Oridonin: targeting programmed cell death pathways as an anti-tumour agent

scientific article

Oridonin: targeting programmed cell death pathways as an anti-tumour agent is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/J.1365-2184.2012.00849.X
P932PMC publication ID6496291
P698PubMed publication ID23106297

P2093author name stringH Peng
Z Liu
L Ouyang
W-Z Zhang
P2860cites workThe Hallmarks of CancerQ221226
Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factorQ22009126
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machineryQ27860586
NF-kappaB is a target of AKT in anti-apoptotic PDGF signallingQ28144330
Proliferation, cell cycle and apoptosis in cancerQ28189476
Regulation of cell death protease caspase-9 by phosphorylationQ28288607
Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammationQ29614227
ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functionsQ29615216
Targeting PI3K signalling in cancer: opportunities, challenges and limitationsQ29617685
The Ste20 group kinases as regulators of MAP kinase cascadesQ29619312
Oridonin induced A375-S2 cell apoptosis via bax-regulated caspase pathway activation, dependent on the cytochrome c/caspase-9 apoptosomeQ33199100
Antiproliferation effects of ponicidin on human myeloid leukemia cells in vitro.Q33212682
Oridonin inhibits cell growth by induction of apoptosis on human hepatocelluar carcinoma BEL-7402 cellsQ33241115
Effects of oridonin on proliferation of HT29 human colon carcinoma cell lines both in vitro and in vivo in mice.Q33292385
Oridonin, a diterpenoid purified from Rabdosia rubescens, inhibits the proliferation of cells from lymphoid malignancies in association with blockade of the NF-kappa B signal pathwaysQ40435902
Cytochrome c release from oridonin-treated apoptotic A375-S2 cells is dependent on p53 and extracellular signal-regulated kinase activationQ40502547
Oridonin induces a caspase-independent but mitochondria- and MAPK-dependent cell death in the murine fibrosarcoma cell line L929.Q40507634
Oridonin induces growth inhibition and apoptosis of a variety of human cancer cells.Q40636149
Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways.Q41205566
Triggering Fbw7-mediated proteasomal degradation of c-Myc by oridonin induces cell growth inhibition and apoptosis.Q43508536
Oridonin enhances phagocytosis of UV-irradiated apoptotic U937 cellsQ45296035
Molecular mechanisms of oridonin-induced apoptosis and autophagy in murine fibrosarcoma L929 cellsQ46128790
Multiple-modulation effects of Oridonin on the production of proinflammatory cytokines and neurotrophic factors in LPS-activated microgliaQ46137751
Involvement of PKC signal pathways in oridonin-induced autophagy in HeLa cells: a protective mechanism against apoptosisQ46232893
Oridonin-induced apoptosis in leukemia K562 cells and its mechanismQ46473086
Activation of phosphoinositide 3-kinase, protein kinase C, and extracellular signal-regulated kinase is required for oridonin-enhanced phagocytosis of apoptotic bodies in human macrophage-like U937 cellsQ46633854
Oridonin induced autophagy in human cervical carcinoma HeLa cells through Ras, JNK, and P38 regulationQ46840428
Roles of Ras and extracellular signal-regulated kinase-dependent IkappaBalpha degradation in oridonin-enhanced phagocytosis of apoptotic cells by human macrophage-like U937 cellsQ46884524
Phagocytosis of Escherichia coli by insect hemocytes requires both activation of the Ras/mitogen-activated protein kinase signal transduction pathway for attachment and beta3 integrin for internalizationQ48010805
Targeting of AML1-ETO in t(8;21) leukemia by oridonin generates a tumor suppressor-like protein.Q53176666
Antitumor activity of diterpenoids, trichorabdals A, B, and C, and the related compounds: synergism of two active sitesQ71063932
BCL-2 gene family and the regulation of programmed cell deathQ77303933
Oridonin-induced A431 cell apoptosis partially through blockage of the Ras/Raf/ERK signal pathwayQ79656081
Fas/FasL signaling allows extracelluar-signal regulated kinase to regulate cytochrome c release in oridonin-induced apoptotic U937 cellsQ80199791
Autophagy enhanced phagocytosis of apoptotic cells by oridonin-treated human histocytic lymphoma U937 cellsQ82878219
Oridonin induces apoptosis via PI3K/Akt pathway in cervical carcinoma HeLa cell lineQ33303792
Reactive oxygen species contribute to oridonin-induced apoptosis and autophagy in human cervical carcinoma HeLa cellsQ33566142
Autophagy counteracts apoptosis in human multiple myeloma cells exposed to oridonin in vitro via regulating intracellular ROS and SIRT1Q33566976
Oridonin induces apoptosis and senescence in colorectal cancer cells by increasing histone hyperacetylation and regulation of p16, p21, p27 and c-mycQ33740026
Bcl-2 family: life-or-death switchQ33825160
Augmentation of oridonin-induced apoptosis observed with reduced autophagyQ33997847
And all of a sudden it's over: mitochondrial outer-membrane permeabilization in apoptosisQ34648801
Initiator caspases in apoptosis signaling pathwaysQ34724282
The role of mitochondrial factors in apoptosis: a Russian roulette with more than one bullet.Q34859478
Mitochondria: releasing power for life and unleashing the machineries of deathQ35071387
Oridonin, a diterpenoid extracted from medicinal herbs, targets AML1-ETO fusion protein and shows potent antitumor activity with low adverse effects on t(8;21) leukemia in vitro and in vivoQ35751083
Functions of the MAPK family in vertebrate-developmentQ36584183
Autophagic pathways as new targets for cancer drug developmentQ36654185
An introduction to death receptors in apoptosisQ36802828
Autophagy and human diseaseQ36900047
Living with death: the evolution of the mitochondrial pathway of apoptosis in animals.Q37152726
Autophagy and cancer: dynamism of the metabolism of tumor cells and tissuesQ37323895
Electron microscopy morphology of the mitochondrial network in human cancerQ37585762
Targeting apoptotic and autophagic pathways for cancer therapeuticsQ37805225
Oridonin: An active diterpenoid targeting cell cycle arrest, apoptotic and autophagic pathways for cancer therapeuticsQ37835927
Core signaling pathways of survival/death in autophagy-related cancer networksQ37884816
Mitochondrial ROS generation for regulation of autophagic pathways in cancerQ37939467
MicroRNA-modulated autophagic signaling networks in cancerQ37985341
Caspase-mediated programmed cell death pathways as potential therapeutic targets in cancerQ37994921
Plant natural compounds: targeting pathways of autophagy as anti-cancer therapeutic agentsQ38024145
Oridonin induces G2/M arrest and apoptosis via activating ERK-p53 apoptotic pathway and inhibiting PTK-Ras-Raf-JNK survival pathway in murine fibrosarcoma L929 cellsQ39809734
NF-kappab facilitates oridonin-induced apoptosis and autophagy in HT1080 cells through a p53-mediated pathwayQ39818380
Autophagy inhibits reactive oxygen species-mediated apoptosis via activating p38-nuclear factor-kappa B survival pathways in oridonin-treated murine fibrosarcoma L929 cellsQ39888530
Reactive oxygen species mediate oridonin-induced HepG2 apoptosis through p53, MAPK, and mitochondrial signaling pathwaysQ39948397
Oridonin induces human melanoma A375-S2 cell death partially through inhibiting insulin-like growth factor 1 receptor signalingQ39951528
Apoptosis-suppressing and autophagy-promoting effects of calpain on oridonin-induced L929 cell deathQ39983974
Inactivation of ras and changes of mitochondrial membrane potential contribute to oridonin-induced autophagy in a431 cellsQ40076228
Autophagy preceded apoptosis in oridonin-treated human breast cancer MCF-7 cellsQ40138436
Oridonin inhibited the tyrosine kinase activity and induced apoptosis in human epidermoid carcinoma A431 cellsQ40176455
Oridonin induced apoptosis through Akt and MAPKs signaling pathways in human osteosarcoma cellsQ40183990
Fibroblast growth factor-2 suppresses oridonin-induced L929 apoptosis through extracellular signal-regulated kinase-dependent and phosphatidylinositol 3-kinase-independent pathwayQ40206093
Back to the future of oridonin: again, compound from medicinal herb shows potent antileukemia efficacies in vitro and in vivoQ40224511
A comparison of the signal pathways between the TNF alpha- and oridonin-induced murine L929 fibrosarcoma cell deathQ40328365
Bcl-2 up-regulation and P-p53 down-regulation account for the low sensitivity of murine L929 fibrosarcoma cells to oridonin-induced apoptosisQ40354165
Apoptotic effect of oridonin on NB4 cells and its mechanismQ40397708
P433issue6
P921main subjectcell deathQ2383867
P304page(s)499-507
P577publication date2012-12-01
P1433published inCell ProliferationQ1952798
P1476titleOridonin: targeting programmed cell death pathways as an anti-tumour agent
P478volume45

