumbagin on Invasion and Migration of Breast Cancer Cells via the Inhibition of STAT3 Signaling and Down-regulation of Inflammatory Cytokine ExpressionsQ35755120
Activation of stat3 in human melanoma promotes brain metastasisQ48616814
Drug combination studies and their synergy quantification using the Chou-Talalay method--letter.Q50913842
NCPMF-60 induces G2/M cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells.Q54642733
How melanomas bypass new therapyQ59043395
Acute intravenous toxicity of dimethyl sulfoxide, polyethylene glycol 400, dimethylformamide, absolute ethanol, and benzyl alcohol in inbred mouse strainsQ72014136
Observations on the pharmacology and hemolytic activity of dimethyl sulfoxideQ72657553
Activity of paclitaxel liposome formulations against human ovarian tumor xenograftsQ73209085
Loss of PTEN promotes tumor development in malignant melanomaQ73469277
UV/Vis spectra and solubility of some naphthoquinones, and the extraction behavior of plumbagin from Plumbago scandens roots in supercritical CO2Q79768820
Mechanisms of drug combinations: interaction and network perspectivesQ83265745
MUC16 induced rapid G2/M transition via interactions with JAK2 for increased proliferation and anti-apoptosis in breast cancer cellsQ35784718
Targeting sphingosine kinase-1 to inhibit melanoma.Q35789935
The pivotal role of drug metabolism and pharmacokinetics in the discovery and development of new medicines.Q35873359
The Akt signaling pathway: an emerging therapeutic target in malignant melanoma.Q35911227
Targeting STAT3 affects melanoma on multiple frontsQ36178382
Plumbagin, a plant derived natural agent inhibits the growth of pancreatic cancer cells in in vitro and in vivo via targeting EGFR, Stat3 and NF-κB signaling pathwaysQ36466176
Simultaneous targeting of COX-2 and AKT using selenocoxib-1-GSH to inhibit melanomaQ36536476
Identification of aurora kinase B and Wee1-like protein kinase as downstream targets of (V600E)B-RAF in melanomaQ36750123
Is it time for a new paradigm for systemic cancer treatment? Lessons from a century of cancer chemotherapyQ36952188
STAT3 as a target for inducing apoptosis in solid and hematological tumorsQ37029162
Is B-Raf a good therapeutic target for melanoma and other malignancies?Q37048982
The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironmentQ37366259
Celecoxib antagonizes perifosine's anticancer activity involving a cyclooxygenase-2-dependent mechanismQ37370608
COX-2 as a target for cancer chemotherapyQ37761270
The solubility-permeability interplay and its implications in formulation design and development for poorly soluble drugsQ37990748
Discovery of small molecule cancer drugs: successes, challenges and opportunitiesQ37996113
From genes to drugs: targeted strategies for melanomaQ37999967
Nanotechnology-based combinational drug delivery: an emerging approach for cancer therapyQ38015042
Nanoparticle-assisted combination therapies for effective cancer treatment.Q38027852
Biopharmaceutical classification of poorly soluble drugs with respect to "enabling formulations".Q38098816
Nanomedicine applied to translational oncology: A future perspective on cancer treatmentQ38586904
Survival of patients with advanced metastatic melanoma: The impact of novel therapiesQ38680472
Nanotechnology-based strategies for combating toxicity and resistance in melanoma therapyQ38716666
Plumbagin shows anti-cancer activity in human breast cancer cells by the upregulation of p53 and p21 and suppression of G1 cell cycle regulatorsQ38780551
Stat3-targeted therapies overcome the acquired resistance to vemurafenib in melanomasQ39205805
Plumbagin, a medicinal plant (Plumbago zeylanica)-derived 1,4-naphthoquinone, inhibits growth and metastasis of human prostate cancer PC-3M-luciferase cells in an orthotopic xenograft mouse modelQ39219294
Genotype-selective combination therapies for melanoma identified by high-throughput drug screeningQ39226193
Selenium-containing histone deacetylase inhibitors for melanoma managementQ39336516
MHC class I molecules act as tumor suppressor genes regulating the cell cycle gene expression, invasion and intrinsic tumorigenicity of melanoma cells.Q39417513
Preparation, characterization, and in vitro release study of albendazole-encapsulated nanosize liposomes.Q39694546
Targeting V600EB-Raf and Akt3 using nanoliposomal-small interfering RNA inhibits cutaneous melanocytic lesion development.Q39899988
Anticancer mechanism of plumbagin, a natural compound, on non-small cell lung cancer cells.Q39977960
Plumbagin Inhibits Prostate Carcinogenesis in Intact and Castrated PTEN Knockout Mice via Targeting PKCε, Stat3, and Epithelial-to-Mesenchymal Transition MarkersQ40185493
ET-18-O-CH3-induced apoptosis is causally linked to COX-2 upregulation in H-ras transformed human breast epithelial cellsQ40357493
Up-regulation of cyclooxygenase-2 expression is involved in R(+)-methanandamide-induced apoptotic death of human neuroglioma cellsQ40516675
Enhanced expression of cyclooxygenase (COX)-2 in human skin epidermal cancer cells: evidence for growth suppression by inhibiting COX-2 expressionQ40882239
COX-2 in cancer--a player that's defining the rulesQ43963620
COX-2 expression in malignant melanoma: a novel prognostic marker?Q47833354
P4510describes a project that usesImageJQ1659584
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectnanoparticleQ61231
P304page(s)440-452
P577publication date2016-12-21
P1433published inMolecular Cancer TherapeuticsQ2363144
P1476titleNanoparticle-Based Celecoxib and Plumbagin for the Synergistic Treatment of Melanoma
P478volume16

Reverse relations

cites work (P2860)
Q92744195Celecoxib inhibits the epithelial-to-mesenchymal transition in bladder cancer via the miRNA-145/TGFBR2/Smad3 axis
Q88795679Cutaneous Melanoma-A Long Road from Experimental Models to Clinical Outcome: A Review
Q92373586Discovery of Noncancer Drug Effects on Survival in Electronic Health Records of Patients With Cancer: A New Paradigm for Drug Repurposing
Q90723914Emergent Nanotechnological Strategies for Systemic Chemotherapy against Melanoma
Q48155250Identification of WEE1 as a target to make AKT inhibition more effective in melanoma.
Q33709666Identifying the structure-activity relationship of leelamine necessary for inhibiting intracellular cholesterol transport
Q92315508Liposome Delivery of Natural STAT3 Inhibitors for the Treatment of Cancer
Q93379379Molecular simulation and in vitro evaluation of chitosan nanoparticles as drug delivery systems for the controlled release of anticancer drug cytarabine against solid tumours
Q50113740Nanoliposomal delivery of cytosolic phospholipase A2 inhibitor arachidonyl trimethyl ketone for melanoma treatment
Q90611684Recent strategies towards the surface modification of liposomes: an innovative approach for different clinical applications
Q64062363Traditional Chinese medicine-combination therapies utilizing nanotechnology-based targeted delivery systems: a new strategy for antitumor treatment

Search more.