Association of phosphatase and tensin homolog low and phosphatidylinositol 3-kinase catalytic subunit alpha gene mutations on outcome in human epidermal growth factor receptor 2-positive metastatic breast cancer patients treated with first-line lapa

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Association of phosphatase and tensin homolog low and phosphatidylinositol 3-kinase catalytic subunit alpha gene mutations on outcome in human epidermal growth factor receptor 2-positive metastatic breast cancer patients treated with first-line lapa is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1044669857
P356DOI10.1186/S13058-014-0405-Y
P932PMC publication ID4187249
P698PubMed publication ID25056500
P5875ResearchGate publication ID264245534

P2093author name stringBinghe Xu
Zhenzhou Shen
Michelle DeSilvio
Junlan Yang
Mark Russo
Zhongzhen Guan
Catherine Ellis
Zefei Jiang
Meggan Leigh
Zhongshen Tong
P2860cites workRandomized trial of lapatinib versus placebo added to paclitaxel in the treatment of human epidermal growth factor receptor 2-overexpressing metastatic breast cancer.Q54443173
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Ligand-independent HER2/HER3/PI3K complex is disrupted by trastuzumab and is effectively inhibited by the PI3K inhibitor GDC-0941Q24321567
Comprehensive molecular portraits of human breast tumoursQ24630844
PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients.Q27824819
Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenicQ27824826
A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancerQ27851414
PTEN, PIK3CA, p-AKT, and p-p70S6K status: association with trastuzumab response and survival in patients with HER2-positive metastatic breast cancer.Q27851582
Exploiting the PI3K/AKT pathway for cancer drug discoveryQ29615120
Lapatinib plus capecitabine in treating HER2-positive advanced breast cancer: efficacy, safety, and biomarker results from Chinese patients.Q33579653
PIK3CA mutations associated with gene signature of low mTORC1 signaling and better outcomes in estrogen receptor-positive breast cancerQ33933172
PI3K pathway activation results in low efficacy of both trastuzumab and lapatinibQ33933626
Deconstructing the molecular portraits of breast cancerQ34154147
Loss of phosphatase and tensin homolog or phosphoinositol-3 kinase activation and response to trastuzumab or lapatinib in human epidermal growth factor receptor 2-overexpressing locally advanced breast cancersQ34679149
Targeting the phosphatidylinositol 3-kinase signaling pathway in breast cancerQ35584560
PIK3CA mutation impact on survival in breast cancer patients and in ERα, PR and ERBB2-based subgroupsQ36393206
Phosphatidylinositol 3-kinase hyperactivation results in lapatinib resistance that is reversed by the mTOR/phosphatidylinositol 3-kinase inhibitor NVP-BEZ235.Q36983065
Impact of PTEN protein expression on benefit from adjuvant trastuzumab in early-stage human epidermal growth factor receptor 2-positive breast cancer in the North Central Cancer Treatment Group N9831 trialQ37065849
An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancerQ37187915
Lapatinib monotherapy in patients with relapsed, advanced, or metastatic breast cancer: efficacy, safety, and biomarker results from Japanese patients phase II studies.Q37424096
Mutation profiling identifies numerous rare drug targets and distinct mutation patterns in different clinical subtypes of breast cancers.Q37454306
Evaluation of the association of PIK3CA mutations and PTEN loss with efficacy of trastuzumab therapy in metastatic breast cancer.Q37877173
PIK3CA mutation associates with improved outcome in breast cancer.Q38420422
Activated phosphoinositide 3-kinase/AKT signaling confers resistance to trastuzumab but not lapatinibQ39700483
Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cellsQ40345016
Luminal expression of PIK3CA mutant H1047R in the mammary gland induces heterogeneous tumorsQ42486625
Exon 20 PIK3CA mutations decreases survival in aggressive (HER-2 positive) breast carcinomas.Q43579660
PIK3CA mutations, PTEN, and pHER2 expression and impact on outcome in HER2-positive early-stage breast cancer patients treated with adjuvant chemotherapy and trastuzumab.Q45903277
Biomarker analyses in CLEOPATRA: a phase III, placebo-controlled study of pertuzumab in human epidermal growth factor receptor 2-positive, first-line metastatic breast cancer.Q45945230
Genetic alterations and oncogenic pathways associated with breast cancer subtypesQ46047984
Phase II study of predictive biomarker profiles for response targeting human epidermal growth factor receptor 2 (HER-2) in advanced inflammatory breast cancer with lapatinib monotherapyQ46796554
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue4
P921main subjectmetastatic breast cancerQ12859063
P304page(s)405
P577publication date2014-07-24
P1433published inBreast Cancer ResearchQ2208481
P1476titleAssociation of phosphatase and tensin homolog low and phosphatidylinositol 3-kinase catalytic subunit alpha gene mutations on outcome in human epidermal growth factor receptor 2-positive metastatic breast cancer patients treated with first-line lapa
P478volume16

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cites work (P2860)
Q37221249Benefit to neoadjuvant anti-human epidermal growth factor receptor 2 (HER2)-targeted therapies in HER2-positive primary breast cancer is independent of phosphatase and tensin homolog deleted from chromosome 10 (PTEN) status
Q92520871BioPATH: A Biomarker Study in Asian Patients with HER2+ Advanced Breast Cancer Treated with Lapatinib and Other Anti-HER2 Therapy
Q52595390Characterization of PIK3CA and PIK3R1 somatic mutations in Chinese breast cancer patients.
Q54259231HSP60 overexpression increases the protein levels of the p110α subunit of  phosphoinositide 3-kinase and c-Myc.
Q90729183Lapatinib in combination with capecitabine versus continued use of trastuzumab in breast cancer patients with trastuzumab-resistance: a retrospective study of a Chinese population
Q38812867Lapatinib resistance in HER2+ cancers: latest findings and new concepts on molecular mechanisms
Q28081992PI3K mutations in breast cancer: prognostic and therapeutic implications
Q64106572PIK3CA alterations and benefit with neratinib: analysis from the randomized, double-blind, placebo-controlled, phase III ExteNET trial
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Q64256540The role of the phosphatase and tensin homolog status in predicting pathological complete response to neoadjuvant anti-HER2 therapies in HER2-positive primary breast cancer: A meta-analysis

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