Identification of WEE1 as a target to make AKT inhibition more effective in melanoma.

scientific article

Identification of WEE1 as a target to make AKT inhibition more effective in melanoma. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1080/15384047.2017.1360446
P932PMC publication ID5790369
P698PubMed publication ID28853983

P50authorOmer F KuzuQ86518955
Gregory R KardosQ87832569
Raghavendra GowdaQ88023903
Mohammad A NooryQ88875797
Joseph J DrabickQ88875800
SubbaRao V MadhunapantulaQ41550165
Gavin P. RobertsonQ55873679
Arati SharmaQ63934950
P2093author name stringGavin P Robertson
Omer F Kuzu
Joseph J Drabick
Arati Sharma
Mohammad A Noory
Gregory Kardos
P2860cites workActivation of Akt/protein kinase B overcomes a G(2)/m cell cycle checkpoint induced by DNA damageQ24537734
Regulation of the human WEE1Hu CDK tyrosine 15-kinase during the cell cycleQ24568298
Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulationQ24629474
Improved survival with vemurafenib in melanoma with BRAF V600E mutationQ24631953
TopHat: discovering splice junctions with RNA-SeqQ24655505
AKT/PKB signaling: navigating downstreamQ24657857
Polo-like kinase (Plk)1 depletion induces apoptosis in cancer cellsQ24675189
First-in-man clinical trial of the oral pan-AKT inhibitor MK-2206 in patients with advanced solid tumorsQ27851678
Reversing melanoma cross-resistance to BRAF and MEK inhibitors by co-targeting the AKT/mTOR pathway.Q27851698
Effects of AKT inhibitor therapy in response and resistance to BRAF inhibition in melanomaQ27852994
Inhibition of Mutated, Activated BRAF in Metastatic MelanomaQ27860458
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FOXM1, a typical proliferation-associated transcription factorQ28257808
Wee1 inhibition by MK-1775 leads to tumor inhibition and enhances efficacy of gemcitabine in human sarcomasQ28487835
Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitorsQ29547463
The phosphatidylinositol 3-Kinase AKT pathway in human cancerQ29547860
Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trialQ29614756
Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3KQ29614757
Improved survival with MEK inhibition in BRAF-mutated melanomaQ29620663
PI 3-kinase-dependent phosphorylation of Plk1-Ser99 promotes association with 14-3-3γ and is required for metaphase-anaphase transitionQ30540402
Trametinib for patients with advanced melanomaQ95424350
Identification of glycogen synthase kinase 3α as a therapeutic target in melanomaQ33569998
Akt/PKB suppresses DNA damage processing and checkpoint activation in late G2.Q33647680
Akt activation emulates Chk1 inhibition and Bcl2 overexpression and abrogates G2 cell cycle checkpoint by inhibiting BRCA1 fociQ34025378
Akt: a double-edged sword in cell proliferation and genome stabilityQ34223641
DNA damage-induced apoptosisQ34312499
Deregulated Akt3 activity promotes development of malignant melanomaQ34355872
Leelamine mediates cancer cell death through inhibition of intracellular cholesterol transport.Q34413011
PTEN loss confers BRAF inhibitor resistance to melanoma cells through the suppression of BIM expressionQ34761941
Inhibition of cyclin-dependent kinase 2 by p21 is necessary for retinoblastoma protein-mediated G1 arrest after gamma-irradiationQ34946238
New roles for p21 and p27 cell-cycle inhibitors: a function for each cell compartment?Q35057304
BRAF inhibitor resistance mediated by the AKT pathway in an oncogenic BRAF mouse melanoma modelQ35090029
Targeting multiple key signaling pathways in melanoma using leelamine.Q35136450
Nanolipolee-007, a novel nanoparticle-based drug containing leelamine for the treatment of melanoma.Q35225907
BRAF in Melanoma: Pathogenesis, Diagnosis, Inhibition, and ResistanceQ35607456
Akt inhibitors in clinical development for the treatment of cancerQ35628576
The c-Jun/RHOB/AKT pathway confers resistance of BRAF-mutant melanoma cells to MAPK inhibitors.Q36020990
Identification of aurora kinase B and Wee1-like protein kinase as downstream targets of (V600E)B-RAF in melanomaQ36750123
A requirement for cyclin-dependent kinase 6 in thymocyte development and tumorigenesisQ37085216
Targeting mitogen-activated protein kinase/extracellular signal-regulated kinase kinase in the mutant (V600E) B-Raf signaling cascade effectively inhibits melanoma lung metastasesQ37421620
The "SWOT" of BRAF inhibition in melanoma: RAF inhibitors, MEK inhibitors or both?Q37945533
Wee1 controls genomic stability during replication by regulating the Mus81-Eme1 endonucleaseQ38256335
Nanoparticle-Based Celecoxib and Plumbagin for the Synergistic Treatment of Melanoma.Q38724921
Synergistic inhibitory effects of Celecoxib and Plumbagin on melanoma tumor growth.Q38738291
Systems-pharmacology dissection of a drug synergy in imatinib-resistant CML.Q39268913
The tricyclic antidepressant imipramine induces autophagic cell death in U-87MG glioma cellsQ39479966
Vemurafenib and BRAF inhibition: a new class of treatment for metastatic melanomaQ39687000
Targeting V600EB-Raf and Akt3 using nanoliposomal-small interfering RNA inhibits cutaneous melanocytic lesion development.Q39899988
PRAS40 deregulates apoptosis in malignant melanomaQ40144591
Mutant V599EB-Raf regulates growth and vascular development of malignant melanoma tumorsQ40444060
Inhibition of Chk1 by activated PKB/Akt.Q40563144
Akt3 and mutant V600E B-Raf cooperate to promote early melanoma development.Q41859138
In silico analysis of kinase expression identifies WEE1 as a gatekeeper against mitotic catastrophe in glioblastomaQ42758535
Akt is more than just a Bad kinaseQ59068251
P4510describes a project that usesImageJQ1659584
P433issue1
P304page(s)53-62
P577publication date2017-11-30
P1433published inCancer Biology and TherapyQ2544651
P1476titleIdentification of WEE1 as a target to make AKT inhibition more effective in melanoma
P478volume19

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cites work (P2860)
Q90044630Combining ERBB family and MET inhibitors is an effective therapeutic strategy in cutaneous malignant melanoma independent of BRAF/NRAS mutation status
Q57044361Exploring major signaling cascades in melanomagenesis: a rationale route for targetted skin cancer therapy
Q47292160Moving synergistically acting drug combinations to the clinic by comparing sequential versus simultaneous drug administrations
Q49724275Repression of Akt3 gene transcription by the tumor suppressor RIZ1.

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