Klotho is associated with VEGF receptor-2 and the transient receptor potential canonical-1 Ca 2+ channel to maintain endothelial integrity

scientific article published on October 21, 2010

Klotho is associated with VEGF receptor-2 and the transient receptor potential canonical-1 Ca 2+ channel to maintain endothelial integrity is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2010PNAS..10719308K
P356DOI10.1073/PNAS.1008544107
P8608Fatcat IDrelease_rev73vlq7bf2bdinvxtydoahii
P953full work available at URLhttps://europepmc.org/articles/pmc2984167?pdf=render
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20966350/?tool=EBI
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20966350/pdf/?tool=EBI
https://europepmc.org/articles/PMC2984167
https://doi.org/10.1073/pnas.1008544107
https://europepmc.org/articles/PMC2984167?pdf=render
https://pnas.org/doi/pdf/10.1073/pnas.1008544107
P932PMC publication ID2984167
P698PubMed publication ID20966350
P5875ResearchGate publication ID47520121

P2093author name stringHiroaki Matsubara
Masabumi Shibuya
Kazuhiko Ishikawa
Yasushi Adachi
Manabu Murakami
Kazuhiro Sonomura
Taikou Kimura
Yasukiyo Mori
Tetsuro Kusaba
Takeshi Shirayama
Mitsuhiko Okigaki
Tsuguru Hatta
Susumu Sasaki
Shuji Tanda
Akihiro Matui
P2860cites workTransient receptor potential channels in cardiovascular function and disease.Q36542546
The beta-glucuronidase klotho hydrolyzes and activates the TRPV5 channelQ40359636
HMG-CoA reductase inhibitors up-regulate anti-aging klotho mRNA via RhoA inactivation in IMCD3 cells.Q40504299
Hypercholesterolemia induces regression in neointimal thickening due to apoptosis of vascular smooth muscle cells in the hamster endothelial injury modelQ43876797
Klotho is a novel beta-glucuronidase capable of hydrolyzing steroid beta-glucuronidesQ44710659
Angiopoietin-1 opposes VEGF-induced increase in endothelial permeability by inhibiting TRPC1-dependent Ca2 influxQ46513387
Severely reduced production of klotho in human chronic renal failure kidneyQ49064415
In vivo klotho gene delivery protects against endothelial dysfunction in multiple risk factor syndromeQ64380372
Klotho protein deficiency leads to overactivation of mu-calpainQ74465374
Homer Binds TRPC Family Channels and Is Required for Gating of TRPC1 by IP3 ReceptorsQ24295021
Mutation of the mouse klotho gene leads to a syndrome resembling ageingQ24328782
Suppression of aging in mice by the hormone KlothoQ24650916
Cellular levels of p120 catenin function as a set point for cadherin expression levels in microvascular endothelial cellsQ24672311
Klotho converts canonical FGF receptor into a specific receptor for FGF23Q28272505
alpha-Klotho as a regulator of calcium homeostasisQ28306317
In vivo klotho gene transfer ameliorates angiotensin II-induced renal damageQ28574231
Angiogenesis and vasculogenesis are impaired in the precocious-aging klotho mouseQ33205670
Ion channels and their functional role in vascular endotheliumQ34388070
Role of Ca2+ signaling in the regulation of endothelial permeabilityQ35127956
Traffic control: p120-catenin acts as a gatekeeper to control the fate of classical cadherins in mammalian cellsQ35580785
Amelioration of progressive renal injury by genetic manipulation of Klotho geneQ35844644
Functional role of TRPC channels in the regulation of endothelial permeabilityQ36179335
Recent developments in vascular endothelial cell transient receptor potential channelsQ36299266
P433issue45
P407language of work or nameEnglishQ1860
P921main subjectendotheliumQ111140
P304page(s)19308-19313
P577publication date2010-10-21
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleKlotho is associated with VEGF receptor-2 and the transient receptor potential canonical-1 Ca2+ channel to maintain endothelial integrity
Klotho is associated with VEGF receptor-2 and the transient receptor potential canonical-1 Ca 2+ channel to maintain endothelial integrity
P478volume107