Reverse relations

cites work (P2860)
Q37714055Anti-proliferative effect of Jesridonin on paclitaxel-resistant EC109 human esophageal carcinoma cells
Q38773218Antitumor and Antibacterial Derivatives of Oridonin: A Main Composition of Dong-Ling-Cao.
Q92668992Capsaicin induces apoptosis and autophagy in human melanoma cells
Q37197661Cold-water extracts of Grifola frondosa and its purified active fraction inhibit hepatocellular carcinoma in vitro and in vivo
Q28387804Discovery and development of natural product oridonin-inspired anticancer agents
Q39167609ER stress and ASK1-JNK activation contribute to oridonin-induced apoptosis and growth inhibition in cultured human hepatoblastoma HuH-6 cells
Q48131676Effects of dietary supplementation with oridonin on the growth performance, relative organ weight, lymphocyte proliferation, and cytokine concentration in broiler chickens
Q36259454Enhanced effects of novel oridonin analog CYD0682 for hepatic fibrosis
Q38724028Geridonin, a novel derivative of oridonin, inhibits proliferation of MGC 803 cells both in vitro and in vivo through elevating the intracellular ROS.
Q34651881Identifying molecular targets of lifestyle modifications in colon cancer prevention
Q39007335Lasiokaurin derivatives: synthesis, antimicrobial and antitumor biological evaluation, and apoptosis-inducing effects
Q38632963Natural products against hematological malignancies and identification of their targets
Q33598550Oridonin induces G2/M cell cycle arrest and apoptosis via the PI3K/Akt signaling pathway in hormone-independent prostate cancer cells
Q48105319Oridonin induces apoptosis in human oral cancer cells via phosphorylation of histone H2AX.
Q38912986Oridonin inhibits BxPC-3 cell growth through cell apoptosis
Q26738633Oridonin, a Promising ent-Kaurane Diterpenoid Lead Compound
Q38707589Single molecule force spectroscopy for in-situ probing oridonin inhibited ROS-mediated EGF-EGFR interactions in living KYSE-150 cells.
Q36913614Targeting signaling pathways in epithelial ovarian cancer
Q28548596The Antitumor Activity of the Novel Compound Jesridonin on Human Esophageal Carcinoma Cells
Q38786015Unravelling the relationship between macroautophagy and mitochondrial ROS in cancer therapy

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