The beta-glucuronidase klotho hydrolyzes and activates the TRPV5 channel

scientific article

The beta-glucuronidase klotho hydrolyzes and activates the TRPV5 channel is …
instance of (P31):
scholarly articleQ13442814

External links are
P819ADS bibcode2005Sci...310..490C
P356DOI10.1126/SCIENCE.1114245
P698PubMed publication ID16239475
P5875ResearchGate publication ID7527980

P2093author name stringChang Q
Bindels RJ
Hoenderop JG
van der Kemp AW
Hoefs S
Topala CN
P433issue5747
P407language of work or nameEnglishQ1860
P304page(s)490-493
P577publication date2005-10-01
P1433published inScienceQ192864
P1476titleThe beta-glucuronidase klotho hydrolyzes and activates the TRPV5 channel
P478volume310

Reverse relations

cites work (P2860)
Q42214079A helix-breaking mutation in the epithelial Ca(2+) channel TRPV5 leads to reduced Ca(2+)-dependent inactivation
Q24309111A missense mutation in the Kv1.1 voltage-gated potassium channel-encoding gene KCNA1 is linked to human autosomal dominant hypomagnesemia
Q46182549A population of selected renal cells augments renal function and extends survival in the ZSF1 model of progressive diabetic nephropathy
Q43072181A sensitive gel-based method combining distinct cyclophellitol-based probes for the identification of acid/base residues in human retaining β-glucosidases.
Q37943014A spoonful of sugar makes the melanoma go: the role of heparan sulfate proteoglycans in melanoma metastasis.
Q36491105A translocation causing increased alpha-klotho level results in hypophosphatemic rickets and hyperparathyroidism
Q47794863Ablation of klotho and premature aging: is 1,25-dihydroxyvitamin D the key middleman?
Q35574809Ablation of the p16(INK4a) tumour suppressor reverses ageing phenotypes of klotho mice
Q37319469Active Ca(2+) reabsorption in the connecting tubule
Q55089216Acute Adaption to Oral or Intravenous Phosphate Requires Parathyroid Hormone.
Q43239627Age-dependent changes in the expression of klotho protein, TRPV5 and TRPV6 in mouse inner ear.
Q37459100Ageing and vitamin D deficiency: effects on calcium homeostasis and considerations for vitamin D supplementation
Q38348935Aging and uremia: Is there cellular and molecular crossover?
Q57751778Agonistic β-Klotho antibody mimics fibroblast growth factor 21 (FGF21) functions
Q44037637Altered regulation of cytosolic Ca²⁺ concentration in dendritic cells from klotho hypomorphic mice
Q38454084Angiotensin II blockade: how its molecular targets may signal to mitochondria and slow aging. Coincidences with calorie restriction and mTOR inhibition
Q36049831Antiaging gene Klotho enhances glucose-induced insulin secretion by up-regulating plasma membrane levels of TRPV2 in MIN6 β-cells
Q26827655Arterial calcification in chronic kidney disease: key roles for calcium and phosphate
Q37404983Biochemical and functional characterization of the klotho-VS polymorphism implicated in aging and disease risk
Q26777149Biological Role of Anti-aging Protein Klotho
Q47989110Biology of Fibroblast Growth Factor 23: From Physiology to Pathology
Q37195350Bone disease in pediatric idiopathic hypercalciuria
Q37082368Calciotropic and magnesiotropic TRP channels
Q48038085Calcium Homeostasis in Health and in Kidney Disease
Q37091865Calcium and phosphate homeostasis: concerted interplay of new regulators
Q26863412Calcium regulation and bone mineral metabolism in elderly patients with chronic kidney disease
Q37072422Calcium-permeable ion channels in the kidney
Q38585448Capacitation-Associated Glycocomponents of Mammalian Sperm
Q36479676Cardioprotection by Klotho through downregulation of TRPC6 channels in the mouse heart
Q100440285Changes in Fibroblast Growth Factor 23 and Soluble Klotho Levels After Hemodialysis Initiation
Q37483194Changes in Serum Concentrations of Fibroblast Growth Factor 23 and Soluble Klotho in Hemodialysis Patients after Total Parathyroidectomy.
