Prospective Biomarker Analysis of the Randomized CHER-LOB Study Evaluating the Dual Anti-HER2 Treatment With Trastuzumab and Lapatinib Plus Chemotherapy as Neoadjuvant Therapy for HER2-Positive Breast Cancer

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Prospective Biomarker Analysis of the Randomized CHER-LOB Study Evaluating the Dual Anti-HER2 Treatment With Trastuzumab and Lapatinib Plus Chemotherapy as Neoadjuvant Therapy for HER2-Positive Breast Cancer is …
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scholarly articleQ13442814

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P356DOI10.1634/THEONCOLOGIST.2015-0138
P932PMC publication ID4571802
P698PubMed publication ID26245675

P50authorStefania BettelliQ51702921
Antonino MaioranaQ51702925
Enrico TagliaficoQ53072094
Pierfranco ConteQ56798835
Antonio FrassoldatiQ56826846
Daniele GeneraliQ56946462
A MusolinoQ57076640
Maria Vittoria DieciQ57656975
Valentina GuarneriQ58283362
P2093author name stringSamanta Sarti
Silvio Bicciato
Rocco Crescenzo
Catherine Ellis
Guido Ficarra
Giancarlo Bisagni
Katia Cagossi
P2860cites workA functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancerQ27851414
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Loss of phosphatase and tensin homolog or phosphoinositol-3 kinase activation and response to trastuzumab or lapatinib in human epidermal growth factor receptor 2-overexpressing locally advanced breast cancersQ34679149
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PIK3CA mutations are associated with decreased benefit to neoadjuvant human epidermal growth factor receptor 2-targeted therapies in breast cancerQ37380424
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Quantitation of p95HER2 in Paraffin Sections by Using a p95-Specific Antibody and Correlation with Outcome in a Cohort of Trastuzumab-Treated Breast Cancer PatientsQ39674995
Expression of p95HER2, a truncated form of the HER2 receptor, and response to anti-HER2 therapies in breast cancer.Q40144433
High HER2 expression correlates with response to the combination of lapatinib and trastuzumab.Q41735415
Loss of HER2 positivity and prognosis after neoadjuvant therapy in HER2-positive breast cancer patients.Q44723581
Biomarker analyses in CLEOPATRA: a phase III, placebo-controlled study of pertuzumab in human epidermal growth factor receptor 2-positive, first-line metastatic breast cancer.Q45945230
Quantitative measurements of tumoral p95HER2 protein expression in metastatic breast cancer patients treated with trastuzumab: independent validation of the p95HER2 clinical cutoffQ46058629
A prognostic model based on nodal status and Ki-67 predicts the risk of recurrence and death in breast cancer patients with residual disease after preoperative chemotherapyQ46120275
Prognostic value of pathologic complete response after primary chemotherapy in relation to hormone receptor status and other factors.Q46966638
PIK3CA mutations are associated with lower rates of pathologic complete response to anti-human epidermal growth factor receptor 2 (her2) therapy in primary HER2-overexpressing breast cancer.Q52874022
The prognostic significance of Ki67 before and after neoadjuvant chemotherapy in breast cancerQ81557497
P433issue9
P921main subjecttrastuzumabQ412616
biomarkerQ864574
chemotherapyQ974135
P304page(s)1001-1010
P577publication date2015-08-05
P1433published inOncologistQ2122327
P1476titleProspective Biomarker Analysis of the Randomized CHER-LOB Study Evaluating the Dual Anti-HER2 Treatment With Trastuzumab and Lapatinib Plus Chemotherapy as Neoadjuvant Therapy for HER2-Positive Breast Cancer
P478volume20

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