Targeting Akt3 signaling in malignant melanoma using isoselenocyanates

scientific article

Targeting Akt3 signaling in malignant melanoma using isoselenocyanates is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1158/1078-0432.CCR-08-2214
P932PMC publication ID2766355
P698PubMed publication ID19208796
P5875ResearchGate publication ID23999208

P50authorGavin P. RobertsonQ55873679
P2093author name stringDhimant Desai
Shantu Amin
Arun K Sharma
Subbarao V Madhunapantula
Arati Sharma
Sung Jin Huh
Paul Mosca
P2860cites workAnticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanatesQ24563653
Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activityQ24652600
Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide stainingQ24682187
Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancerQ27860681
Mutations of the BRAF gene in human cancerQ27860760
Sunitinib versus interferon alfa in metastatic renal-cell carcinomaQ28282757
Sorafenib in advanced clear-cell renal-cell carcinomaQ28282767
The protein kinase B/Akt signalling pathway in human malignancyQ28645742
Natural products as sources of new drugs over the last 25 yearsQ29615119
Inhibition of nuclear factor-kappaB DNA binding by organoselenocyanates through covalent modification of the p50 subunitQ30835417
Treatments for metastatic melanoma: synthesis of evidence from randomized trialsQ33301788
Drug-resistance in human melanomaQ34321923
Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumor activity in cancer cells overexpressing Akt.Q34330731
Deregulated Akt3 activity promotes development of malignant melanomaQ34355872
Ten years of protein kinase B signalling: a hard Akt to followQ34432885
STI571: a paradigm of new agents for cancer therapeuticsQ34482385
Cancer-preventive isothiocyanates: measurement of human exposure and mechanism of action.Q35914374
Chemoprevention by isothiocyanates and their underlying molecular signaling mechanismsQ35914378
Functional and therapeutic significance of Akt deregulation in malignant melanoma.Q36178371
Vegetable-derived isothiocyanates: anti-proliferative activity and mechanism of actionQ36379685
Cancer chemoprevention by garlic and garlic-containing sulfur and selenium compoundsQ36399294
Drug discovery from natural productsQ36424053
Discovery and development of sorafenib: a multikinase inhibitor for treating cancer.Q36610990
Sorafenib in advanced melanoma: a Phase II randomised discontinuation trial analysisQ36612290
Melanoma biology and new targeted therapyQ36742015
Malignant melanoma in the 21st century, part 1: epidemiology, risk factors, screening, prevention, and diagnosisQ36757554
From traditional Chinese medicine to rational cancer therapy.Q36888420
Development of sorafenib and other molecularly targeted agents in hepatocellular carcinomaQ37015632
Is B-Raf a good therapeutic target for melanoma and other malignancies?Q37048982
Microtubule-stabilizing natural products as promising cancer therapeuticsQ37066030
Selenium compounds and selenoproteins in cancerQ37115535
Emerging therapies for melanomaQ37134426
Targeting mitogen-activated protein kinase/extracellular signal-regulated kinase kinase in the mutant (V600E) B-Raf signaling cascade effectively inhibits melanoma lung metastasesQ37421620
Meta-analysis of phase II cooperative group trials in metastatic stage IV melanoma to determine progression-free and overall survival benchmarks for future phase II trialsQ38502534
PBISe, a novel selenium-containing drug for the treatment of malignant melanomaQ39981770
A novel activation-induced suicidal degradation mechanism for Akt by selenium.Q40032055
PRAS40 deregulates apoptosis in malignant melanomaQ40144591
Differential effects of selenite and selenate on human melanocytes, keratinocytes, and melanoma cellsQ40426301
PKB/AKT and ERK regulation of caspase-mediated apoptosis by methylseleninic acid in LNCaP prostate cancer cellsQ40432054
Mutant V599EB-Raf regulates growth and vascular development of malignant melanoma tumorsQ40444060
Ingestion of an isothiocyanate metabolite from cruciferous vegetables inhibits growth of human prostate cancer cell xenografts by apoptosis and cell cycle arrestQ40579395
Suppressing effects of dietary supplementation of the organoselenium 1,4-phenylenebis(methylene)selenocyanate and the Citrus antioxidant auraptene on lung metastasis of melanoma cells in miceQ40754469
Chemoprevention by isothiocyanatesQ40933059
Akt3 and mutant V600E B-Raf cooperate to promote early melanoma development.Q41859138
A link between benzyl isothiocyanate-induced cell cycle arrest and apoptosis: involvement of mitogen-activated protein kinases in the Bcl-2 phosphorylationQ44802895
Double-blind randomized phase II study of the combination of sorafenib and dacarbazine in patients with advanced melanoma: a report from the 11715 Study GroupQ46619788
Delineating the mechanism by which selenium deactivates Akt in prostate cancer cellsQ46966363
Structure-activity relationships for inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone lung tumorigenesis by arylalkyl isothiocyanates in A/J mice.Q53499435
Serum selenium levels in patients with malignant melanomaQ69368064
Loss of PTEN promotes tumor development in malignant melanomaQ73469277
P433issue5
P407language of work or nameEnglishQ1860
P304page(s)1674-1685
P577publication date2009-02-10
P1433published inClinical Cancer ResearchQ332253
P1476titleTargeting Akt3 signaling in malignant melanoma using isoselenocyanates
P478volume15