Q51104948Comparative proteome analysis of wild-type and klotho-knockout mouse kidneys using a combination of MALDI-IMS and LC-MS/MS.
Q37405002Complex N-glycosylation stabilizes surface expression of transient receptor potential melastatin 4b protein
Q35912924Conditional Deletion of Fgfr1 in the Proximal and Distal Tubule Identifies Distinct Roles in Phosphate and Calcium Transport.
Q33374711Conditional fast expression and function of multimeric TRPV5 channels using Shield-1.
Q50460870Coordinated regulation of TRPV5-mediated Ca²⁺ transport in primary distal convolution cultures.
Q35210184Cross talk between the renin-angiotensin-aldosterone system and vitamin D-FGF-23-klotho in chronic kidney disease
Q37087785Current understanding of klotho
Q83177528Decreased renal α-Klotho expression in early diabetic nephropathy in humans and mice and its possible role in urinary calcium excretion
Q52689816Deficient transient receptor potential vanilloid type 4 function contributes to compromised [Ca2+]i homeostasis in human autosomal-dominant polycystic kidney disease cells.
Q57717034Dehydration: a new modulator of klotho expression
Q27333726Deletion of PTH rescues skeletal abnormalities and high osteopontin levels in Klotho-/- mice
Q35841012Deregulated Renal Calcium and Phosphate Transport during Experimental Kidney Failure
Q38302200Development and characterization of monoclonal antibodies to detect klotho
Q35003219Dietary and genetic evidence for enhancing glucose metabolism and reducing obesity by inhibiting klotho functions
Q36472485Discovery of alpha-Klotho unveiled new insights into calcium and phosphate homeostasis
Q48821290Disorders of calcium metabolism
Q34629804Distal convoluted tubule
Q52975643Distal convoluted tubule.
Q34299107Down-regulation of Intestinal Apical Calcium Entry Channel TRPV6 by Ubiquitin E3 Ligase Nedd4-2
Q36016804Dynamics and Distribution of Klothoβ (KLB) and fibroblast growth factor receptor-1 (FGFR1) in living cells reveal the fibroblast growth factor-21 (FGF21)-induced receptor complex
Q41345368Effects of N-Glycosylation of the human cation channel TRPA1 on agonist-sensitivity.
Q90812884Elevated FGF23 and disordered renal mineral handling with reduced bone mineralization in chronically erythropoietin over-expressing transgenic mice
Q34005604Endocrine regulation of ageing
Q37007210Expression and function of the HNK-1 carbohydrate.
Q37318049Extracellular interactome of the FGF receptor-ligand system: complexities and the relative simplicity of the worm
Q41774411Extracellular pH dynamically controls cell surface delivery of functional TRPV5 channels
Q54960612FGF23 Actions on Target Tissues-With and Without Klotho.
Q90105707FGF23 Synthesis and Activity
Q42256983FGF23 acts directly on renal proximal tubules to induce phosphaturia through activation of the ERK1/2-SGK1 signaling pathway
Q42878661FGF23 and Klotho: the new cornerstones of phosphate/calcium metabolism
Q37996937FGF23 and PTH--double agents at the heart of CKD.
Q37584801FGF23 and syndromes of abnormal renal phosphate handling
Q36750178FGF23 as a calciotropic hormone
Q38087548FGF23 associated bone diseases
Q38728860FGF23 from bench to bedside.
Q28509196FGF23 promotes renal calcium reabsorption through the TRPV5 channel
Q36985772FGFR3 and FGFR4 do not mediate renal effects of FGF23.
Q30544587Fibroblast growth factor 23 and Klotho: physiology and pathophysiology of an endocrine network of mineral metabolism
Q93208168Fibroblast growth factor 23 and α-Klotho co-dependent and independent functions
Q28570342Fibroblast growth factor 23 enhances renal klotho abundance
Q28272364Fibroblast growth factors as tissue repair and regeneration therapeutics
Q37598664Flow-induced activation of TRPV5 and TRPV6 channels stimulates Ca(2+)-activated K(+) channel causing membrane hyperpolarization
Q38076051From bone abnormalities to mineral metabolism dysregulation in autosomal dominant polycystic kidney disease.
