Role of HER2-Related Biomarkers (HER2, p95HER2, HER3, PTEN, and PIK3CA) in the Efficacy of Lapatinib plus Capecitabine in HER2-Positive Advanced Breast Cancer Refractory to Trastuzumab.

scientific article published on 6 May 2017

Role of HER2-Related Biomarkers (HER2, p95HER2, HER3, PTEN, and PIK3CA) in the Efficacy of Lapatinib plus Capecitabine in HER2-Positive Advanced Breast Cancer Refractory to Trastuzumab. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1159/000468521
P698PubMed publication ID28478451

P50authorUhi TohQ88213258
P2093author name stringSatoshi Hasegawa
Tsuyoshi Saito
Reiki Nishimura
Toshihiro Tanaka
Maki Tanaka
Nobuyuki Arima
Kazuo Tamura
Yasuyo Ohi
Satoshi Toyoshima
Shoshu Mitsuyama
Kaname Kurashita
Michiyo Saimura
Yuichiro Kai
Hidekazu Todoroki
Kazuhisa Katayama
Kazuo Shimada
Megumi Teraoka
Toshihiro Koga
Yasuhiro Okumura
P2860cites workLapatinib plus capecitabine for HER2-positive advanced breast cancerQ27851403
A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancerQ27851414
Correlation of HER2, p95HER2 and HER3 expression and treatment outcome of lapatinib plus capecitabine in her2-positive metastatic breast cancerQ28728701
ERBB receptors and cancer: the complexity of targeted inhibitorsQ29619520
Estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2 (HER2), and epidermal growth factor receptor expression and benefit from lapatinib in a randomized trial of paclitaxel with lapatinib or placebo as first-line treatmeQ33561588
PI3K pathway activation results in low efficacy of both trastuzumab and lapatinibQ33933626
Disruption of the ER-α36-EGFR/HER2 positive regulatory loops restores tamoxifen sensitivity in tamoxifen resistance breast cancer cellsQ34156192
Analytical Validation of a Highly Quantitative, Sensitive, Accurate, and Reproducible Assay (HERmark) for the Measurement of HER2 Total Protein and HER2 Homodimers in FFPE Breast Cancer Tumor SpecimensQ34342079
Loss of phosphatase and tensin homolog or phosphoinositol-3 kinase activation and response to trastuzumab or lapatinib in human epidermal growth factor receptor 2-overexpressing locally advanced breast cancersQ34679149
Lapatinib plus capecitabine in women with HER-2-positive advanced breast cancer: final survival analysis of a phase III randomized trialQ35584284
Different mechanisms for resistance to trastuzumab versus lapatinib in HER2-positive breast cancers--role of estrogen receptor and HER2 reactivationQ35889621
Upregulation of ER Signaling as an Adaptive Mechanism of Cell Survival in HER2-Positive Breast Tumors Treated with Anti-HER2 Therapy.Q36021424
Prospective Biomarker Analysis of the Randomized CHER-LOB Study Evaluating the Dual Anti-HER2 Treatment With Trastuzumab and Lapatinib Plus Chemotherapy as Neoadjuvant Therapy for HER2-Positive Breast CancerQ36064908
HER3, p95HER2, and HER2 protein expression levels define multiple subtypes of HER2-positive metastatic breast cancerQ37136419
Benefit to neoadjuvant anti-human epidermal growth factor receptor 2 (HER2)-targeted therapies in HER2-positive primary breast cancer is independent of phosphatase and tensin homolog deleted from chromosome 10 (PTEN) statusQ37221249
Role of HER3 expression and PTEN loss in patients with HER2-overexpressing metastatic breast cancer (MBC) who received taxane plus trastuzumab treatmentQ37507467
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P95 HER2 fragments and breast cancer outcomeQ38223511
Quantitation of p95HER2 in Paraffin Sections by Using a p95-Specific Antibody and Correlation with Outcome in a Cohort of Trastuzumab-Treated Breast Cancer PatientsQ39674995
Expression of p95HER2, a truncated form of the HER2 receptor, and response to anti-HER2 therapies in breast cancer.Q40144433
Phase I pharmacokinetic studies evaluating single and multiple doses of oral GW572016, a dual EGFR-ErbB2 inhibitor, in healthy subjectsQ45141053
Quantitative measurements of tumoral p95HER2 protein expression in metastatic breast cancer patients treated with trastuzumab: independent validation of the p95HER2 clinical cutoffQ46058629
Efficacy and safety of lapatinib as first-line therapy for ErbB2-amplified locally advanced or metastatic breast cancerQ46610979
p95HER-2 predicts worse outcome in patients with HER-2-positive breast cancerQ46905262
PIK3CA mutations are associated with lower rates of pathologic complete response to anti-human epidermal growth factor receptor 2 (her2) therapy in primary HER2-overexpressing breast cancer.Q52874022
Prognostic importance of c-erbB-2 expression in breast cancer. International (Ludwig) Breast Cancer Study Group.Q53394493
Quantitative HER2 protein levels predict outcome in fluorescence in situ hybridization-positive patients with metastatic breast cancer treated with trastuzumab.Q54660064
P433issue1
P921main subjectcapecitabineQ420207
biomarkerQ864574
P304page(s)51-61
P577publication date2017-05-06
P1433published inOncologyQ2016300
P1476titleRole of HER2-Related Biomarkers (HER2, p95HER2, HER3, PTEN, and PIK3CA) in the Efficacy of Lapatinib plus Capecitabine in HER2-Positive Advanced Breast Cancer Refractory to Trastuzumab.
P478volume93

Reverse relations

cites work (P2860)
Q100751537Attenuation of p53 mutant as an approach for treatment Her2-positive cancer
Q58112887Clinicopathological and prognostic correlations of HER3 expression and its degradation regulators, NEDD4-1 and NRDP1, in primary breast cancer
Q59798481Human epithelial growth factor receptor 2 in human salivary carcinoma ex pleomorphic adenoma: a potential therapeutic target
Q90729183Lapatinib in combination with capecitabine versus continued use of trastuzumab in breast cancer patients with trastuzumab-resistance: a retrospective study of a Chinese population
Q90316294MiR-519d targets HER3 and can be used as a potential serum biomarker for non-small cell lung cancer
Q47136119Predictive value of quantitative HER2, HER3 and p95HER2 levels in HER2-positive advanced breast cancer patients treated with lapatinib following progression on trastuzumab
Q90862850Targeted therapeutic options and future perspectives for HER2-positive breast cancer

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