Adoptive transfer of syngeneic T cells transduced with a chimeric antigen receptor that recognizes murine CD19 can eradicate lymphoma and normal B cells

scientific article

Adoptive transfer of syngeneic T cells transduced with a chimeric antigen receptor that recognizes murine CD19 can eradicate lymphoma and normal B cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1182/BLOOD-2010-01-265041
P932PMC publication ID2981541
P698PubMed publication ID20631379
P5875ResearchGate publication ID45188608

P50authorSteven RosenbergQ2347448
P2093author name stringNicholas P Restifo
Zhiya Yu
James N Kochenderfer
Dorina Frasheri
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Effector CD4 cells are tolerized upon exposure to parenchymal self-antigenQ33791198
Characterization and expression of the gene for the human Fc receptor gamma subunit. Definition of a new gene familyQ33840543
Expression of immunoglobulin-T-cell receptor chimeric molecules as functional receptors with antibody-type specificityQ34326400
Eradication of B-lineage cells and regression of lymphoma in a patient treated with autologous T cells genetically engineered to recognize CD19Q34360292
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Transfer of a TCR gene derived from a patient with a marked antitumor response conveys highly active T-cell effector functionsQ34669675
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Cyclophosphamide-facilitated adoptive immunotherapy of an established tumor depends on elimination of tumor-induced suppressor T cellsQ36346300
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Redirecting specificity of T-cell populations for CD19 using the Sleeping Beauty systemQ36713904
Adoptive immunotherapy for indolent non-Hodgkin lymphoma and mantle cell lymphoma using genetically modified autologous CD20-specific T cellsQ36868712
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Natural expression of the CD19 antigen impacts the long-term engraftment but not antitumor activity of CD19-specific engineered T cells.Q39749811
A herceptin-based chimeric antigen receptor with modified signaling domains leads to enhanced survival of transduced T lymphocytes and antitumor activityQ39785306
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Adoptive immunotherapy of prostate cancer bone lesions using redirected effector lymphocytesQ40619033
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Redirecting mouse CTL against colon carcinoma: superior signaling efficacy of single-chain variable domain chimeras containing TCR-zeta vs Fc epsilon RI-gammaQ42833240
Chimeric receptors containing CD137 signal transduction domains mediate enhanced survival of T cells and increased antileukemic efficacy in vivoQ42938990
Identification of a murine CD28 dileucine motif that suppresses single-chain chimeric T-cell receptor expression and function.Q43678706
Human-mouse lymphoid chimeras: host-vs.-graft and graft-vs.-host reactionsQ45126833
Addition of the CD28 signaling domain to chimeric T-cell receptors enhances chimeric T-cell resistance to T regulatory cellsQ45862006
T-cell mediated rejection of gene-modified HIV-specific cytotoxic T lymphocytes in HIV-infected patientsQ45876112
CD28 costimulation provided through a CD19-specific chimeric antigen receptor enhances in vivo persistence and antitumor efficacy of adoptively transferred T cells.Q45984095
Monoclonal antibody therapy of B cell lymphoma: signaling activity on tumor cells appears more important than recruitment of effectors.Q49094344
Rapid specific amplification of rat antibody cDNA from nine hybridomas in the presence of myeloma light chains.Q51805063
Eradication of systemic B-cell tumors by genetically targeted human T lymphocytes co-stimulated by CD80 and interleukin-15.Q53659254
Early and prolonged intravenous immunoglobulin replacement therapy in childhood agammaglobulinemia: A retrospective survey of 31 patientsQ61831538
Immunotherapy of established murine B cell lymphoma. Combination of idiotype immunization and cyclophosphamideQ70215333
B4, a human B lymphocyte-associated antigen expressed on normal, mitogen-activated, and malignant B lymphocytesQ70437885
Use of monoclonal anti-mouse immunoglobulin to detect mouse antibodiesQ71650396
P433issue19
P407language of work or nameEnglishQ1860
P304page(s)3875-3886
P577publication date2010-07-14
P1433published inBloodQ885070
P1476titleAdoptive transfer of syngeneic T cells transduced with a chimeric antigen receptor that recognizes murine CD19 can eradicate lymphoma and normal B cells
P478volume116

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