Q39997971Function and regulation of the Na+-Ca2+ exchanger NCX3 splice variants in brain and skeletal muscle.
Q39776568Functional analysis of the Kv1.1 N255D mutation associated with autosomal dominant hypomagnesemia.
Q38072903Gastric acid, calcium absorption, and their impact on bone health
Q36763582Genetic basis of renal cellular dysfunction and the formation of kidney stones
Q38244118Genetic diseases of renal phosphate handling
Q89161363Hyperphosphatemic familial tumoral calcinosis secondary to fibroblast growth factor 23 (FGF23) mutation: a report of two affected families and review of the literature
Q30437039Identification of calcium-binding proteins associated with the human sperm plasma membrane
Q38305115Identification of cleavage sites leading to the shed form of the anti-aging protein klotho
Q35916097Impaired basolateral sorting of pro-EGF causes isolated recessive renal hypomagnesemia
Q34780123Implications of Klotho in vascular health and disease.
Q33572351In vivo genetic evidence for suppressing vascular and soft-tissue calcification through the reduction of serum phosphate levels, even in the presence of high serum calcium and 1,25-dihydroxyvitamin d levels
Q28583360Increased parathyroid expression of klotho in uremic rats
Q58798347Inhibition of Transient Receptor Potential Vanilloid 6 channel, elevated in human ovarian cancers, reduces tumour growth in a xenograft model
Q52721559Interrelated role of Klotho and calcium-sensing receptor in parathyroid hormone synthesis and parathyroid hyperplasia.
Q36740455Is Klotho deficiency independently associated with cardiovascular risk in chronic kidney disease?
Q54382027KLOTHO gene polymorphism of G395A is associated with kidney stones.
Q38181483Kidney and calcium homeostasis
Q37591992Klotho
Q38732756Klotho Lacks an FGF23-Independent Role in Mineral Homeostasis
Q53595930Klotho RNAi induces premature senescence of human cells via a p53/p21 dependent pathway.
Q51745509Klotho ameliorates sepsis-induced acute kidney injury but is irrelevant to autophagy.
Q41900414Klotho and Na+,K+-ATPase activity: solving the calcium metabolism dilemma?
Q24654902Klotho and aging
Q38104935Klotho and chronic kidney disease
Q35582566Klotho and kidney disease
Q35033538Klotho and the aging process
Q37051351Klotho as a regulator of oxidative stress and senescence
Q35611229Klotho deficiency is an early biomarker of renal ischemia–reperfusion injury and its replacement is protective
Q28287609Klotho endows hepatoma cells with resistance to anoikis via VEGFR2/PAK1 activation in hepatocellular carcinoma
Q37678608Klotho has dual protective effects on cisplatin-induced acute kidney injury
Q26775409Klotho in cardiovascular disease: Current and future perspectives
Q34624546Klotho inhibits transforming growth factor-beta1 (TGF-beta1) signaling and suppresses renal fibrosis and cancer metastasis in mice
Q42078322Klotho is a substrate for alpha-, beta- and gamma-secretase
Q34320354Klotho is associated with VEGF receptor-2 and the transient receptor potential canonical-1 Ca 2+ channel to maintain endothelial integrity
Q28480498Klotho lacks a vitamin D independent physiological role in glucose homeostasis, bone turnover, and steady-state PTH secretion in vivo
Q88580595Klotho preservation by Rhein promotes toll-like receptor 4 proteolysis and attenuates lipopolysaccharide-induced acute kidney injury
Q41989687Klotho prevents renal calcium loss.
Q94600774Klotho rewires cellular metabolism of breast cancer cells through alteration of calcium shuttling and mitochondrial activity
Q48626410Klotho sensitivity of the hERG channel
Q54611511Klotho suppresses RIG-I-mediated senescence-associated inflammation.
