COX-2 as a target for cancer chemotherapy

scientific article published on March 2010

COX-2 as a target for cancer chemotherapy is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1016/S1734-1140(10)70262-0
P698PubMed publication ID20508278
P5875ResearchGate publication ID44635864

P2093author name stringNilanjan Ghosh
Vivekananda Mandal
Subhash C Mandal
Rituparna Chaki
P2860cites workHuman cyclooxygenase-2 cDNAQ24293134
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COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expressionQ24536398
Tumor angiogenesis: therapeutic implicationsQ27860595
Why there are two cyclooxygenase isozymesQ27863307
The cyclo-oxygenase-2 inhibitor celecoxib perturbs intracellular calcium by inhibiting endoplasmic reticulum Ca2+-ATPases: a plausible link with its anti-tumour effect and cardiovascular risksQ28193254
Induction of cyclooxygenase-2 by activated Ha-ras oncogene in Rat-1 fibroblasts and the role of mitogen-activated protein kinase pathwayQ28279767
The cyclooxygenase-2 inhibitor celecoxib induces apoptosis by blocking Akt activation in human prostate cancer cells independently of Bcl-2Q28375904
Acceleration of intestinal polyposis through prostaglandin receptor EP2 in Apc(Delta 716) knockout miceQ28585868
Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2)Q28586461
Tumour-educated macrophages promote tumour progression and metastasisQ29614307
Cyclooxygenases: structural, cellular, and molecular biologyQ29616510
Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomasQ29620630
Carcinogen substrate specificity of human COX-1 and COX-2.Q31835278
Tumor necrosis factor-alpha-induced cyclooxygenase-2 expression via sequential activation of ceramide-dependent mitogen-activated protein kinases, and IkappaB kinase 1/2 in human alveolar epithelial cells.Q31942027
Clinical translation of angiogenesis inhibitorsQ34152769
Transgenic cyclooxygenase-2 overexpression sensitizes mouse skin for carcinogenesisQ34156486
Cyclooxygenase-2: a novel target for cancer chemotherapy?Q34317347
Cyclo-oxygenase 2: a pharmacological target for the prevention of cancer.Q34571903
Calcium-activated endoplasmic reticulum stress as a major component of tumor cell death induced by 2,5-dimethyl-celecoxib, a non-coxib analogue of celecoxib.Q34618673
Cyclooxygenase-2 and epidermal growth factor receptor: pharmacologic targets for chemopreventionQ36002131
Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potentialQ36085224
Inhibition of haematogenous metastasis of colon cancer in mice by a selective COX-2 inhibitor, JTE-522Q36620003
Immune changes in patients with advanced breast cancer undergoing chemotherapy with taxanesQ36624237
Prostaglandin H synthase and xenobiotic oxidationQ37813447
Host cyclooxygenase-2 modulates carcinoma growth.Q40365112
From the cyclooxygenase-2 inhibitor celecoxib to a novel class of 3-phosphoinositide-dependent protein kinase-1 inhibitorsQ40543789
3-phosphoinositide-dependent protein kinase-1/Akt signaling represents a major cyclooxygenase-2-independent target for celecoxib in prostate cancer cellsQ40588085
Celecoxib induces apoptosis by inhibiting 3-phosphoinositide-dependent protein kinase-1 activity in the human colon cancer HT-29 cell lineQ40733087
Prostaglandin E2 transactivates EGF receptor: a novel mechanism for promoting colon cancer growth and gastrointestinal hypertrophyQ40747279
Transforming growth factor-beta1 enhances Ha-ras-induced expression of cyclooxygenase-2 in intestinal epithelial cells via stabilization of mRNA.Q40897760
Epidermal growth factor-induced actin remodeling is regulated by 5-lipoxygenase and cyclooxygenase productsQ41534223
Specific inhibition of cyclooxygenase 2 restores antitumor reactivity by altering the balance of IL-10 and IL-12 synthesisQ41709477
Inflammatory response: pathway across the blood-brain barrier.Q43549107
Targeting cyclooxygenase 2 and HER-2/neu pathways inhibits colorectal carcinoma growthQ43619428
Prostaglandin E2 regulates cell migration via the intracellular activation of the epidermal growth factor receptorQ44375278
Celecoxib, a selective cyclo-oxygenase-2 inhibitor, enhances the response to preoperative paclitaxel and carboplatin in early-stage non-small-cell lung cancerQ44513206
Celecoxib anti-aromatase neoadjuvant (CAAN) trial for locally advanced breast cancer: preliminary reportQ44659442
Activators of the nuclear receptor PPARgamma enhance colon polyp formationQ46754355
High expression of cyclooxygenase-2 in macrophages of human colonic adenoma.Q53418211
Chemoprevention of colonic aberrant crypt foci by an inducible nitric oxide synthase-selective inhibitor.Q53424163
Peroxisome proliferators enhance cyclooxygenase-2 expression in epithelial cells.Q53425584
Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2Q70787131
Cyclooxygenase and lipoxygenase inhibitors as modulators of cancer therapiesQ72314332
Anti-inflammatory and upper gastrointestinal effects of celecoxib in rheumatoid arthritis: a randomized controlled trialQ73224851
Overexpression of cyclooxygenase-2 is sufficient to induce tumorigenesis in transgenic miceQ73693790
Dihydroxy bile acids activate the transcription of cyclooxygenase-2Q74088917
P433issue2
P921main subjectchemotherapyQ974135
P304page(s)233-244
P577publication date2010-03-01
P1433published inPharmacological ReportsQ15766499
P1476titleCOX-2 as a target for cancer chemotherapy
P478volume62

Reverse relations

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