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cites work (P2860)
Q34595154A decreased level of serum soluble Klotho is an independent biomarker associated with arterial stiffness in patients with chronic kidney disease
Q39203308Acute lung injury complicating acute kidney injury: A model of endogenous αKlotho deficiency and distant organ dysfunction
Q54466491Aerobic exercise training increases plasma Klotho levels and reduces arterial stiffness in postmenopausal women.
Q89985486Alpha-Klotho, a critical protein for lung health, is not expressed in normal lung
Q41169103Angiogenesis Dysregulation in the Pathogenesis of Systemic Sclerosis.
Q40896471Antialbuminuric actions of calcilytics in the remnant kidney
Q56964890Atrial fibrillation and low vitamin D levels are associated with severe vascular calcifications in hemodialysis patients
Q37404983Biochemical and functional characterization of the klotho-VS polymorphism implicated in aging and disease risk
Q38016491Chronic kidney disease and vascular remodelling: molecular mechanisms and clinical implications
Q35210184Cross talk between the renin-angiotensin-aldosterone system and vitamin D-FGF-23-klotho in chronic kidney disease
Q35159723Cyclic stretch induces alveolar epithelial barrier dysfunction via calpain-mediated degradation of p120-catenin
Q61813239Endogenous Calcification Inhibitors in the Prevention of Vascular Calcification: A Consensus Statement From the COST Action EuroSoftCalcNet
Q92642755Endothelial Ca2+ Signaling, Angiogenesis and Vasculogenesis: just What It Takes to Make a Blood Vessel
Q89620105Endothelial Transient Receptor Potential Channels and Vascular Remodeling: Extracellular Ca2 + Entry for Angiogenesis, Arteriogenesis and Vasculogenesis
Q92666465Endothelial cell Piezo1 mediates pressure-induced lung vascular hyperpermeability via disruption of adherens junctions
Q37698288Ethanol promotes arteriogenesis and restores perfusion to chronically ischemic myocardium
Q37996937FGF23 and PTH--double agents at the heart of CKD.
Q99711241High Phosphate Induces and Klotho Attenuates Kidney Epithelial Senescence and Fibrosis
Q34088174Infection and smoking are associated with decreased plasma concentration of the anti-aging protein, α-klotho
Q38184990Ion channels in cancer: future perspectives and clinical potential
Q48222023Klotho attenuates isoproterenol-induced hypertrophic response in H9C2 cells by activating Na+/K+-ATPase and inhibiting the reverse mode of Na+/Ca2+-exchanger
Q28287609Klotho endows hepatoma cells with resistance to anoikis via VEGFR2/PAK1 activation in hepatocellular carcinoma
Q37261449Klotho regulates retinal pigment epithelial functions and protects against oxidative stress
Q28079797Klotho: a humeral mediator in CSF and plasma that influences longevity and susceptibility to multiple complex disorders, including depression
Q46851255Laboratory aspects of circulating α-Klotho
Q41622879Measurement of Serum Klotho in Systemic Sclerosis.
Q90040434Modifying Phosphate Toxicity in Chronic Kidney Disease
Q35441666Molecular basis of Klotho: from gene to function in aging
Q47132894New Insights into the Mechanism of Action of Soluble Klotho
Q36364310Plasma klotho and cardiovascular disease in adults
Q28087392Polymorphism of klotho G-395A and susceptibility of coronary artery disease in East-Asia population: a meta-analysis
Q37635275Proangiogenic effects of soluble α-Klotho on systemic sclerosis dermal microvascular endothelial cells
Q54237788Reduced Klotho is associated with the presence and severity of coronary artery disease.
Q59797891Renal Klotho is Reduced in Septic Patients and Pretreatment With Recombinant Klotho Attenuates Organ Injury in Lipopolysaccharide-Challenged Mice
Q42427220Role of Klotho in migration and proliferation of human dermal microvascular endothelial cells
Q38110755Role of ion transport in control of apoptotic cell death
Q26782946Significant roles of anti-aging protein klotho and fibroblast growth factor23 in cardiovascular disease
Q92663763Soluble Klotho is associated with mortality and cardiovascular events in hemodialysis
Q97681286Soluble Klotho, a biomarker and therapeutic strategy to reduce bronchopulmonary dysplasia and pulmonary hypertension in preterm infants
Q42640559Systemic and placental α-klotho: Effects of preeclampsia in the last trimester of gestation
Q51765638The association between soluble klotho and cardiovascular parameters in chronic kidney disease: results from the KNOW-CKD study.
Q28565261The erythropoietin receptor is a downstream effector of Klotho-induced cytoprotection
Q38730521The neuroprotective effect of latanoprost acts via klotho-mediated suppression of calpain activation after optic nerve transection
Q47592089The role of ubiquitination and deubiquitination in the regulation of cell junctions
Q36385420Transient receptor potential channel 1 maintains adherens junction plasticity by suppressing sphingosine kinase 1 expression to induce endothelial hyperpermeability.
Q26849317Transient receptor potential channels as drug targets: from the science of basic research to the art of medicine
Q36170493Update on vascular endothelial Ca(2+) signalling: A tale of ion channels, pumps and transporters
Q58127469Vitamin D Attenuates Endothelial Dysfunction in Uremic Rats and Maintains Human Endothelial Stability
Q38842548Xeno-Klotho Inhibits Parathyroid Hormone Signaling
Q38065309p120-Catenin: a novel regulator of innate immunity and inflammation
Q37204601p120catenin alteration in cancer and its role in tumour invasion.
Q33626706α-Klotho expression determines nitric oxide synthesis in response to FGF-23 in human aortic endothelial cells
Q39812781αKlotho and Chronic Kidney Disease
Q34078872αKlotho and vascular calcification: an evolving paradigm

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