Q91555930Klotho suppresses colorectal cancer through modulation of the unfolded protein response
Q34774466Klotho up-regulates renal calcium channel transient receptor potential vanilloid 5 (TRPV5) by intra- and extracellular N-glycosylation-dependent mechanisms
Q37396631Klotho variants and chronic hemodialysis mortality
Q26783185Klotho, stem cells, and aging
Q38842162Klotho, the Holy Grail of the kidney: from salt sensitivity to chronic kidney disease
Q28079797Klotho: a humeral mediator in CSF and plasma that influences longevity and susceptibility to multiple complex disorders, including depression
Q35870769Klotho: a novel and early biomarker of acute kidney injury after cardiac valve replacement surgery in adults
Q34072230Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule
Q37858474Klotho: a novel regulator of calcium and phosphorus homeostasis
Q39944675Klotho: a tumor suppressor and a modulator of the IGF-1 and FGF pathways in human breast cancer
Q26799745Klotho: a tumor suppressor and modulator of the Wnt/β-catenin pathway in human hepatocellular carcinoma
Q28291037Klotho: an antiaging protein involved in mineral and vitamin D metabolism
Q35053874Klotho: its various functions and association with sickle cell disease subphenotypes
Q46851255Laboratory aspects of circulating α-Klotho
Q37384718Latest findings in phosphate homeostasis
Q34252649Life extension factor klotho enhances cognition
Q34462326Life extension factor klotho prevents mortality and enhances cognition in hAPP transgenic mice
Q35813165Longevity factor klotho and chronic psychological stress
Q34493922Loss of Klotho during melanoma progression leads to increased filamin cleavage, increased Wnt5A expression, and enhanced melanoma cell motility.
Q36444555Low Plasma Klotho Concentrations and Decline of Knee Strength in Older Adults
Q52934731Membrane-bound Klotho is not expressed endogenously in healthy or uraemic human vascular tissue.
Q33982618Mineral metabolism and aging: the fibroblast growth factor 23 enigma
Q37371915Mining the depths: metabolic insights into mineral nutrition
Q38116835Modulation of voltage-gated ion channels by sialylation
Q35441666Molecular basis of Klotho: from gene to function in aging
Q37805923Molecular basis of epithelial Ca2+ and Mg2+ transport: insights from the TRP channel family
Q37448279Molecular genetics of parathyroid disease.
Q35059924Molecular regulation of phosphate metabolism by fibroblast growth factor-23-klotho system
Q51016091Monitoring for potential residual disease activity by serum insulin-like growth factor 1 and soluble Klotho in patients with acromegaly after pituitary surgery: is there an impact of the genomic deletion of exon 3 in the growth hormone receptor (d3-
Q30386353Mucin-1 Increases Renal TRPV5 Activity In Vitro, and Urinary Level Associates with Calcium Nephrolithiasis in Patients
Q38287732N-glycan content modulates kainate receptor functional properties
Q36052386N-glycosylation determines ionic permeability and desensitization of the TRPV1 capsaicin receptor.
Q33652154N-glycosylation determines the abundance of the transient receptor potential channel TRPP2
Q41842547N-glycosylation in regulation of the nervous system
Q39366129N-glycosylation of TRPM8 ion channels modulates temperature sensitivity of cold thermoreceptor neurons.
Q47132894New Insights into the Mechanism of Action of Soluble Klotho
Q36618101New insights into the pathogenesis of idiopathic hypercalciuria
Q39378500Novel roles for mucin 1 in the kidney
Q42541748Nuclear localization of Klotho in brain: an anti-aging protein
Q37559361Overview of the FGF23-Klotho axis
Q88062876P2X7 receptor and klotho expressions in diabetic nephropathy progression
Q42945861Parathyroid Klotho and FGF-receptor 1 expression decline with renal function in hyperparathyroid patients with chronic kidney disease and kidney transplant recipients
Q36425115Pathophysiology of the chronic kidney disease-mineral bone disorder
Q35546322Phosphate Metabolism in Cardiorenal Metabolic Disease
Q37224025Plasma Klotho and Cognitive Decline in Older Adults: Findings From the InCHIANTI Study
Q92524220Plasma Klotho concentration is associated with the presence, burden and progression of cerebral small vessel disease in patients with acute ischaemic stroke
Q36364310Plasma klotho and cardiovascular disease in adults
Q46946131Plasma klotho and frailty in older adults: Findings from the InCHIANTI Study
Q35127280Plasma klotho and mortality risk in older community-dwelling adults
Q36800779Plasma soluble α-klotho protein levels in premature and term neonates: correlations with growth and metabolic parameters
Q38327224Plasticity of renal endocrine function
Q38203371Post-Translational Modifications of TRP Channels
Q37126253Post-translational loss of renal TRPV5 calcium channel expression, Ca(2+) wasting, and bone loss in experimental colitis.
