Elevated FGF23 and disordered renal mineral handling with reduced bone mineralization in chronically erythropoietin over-expressing transgenic mice

scientific article published on 18 October 2019

Elevated FGF23 and disordered renal mineral handling with reduced bone mineralization in chronically erythropoietin over-expressing transgenic mice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S41598-019-51577-Z
P932PMC publication ID6802194
P698PubMed publication ID31628396

P50authorCarsten A. WagnerQ57045232
P2093author name stringMax Gassmann
Udo Schnitzbauer
Carla Bettoni
Arezoo Daryadel
Luciano Natale
Petra Seebeck
P2860cites workBone tissue as a systemic endocrine regulatorQ26825306
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Nitric oxide prevents cardiovascular disease and determines survival in polyglobulic mice overexpressing erythropoietinQ35328384
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Colocalization of the (Pro)renin Receptor/Atp6ap2 with H+-ATPases in Mouse Kidney but Prorenin Does Not Acutely Regulate Intercalated Cell H+-ATPase ActivityQ35908500
Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1Q36775194
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The beta-glucuronidase klotho hydrolyzes and activates the TRPV5 channelQ40359636
Spleen contributes significantly to increased circulating levels of fibroblast growth factor 23 in response to lipopolysaccharide-induced inflammation.Q40478704
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The intestinal phosphate transporter NaPi-IIb (Slc34a2) is required to protect bone during dietary phosphate restrictionQ41477711
Erythropoietin stimulates murine and human fibroblast growth factor-23, revealing novel roles for bone and bone marrowQ45109843
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FGF23 expression in rodents is directly induced via erythropoietin after inhibition of hypoxia inducible factor proline hydroxylaseQ47099652
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Excessive erythrocytosis in adult mice overexpressing erythropoietin leads to hepatic, renal, neuronal, and muscular degenerationQ48544000
α-Klotho is a non-enzymatic molecular scaffold for FGF23 hormone signallingQ50001744
Acute blood loss stimulates fibroblast growth factor 23 production.Q50197535
Erythropoietin induces bone marrow and plasma fibroblast growth factor 23 during acute kidney injuryQ50209133
Coordinated regulation of TRPV5-mediated Ca²⁺ transport in primary distal convolution cultures.Q50460870
Inhibition of fibroblast growth factor 23 (FGF23) signaling rescues renal anemia.Q52685153
Renal expression of FGF23 and peripheral resistance to elevated FGF23 in rodent models of polycystic kidney disease.Q53074041
Transgenic mice overexpressing erythropoietin adapt to excessive erythrocytosis by regulating blood viscosityQ57109221
The elevation of circulating fibroblast growth factor 23 without kidney disease does not increase cardiovascular disease riskQ57314982
Expression of Na-P(i) cotransport in rat kidney: localization by RT-PCR and immunohistochemistryQ71626282
Chronic inborn erythrocytosis leads to cardiac dysfunction and premature death in mice overexpressing erythropoietinQ73387927
Abortion in mice with excessive erythrocytosis is due to impaired arteriogenesis of the uterine arcadeQ80650182
Erythropoietin administration is associated with short-term improvement in glomerular filtration rate after ischemia-reperfusion injuryQ83176720
Secreted Klotho and FGF23 in chronic kidney disease Stage 1 to 5: a sequence suggested from a cross-sectional studyQ85370116
Hepatic Production of Fibroblast Growth Factor 23 in Autosomal Dominant Polycystic Kidney DiseaseQ88265833
Erythropoietin stimulates fibroblast growth factor 23 (FGF23) in mice and menQ89370041
Expression and localization of fibroblast growth factor (FGF)23 and Klotho in the spleen: its physiological and functional implicationsQ89950540
Effects of erythropoietin on fibroblast growth factor 23 in mice and humansQ90209853
P433issue1
P304page(s)14989
P577publication date2019-10-18
P1433published inScientific ReportsQ2261792
P1476titleElevated FGF23 and disordered renal mineral handling with reduced bone mineralization in chronically erythropoietin over-expressing transgenic mice
P478volume9