Reverse relations

cites work (P2860)
Q36413704AKT3 promotes prostate cancer proliferation cells through regulation of Akt, B-Raf, and TSC1/TSC2.
Q39445926Akt and RhoA inhibition promotes anoikis of aggregated B16F10 melanoma cells.
Q39648084Antileishmanial activity of imidothiocarbamates and imidoselenocarbamates
Q38127412Applications of nanotechnology for melanoma treatment, diagnosis, and theranostics
Q99605575COL2A1 Is a Novel Biomarker of Melanoma Tumor Repopulating Cells
Q36769227Cancer chemoprevention research with selenium in the post-SELECT era: Promises and challenges
Q84948297Chemoprevention of melanoma
Q26781652Current State of Animal (Mouse) Modeling in Melanoma Research
Q39418345Diphenyl diselenide protects cultured MCF-7 cells against tamoxifen-induced oxidative DNA damage
Q28390405Drug delivery nanoparticles in skin cancers
Q35628374Expression of the platelet-activating factor receptor enhances benzyl isothiocyanate-induced apoptosis in murine and human melanoma cells
Q36288650Flotillin-2 promotes metastasis of nasopharyngeal carcinoma by activating NF-κB and PI3K/Akt3 signaling pathways
Q36563659Genetics of melanoma
Q58895043Identification and Distribution of Selenium-Containing Glucosinolate Analogues in Tissues of Three Brassicaceae Species
Q36750123Identification of Aurora Kinase B and Wee1-Like Protein Kinase as Downstream Targets of V600EB-RAF in Melanoma
Q64273467Identification of a Novel Quinoxaline-Isoselenourea Targeting the STAT3 Pathway as a Potential Melanoma Therapeutic
Q33569998Identification of glycogen synthase kinase 3α as a therapeutic target in melanoma
Q38639775Mechanisms of Selenium Enrichment and Measurement in Brassicaceous Vegetables, and Their Application to Human Health
Q36384802Melanoma Prevention Using Topical PBISe
Q35535167Melanoma chemoprevention in skin reconstructs and mouse xenografts using isoselenocyanate-4.
Q37262390MicroRNAs 15a and 16 regulate tumor proliferation in multiple myeloma
Q33567626Mining mammalian transcript data for functional long non-coding RNAs
Q35225907Nanolipolee-007, a novel nanoparticle-based drug containing leelamine for the treatment of melanoma.
Q38724921Nanoparticle-Based Celecoxib and Plumbagin for the Synergistic Treatment of Melanoma.
Q33973521Novel library of selenocompounds as kinase modulators.
Q38907413Patient-derived tumor xenograft models for melanoma drug discovery
Q36345357Phenylalkyl isoselenocyanates vs phenylalkyl isothiocyanates: Thiol reactivity and its implications
Q35523031Phenylbutyl isoselenocyanate modulates phase I and II enzymes and inhibits 4-(methylnitrosamino)-1-(3-pyridyl)- 1-butanone-induced DNA adducts in mice
Q38077547Post SELECT: Selenium on Trial
Q33907135Prostate apoptosis response protein 4 sensitizes human colon cancer cells to chemotherapeutic 5-FU through mediation of an NF kappaB and microRNA network.
Q28482143Rational incorporation of selenium into temozolomide elicits superior antitumor activity associated with both apoptotic and autophagic cell death
Q82445737Reactions of nitroxides. Part X: Antifungal activity of selected sulfur and selenium derivatives of 2,2,6,6-tetramethylpiperidine
Q39336516Selenium-containing histone deacetylase inhibitors for melanoma management
Q36536476Simultaneous targeting of COX-2 and AKT using selenocoxib-1-GSH to inhibit melanoma
Q43240660Synthesis and antitumor properties of selenocoxib-1 against rat prostate adenocarcinoma cells
Q35606342Synthesis and biological evaluation of a novel class of isatin analogs as dual inhibitors of tubulin polymerization and Akt pathway
Q35136450Targeting multiple key signaling pathways in melanoma using leelamine.
Q37745182Targeting the MAPK pathway in melanoma: why some approaches succeed and other fail
Q35091427The Akt inhibitor ISC-4 activates prostate apoptosis response protein-4 and reduces colon tumor growth in a nude mouse model.
Q34649075The Akt inhibitor ISC-4 synergizes with cetuximab in 5-FU-resistant colon cancer
Q35911227The Akt signaling pathway: an emerging therapeutic target in malignant melanoma.
Q91975278The PI3K/AKT Pathway Inhibitor ISC-4 Induces Apoptosis and Inhibits Growth of Leukemia in Preclinical Models of Acute Myeloid Leukemia
Q37506648The PTEN-AKT3 signaling cascade as a therapeutic target in melanoma
Q64903636The Role of Isothiocyanates as Cancer Chemo-Preventive, Chemo-Therapeutic and Anti-Melanoma Agents.
Q35176448The T-box transcription factor, TBX3, is a key substrate of AKT3 in melanomagenesis
Q24631438Therapeutic Implications of Targeting AKT Signaling in Melanoma
Q36973754miR-29 targets Akt3 to reduce proliferation and facilitate differentiation of myoblasts in skeletal muscle development.

Search more.