Q53151181Potential Role of Placental Klotho in the Pathogenesis of Preeclampsia.
Q40245905RGS2 inhibits the epithelial Ca2+ channel TRPV6.
Q34260123Reduced renal calcium excretion in the absence of sclerostin expression: evidence for a novel calcium-regulating bone kidney axis.
Q33492044Regulated and aberrant glycosylation modulate cardiac electrical signaling
Q38016324Regulated expression and neural functions of human natural killer-1 (HNK-1) carbohydrate.
Q26860470Regulation and function of the FGF23/klotho endocrine pathways
Q36472107Regulation of TRPV5 and TRPV6 by associated proteins
Q28279142Regulation of ion channels by secreted Klotho: mechanisms and implications
Q36649088Regulation of phosphate homeostasis by PTH, vitamin D, and FGF23.
Q37256511Regulation of phosphate transport in proximal tubules.
Q24658068Regulation of renal outer medullary potassium channel and renal K(+) excretion by Klotho
Q48672869Regulation of the Na+/K+ ATPase by Klotho
Q36450027Regulation of transport in the connecting tubule and cortical collecting duct
Q36212506Relationship of low plasma klotho with poor grip strength in older community-dwelling adults: the InCHIANTI study
Q36775194Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1
Q36417890Renal Production, Uptake, and Handling of Circulating αKlotho
Q35976038Renal adaptation to gentamicin-induced mineral loss
Q36672616Renal and extrarenal actions of Klotho
Q37201509Renal senescence in 2008: progress and challenges
Q49865594Role of FGF23 in Pediatric Hypercalciuria
Q35318410Role of Klotho in aging, phosphate metabolism, and CKD.
Q36703547Role of renal TRP channels in physiology and pathology
Q38420343Role of the transient receptor potential vanilloid 5 (TRPV5) protein N terminus in channel activity, tetramerization, and trafficking
Q26768186Roles of the kidney in the formation, remodeling and repair of bone
Q37190542Secreted klotho and chronic kidney disease
Q38012604Sensing mechanisms involved in Ca2+ and Mg2+ homeostasis.
Q36008059Serum 25-Hydroxyvitamin D, Plasma Klotho, and Lower-Extremity Physical Performance Among Older Adults: Findings From the InCHIANTI Study
Q64117609Serum klotho: a potential predictor of cerebrovascular disease in hemodialysis patients
Q45014648Serum levels of soluble secreted α-Klotho are decreased in the early stages of chronic kidney disease, making it a probable novel biomarker for early diagnosis
Q38855334Shedding of klotho by ADAMs in the kidney
Q38152465Significance of the anti-aging protein Klotho
Q34394061Small-molecule Klotho enhancers as novel treatment of neurodegeneration
Q35550609Soluble Klotho Protects against Uremic Cardiomyopathy Independently of Fibroblast Growth Factor 23 and Phosphate
Q34941418Soluble Klotho is not independently associated with cardiovascular disease in a population of dialysis patients
Q38861058Soluble extracellular Klotho decreases sensitivity to cigarette smoke induced cell death in human lung epithelial cells
Q37612604Soluble klotho binds monosialoganglioside to regulate membrane microdomains and growth factor signaling
Q91823533Soluble klotho regulates TRPC6 calcium signaling via lipid rafts, independent of the FGFR-FGF23 pathway
Q33988884Soluble α-klotho as a novel biomarker in the early stage of nephropathy in patients with type 2 diabetes
Q89473460Structure-function relationships of the soluble form of the antiaging protein Klotho have therapeutic implications for managing kidney disease
Q37739046Systemic klotho is associated with KLOTHO variation and predicts intrinsic cortical connectivity in healthy human aging
Q24312097TRP channel-associated factors are a novel protein family that regulates TRPM8 trafficking and activity
Q29616673TRP channels
Q38111283TRP channels
Q35915824TRP channels and Ca2+ signaling
Q37205820TRPV5: an ingeniously controlled calcium channel
Q92383138TRPV6 as A Target for Cancer Therapy
Q36280331Targeted deletion of Klotho in kidney distal tubule disrupts mineral metabolism.
Q52905611Targeted deletion of murine Cldn16 identifies extra- and intrarenal compensatory mechanisms of Ca2+ and Mg2+ wasting.
Q36933339The FGF family: biology, pathophysiology and therapy
Q39006777The FGF23 and Klotho system beyond mineral metabolism.
Q30836888The First Extracellular Linker Is Important for Several Aspects of the Gating Mechanism of Human TRPA1 Channel.
Q93222971The Klotho proteins in health and disease
Q44125135The Xenopus TRPV6 homolog encodes a Mg(2+) -permeant channel that is inhibited by interaction with TRPC1.
Q38983596The aging suppressor klotho: a potential regulator of growth hormone secretion
Q39979858The beta-glucuronidase klotho exclusively activates the epithelial Ca2+ channels TRPV5 and TRPV6.
Q39101623The chronic kidney disease - Mineral bone disorder (CKD-MBD): Advances in pathophysiology
Q34568579The cooperation of FGF receptor and Klotho is involved in excretory canal development and regulation of metabolic homeostasis in Caenorhabditis elegans.
Q38545213The dynamic skeleton
Q37710161The effect of nephrectomy on Klotho, FGF-23 and bone metabolism
Q42666228The epithelial calcium channel TRPV5 is regulated differentially by klotho and sialidase
Q34121153The identification of Histidine 712 as a critical residue for constitutive TRPV5 internalization
Q48100012The impact of klotho gene polymorphisms on urinary tract stone disease.
Q34260105The kidney is the principal organ mediating klotho effects
Q50096271The klotho-related protein KLPH (lctl) has preferred expression in lens and is essential for expression of clic5 and normal lens suture formation
Q38730521The neuroprotective effect of latanoprost acts via klotho-mediated suppression of calpain activation after optic nerve transection
Q28572613The parathyroid is a target organ for FGF23 in rats
Q37802467The renal connecting tubule: Resolved and unresolved issues in Ca2+ transport
Q36992839The role of Klotho in energy metabolism
Q57801450The role of klotho in chronic kidney disease
Q38197055The role of protein N-glycosylation in neural transmission
Q37527790The role of transient receptor potential channels in kidney disease
Q39235785The role of vitamin D in the endocrinology controlling calcium homeostasis
Q38774298Tissue kallikrein stimulates Ca(2+) reabsorption via PKC-dependent plasma membrane accumulation of TRPV5.
Q85000782Tissue transglutaminase inhibits the TRPV5-dependent calcium transport in an N-glycosylation-dependent manner
Q26849317Transient receptor potential channels as drug targets: from the science of basic research to the art of medicine
Q36266724Tumor necrosis factor and interferon-gamma down-regulate Klotho in mice with colitis
Q36979830Uromodulin upregulates TRPV5 by impairing caveolin-mediated endocytosis
Q35204874Variation in longevity gene KLOTHO is associated with greater cortical volumes
Q34621641Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects.
Q24310130WNK3 positively regulates epithelial calcium channels TRPV5 and TRPV6 via a kinase-dependent pathway
Q38786641Ways of calcium reabsorption in the kidney.
Q37198480What do we know about the transient receptor potential vanilloid 2 (TRPV2) ion channel?
Q39107200X-linked hypophosphatemia and growth.
Q38842548Xeno-Klotho Inhibits Parathyroid Hormone Signaling
Q86277253[FGF23 and the heart]
Q50001744α-Klotho is a non-enzymatic molecular scaffold for FGF23 hormone signalling
Q55263123α-Klotho's effects on mineral homeostasis are fibroblast growth factor-23 dependent.
Q37758405β-Glucosidases.
Q34073956β1-Adrenergic receptor signaling activates the epithelial calcium channel, transient receptor potential vanilloid type 5 (TRPV5), via the protein kinase A pathway